The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Interactions between JARID2 and Noncoding RNAs Regulate PRC2 Recruitment to Chromatin
Open accessAbstract
Summary JARID2 is an accessory component of Polycomb repressive complex-2 (PRC2) required for the differentiation of embryonic stem cells (ESCs). A role for JARID2 in the recruitment of PRC2 to target genes silenced during differentiation has been put forward, but the molecular details remain unclear. We identified a 30-amino acid region of JARID2 that mediates interactions with long noncoding RNAs (lncRNAs) and found that the presence of lncRNAs stimulated JARID2–EZH2 interactions in vitro and JARID2-mediated recruitment of PRC2 to chromatin in vivo. Native and crosslinked RNA immunoprecipitations of JARID2 revealed that Meg3 and other lncRNAs from the imprinted Dlk1-Dio3 locus, an important regulator of development, interacted with PRC2 via JARID2. Lack of MEG3 expression in human induced pluripotent cells altered the chromatin distribution of JARID2, PRC2, and H3K27me3. Our findings show that lncRNAs facilitate JARID2–PRC2 interactions on chromatin and suggest a mechanism by which lncRNAs contribute to PRC2 recruitment.
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Cites
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Cited by
RNA Binding to CBP Stimulates Histone Acetylation and Transcription
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The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan
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Metadata
- Authors
- Kaneko, S., Bonasio, R., Saldaña-Meyer, R., Yoshida, T., Son, J., Nishino, K., Umezawa, A., & Reinberg, D.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 53
- Issue
- 2
- Pages
- 290-300
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2136696487
- Cited by
- 371
- References
- 49
- FWCI
- 16.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kaneko, S., Bonasio, R., Saldaña-Meyer, R., Yoshida, T., Son, J., Nishino, K., Umezawa, A., & Reinberg, D. (2014). Interactions between JARID2 and Noncoding RNAs Regulate PRC2 Recruitment to Chromatin. Molecular Cell. https://doi.org/10.1016/j.molcel.2013.11.012
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