The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.
Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed
Open accessAbstract
Circular RNAs (circRNAs) are an endogenous class of animal RNAs. Despite their abundance, their function and expression in the nervous system are unknown. Therefore, we sequenced RNA from different brain regions, primary neurons, isolated synapses, as well as during neuronal differentiation. Using these and other available data, we discovered and analyzed thousands of neuronal human and mouse circRNAs. circRNAs were extraordinarily enriched in the mammalian brain, well conserved in sequence, often expressed as circRNAs in both human and mouse, and sometimes even detected in Drosophila brains. circRNAs were overall upregulated during neuronal differentiation, highly enriched in synapses, and often differentially expressed compared to their mRNA isoforms. circRNA expression correlated negatively with expression of the RNA-editing enzyme ADAR1. Knockdown of ADAR1 induced elevated circRNA expression. Together, we provide a circRNA brain expression atlas and evidence for important circRNA functions and values as biomarkers.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Many circRNAs are significantly upregulated at different time points of neuron maturation in vitro.293”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [293]
In the citing paper
“They are highly expressed in the brain from the embryonic stage to adulthood and substantially upregulated during the differentiation and maturation of neurons.293”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [293]
In the citing paper
“CircRNAs maintain specificity and conservatism in the process of dynamic expression and are highly enriched in the mammalian brain, independent of linear transcripts [62].”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [62]
In the citing paper
“CiRS-7 is abundantly expressed in the mammalian brain [49,62], where it increases the translation of the miR-7 target mRNA [14,49].”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [62]
In the citing paper
“A study by Rybak et al. demonstrated that more than half of 15,849 mouse circRNAs, which are highly abundant, conserved, and dynamically expressed in the brain, are upregulated during the maturation of neurons [62,65].”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [62]
In the citing paper
“Compared with other cytoplasmic RNAs, circRNAs seem to be more prone to being localized in synapses and their expression is correlated with neural plasticity, which further supports an important function of circRNAs in synaptic transmission [50,62].”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [62]
Citations
Cites
An integrated encyclopedia of DNA elements in the human genome
The ENCODE Project Consortium (2012) · Nature · doi:10.1038/nature11247 · Cited by 18,072
Circular RNAs are a large class of animal RNAs with regulatory potency
Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S. D., Gregersen, L. H., Munschauer, M., et al. (2013) · Nature · doi:10.1038/nature11928 · Cited by 7,990
Self-citationNatural RNA circles function as efficient microRNA sponges
Hansen, T. B., Jensen, T. I., Clausen, B. H., Bramsen, J. B., Finsen, B., Damgaard, C. K., & Kjems, J. (2013) · Nature · doi:10.1038/nature11993 · Cited by 7,985
Combinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603
Self-citationCircular RNAs are abundant, conserved, and associated with ALU repeats
Jeck, W. R., Sorrentino, J. A., Wang, K., Slevin, M. K., Burd, C. E., Liu, J., Marzluff, W. F., & Sharpless, N. E. (2013) · RNA · doi:10.1261/rna.035667.112 · Cited by 4,388
circRNA biogenesis competes with pre-mRNA splicing
Ashwal-Fluss, R., Meyer, M., Pamudurti, N. R., Ivanov, A., Bartok, O., Hanan, M., Evantal, N., Memczak, S., Rajewsky, N., & Kadener, S. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.019 · Cited by 3,083
Self-citationDetecting and characterizing circular RNAs
Jeck, W. R., & Sharpless, N. E. (2014) · Nature Biotechnology · doi:10.1038/nbt.2890 · Cited by 2,710
Detection of nonneutral substitution rates on mammalian phylogenies
Pollard, K. S., Hubisz, M. J., Rosenbloom, K. R., & Siepel, A. (2010) · Genome Research · doi:10.1101/gr.097857.109 · Cited by 2,353
Salzman, J., Gawad, C., Wang, P. L., Lacayo, N., & Brown, P. O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030733 · Cited by 2,239
The RNA Binding Protein Quaking Regulates Formation of circRNAs
Conn, S. J., Pillman, K. A., Toubia, J., Conn, V. M., Salmanidis, M., Phillips, C. A., Roslan, S., SCHREIBER, A. W., Gregory, P. A., & Goodall, G. J. (2015) · Cell · doi:10.1016/j.cell.2015.02.014 · Cited by 2,205
Flagged first, then by citations
1 of the 40 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Gray, 1960, The isolation of synaptic vesicles from the central nervous system, J. Physiol., 153, 35
Cited by
Sorted by citations
Items 801–900 of 1,003
Regulation of Non-Coding RNA in the Growth and Development of Skeletal Muscle in Domestic Chickens
Shi, H., He, Y., Li, X., Du, Y., Zhao, J., & Ge, C. (2022) · Genes · doi:10.3390/genes13061033 · Cited by 34
Filippenkov, I. B., Sudarkina, O. Y., Limborska, S. A., & Dergunova, L. V. (2015) · RNA Biology · doi:10.1080/15476286.2015.1076611 · Cited by 34
“A high content of circRNAs has been shown in the human and murine brain.(20,21,23) There is evidence that circRNAs may exist at different levels in various brain parts.”
