The Cohesin Complex Prevents the End Joining of Distant DNA Double-Strand Ends

Pathways of DNA Double-Strand Break Repair during the Mammalian Cell Cycle

Rothkamm, K., Krüger, I., Thompson, L. H., & Lübrich, M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.16.5706-5715.2003 · Cited by 1,187

A Direct Link between Sister Chromatid Cohesion and Chromosome Condensation Revealed through the Analysis of MCD1 in S. cerevisiae

Guacci, V., Koshland, D. E., & Strunnikov, A. V. (1997) · Cell · doi:10.1016/s0092-8674(01)80008-8 · Cited by 828

A Central Role for Cohesins in Sister Chromatid Cohesion, Formation of Axial Elements, and Recombination during Yeast Meiosis

Klein, F., Mahr, P., Gálová, M., Buonomo, S. B. C., Michaelis, C., Nairz, K., & Nasmyth, K. (1999) · Cell · doi:10.1016/s0092-8674(00)80609-1 · Cited by 731

Homology-directed repair is a major double-strand break repair pathway in mammalian cells

Liang, F., Han, M., Romanienko, P. J., & Jasin, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5172 · Cited by 649

DNA Damage Response Pathway Uses Histone Modification to Assemble a Double-Strand Break-Specific Cohesin Domain

Ünal, E., Arbel‐Eden, A., Sattler, U., Shroff, R., Lichten, M., Haber, J. E., & Koshland, D. E. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.11.027 · Cited by 589

Postreplicative Recruitment of Cohesin to Double-Strand Breaks Is Required for DNA Repair

Ström, L., Lindroos, H. B., Shirahige, K., & Sjögren, C. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.11.026 · Cited by 546

AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching

Petersen, S., Casellas, R. C., Reina‐San‐Martin, B., Chen, H. T., Difilippantonio, M. J., Wilson, P. C., Hanitsch, L. G., Celeste, A., Muramatsu, M., Pilch, D. R., et al. (2001) · Nature · doi:10.1038/414660a · Cited by 512

Positional stability of single double-strand breaks in mammalian cells

Soutoglou, E., Dorn, J. F., Sengupta, K., Jasin, M., Nussenzweig, A., Ried, T., Danuser, G., & Misteli, T. (2007) · Nature Cell Biology · doi:10.1038/ncb1591 · Cited by 509

Is Non-Homologous End-Joining Really an Inherently Error-Prone Process?

Bétermier, M., Bertrand, P., & López, B. S. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004086 · Cited by 420

Cohesin-mediated interactions organize chromosomal domain architecture

Sofueva, S., Yaffe, E., Chan, W., Georgopoulou, D., Vietri Rudan, M., Mira‐Bontenbal, H., Pollard, S. M., Schroth, G. P., Tanay, A., & Hadjur, S. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.237 · Cited by 394

Role of mammalian Mre11 in classical and alternative nonhomologous end joining

Xie, A., Kwok, A., & Scully, R. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1640 · Cited by 390

Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells

Rass, E., Grabarz, A., Plo, I., Gautier, J., Bertrand, P., & López, B. S. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1641 · Cited by 370

Impact of the KU80 Pathway on NHEJ-Induced Genome Rearrangements in Mammalian Cells

Guirouilh‐Barbat, J., Huck, S., Bertrand, P., Pirzio, L. M., Desmaze, C., Sabatier, L., & López, B. S. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.05.008 · Cited by 335

Characterization of homologous recombination induced by replication inhibition in mammalian cells

Saintigny, Y., Delacôte, F., Varès, G., Petitot, F., Lambert, S., Averbeck, D., & López, B. S. (2001) · The EMBO Journal · doi:10.1093/emboj/20.14.3861 · Cited by 334

DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation

Simsek, D., Brunet, E., Wong, S., Katyal, S., Gao, Y., McKinnon, P. J., Lou, J. F., Zhang, L., Li, J., Rebar, E. J., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002080 · Cited by 327

Preventing Nonhomologous End Joining Suppresses DNA Repair Defects of Fanconi Anemia

Adamo, A., Collis, S. J., Adelman, C. A., Silva, N., Hořejšı́, Z., Ward, J. D., Martínez-Pérez, E., Boulton, S. J., & Volpe, A. L. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.026 · Cited by 297

Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double‐strand breaks

Potts, P. R., Porteus, M. H., & Yu, H. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601218 · Cited by 282

Ku70 Corrupts DNA Repair in the Absence of the Fanconi Anemia Pathway

Pace, P., Mosedale, G., Hodskinson, M. R. G., Rosado, I. V., Sivasubramaniam, M., & Patel, K. J. (2010) · Science · doi:10.1126/science.1192277 · Cited by 248

The maintenance of chromosome structure: positioning and functioning of SMC complexes

Jeppsson, K. E., Kanno, T., Shirahige, K., & Sjögren, C. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3857 · Cited by 220

The causes of replication stress and their consequences on genome stability and cell fate

Magdalou, I., López, B. S., Pasero, P., & Lambert, S. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.04.035 · Cited by 183

Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends

Guirouilh‐Barbat, J., Rass, E., Plo, I., Bertrand, P., & López, B. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708541104 · Cited by 180

A role for CTCF and cohesin in subtelomere chromatin organization, TERRA transcription, and telomere end protection

Deng, Z., Wang, Z., Stong, N., Plasschaert, R. N., Moczan, A., Chen, H.-S., Hu, S., Wickramasinghe, P., Davuluri, R. V., Bartolomei, M. S., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.266 · Cited by 174

Activation-Induced Cytidine Deaminase-Dependent DNA Breaks in Class Switch Recombination Occur during G1 Phase of the Cell Cycle and Depend upon Mismatch Repair

Schrader, C. E., Guikema, J. E. J., Linehan, E. K., Selsing, E., & Stavnezer, J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.9.6064 · Cited by 164

Is homologous recombination really an error-free process?

Guirouilh‐Barbat, J., Lambert, S., Bertrand, P., & López, B. S. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00175 · Cited by 161

Cohesin Association to Replication Sites Depends on Rad50 and Promotes Fork Restart

Tittel-Elmer, M., Lengronne, A., Davidson, M. B., Bacal, J., François, P., Hohl, M., Petrini, J. H. J., Pasero, P., & Cobb, J. A. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.07.004 · Cited by 137

Cohesin Protects Genes against γH2AX Induced by DNA Double-Strand Breaks

Caron, P., Aymard, F., Iacovoni, J. S., Briois, S., Canitrot, Y., Bugler, B., Massip, L., Losada, A., & Legube, G. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002460 · Cited by 135

Chromosome translocation based on illegitimate recombination in human tumors

Zucman‐Rossi, J., Legoix, P., Victor, J., López, B. S., & Thomas, G. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11786 · Cited by 111

Cohesin promotes the repair of ionizing radiation-induced DNA double-strand breaks in replicated chromatin

Bauerschmidt, C., Arrichiello, C., Burdak‐Rothkamm, S., Woodcock, M., Hill, M. A., Stevens, D. L., & Rothkamm, K. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp976 · Cited by 105

SMC1 involvement in fragile site expression

Musio, A., Montagna, C., Mariani, T., Tilenni, M., Focarelli, M. L., Brait, L., Indino, E., Benedetti, P. A., Chessa, L., Albertini, A., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi049 · Cited by 105

Cohesin and the nucleolus constrain the mobility of spontaneous repair foci

Dion, V., Kalck, V., Seeber, A., Schleker, T., & Gasser, S. M. (2013) · EMBO Reports · doi:10.1038/embor.2013.142 · Cited by 103

Distinct Functions of Human Cohesin-SA1 and Cohesin-SA2 in Double-Strand Break Repair

Kong, X., Ball, A. R., Pham, H. X., Zeng, W., Chen, H.-Y., Schmiesing, J. A., Kim, J.-S., Berns, M. W., & Yokomori, K. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01503-13 · Cited by 102

Importance of the cell cycle phase for the choice of the appropriate DSB repair pathway, for genome stability mintenance: the trans-S double-strand break repair model

Delacôte, F., & López, B. S. (2008) · Cell Cycle · doi:10.4161/cc.7.1.5149 · Cited by 100

Suppression of RAD21 gene expression decreases cell growth and enhances cytotoxicity of etoposide and bleomycin in human breast cancer cells

Atienza, J. M., Roth, R. B., Rosette, C., Smylie, K. J., Kammerer, S., Rehbock, J., Ekblom, J., & Denissenko, M. F. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-04-0241 · Cited by 96

Initiation of DNA double strand break repair: signaling and single-stranded resection dictate the choice between homologous recombination, non-homologous end-joining and alternative end-joining.

