The translational landscape of mTOR signalling steers cancer initiation and metastasis

Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling

Ingolia, N. T., Ghaemmaghami, S., Newman, J. R. S., & Weissman, J. S. (2009) · Science · doi:10.1126/science.1168978 · Cited by 3,853 · see citing works

Integrative Genomic Profiling of Human Prostate Cancer

Taylor, B. S., Schultz, N. D., Hieronymus, H., Gopalan, A., Xiao, Y., Carver, B. S., Arora, V. K., Kaushik, P., Cerami, E. G., Reva, B. A., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.05.026 · Cited by 3,653 · see citing works

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.

Kim, D.-H., Sarbassov, D., Ali, S. M., King, J. E., Latek, R., Erdjument-Bromage, H., Tempst, P., & Sabatini, D. (2002) · Cell · doi:10.1016/s0092-8674(02)00808-5 · Cited by 3,135 · see citing works

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

Sarbassov, D. D., Ali, S. M., Kim, D.-H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P., & Sabatini, D. M. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.054 · Cited by 2,665 · see citing works

Regulation of translation initiation by FRAP/mTOR

Gingras, A.-C., Raught, B., & Sonenberg, N. (2001) · Genes & Development · doi:10.1101/gad.887201 · Cited by 1,545 · see citing works

SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity

Jacinto, E., Facchinetti, V., Liu, D., Soto, N., Wei, S., Jung, S. Y., Huang, Q., Qin, J., & Su, B. (2006) · Cell · doi:10.1016/j.cell.2006.08.033 · Cited by 1,407 · see citing works

The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

Liu, C., Kelnar, K., Liu, B., Chen, X., Calhoun‐Davis, T., Li, H., Patrawala, L., Yan, H., Jeter, C. R., Honorio, S., et al. (2011) · Nature Medicine · doi:10.1038/nm.2284 · Cited by 1,401 · see citing works

MicroRNA-10a binds the 5’UTR of ribosomal protein mRNAs and enhances their translation

Ørom, U. A., Nielsen, F. C., & Lund, A. H. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.05.001 · Cited by 1,384 · see citing works

Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

Wang, S., Gao, J., Lei, Q., Rozengurt, N., Pritchard, C., Jiao, J., Thomas, G. V., Li, G., Roy-Burman, P., Nelson, P. S., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00215-0 · Cited by 1,109 · see citing works

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

Feldman, M. E., Apsel, B., Uotila, A., Loewith, R., Knight, Z. A., Ruggero, D., & Shokat, K. M. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000038 · Cited by 1,080 · see citing works

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathwayPreprint

Gingras, A., Kennedy, S. G., O'Leary, M., Sonenberg, N., & Hay, N. (1998) · Genes & Development · doi:10.1101/gad.12.4.502 · Cited by 885 · see citing works

Ribosomal protein S6 phosphorylation: from protein synthesis to cell size

Ruvinsky, I., & Meyuhas, O. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.04.003 · Cited by 780 · see citing works

A luminal epithelial stem cell that is a cell of origin for prostate cancer

Wang, X., Julio, M. K., Economides, K. D., Walker, D., Yu, H., Halili, M. V., Hu, Y.-P., Price, S. M., Abate-Shen, C. T., & Shen, M. M. (2009) · Nature · doi:10.1038/nature08361 · Cited by 734 · see citing works

mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs

Dowling, R. J. O., Topisirović, I., Alain, T., Bidinosti, M., Fonseca, B. D., Petroulakis, E., Wang, X., Larsson, O. S., Selvaraj, A., Liu, Y., et al. (2010) · Science · doi:10.1126/science.1187532 · Cited by 726 · see citing works

Control of p70 S6 kinase by kinase activity of FRAP in vivo

Brown, E. J., Beal, P. A., Keith, C. T., Chen, J., Shin, T. B., & Schreiber, S. L. (1995) · Nature · doi:10.1038/377441a0 · Cited by 705 · see citing works

The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

Ruggero, D., Montanaro, L., Ma, L., Xu, W. G., Londei, P., Cordon‐Cardo, C., & Pandolfi, P. P. (2004) · Nature Medicine · doi:10.1038/nm1042 · Cited by 592 · see citing works

Synthesis of the translational apparatus is regulated at the translational level.