BackgroundMethodTeng, L., Chen, Y., Chen, H., He, X., Wang, J., Peng, Y., Duan, H., Li, H., Lin, D., & Shao, B. (2017) · Oncotarget · doi:10.18632/oncotarget.22349 · Cited by 34
“Recently, researchers have found that circRNAs are involved in the development of many diseases, such as atherosclerosis and nervous system diseases [14].”
BackgroundCell Type-Selective Expression of Circular RNAs in Human Pancreatic Islets
Kaur, S., Mirza, A. H., & Pociot, F. (2018) · Non-Coding RNA · doi:10.3390/ncrna4040038 · Cited by 34
“circRNAs are a highly abundant, conserved, stable, and highly regulated phenomenon across many species [12,13].”
BackgroundLi, J., Shi, Q., Wang, Q., Tan, X., Pang, K., Liu, X., Zhu, S., Xi, K., Zhang, J., Gao, Q., et al. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.02.032 · Cited by 34
Epigenetics of the Synapse in Neurodegeneration
Xylaki, M., Atzler, B., & Outeiro, T. F. (2019) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-019-0995-y · Cited by 36
Cocaine induces differential circular RNA expression in striatum
Bu, Q., Long, H., Shao, X., Gu, H., Kong, J., Luo, L., Liu, B., Guo, W., Wang, H., Tian, J., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0527-1 · Cited by 34
Circ0004390 promotes cell proliferation through sponging miR-198 in ovarian cancer
Xu, F., Ni, M., Li, J., Cheng, J., Zhao, H., Zhao, J., Huang, S., & Wu, X. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.03.024 · Cited by 32
Insights into the role of circular RNA in macrophage activation and fibrosis disease
Xu, M., Xie, F., Tang, X., Wang, T., & Wang, S.-J. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104777 · Cited by 34
Zhang, Y., Guo, X., Pei, J., Chu, M., Ding, X., Wu, X., Liang, C., & Yan, P. (2020) · Genes · doi:10.3390/genes11040414 · Cited by 34
“The continued discoveries of functional circRNAs showed that circRNAs as a transcriptional product had an essential role in various tissues and cell types of animals [8,31,36].”
BackgroundRole of Circular RNAs in Cardiovascular Disease
Kishore, R., Garikipati, V. N. S., & González, C. (2020) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000841 · Cited by 35
Construction of a circRNA-Related ceRNA Prognostic Regulatory Network in Breast Cancer
Song, H., Sun, J., Kong, W., Ji, Y., Xu, D., & Wang, J. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s266507 · Cited by 34
Role of circRNAs in neurodevelopment and neurodegenerative diseases
Li, J., Sun, C., Cui, H., Sun, J., & Zhou, P. (2021) · Journal of Molecular Neuroscience · doi:10.1007/s12031-021-01882-y · Cited by 36
“In particular, it has been demonstrated that circRNAs are abundant and dynamically expressed in the nervous system in association with neuronal diseases, and are highly conserved among different species (Rybak-Wolf et al. 2015; Veno et al. 2015).”
BackgroundInfluentialLiu, W., & Cheng, F. (2021) · Bioengineered · doi:10.1080/21655979.2021.1982310 · Cited by 33
“With the emergence and development of high-throughput sequencing technologies, more and more circRNAs have been found to be abnormally expressed in carcinomas and other diseases [24].”
BackgroundLiao, W., Du, J., Li, L., Wu, X. Y., Chen, X., Feng, Q., Xu, L., Chen, X., Liao, M., Huang, J., et al. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02699-w · Cited by 38
“This special structure renders circRNAs particularly resistant to RNase degradation and more stable [15].”
BackgroundPathophysiology of Ischemic Stroke: Noncoding RNA Role in Oxidative Stress
Su, Z., Ye, Y., Shen, C., Qiu, S., Sun, Y., Hu, S., Xiong, X., Li, Y., Li, L., & Wang, H. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/5815843 · Cited by 36
“Stroke. circRNAs (single-stranded and conserved RNA molecules) are formed by the cleavage of many primary RNA transcripts that synthesize mRNA [109].”