Grabarz, A., Barascu, A., Guirouilh‐Barbat, J., & López, B. S. (2012) · Europe PMC (PubMed Central) · Cited by 93

Cohesin in development and disease

Remeseiro, S., Cuadrado, A., & Losada, A. (2013) · Development · doi:10.1242/dev.090605 · Cited by 87

The cohesin complex regulates immunoglobulin class switch recombination

Thomas-Claudepierre, A.-S., Schiavo, E., Heyer, V., Fournier, M. L., Page, A., Robert, I., & Reina‐San‐Martin, B. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20130166 · Cited by 67

Recruitment of the cohesin loading factor NIPBL to DNA double-strand breaks depends on MDC1, RNF168 and HP1γ in human cells

Oka, Y., Suzuki, K., Yamauchi, M., Mitsutake, N., & Yamashita, S. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.07.021 · Cited by 44

A regulatory role for the cohesin loader NIPBL in nonhomologous end joining during immunoglobulin class switch recombination

Enervald, E., Du, L., Visnes, T., Björkman, A., Lindgren, E. B., Wincent, J., Borck, G., Colleaux, L., Cormier‐Daire, V., van Gent, D. C., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20130168 · Cited by 44

S-phase progression stimulates both the mutagenic KU-independent pathway and mutagenic processing of KU-dependent intermediates, for nonhomologous end joining

Guirouilh‐Barbat, J., Huck, S., & López, B. S. (2007) · Oncogene · doi:10.1038/sj.onc.1210807 · Cited by 37

SMC complexes: from DNA to chromosomes

Uhlmann, F. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.30 · Cited by 536

Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer’s disease pathology

Mathys, H., Peng, Z., Boix, C. A., Victor, M. B., Leary, N., Babu, S., Abdelhady, G., Jiang, X., Ng, A. P., Ghafari, K., et al. (2023) · Cell · doi:10.1016/j.cell.2023.08.039 · Cited by 495

The molecular basis and disease relevance of non-homologous DNA end joining

Zhao, B., Rothenberg, E., Ramsden, D. A., & Lieber, M. R. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00297-8 · Cited by 411

Loop extrusion as a mechanism for formation of DNA damage repair foci

Arnould, C., Rocher, V., Finoux, A.-L., Clouaire, T., Li, K., Zhou, F., Caron, P., Mangeot, P. E., Ricci, E. P., Mourad, R., et al. (2021) · Nature · doi:10.1038/s41586-021-03193-z · Cited by 341

Sliding sleeves of XRCC4–XLF bridge DNA and connect fragments of broken DNA

Brouwer, I., Sitters, G., Candelli, A., Heerema, S. J., Heller, I., de Melo, A. J., Zhang, H., Normanno, D., Modesti, M., Peterman, E. J. G., et al. (2016) · Nature · doi:10.1038/nature18643 · Cited by 166

The cohesin complex prevents the end-joining of distant DNA double-strand ends in S phase: Consequences on genome stability maintenance

Gelot, C., Guirouilh‐Barbat, J., & López, B. S. (2016) · Nucleus · doi:10.1080/19491034.2016.1194159 · Cited by 15

The Cohesion complex maintains genome stability by preventing end joining of distant DNA ends in S phase

Gelot, C., Guirouilh‐Barbat, J., & López, B. S. (2016) · Molecular & Cellular Oncology · doi:10.1080/23723556.2016.1154123 · Cited by 2

The cohesin complex protects against genome rearrangements by preventing the end-joining of distal DNA double-strand-ends

Gelot, C. (2014) · theses.fr (ABES)

Cohesin complex oligomerization maintains end-tethering at DNA double-strand breaks

Phipps, J., Toulouze, M., Ducrot, C., Costa, R., Brocas, C., & Dubrana, K. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01552-2 · Cited by 23

Cohesin Does the Business

Riddihough, G. (2007) · Science s STKE · doi:10.1126/stke.3952007tw257