Meyuhas, O. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01719.x · Cited by 570 · see citing works

eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression

Furic, L., Rong, L., Larsson, O. S., Koumakpayi, I. H., Yoshida, K., Brueschke, A., Petroulakis, E., Robichaud, N., Pollak, M., Gaboury, L. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005320107 · Cited by 528 · see citing works

Genetic Dissection of the Oncogenic mTOR Pathway Reveals Druggable Addiction to Translational Control via 4EBP-eIF4E

Hsieh, A. C., Costa, M. D., Zollo, O., Davis, C. B., Feldman, M. E., Testa, J. R., Meyuhas, O., Shokat, K. M., & Ruggero, D. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.01.021 · Cited by 464 · see citing works

Translational Activation of Snail1 and Other Developmentally Regulated Transcription Factors by YB-1 Promotes an Epithelial-Mesenchymal Transition

Evdokimova, V. E., Tognon, C. E., Ng, T., Ruzanov, P., Melnyk, N., Fink, D., Sorokin, A. V., Ovchinnikov, L. P., Davicioni, E., Triche, T. J., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.03.017 · Cited by 444 · see citing works

Generation of a prostate from a single adult stem cell

Leong, K. G., Wang, B.-E., Johnson, L., & Gao, W. (2008) · Nature · doi:10.1038/nature07427 · Cited by 420 · see citing works

mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice

Guertin, D. A., Stevens, D. M., Saitoh, M., Kinkel, S., Crosby, K., Sheen, J.-H., Mullholland, D. J., Magnuson, M. A., Wu, H., & Sabatini, D. M. (2009) · Cancer Cell · doi:10.1016/j.ccr.2008.12.017 · Cited by 402 · see citing works

Amino Acid-Induced Translation of TOP mRNAs Is Fully Dependent on Phosphatidylinositol 3-Kinase-Mediated Signaling, Is Partially Inhibited by Rapamycin, and Is Independent of S6K1 and rpS6 Phosphorylation

Tang, H., Hornstein, E., Stolovich, M., Levy, G., Livingstone, M., Templeton, D. J., Avruch, J., & Meyuhas, O. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.24.8671-8683.2001 · Cited by 304 · see citing works

Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells

Sutherland, B. W., Kucab, J. E., Wu, J., Lee, C., Cheang, M. C. U., Yorida, E., Turbin, D. A., Dedhar, S., Nelson, C. C., Pollak, M., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1208590 · Cited by 299 · see citing works

Inhibitor hijacking of Akt activation

Okuzumi, T., Fiedler, D., Zhang, C., Gray, D. C., Aizenstein, B., Hoffman, R., & Shokat, K. M. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.183 · Cited by 294 · see citing works

Basal epithelial stem cells are efficient targets for prostate cancer initiation

Lawson, D. A., Yang, Z., Memarzadeh, S., Li, X., Huang, J.-T., & Witte, O. (2010) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0913873107 · Cited by 291 · see citing works

Vimentin organization modulates the formation of lamellipodia

Helfand, B. T., Mendez, M. G., Murthy, S. N. P., Shumaker, D. K., Grin, B., Mahammad, S., Aebi, U., Wedig, T., Wu, Y., Hahn, K. M., et al. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-08-0699 · Cited by 261 · see citing works

Predictors of Prostate Cancer–Specific Mortality After Radical Prostatectomy or Radiation Therapy

Zhou, P., Chen, M., McLeod, D. G., Carroll, P. R., Moul, J. W., & D'Amico, A. V. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.01.2906 · Cited by 202 · see citing works

Metastasis‐associated protein 1 enhances stability of hypoxia‐inducible factor‐1α protein by recruiting histone deacetylase 1

Yoo, Y., Kong, G., & Lee, M. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601025 · Cited by 200 · see citing works

Isolation, cultivation and characterization of adult murine prostate stem cells

Lukacs, R. U., Goldstein, A. S., Lawson, D. A., Cheng, D., & Witte, O. N. (2010) · Nature Protocols · doi:10.1038/nprot.2010.11 · Cited by 196 · see citing works

Global and Specific Translational Control by Rapamycin in T Cells Uncovered by Microarrays and Proteomics

Grolleau‐Julius, A., Bowman, J., Pradet‐Balade, B., Puravs, E., Hanash, S., García‐Sanz, J. A., & Beretta, L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202014200 · Cited by 187 · see citing works

Lin−Sca-1+CD49fhigh Stem/Progenitors Are Tumor-Initiating Cells in the Pten -Null Prostate Cancer Model

Mulholland, D. J., Xin, L., Morim, A., Lawson, D. A., Witte, O. N., & Wu, H. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4673 · Cited by 179 · see citing works

Enhanced expression of vimentin in motile prostate cell lines and in poorly differentiated and metastatic prostate carcinoma