Li, H. R., Jiang, Y., Hu, J., Xu, J., Chen, L., Zhang, G., Zhao, J., Zong, S., Guo, Z., Li, X., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05556-y · Cited by 37
“DISCUSSION CircRNAs are newly discovered non-coding RNAs with highly stable that are abundant in the brain [32].”
BackgroundJi, Y., Ni, C., Shen, Y., Xu, Z., Tang, L., Yu, F., Zhu, L., Lu, H., Zhang, C., Yang, S., et al. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02056-1 · Cited by 33
“Among them, six circRNAs have been confirmed by four independent sequencing datasets: Jeck 2013 [17], Maass 2017 [18], Rybak 2015 [19], and Salzman 2013 [20].”
BackgroundZC3H14 facilitates backsplicing by binding to exon-intron boundary and 3′ UTR
Li, Q., Yang, G., Ren, B., Liu, X., Tang, L., Shi, Q., Shan, G., & Wang, X. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.10.001 · Cited by 34
Circular RNA in Aging and Age-Related Diseases
Yang, D., Yang, K., & Yang, M. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1117-8_2 · Cited by 33
Circular RNAs as Biomarkers for Cancer
Xia, L., Song, M., Sun, M., Wang, F., & Yang, C. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1426-1_14 · Cited by 33
Fan, B., Chen, F., Li, Y., Wang, Z., Wang, Z., Lu, Y., Wu, Z., Jian, J., & Wang, B. (2019) · Molecular Omics · doi:10.1039/c9mo00025a · Cited by 33
Yang, L., Bin, Z., Hui, S., Li, R., You, B., Wu, P., Han, X., Qian, H., & Xu, W. (2019) · Stem Cells International · doi:10.1155/2019/2316834 · Cited by 31
“High-throughput sequencing technology has revealed that circRNAs are expressed in a cell type- and cell stage-specific manner, serving a critical role in eukaryotes [15, 16].”
BackgroundCapelari, É. F., da Fonseca, G. C., Guzmán, F., & Margis, R. (2019) · Plants · doi:10.3390/plants8090302 · Cited by 34
“In addition, circRNAs exhibited development-specific, tissue-specific and cell type-specific expression in animals, suggesting a regulatory role [18,30,31].”
BackgroundLu, C., Chen, B., Chen, C., Li, H., Wang, D., Tan, Y., & Weng, H. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14863 · Cited by 33
Feng, D., Wang, Z., Zhao, Y., Yang, L., Liu, D., Chen, Z., Ning, S., Hu, Y. W., Yao, J., & Tian, X. (2020) · Theranostics · doi:10.7150/thno.44250 · Cited by 33
“These endogenous ncRNAs display high tissue-specific expression and are generally more stable than their linear counterparts because they lack accessible ends and are thus resistant to exonucleases [21-23].”
BackgroundChen, C., Zhang, M., & Zhang, Y. (2020) · Cell Transplantation · doi:10.1177/0963689720961070 · Cited by 33
Circular RNA repertoires are associated with evolutionarily young transposable elements
Gruhl, F., Janich, P., Kaessmann, H., & Gatfield, D. (2021) · eLife · doi:10.7554/elife.67991 · Cited by 32
“At first sight, this outcome is at odds with previous reports of higher circRNA conservation that were, however, frequently based on more restricted cross-species datasets (e.g. comparison human-mouse in Rybak-Wolf et al. (2015)).”
InfluentialLuminal breast cancer-specific circular RNAs uncovered by a novel tool for data analysis
Tarrero, L. C., Ferrero, G., Miano, V., Intinis, C. D., Ricci, L., Arigoni, M., Riccardo, F., Annaratone, L., Castellano, I., Calogero, R., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.24522 · Cited by 34
“Some proteins have also been related Oncotarget14581www.impactjournals.com/oncotarget to biogenesis of circRNAs like ADAR1 [7] or Quaking [8].”
