The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Assessing the ceRNA Hypothesis with Quantitative Measurements of miRNA and Target Abundance
Open accessAbstract
SUMMARY Recent studies have reported that competitive endogenous RNAs (ceRNAs) can act as sponges for a microRNA (miRNA) through their binding sites and that changes in ceRNA abundances from individual genes can modulate the miRNA’s activity. Consideration of this hypothesis would benefit from knowing the quantitative relationship between a miRNA and its endogenous target sites. Here, we altered intracellular target-site abundance through expression of a miR-122 target in hepatocytes and livers, and analyzed the effects on miR-122 target genes. Target repression was released in a threshold-like manner at high target-site abundance (≥1.5×105 added target sites per cell), and this threshold was insensitive to the effective levels of the miRNA. Furthermore, in response to extreme metabolic liver disease models, global target-site abundance of hepatocytes did not change sufficiently to affect miRNA-mediated repression. Thus, modulation of miRNA target abundance is unlikely to cause significant effects on gene expression and metabolism through a ceRNA effect.
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Self-citationCircular RNAs are a large class of animal RNAs with regulatory potency
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Predicting effective microRNA target sites in mammalian mRNAs
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The biogenesis, biology and characterization of circular RNAs
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Metadata
- Authors
- Denzler, R., Agarwal, V., Stefano, J., Bartel, D. P., & Stoffel, M.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 54
- Issue
- 5
- Pages
- 766-776
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2037691883
- Cited by
- 713
- References
- 13
- FWCI
- 20.12
- Type
- journal article
- Language
- en
- Open access
- bronze
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