Lang, S., Hyde, C., Reid, I. N., Hitchcock, I. S., Hart, C. A., Bryden, A. A. G., Villette, J., Stower, M. J., & Maitland, N. J. (2002) · The Prostate · doi:10.1002/pros.10088 · Cited by 168 · see citing works

The Role of Metastasis-Associated Protein 1 in Prostate Cancer Progression

Hofer, M. D., Kuefer, R., Varambally, S., Li, H., Ma, J., Shapiro, G. I., Gschwend, J. E., Hautmann, R. E., Sanda, M. G., Giehl, K., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2755 · Cited by 130 · see citing works

La protein has a positive effect on the translation of TOP mRNAs in vivo

Crosio, C. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.15.2927 · Cited by 96 · see citing works

Differential Requirement of mTOR in Postmitotic Tissues and Tumorigenesis

Nardella, C., Carracedo, A., Alimonti, A., Hobbs, R. M., Clohessy, J. G., Chen, Z., Egia, A., Fornari, A., Fiorentino, M., Loda, M. F., et al. (2009) · Science Signaling · doi:10.1126/scisignal.2000189 · Cited by 77 · see citing works

Prognostic Factors in Localized Prostatic Carcinoma

Pontes, J. E., Wajsman, Z., Huben, R. P., Wolf, R. M., & Englander, L. S. (1985) · The Journal of Urology · doi:10.1016/s0022-5347(17)47659-2 · Cited by 68 · see citing works

Pilot Study of Rapamycin in Patients with Hormone-Refractory Prostate Cancer

Amato, R. J., Jac, J., Mohammad, T., & Saxena, S. (2008) · Clinical Genitourinary Cancer · doi:10.3816/cgc.2008.n.015 · Cited by 57 · see citing works

Translation initiation factors and active sites of protein synthesis co-localize at the leading edge of migrating fibroblasts

Willett, M., Brocard, M., David, A., & Morley, S. (2011) · Biochemical Journal · doi:10.1042/bj20110435 · Cited by 39 · see citing works

mTOR Signaling in Growth, Metabolism, and Disease

Saxton, R. A., & Sabatini, D. M. (2017) · Cell · doi:10.1016/j.cell.2017.02.004 · Cited by 7,555 · see citing works

Regulation of type I interferon responses

Ivashkiv, L. B., & Donlin, L. T. (2013) · Nature reviews. Immunology · doi:10.1038/nri3581 · Cited by 3,311 · see citing works

On the Dependency of Cellular Protein Levels on mRNA Abundance

Liu, Y., Beyer, A., & Aebersold, R. (2016) · Cell · doi:10.1016/j.cell.2016.03.014 · Cited by 3,221 · see citing works

mTOR at the nexus of nutrition, growth, ageing and disease

Liu, G. Y., & Sabatini, D. M. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0199-y · Cited by 2,737 · see citing works

PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer

Glaviano, A., Foo, A. S. C., Lam, H. Y., Yap, K. C. H., Jacot, W., Jones, R. H., Eng, H., Nair, M. G., Makvandi, P., Geoerger, B., et al. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01827-6 · Cited by 2,138 · see citing works

The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism

Hoxhaj, G., & Manning, B. D. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0216-7 · Cited by 2,137 · see citing works

Small molecules in targeted cancer therapy: advances, challenges, and future perspectives

Zhong, L., Li, Y., Xiong, L., Wang, W., Wu, M., Yuan, T., Yang, W. M., Tian, C., Miao, Z., Wang, T., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00572-w · Cited by 1,735 · see citing works

PI3K and cancer: lessons, challenges and opportunities

Fruman, D. A., & Rommel, C. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4204 · Cited by 1,716 · see citing works

The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments

Ingolia, N. T., Brar, G. A., Rouskin, S., McGeachy, A. M., & Weissman, J. S. (2012) · Nature Protocols · doi:10.1038/nprot.2012.086 · Cited by 1,240 · see citing works

mTOR as a central hub of nutrient signalling and cell growth

Kim, J., & Guan, K. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0205-1 · Cited by 1,067 · see citing works

Making new contacts: the mTOR network in metabolism and signalling crosstalk

Shimobayashi, M., & Hall, M. N. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3757 · Cited by 1,053 · see citing works

Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease

Panwar, V., Singh, A., Bhatt, M., Tonk, R. K., Azizov, S., Raza, A. S., Sengupta, S., Kumar, D., & Garg, M. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01608-z · Cited by 967 · see citing works

mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges

Zou, Z., Tao, T., Li, H., & Zhu, X. M. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-00396-1 · Cited by 930 · see citing works