BackgroundCao, S.-M., Wu, H., Yuan, G.-H., Pan, Y.-H., Zhang, J., Liu, Y.-X., Li, S., Xu, Y.-F., Wei, M.-Y., Yang, L. C., et al. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.05.011 · Cited by 33
Mafi, A., Khoshnazar, S. M., Shahpar, A., Nabavi, N., Hedayati, N., Alimohammadi, M., Hashemi, M., Taheriazam, A., & Farahani, N. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155442 · Cited by 33
Vidal, A. F., Ribeiro-dos-Santos, A. M., Vinasco‐Sandoval, T., de Magalhães, L. L., Pinto, P., Anaissi, A. K. M., Demachki, S., de Assumpção, P. P., dos Santos, S. E. B., & Ribeiro‐dos‐Santos, Â. (2017) · Scientific Reports · doi:10.1038/s41598-017-15061-w · Cited by 32
Circular RNAs as Novel Biomarkers for Cardiovascular Diseases
Zhou, Q., Zhang, Z., Bei, Y., Li, G., & Wang, T. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1426-1_13 · Cited by 32
Circular RNAs Serve as Novel Biomarkers and Therapeutic Targets in Cancers
Fang, S., Pan, J., Zhou, C., Tian, H., He, J., Shen, W., Jin, X., Meng, X., Jiang, N., & Gong, Z. (2018) · Current Gene Therapy · doi:10.2174/1566523218666181109142756 · Cited by 32
Association of circular RNAs and environmental risk factors with coronary heart disease
Sun, Y., Chen, R., Lin, S., Xie, X., Ye, H., Zheng, F., Lin, J., Huang, Q., Huang, S., Ruan, Q., et al. (2019) · BMC Cardiovascular Disorders · doi:10.1186/s12872-019-1191-3 · Cited by 32
Wang, H., Zhang, J., Xu, Z., Yang, J., Xu, Y., Liu, Y., Li, B., Xie, J., & Li, J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00278 · Cited by 31
Han, B., Shaolong, E., Luan, L., Li, N., & Liu, X. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s251436 · Cited by 32
Hsa_circ_0044226 knockdown attenuates progression of pulmonary fibrosis by inhibiting CDC27
Qi, F., Li, Y., Yang, X. F., Wu, Y., Lin, L., & Liu, X. (2020) · Aging · doi:10.18632/aging.103543 · Cited by 32
Meng, L., Jia, X., Yu, W., Wang, C., Chen, J., & Liu, F. (2020) · Cancer Cell International · doi:10.1186/s12935-020-01436-z · Cited by 32
Ma, Y., Xu, Y., Zhang, J., & Zheng, L. (2020) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-020-00653-5 · Cited by 33
“Similar methods were used to detect 10, 032 circRNAs from 2974 host genes in human preimplantation embryos on the basis of differentially expressed genes [38].”
BackgroundMethodCircular RNA circ_HECTD1 regulates cell injury after cerebral infarction by miR-27a-3p/FSTL1 axis
Zhang, Z., He, J.-B., & Wang, B. (2021) · Cell Cycle · doi:10.1080/15384101.2021.1909885 · Cited by 33
CircRNAs: Decrypting the novel targets of fibrosis and aging
Yang, Y., Lei, W., Jiang, S., Ding, B., Wang, C., Chen, Y., Shi, W., Wu, Z., & Tian, Y. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101390 · Cited by 32
Circular RNAs in Alzheimer’s Disease: A New Perspective of Diagnostic and Therapeutic Targets
Vakili, O., Asili, P., Babaei, Z., Mirahmad, M., Keshavarzmotamed, A., Asemi, Z., & Mafi, A. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220829164211 · Cited by 34
miR-142: A Master Regulator in Hematological Malignancies and Therapeutic Opportunities
Huang, W., Paul, D., Călin, G. A., & Bayraktar, R. (2023) · Cells · doi:10.3390/cells13010084 · Cited by 35
“Still, CRISPR-Cas9 has disadvantages.”
Computational approaches and challenges in the analysis of circRNA data
Digby, B., Finn, S. P., & Broin, P. Ó. (2024) · BMC Genomics · doi:10.1186/s12864-024-10420-0 · Cited by 32
“These foundational works ushered in a plethora of novel research on circRNAs characterising their origin, biogenesis, structure and functions [23–26]. circRNAs exhibit stage and tissue-specific expression [27–29] and are enriched in exosomes [30].”
BackgroundMethodProfiling of the Predicted Circular RNAs in Ductal In Situ and Invasive Breast Cancer: A Pilot Study
Galasso, M., Costantino, G., Pasquali, L., Minotti, L., Baldassari, F., Corrà, F., Agnoletto, C., & Volinia, S. (2016) · International Journal of Genomics · doi:10.1155/2016/4503840 · Cited by 31
“The majority of circRNAs often exhibit tissue/developmental-stage-specific expression, described recently for the brain [13].”
RNA Editing and Retrotransposons in Neurology
Krestel, H. E., & Meier, J. C. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00163 · Cited by 32
“CircRNAs were indeed shown to be upregulated during neuronal differentiation and after ADAR1 siRNA knockdown in neuroblastoma cells (Rybak-Wolf et al., 2015).”
