Cited by 101DNA Repair MechanismsGenomics and Chromatin DynamicsCRISPR and Genetic Engineering

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The Cohesin Complex Prevents the End Joining of Distant DNA Double-Strand Ends

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Gelot, Camille, Guirouilh-Barbat, Josée, Le Guen, Tangui, Dardillac, Elodie, Chailleux, Catherine, Canitrot, Yvan, Lopez, Bernard S.·2016·Molecular Cell

DOI 10.1016/j.molcel.2015.11.002

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Abstract

The end joining of distant DNA double-strand ends (DSEs) can produce potentially deleterious rearrangements. We show that depletion of cohesion complex proteins specifically stimulates the end joining (both C-NHEJ and A-EJ) of distant, but not close, I-SceI-induced DSEs in S/G2 phases. At the genome level, whole-exome sequencing showed that ablation of RAD21 or Sororin produces large chromosomal rearrangements (translocation, duplication, deletion). Moreover, cytogenetic analysis showed that RAD21 silencing leads to the formation of chromosome fusions synergistically with replication stress, which generates distant single-ended DSEs. These data reveal a role for the cohesin complex in protecting against genome rearrangements arising from the ligation of distant DSEs in S/G2 phases (both long-range DSEs and those that are only a few kilobases apart), while keeping end joining fully active for close DSEs. Therefore, this role likely involves limitation of DSE motility specifically in S phase, rather than inhibition of the end-joining machinery itself.

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Authors: Gelot, C., Guirouilh-Barbat, J., Le Guen, T., Dardillac, E., Chailleux, C., Canitrot, Y., & Lopez, B. S.
Affiliations: Centre National de la Recherche Scientifique (FR)
ORCID: Gelot, Camille
Dardillac, Elodie
Chailleux, Catherine
Canitrot, Yvan
Venue: Molecular Cell
Publisher: Elsevier BV
Published: 2016-01
Volume: 61
Issue: 1
Pages: 15-26
ISSN: 1097-2765 (ISSN-L)
DOI: 10.1016/j.molcel.2015.11.002
OpenAlex: W2195792396
Cited by: 101
References: 39
Citations by year: 2026: 5 · 2025: 10 · 2024: 10 · 2023: 13 · 2022: 5 · 2021: 12 · 2020: 11 · 2019: 8 · 2018: 9 · 2017: 8 · 2016: 10
FWCI: 3.91
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 372 d)
Locations: Molecular Cell (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: Agence Nationale de la Recherche (ANR-14-CE10-0010)
Ligue Contre le Cancer
Institut National Du Cancer
Institute of Cancer Research
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
Keywords: cohesin, non-homologous end joining, alternative end-joining, RAD21, Sororin, chromosomal rearrangements, chromosome fusion, replication stress, S/G2 phase, I-SceI, genome stability
MeSH terms: Cohesins, Cell Line, Chromosomal Proteins, Non-Histone, Chromosome Aberrations, DNA Repair, DNA Replication, DNA-Binding Proteins, Humans, Nuclear Proteins, Phosphoproteins, Time Factors, Transfection, Deoxyribonucleases, Type II Site-Specific, Gene Rearrangement, Cell Cycle Proteins, RNA Interference, Adaptor Proteins, Signal Transducing, DNA Breaks, Double-Stranded, G2 Phase Cell Cycle Checkpoints, S Phase Cell Cycle Checkpoints

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The Cohesin Complex Prevents the End Joining of Distant DNA Double-Strand Ends

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