The lysosome as a cellular centre for signalling, metabolism and quality control

Lawrence, R. E., & Zoncu, R. (2019) · Nature Cell Biology · doi:10.1038/s41556-018-0244-7 · Cited by 920 · see citing works

mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation

Morita, M., Gravel, S.-P., Chénard, V., Sikström, K., Zheng, L., Alain, T., Gandin, V., Avizonis, D., Arguello, M., Zakaria, C., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.10.001 · Cited by 842 · see citing works

Regulation of innate immune cell function by mTOR

Weichhart, T., Hengstschläger, M., & Linke, M. (2015) · Nature reviews. Immunology · doi:10.1038/nri3901 · Cited by 836 · see citing works

Codon optimality, bias and usage in translation and mRNA decay

Hanson, G., & Coller, J. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.91 · Cited by 825 · see citing works

Glucose–TOR signalling reprograms the transcriptome and activates meristems

Xiong, Y., McCormack, M., Li, L., Hall, Q., Xiang, C., & Sheen, J. (2013) · Nature · doi:10.1038/nature12030 · Cited by 811 · see citing works

Ribosome biogenesis in cancer: new players and therapeutic avenues

Pelletier, J., Thomas, G., & Volarević, S. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.104 · Cited by 802 · see citing works

Targeting the translation machinery in cancer

Bhat, M., Robichaud, N., Hulea, L., Sonenberg, N., Pelletier, J., & Topisirovic, I. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4505 · Cited by 799 · see citing works

BM mesenchymal stromal cell–derived exosomes facilitate multiple myeloma progression

Roccaro, A. M., Sacco, A., Maiso, P., Azab, A. K., Tai, Y., Reagan, M. R., Azab, F., Flores, L. M., Campigotto, F., Weller, E. A., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66517 · Cited by 794 · see citing works

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

Herranz, N., Gallage, S., Mellone, M., Wuestefeld, T., Klotz, S., Hanley, C. J., Raguz, S., Acosta, J. C., Innes, A. J., Banito, A., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3225 · Cited by 788 · see citing works

Signal integration by mTORC1 coordinates nutrient input with biosynthetic output

Dibble, C. C., & Manning, B. D. (2013) · Nature Cell Biology · doi:10.1038/ncb2763 · Cited by 716 · see citing works

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

Egan, D. F., Chun, M. G. H., Vamos, M., Zou, H., Rong, J., Miller, C. J., Lou, H. J., Raveendra-Panickar, D., Yang, C.-C., Sheffler, D. J., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.05.031 · Cited by 715 · see citing works

Specialized ribosomes: a new frontier in gene regulation and organismal biology

Xue, S., & Barna, M. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3359 · Cited by 687 · see citing works

Haematopoietic stem cells require a highly regulated protein synthesis rate

Signer, R. A. J., Magee, J. A., Salic, A., & Morrison, S. J. (2014) · Nature · doi:10.1038/nature13035 · Cited by 674 · see citing works

mTORC1 signaling and the metabolic control of cell growth

Ben‐Sahra, I., & Manning, B. D. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.02.012 · Cited by 641 · see citing works

Ribosome profiling: new views of translation, from single codons to genome scale

Ingolia, N. T. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3645 · Cited by 636 · see citing works

RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer

Wolfe, A. L., Singh, K., Zhong, Y., Drewe, P., Rajasekhar, V. K., Sanghvi, V. R., Mavrakis, K. J., Jiang, M., Roderick, J. E., Van der Meulen, J., et al. (2014) · Nature · doi:10.1038/nature13485 · Cited by 635 · see citing works

The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly

Sidrauski, C., McGeachy, A. M., Ingolia, N. T., & Walter, P. (2015) · eLife · doi:10.7554/elife.05033 · Cited by 616 · see citing works

mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review

Weichhart, T. (2018) · Gerontology · doi:10.1159/000484629 · Cited by 596 · see citing works

mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy

Tian, T., Li, X., & Zhang, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030755 · Cited by 581 · see citing works

mTOR coordinates protein synthesis, mitochondrial activity and proliferation

Morita, M., Gravel, S.-P., Hulea, L., Larsson, O., Pollak, M., St-Pierre, J., & Topisirovic, I. (2015) · Cell Cycle · doi:10.4161/15384101.2014.991572 · Cited by 552 · see citing works

Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis

Wenes, M., Shang, M., Di Matteo, M., Goveia, J., Martín-Pérez, R., Serneels, J., Prenen, H., Ghesquière, B., Carmeliet, P., & Mazzone, M. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.008 · Cited by 496 · see citing works

Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy

Rehman, S. K., Haynes, J., Collignon, E., Brown, K. R., Wang, Y., Nixon, A. M. L., Bruce, J. P., Wintersinger, J. A., Singh Mer, A., Lo, E. B. L., et al. (2021) · Cell · doi:10.1016/j.cell.2020.11.018 · Cited by 495 · see citing works

A Dual Program for Translation Regulation in Cellular Proliferation and Differentiation

Gingold, H., Tehler, D., Christoffersen, N. R., Nielsen, M. M., Asmar, F., Kooistra, S. M., Christophersen, N. S., Christensen, L. L., Borre, M., Sørensen, K. D., et al. (2014) · Cell · doi:10.1016/j.cell.2014.08.011 · Cited by 487 · see citing works

mTOR: Role in cancer, metastasis and drug resistance

Murugan, A. K. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.07.003 · Cited by 483 · see citing works

Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor

Rodrik-Outmezguine, V. S., Okaniwa, M., Yao, Z., Novotny, C. J., McWhirter, C., Banaji, A., Won, H., Wong, W., Berger, M., de Stanchina, E., et al. (2016) · Nature · doi:10.1038/nature17963 · Cited by 479 · see citing works

CGG Repeat-Associated Translation Mediates Neurodegeneration in Fragile X Tremor Ataxia Syndrome

Todd, P. K., Oh, S. Y., Krans, A., He, F., Sellier, C., Frazer, M. A., Renoux, A. J., Chen, K.-C., Scaglione, K. M., Basrur, V., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.03.026 · Cited by 471 · see citing works

Inhibition of the PI3K/AKT/mTOR Pathway in Solid Tumors

LoRusso, P. M. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2014.59.0018 · Cited by 467 · see citing works

Picking the Point of Inhibition: A Comparative Review of PI3K/AKT/mTOR Pathway Inhibitors

Dienstmann, R., Rodon, J. A., Serra, V., & Tabernero, J. M. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0639 · Cited by 464 · see citing works

Dynamic profiling of the protein life cycle in response to pathogens

Jovanovic, M., Rooney, M. S., Mertins, P., Przybylski, D., Chevrier, N., Satija, R., Rodriguez, E. H., Fields, A. P., Schwartz, S., Raychowdhury, R., et al. (2015) · Science · doi:10.1126/science.1259038 · Cited by 460 · see citing works

mTOR in aging, metabolism, and cancer

Cornu, M., Albert, V., & Hall, M. N. (2013) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2012.12.005 · Cited by 446 · see citing works

PI3K signaling in cancer: beyond AKT

Lien, E. C., Dibble, C. C., & Toker, A. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.02.007 · Cited by 446 · see citing works

mTORC1 and mTORC2 in cancer and the tumor microenvironment

Kim, L. C., Cook, R. S., & Chen, J. (2016) · Oncogene · doi:10.1038/onc.2016.363 · Cited by 443 · see citing works

<scp>mTOR</scp> , metabolism, and the regulation of T‐cell differentiation and function

Waickman, A. T., & Powell, J. D. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01152.x · Cited by 420 · see citing works

Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis

Khajuria, R. K., Munschauer, M., Ulirsch, J. C., Fiorini, C., Ludwig, L. S., McFarland, S. K., Abdulhay, N. J., Specht, H., Keshishian, H., Mani, D. R., et al. (2018) · Cell · doi:10.1016/j.cell.2018.02.036 · Cited by 416 · see citing works

Ibrutinib Unmasks Critical Role of Bruton Tyrosine Kinase in Primary CNS Lymphoma

Grommes, C., Pastore, A., Palaskas, N. J., Tang, S. S. K., Campos, C., Schartz, D. A., Codega, P., Nichol, D., Clark, O., Hsieh, W.-Y., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-0613 · Cited by 410 · see citing works

mTORC2 Promotes Tumorigenesis via Lipid Synthesis

Guri, Y., Colombi, M., Dazert, E., Hindupur, S. K., Roszik, J., Moes, S., Jenoe, P., Heim, M. H., Riezman, I., Riezman, H., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.11.011 · Cited by 410 · see citing works

Nutrient signaling to mTOR and cell growth

Jewell, J. L., & Guan, K. (2013) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.01.004 · Cited by 407 · see citing works