BackgroundSystematic investigation of circular RNAs in Ascosphaera apis, a fungal pathogen of honeybee larvae
Guo, R., Chen, D., Chen, H., Fu, Z., Xiong, C., Hou, C., Zheng, Y., Guo, Y., Wang, H., Du, Y., et al. (2018) · Gene · doi:10.1016/j.gene.2018.07.076 · Cited by 31
The landscape of circular RNAs and mRNAs in bovine milk exosomes
Wang, Y., Li, D., Wang, Y., Li, M., Fang, X., Chen, H., & Zhang, C. (2018) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2018.12.004 · Cited by 31
An, X., Liu, X., Ma, G., & Li, C. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.04.017 · Cited by 31
Identification of Circular RNAs using RNA Sequencing
Sekar, S., Geiger, P. A., Cuyugan, L., Boyle, A., Serrano, G. E., Beach, T. G., & Liang, W. S. (2019) · Journal of Visualized Experiments · doi:10.3791/59981 · Cited by 34
Decoding mixed messages in the developing cortex: translational regulation of neural progenitor fate
Hoye, M. L., & Silver, D. L. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.10.001 · Cited by 34
“Moreover, circular non-coding RNAs, many of which show brain-specific and developmentally regulated expression [59,60], can act as sponges for miRNAs to further refine gene regulation.”
BackgroundGenomic analysis of circular RNAs in heart
Dong, K., He, X., Su, H., Fulton, D. J., & Zhou, J. (2020) · BMC Medical Genomics · doi:10.1186/s12920-020-00817-7 · Cited by 31
Circular RNAs in the Central Nervous System
Li, M., Wang, W., & Jin, Z. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.629593 · Cited by 31
“The length of circRNAs ranges from 100 bp to 4 kb (Salzman et al., 2013).”
BackgroundThe Role of N6-Methyladenosine Modified Circular RNA in Pathophysiological Processes
Tang, M., & Lv, Y. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.60131 · Cited by 32
“Circular RNAs (circRNAs) are single-stranded and covalently closed endogenous ncRNAs that mainly exist in cytoplasm and have evolutionary conservation and specific expression pattern of tissue and developmental stage [3,4].”
BackgroundWu, Q., Yin, X., Zhao, W., Xu, W., & Chen, L. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-00979-6 · Cited by 31
“circRNAs are abundantly expressed in the brain tissues, indicating their critical roles in various brain diseases [6].”
BackgroundNSECDA: Natural Semantic Enhancement for CircRNA-Disease Association Prediction
Wang, L., Wong, L., You, Z., Huang, D.-S., Su, X., & Zhao, B.-W. (2022) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2022.3199462 · Cited by 31
“The most recent research indicate that circRNA are rich in miRNA binding sites, which can reduce the inhibition of miRNA on target gene and improve the expression level of target gene as miRNA sponge in cells [4], [5], [6].”
BackgroundCircular RNAs as Novel Biomarkers with Regulatory Potency in Human Diseases
Fang, Y. (2018) · Future Science OA · doi:10.4155/fsoa-2018-0036 · Cited by 30
Sun, B., Shi, L., Shi, Q., Jiang, Y., Su, Z., Yang, X., & Zhang, Y. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-1046-3 · Cited by 30
Wen, Z., Shen, Q., Zhang, H., Su, Y., Zhu, Z., Chen, G., Peng, L., Li, H., Du, C., Xie, H., et al. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27733 · Cited by 30
Circular RNAS: novel biomarkers of disease activity in systemic lupus erythematosus?
Cortés, R., & Forner, M. J. (2019) · Clinical Science · doi:10.1042/cs20180826 · Cited by 29
Ma, Q., Li, L., Yu, B., Jiao, L., Han, Z., Zhao, H., Li, G., Ma, Y., & Luo, Y. (2019) · Brain Research · doi:10.1016/j.brainres.2019.05.033 · Cited by 30
CircCDYL Serves as a New Biomarker in Mantle Cell Lymphoma and Promotes Cell Proliferation
Mei, M., Wang, Y., Wang, Q., Liu, Y., Song, W., & Zhang, M. (2019) · Cancer Management and Research · doi:10.2147/cmar.s232075 · Cited by 30
“CircRNA has shown great potential to become a biomarker because of its conserved, stable, and specific characteristics for developmental stages and tissues.(8,9) In addition, circRNAs exist widely in the blood where they can be measured easily.”
