The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Regulatory Interactions between RNA and Polycomb Repressive Complex 2
Open accessAbstract
SUMMARY Polycomb repressive complex 2 (PRC2) is a histone methyltransferase that is localized to thousands of mammalian genes. Though important to human disease and as a drug target, how PRC2 is recruited remains unclear. One model invokes cis-regulatory RNA. Herein, we biochemically and functionally probe PRC2’s recognition of RNA using the X-inactivation model. We observe surprisingly high discriminatory capabilities. While SUZ12 and JARID2 subunits can bind RNA, EZH2 has highest affinity and is somewhat promiscuous. EED regulates the affinity of EZH2 for RNA, lending greater specificity to PRC2-RNA interactions. Intriguingly, while RNA is crucial for targeting, RNA inhibits EZH2’s catalytic activity. JARID2 weakens PRC2’s binding to RNA and relieves catalytic inhibition. We propose that RNA guides PRC2 to its target, but inhibits its enzymatic activity until PRC2 associates with JARID2 on chromatin. Our study provides a molecular view of regulatory interactions between RNA and PRC2 at the chromatin interface.
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Cites
The Polycomb complex PRC2 and its mark in life
Margueron, R., & Reinberg, D. (2011) · Nature · doi:10.1038/nature09784 · Cited by 3,347
Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
Tsai, M.-C., Manor, O., Wan, Y., Mosammaparast, N., Wang, J. K., Lan, F., Shi, Y., Segal, E., & Chang, H. Y. (2010) · Science · doi:10.1126/science.1192002 · Cited by 3,290 · cited 1×
“Likewise, PRC2 shifted the first 300 nt of human HOTAIR (mHotair 1– 310, hHOTAIR 1–300) containing the domain shown to contact PRC2 (Kaneko et al., 2010; Tsai et al., 2010; Wu et al., 2013).”
Khalil, A. M., Guttman, M., Huarte, M., Garber, M., Raj, A., Rivea Morales, D., Thomas, K., Presser, A., Bernstein, B. E., van Oudenaarden, A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904715106 · Cited by 2,872
Yap, K. L., Li, S., Muñoz-Cabello, A. M., Raguz, S., Zeng, L., Mujtaba, S., Gil, J., Walsh, M. J., & Zhou, M.-M. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.03.021 · Cited by 1,391
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Self-citationGenome Regulation by Polycomb and Trithorax: 70 Years and Counting
Schuettengruber, B., Bourbon, H.-M., Di Croce, L., & Cavalli, G. (2017) · Cell · doi:10.1016/j.cell.2017.08.002 · Cited by 1,094
Integrated lncRNA function upon genomic and epigenomic regulation
Herman, A. B., Tsitsipatis, D., & Gorospe, M. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.05.027 · Cited by 747
Regulation of gene expression by cis-acting long non-coding RNAs
Gil, N., & Ulitsky, I. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-019-0184-5 · Cited by 720
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Metadata
- Authors
- Cifuentes-Rojas, C., Hernandez, A. J., Sarma, K., & Lee, J. T.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 55
- Issue
- 2
- Pages
- 171-185
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2033586326
- Cited by
- 283
- References
- 4
- FWCI
- 14.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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