The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
The Cohesin Complex Prevents the End Joining of Distant DNA Double-Strand Ends
Open accessAbstract
The end joining of distant DNA double-strand ends (DSEs) can produce potentially deleterious rearrangements. We show that depletion of cohesion complex proteins specifically stimulates the end joining (both C-NHEJ and A-EJ) of distant, but not close, I-SceI-induced DSEs in S/G2 phases. At the genome level, whole-exome sequencing showed that ablation of RAD21 or Sororin produces large chromosomal rearrangements (translocation, duplication, deletion). Moreover, cytogenetic analysis showed that RAD21 silencing leads to the formation of chromosome fusions synergistically with replication stress, which generates distant single-ended DSEs. These data reveal a role for the cohesin complex in protecting against genome rearrangements arising from the ligation of distant DSEs in S/G2 phases (both long-range DSEs and those that are only a few kilobases apart), while keeping end joining fully active for close DSEs. Therefore, this role likely involves limitation of DSE motility specifically in S phase, rather than inhibition of the end-joining machinery itself.
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“cohesin has been shown to protect against genome structural variations”
From Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration (2023) · cites this paper as [80]
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Pathways of DNA Double-Strand Break Repair during the Mammalian Cell Cycle
Rothkamm, K., Krüger, I., Thompson, L. H., & Lübrich, M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.16.5706-5715.2003 · Cited by 1,187
Guacci, V., Koshland, D. E., & Strunnikov, A. V. (1997) · Cell · doi:10.1016/s0092-8674(01)80008-8 · Cited by 828
Klein, F., Mahr, P., Gálová, M., Buonomo, S. B. C., Michaelis, C., Nairz, K., & Nasmyth, K. (1999) · Cell · doi:10.1016/s0092-8674(00)80609-1 · Cited by 731
Homology-directed repair is a major double-strand break repair pathway in mammalian cells
Liang, F., Han, M., Romanienko, P. J., & Jasin, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5172 · Cited by 649
Ünal, E., Arbel‐Eden, A., Sattler, U., Shroff, R., Lichten, M., Haber, J. E., & Koshland, D. E. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.11.027 · Cited by 589
Postreplicative Recruitment of Cohesin to Double-Strand Breaks Is Required for DNA Repair
Ström, L., Lindroos, H. B., Shirahige, K., & Sjögren, C. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.11.026 · Cited by 546
AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
Petersen, S., Casellas, R. C., Reina‐San‐Martin, B., Chen, H. T., Difilippantonio, M. J., Wilson, P. C., Hanitsch, L. G., Celeste, A., Muramatsu, M., Pilch, D. R., et al. (2001) · Nature · doi:10.1038/414660a · Cited by 512
Positional stability of single double-strand breaks in mammalian cells
Soutoglou, E., Dorn, J. F., Sengupta, K., Jasin, M., Nussenzweig, A., Ried, T., Danuser, G., & Misteli, T. (2007) · Nature Cell Biology · doi:10.1038/ncb1591 · Cited by 509
Is Non-Homologous End-Joining Really an Inherently Error-Prone Process?
Bétermier, M., Bertrand, P., & López, B. S. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004086 · Cited by 420
Cohesin-mediated interactions organize chromosomal domain architecture
Sofueva, S., Yaffe, E., Chan, W., Georgopoulou, D., Vietri Rudan, M., Mira‐Bontenbal, H., Pollard, S. M., Schroth, G. P., Tanay, A., & Hadjur, S. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.237 · Cited by 394
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Metadata
- Authors
- Gelot, C., Guirouilh-Barbat, J., Le Guen, T., Dardillac, E., Chailleux, C., Canitrot, Y., & Lopez, B. S.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 61
- Issue
- 1
- Pages
- 15-26
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2195792396
- Cited by
- 101
- References
- 39
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 10 · 2023: 13 · 2022: 5 · 2021: 12 · 2020: 11 · 2019: 8 · 2018: 9 · 2017: 8 · 2016: 10
- FWCI
- 3.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-14-CE10-0010)
- Ligue Contre le Cancer
- Institut National Du Cancer
- Institute of Cancer Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Keywords
- cohesin, non-homologous end joining, alternative end-joining, RAD21, Sororin, chromosomal rearrangements, chromosome fusion, replication stress, S/G2 phase, I-SceI, genome stability
- MeSH terms
- Cohesins, Cell Line, Chromosomal Proteins, Non-Histone, Chromosome Aberrations, DNA Repair, DNA Replication, DNA-Binding Proteins, Humans, Nuclear Proteins, Phosphoproteins, Time Factors, Transfection, Deoxyribonucleases, Type II Site-Specific, Gene Rearrangement, Cell Cycle Proteins, RNA Interference, Adaptor Proteins, Signal Transducing, DNA Breaks, Double-Stranded, G2 Phase Cell Cycle Checkpoints, S Phase Cell Cycle Checkpoints
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