BackgroundThe Circular RNome of Developmental Retina in Mice
Chen, X., Zhang, Z., Wang, X.-Y., Zhao, H., Li, M., Ma, Y., Ji, Y., Zhang, C.-J., Wu, K., Xiang, L., et al. (2019) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2019.11.016 · Cited by 30
“Computational analysis was performed as described in a previous report.(1) FASTQ data were mapped to the mouse reference genome mm9.”
BackgroundMethodInfluentialSphingomyelin Synthases in Neuropsychiatric Health and Disease
Mühle, C., Canalejas, R. D. B., & Kornhuber, J. (2019) · Neurosignals · doi:10.33594/000000200 · Cited by 29
Cao, Q., Shi, Y., Wang, X., Yang, J., Mi, Y., Guan, Z., & Zhang, M. (2019) · Scientific Reports · doi:10.1038/s41598-019-56417-8 · Cited by 30
Non-coding RNAs in drug resistance of head and neck cancers: A review
Dai, F., Dai, L., Zheng, X., Guo, Y., Zhang, Y., Niu, M., Lü, Y., Li, H., Hou, R., Zhang, Y., et al. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110231 · Cited by 30
Profiling and Functional Analysis of Circular RNAs in Porcine Fast and Slow Muscles
Li, B., Yin, D., Li, P., Zhang, Z., Zhang, X., Li, H., Li, R., Hou, L., Liu, H., & Wu, W. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00322 · Cited by 30
Underlying metastasis mechanism and clinical application of exosomal circular RNA in tumors (Review)
Wei, X., Shi, Y., Dai, Z., Wang, P., Meng, X., & Yin, B. (2021) · International Journal of Oncology · doi:10.3892/ijo.2021.5179 · Cited by 30
“Similarly, recent studies have suggested that circRNA can display tissue‐dependent expression in neurodegenerative diseases (39).”
BackgroundCircHIPK3: Key Player in Pathophysiology and Potential Diagnostic and Therapeutic Tool
Zhou, J., Wang, B., Bin, X., Xie, C., Li, B., Liu, O., & Tang, Z. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.615417 · Cited by 29
“In addition, circRNA is highly enriched in synapses, and its levels are regulated by neuronal activity, suggesting that circRNA has a specific role in the brain (2, 14, 15), and the latest research has shown this in the mammalian brain.”
BackgroundLiu, Y., Li, J., Bu, H., Wang, H., Zhang, Y., Shen, Q., Li, M., Lu, Z., Rong, X., Zheng, D., et al. (2021) · Addiction Biology · doi:10.1111/adb.13031 · Cited by 30
Gao, C., Zhang, Y., Tian, Y., Han, C., Wang, L., Ding, B., Tian, H., Zhou, C., Ju, Y., Peng, A., et al. (2021) · World Journal of Surgical Oncology · doi:10.1186/s12957-021-02234-1 · Cited by 29
“CircRNA commonly acts as a ceRNA to repress the activity of miRNA, which further leads to the downregulation of the miRNA expression as well as the decrease of the mRNA targeted by miRNA [34].”
BackgroundD’Ambra, E., Santini, T., Vitiello, E., D’Uva, S., Silenzi, V., Morlando, M., & Bozzoni, I. (2021) · iScience · doi:10.1016/j.isci.2021.103504 · Cited by 30
Sayad, A., Najafi, S., Kashi, A. H., Hosseini, J., Akrami, S. M., Taheri, M. N., & Ghafouri‐Fard, S. (2021) · Pathology - Research and Practice · doi:10.1016/j.prp.2021.153720 · Cited by 30
Song, H., Tian, D., Sun, J., Mao, X., Kong, W., Xu, D., Ji, Y., Qiu, B., Zhan, M., & Wang, J. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04818-5 · Cited by 30
“circRNAs are characterized by high abundance and tissueor developmental stage-specific expression patterns [32], suggesting their unique roles as biomarkers in human diseases.”
BackgroundcircHtra1/miR‐3960/GRB10 Axis Promotes Neuronal Loss and Immune Deficiency in Traumatic Brain Injury
Zheng, P., Shu, L., Ren, D., Kuang, Z., Zhang, Y., & Wan, J. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/3522492 · Cited by 30
“…evaluated tissue-or developmental stage-speci fi c expression patterns of circular RNAs (circRNAs) and their regulatory e ff ects in TBI. circRNAs are highly expressed in the brain, are speci fi cally related to neuronal and synaptic function, and have been identi fi ed as independent biomarkers [4].”
InfluentialShi, J., Rui, X., Han, C., Wang, C., Xu, L., & Jiang, X. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01557-0 · Cited by 30
“The expression pattern and characteristics of circRNAs, including conservation, ubiquity, stability, and tissue/cell speci fi city, enable them to serve as biological markers in various types of tumors [5].”