Regulation of cancer cell metabolism: Oncogenic MYC in the driver’s seat

Dong, Y., Tu, R., Liu, H., & Qing, G. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00235-2 · Cited by 405 · see citing works

Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics

Leppek, K., Byeon, G. W., Kladwang, W., Wayment-Steele, H. K., Kerr, C. H., Xu, A. F., Kim, D. S., Topkar, V. V., Choe, C., Rothschild, D., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28776-w · Cited by 399 · see citing works

Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics

Leppek, K., Byeon, G. W., Kladwang, W., Wayment-Steele, H. K., Kerr, C. H., Xu, A. F., Kim, D. S., Topkar, V. V., Choe, C., Rothschild, D., et al. (2021) · doi:10.1101/2021.03.29.437587 · Cited by 399 · see citing works

Improved ribosome-footprint and mRNA measurements provide insights into dynamics and regulation of yeast translation

Weinberg, D. E., Shah, P., Eichhorn, S. W., Hussmann, J. A., Plotkin, J. B., & Bartel, D. P. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.01.043 · Cited by 392 · see citing works

mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3

Dodd, K. M., Yang, J., Shen, M. H., Sampson, J. R., & Tee, A. R. (2014) · Oncogene · doi:10.1038/onc.2014.164 · Cited by 391 · see citing works

<scp>YB</scp> ‐1 protein: functions and regulation

Lyabin, D. N., Eliseeva, I. A., & Ovchinnikov, L. P. (2014) · WIREs RNA · doi:10.1002/wrna.1200 · Cited by 381 · see citing works

New frontiers in translational control of the cancer genome

Truitt, M. L., & Ruggero, D. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.27 · Cited by 378 · see citing works

Differential Requirements for eIF4E Dose in Normal Development and Cancer

Truitt, M., Conn, C. S., Shi, Z., Pang, X., Tokuyasu, T. A., Coady, A. M., Seo, Y., Barna, M., & Ruggero, D. (2015) · Cell · doi:10.1016/j.cell.2015.05.049 · Cited by 374 · see citing works

Targeting the eIF4F Translation Initiation Complex: A Critical Nexus for Cancer Development

Pelletier, J., Graff, J., Ruggero, D., & Sonenberg, N. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-2789 · Cited by 367 · see citing works

mTOR complexes in neurodevelopmental and neuropsychiatric disorders

Costa-Mattioli, M., & Monteggia, L. M. (2013) · Nature Neuroscience · doi:10.1038/nn.3546 · Cited by 367 · see citing works

Translational Control in Cancer EtiologyPreprint

Ruggero, D. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012336 · Cited by 362 · see citing works

eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation

Lee, A. S. Y., Kranzusch, P. J., Doudna, J. A., & Cate, J. H. D. (2016) · Nature · doi:10.1038/nature18954 · Cited by 358 · see citing works

Oncogenic Roles of the PI3K/AKT/mTOR axis

Aoki, M., & Fujishita, T. (2017) · Current topics in microbiology and immunology · doi:10.1007/82_2017_6 · Cited by 355 · see citing works

Elucidating Compound Mechanism of Action by Network Perturbation Analysis

Woo, J. H., Shimoni, Y., Yang, W. S., Subramaniam, P., Iyer, A., Nicoletti, P., Rodríguez Martínez, M., López, G., Mattioli, M., Realubit, R., et al. (2015) · Cell · doi:10.1016/j.cell.2015.05.056 · Cited by 351 · see citing works

Translational control in synaptic plasticity and cognitive dysfunction

Buffington, S. A., Huang, W., & Costa-Mattioli, M. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014100 · Cited by 348 · see citing works

The Role of PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma Metabolism

Tian, L., Smit, D. J., & Jücker, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032652 · Cited by 345 · see citing works

Translation of 5′ leaders is pervasive in genes resistant to eIF2 repression

Andreev, D. E., O’Connor, P. B. F., Fahey, C., Kenny, E. M., Terenin, I. M., Dmitriev, S. E., Cormican, P., Morris, D. W., Shatsky, I. N., & Baranov, P. V. (2015) · eLife · doi:10.7554/elife.03971 · Cited by 338 · see citing works

Inhibition of mTORC1 by Astrin and Stress Granules Prevents Apoptosis in Cancer Cells

Thedieck, K., Holzwarth, B., Prentzell, M. T., Boehlke, C. S., Kläsener, K., Ruf, S., Sonntag, A., Maerz, L. D., Grellscheid, S., Kremmer, E., et al. (2013) · Cell · doi:10.1016/j.cell.2013.07.031 · Cited by 334 · see citing works

Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines

Pickard, M. R., Mourtada‐Maarabouni, M., & Williams, G. T. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.005 · Cited by 331 · see citing works

Translation from unconventional 5′ start sites drives tumour initiation

Sendoel, A., Dunn, J. G., Rodriguez, E. H., Naik, S., Gomez, N. C., Hurwitz, B. S., Levorse, J. M., Dill, B. D., Schramek, D., Molina, H., et al. (2017) · Nature · doi:10.1038/nature21036 · Cited by 330 · see citing works

Signaling Pathways Involved in the Regulation of mRNA Translation

Roux, P. P., & Topisirović, I. (2018) · Molecular and Cellular Biology · doi:10.1128/mcb.00070-18 · Cited by 314 · see citing works

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance

McCubrey, J. A., Steelman, L. S., Chappell, W. H., Abrams, S. L., Franklin, R. A., Montalto, G., Cervello, M., Libra, M., Candido, S., Malaponte, G., et al. (2012) · Oncotarget · doi:10.18632/oncotarget.659 · Cited by 313 · see citing works

Mechanisms of mitochondrial respiratory adaptation

Bennett, C. F., Latorre‐Muro, P., & Puigserver, P. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00506-6 · Cited by 313 · see citing works

Targeting the PI3K/Akt/mTOR pathway in castration-resistant prostate cancer

Bitting, R. L., & Armstrong, A. J. (2013) · Endocrine Related Cancer · doi:10.1530/erc-12-0394 · Cited by 311 · see citing works

RNA N6-Methyladenosine Methyltransferase METTL3 Facilitates Colorectal Cancer by Activating the m6A-GLUT1-mTORC1 Axis and Is a Therapeutic Target

Chen, H., Gao, S., Liu, W., Wong, C.-C., Wu, J., Wu, J., Liu, D., Gou, H., Kang, W., Zhai, J., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.11.013 · Cited by 308 · see citing works

Lipid Catabolism via CPT1 as a Therapeutic Target for Prostate Cancer

Schlaepfer, I. R., Rider, L. C., Rodrigues, L. U., Gijón, M. A., Pac, C. T., Romero, L. M., Cimic, A., Sirintrapun, S. J., Glodé, L. M., Eckel, R. H., et al. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-14-0183 · Cited by 306 · see citing works

Erratum: New frontiers in translational control of the cancer genome

Truitt, M., & Ruggero, D. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.30 · Cited by 306 · see citing works

mTOR signaling in cellular and organismal energetics

Albert, V., & Hall, M. N. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.12.001 · Cited by 304 · see citing works

Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor

Iwasaki, S., Floor, S. N., & Ingolia, N. T. (2016) · Nature · doi:10.1038/nature17978 · Cited by 304 · see citing works

mTORC1-mediated translational elongation limits intestinal tumour initiation and growth

Faller, W. J., Jackson, T. J., Knight, J. R. P., Ridgway, R. A., Jamieson, T. J., Karim, S. A., Jones, C., Radulescu, S., Huels, D. J., Myant, K., et al. (2014) · Nature · doi:10.1038/nature13896 · Cited by 302 · see citing works

Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes

Takahara, T., Amemiya, Y., Sugiyama, R., Maki, M., & Shibata, H. (2020) · Journal of Biomedical Science · doi:10.1186/s12929-020-00679-2 · Cited by 300 · see citing works

Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation

Su, X., Yu, Y., Zhong, Y., Giannopoulou, E. G., Hu, X., Liu, H., Cross, J. R., Rätsch, G., Rice, C. M., & Ivashkiv, L. B. (2015) · Nature Immunology · doi:10.1038/ni.3205 · Cited by 298 · see citing works

Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression

Ericksen, R. E., Lim, S. L., McDonnell, E., Shuen, W. H., Vadiveloo, M. K., White, P. J., Ding, Z., Kwok, R., Lee, P., Radda, G. K., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.12.020 · Cited by 295 · see citing works

Molecular logic of mTORC1 signalling as a metabolic rheostat

Valvezan, A. J., & Manning, B. D. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0038-7 · Cited by 295 · see citing works

Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers

Pourdehnad, M., Truitt, M., Siddiqi, I. N., Ducker, G. S., Shokat, K. M., & Ruggero, D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310230110 · Cited by 288 · see citing works

Ribosome Profiling: Global Views of TranslationPreprint

Ingolia, N. T., Hussmann, J. A., & Weissman, J. S. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a032698 · Cited by 285 · see citing works