Inducible Expression of Eukaryotic Circular RNAs from Plasmids
Tatomer, D. C., Liang, D., & Wilusz, J. E. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7204-3_11 · Cited by 32
Bratkovič, T., Modic, M., Ortega, G. C., Drukker, M., & Rogelj, B. (2018) · Scientific Reports · doi:10.1038/s41598-018-23293-7 · Cited by 28
Hsa_circ_0086414 Might Be a Diagnostic Biomarker of Oral Squamous Cell Carcinoma
Li, L., & Zhang, Z. (2020) · Medical Science Monitor · doi:10.12659/msm.919383 · Cited by 30
Shen, X., Zhao, X., He, H., Zhao, J., Wei, Y., Chen, Y., Han, S., Zhu, Y., Zhang, Y., Zhu, Q. C., et al. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010923 · Cited by 30
“Numerous studies have demonstrated that certain circRNAs are highly conserved across different species [53].”
Microglial circ-UBE2K exacerbates depression by regulating parental gene UBE2K via targeting HNRNPU
Cai, Y., Ji, Y., Liu, Y., Zhang, D., Gong, Z., Li, L., Chen, X., Liang, C., Feng, S., Lu, J., et al. (2024) · Theranostics · doi:10.7150/thno.96890 · Cited by 32
Current research on circular RNAs associated with colorectal cancer
Wang, P., & He, X. (2017) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2017.1365168 · Cited by 29
“Fifth, with the discovery of the prevalence of circRNAs, some of them have been recognized as being evolutionarily conserved across different species [27,35].”
BackgroundProfile and clinical implication of circular RNAs in human papillary thyroid carcinoma
Ren, H., Liu, Z., Liu, S., Zhou, X., Wang, H., Xu, J., Wang, D. W., & Yuan, G. (2018) · PeerJ · doi:10.7717/peerj.5363 · Cited by 29
“Recently, circRNAs were found to be highly conserved in sequence, maintained stability in mammalian cells, and showed tissue-specific expression (Chen & Schuman, 2016; Rybak-Wolf et al., 2015).”
BackgroundThölken, C., Thamm, M., Erbacher, C., & Lechner, M. (2019) · BMC Genomics · doi:10.1186/s12864-018-5402-6 · Cited by 28
A circular RNA derived from COL6A3 functions as a ceRNA in gastric cancer development
Sun, X., Zhang, X., Zhai, H., Zhang, D., & Ma, S. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.05.079 · Cited by 28
Wu, Y., Xiao, H., Pi, J., Zhang, H., Pan, A., Pu, Y., Liang, Z., Shen, J., & Du, J. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29509 · Cited by 29
Li, Y., Ashraf, U., Chen, Z., Zhou, D., Imran, M., Ye, J., Chen, H., & Cao, S. (2020) · BMC Genomics · doi:10.1186/s12864-020-06822-5 · Cited by 29
“The expression of circRNAs is also evolutionary conserved from mouse to human, highlighting their functions during brain development [28].”
BackgroundDistinct circular RNA expression profiles in pediatric ependymomas
Ahmadov, U., Bendikas, M. M., Ebbesen, K. K., Sehested, A. M., Kjems, J., Broholm, H., & Kristensen, L. S. (2020) · Brain Pathology · doi:10.1111/bpa.12922 · Cited by 30
“They exhibit tissue-specific expression patterns and constitute a significant amount of cellular RNA, particularly in the brain (5).”
BackgroundRole of circular RNA expression in the pathological progression after spinal cord injury
Wang, W., Li, J., Li, J., Zhang, Z., Li, M.-X., Li, Q., Ma, H.-X., Yang, H., & Hou, X.-L. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.308100 · Cited by 28
Validation of Circular RNAs Using RT‐qPCR After Effective Removal of Linear RNAs by Ribonuclease R
Vromman, M., Yigit, N., Verniers, K., Lefever, S., Vandesompele, J., & Volders, P. (2021) · Current Protocols · doi:10.1002/cpz1.181 · Cited by 29
“Furthermore, it was previously detected in different human neural tissues (also by find_circ; Rybak-Wolf et al., 2014) and is present in the circRNA databases circBank (Liu, Wang, Shen, Yang, & Ding, 2019), circbase (Glažar, Papavasileiou, & Rajewsky, 2014), and circAtlas (Wu, Ji, & Zhao, Vromman et al.”
BackgroundPINTology : A short history of the lncRNA LINC‐PINT in different diseases
Bukhari, I., Khan, M. R., Husain, M. A., Thorne, R. F., Yu, Y., Zhang, B., Zheng, P., & Mi, Y. (2022) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1705 · Cited by 28
Li, Y., Wang, F., Teng, P., Ku, L., Chen, L., Feng, Y., & Yao, B. (2022) · Genome biology · doi:10.1186/s13059-022-02621-1 · Cited by 27
“CircRNAs have been reported as critical regulators in many biological processes, including neurodevelopment and functions, but less conserved among species [14, 47, 78].”
BackgroundInfluentialGenetic tools for the stable overexpression of circular RNAs
Mecozzi, N., Nenci, A., Vera, O., Bok, I., Falzone, A., DeNicola, G. M., & Karreth, F. A. (2022) · RNA Biology · doi:10.1080/15476286.2022.2043041 · Cited by 29
Exosomal circRNAs as promising liquid biopsy biomarkers for glioma
Wu, X., Shi, M., Lian, Y., & Zhang, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1039084 · Cited by 29
“Many different processes drive glioma progression, and high levels of circRNA expression have been observed in brain tissue where they can act by sequestering specific miRNAs and thereby influencing tumor proliferative activity, invasion, and therapeutic sensitivity (90, 91).”
BackgroundEmerging roles of noncoding RNAs in human cancers
Wu, S., Wu, Y., Deng, S., Lei, X., & Yang, X. (2023) · Discover Oncology · doi:10.1007/s12672-023-00728-w · Cited by 30
“CircRNAs are gene-regulatory RNA transcripts with covalently closed circular structures that are highly stable, especially in neural tissues circRNAs [14, 15].”
BackgroundMafi, A., Rismanchi, H., Mohammadi, M. M., Hedayati, N., Ghorbanhosseini, S. S., Hosseini, S. A., Gholinezhad, Y., Dehmordi, R. M., Ghezelbash, B., Zarepour, F., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1224138 · Cited by 29
“tissues; for instance, circRNA is widely distributed in the brain and is involved in brain development and function (50, 51).”
BackgroundSingh, M., George, A. K., Homme, R. P., Majumder, A., Laha, A., Sandhu, H. S., & Tyagi, S. C. (2018) · Experimental Eye Research · doi:10.1016/j.exer.2018.05.026 · Cited by 28
Zhou, L., Yang, L., Jiang, W., Zhang, H., Wen, Z., Su, Y., Wu, F., Zhi, Z., Shen, Q., Li, H., et al. (2018) · Cell Cycle · doi:10.1080/15384101.2018.1480210 · Cited by 27
Circular RNAs in human and vertebrate neural retinas
Sun, L., Zhang, B., Chen, X., Wang, X.-Y., Zhang, B., Ji, Y., Wu, K., Wu, J., & Jin, Z. (2019) · RNA Biology · doi:10.1080/15476286.2019.1591034 · Cited by 26
“CircRNAs are remarkably enriched in the nervous system [3,4].”
Background
Metadata
- Authors
- Rybak-Wolf, A., Stottmeister, C., Glažar, P., Jens, M., Pino, N., Giusti, S., Hanan, M., Behm, M., Bartok, O., Ashwal-Fluss, R., Herzog, M., Schreyer, L., Papavasileiou, P., Ivanov, A., Öhman, M., Refojo, D., Kadener, S., & Rajewsky, N.
- Affiliations
- Max Delbrück Center (DE)
- Max Planck Institute of Psychiatry (DE)
- Hebrew University of Jerusalem (IL)
- Stockholm University (SE)
- Corresponding author
- Rajewsky, Nikolaus
- ORCID
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 58
- Issue
- 5
- Pages
- 870-885
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W1991082489
- Semantic Scholar
- 2d5cc6120582eee013b4aab9138fa48d35f384f1
- Cited by
- 2,423
- References
- 40
- Citations by year
- 2026: 68 · 2025: 143 · 2024: 238 · 2023: 246 · 2022: 312 · 2021: 358 · 2020: 344 · 2019: 284 · 2018: 203 · 2017: 122 · 2016: 74 · 2015: 23
- FWCI
- 61.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- Americanae (AECID Library) (publishedVersion, other-oa)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- circular RNA, mammalian brain, neuronal differentiation, synapses, ADAR1, RNA editing, Drosophila brain, circRNA biomarkers
- MeSH terms
- RNA, Circular, Animals, Base Sequence, Brain, Cell Line, Drosophila melanogaster, Humans, Molecular Sequence Data, Organ Specificity, RNA, RNA, Messenger, Synapses, Sequence Analysis, DNA, Mice, Neurogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