Inhibition of mTOR induces a paused pluripotent state

Bulut-Karslioglu, A., Biechele, S., Jin, H., Macrae, T. A., Hejna, M., Gertsenstein, M., Song, J. S., & Ramalho-Santos, M. (2016) · Nature · doi:10.1038/nature20578 · Cited by 283 · see citing works

Tight Coordination of Protein Translation and HSF1 Activation Supports the Anabolic Malignant State

Santagata, S., Mendillo, M. L., Tang, Y., Subramanian, A., Perley, C. C., Roche, S. P., Wong, B., Narayan, R., Kwon, H., Koeva, M., et al. (2013) · Science · doi:10.1126/science.1238303 · Cited by 281 · see citing works

Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis

El-Naggar, A. M., Veinotte, C. J., Cheng, H., Grünewald, T. G. P., Negri, G. L., Somasekharan, S. P., Corkery, D., Tirode, F., Mathers, J. A., Khan, D., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.04.003 · Cited by 280 · see citing works

System wide analyses have underestimated protein abundances and the importance of transcription in mammals

Li, J. J., Bickel, P. J., & Biggin, M. D. (2014) · PeerJ · doi:10.7717/peerj.270 · Cited by 279 · see citing works

Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program

Chauvin, C., Koka, V., Nouschi, A., Mieulet, V., Hoareau‐Aveilla, C., Dreazen, A., Cagnard, N., Carpentier, W., Kiss, T., Meyuhas, O., et al. (2013) · Oncogene · doi:10.1038/onc.2012.606 · Cited by 279 · see citing works

YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1

Somasekharan, S. P., El-Naggar, A. M., Leprivier, G., Cheng, H., Hajee, S., Grünewald, T. G. P., Zhang, F., Ng, T., Delattre, O., Evdokimova, V. E., et al. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201411047 · Cited by 279 · see citing works

PI3K-AKT-mTOR signaling in prostate cancer progression and androgen deprivation therapy resistance

Hsieh, A., & Edlind, M. P. (2014) · Asian Journal of Andrology · doi:10.4103/1008-682x.122876 · Cited by 275 · see citing works

The plasticity of mRNA translation during cancer progression and therapy resistance

Fabbri, L., Chakraborty, A., Robert, C., & Vagner, S. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00380-y · Cited by 273 · see citing works

The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease

Goul, C., Peruzzo, R., & Zoncu, R. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00641-8 · Cited by 269 · see citing works

DawnRank: discovering personalized driver genes in cancer

Hou, J. P., & Ma, J. (2014) · Genome Medicine · doi:10.1186/s13073-014-0056-8 · Cited by 268 · see citing works

Macrophage polarization in diabetic wound healing

Wu, X., He, W., Mu, X., Liu, Y., Deng, J., Liu, Y., & Nie, X. (2022) · Burns & Trauma · doi:10.1093/burnst/tkac051 · Cited by 268 · see citing works

The Role of mTOR Signaling as a Therapeutic Target in Cancer

Popova, N. V., & Jücker, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041743 · Cited by 267 · see citing works

MTOR inhibitors in cancer therapy

Xie, J., Wang, X., & Proud, C. G. (2016) · F1000Research · doi:10.12688/f1000research.9207.1 · Cited by 266 · see citing works

La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1)

Fonseca, B. D., Zakaria, C., Jia, J.-J., Graber, T. E., Svitkin, Y. V., Tahmasebi, S., Healy, D., Hoang, H., Jensen, J. M., Diao, I. T., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.621730 · Cited by 264 · see citing works

The director's cut

Gentilella, A., & Thomas, G. (2012) · Nature · doi:10.1038/485050a · Cited by 29 · see citing works

Profiling the translational targets of mTOR signalling

Burgess, D. J. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3216

Translation initiation: a critical signalling node in cancer

Robert, F., & Pelletier, J. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220903241625 · Cited by 48 · see citing works

P39. Rapamycin and the downstream target of mTOR, ribosomal protein L29 (RPL29), regulate prostate cancer cell growth and bone metastatic potential

Schwarting-Opdenaker, L., Carson, D. D., & Farach‐Carson, M. C. (2008) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2008.03.081

Abstract A49: Transcription factor upregulation after mTOR inhibition by Torin1 induces growth factor receptor expression

Yang, T. T., Negri, G. L., Kristensen, A. M., & Sorensen, P. H. B. (2017) · Cancer Research · doi:10.1158/1538-7445.transcontrol16-a49