The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Redox Nanodomains Are Induced by and Control Calcium Signaling at the ER-Mitochondrial Interface
Open accessAbstract
The ER-mitochondrial interface is central to calcium signaling, organellar dynamics and lipid biosynthesis. The ER and mitochondrial membranes also host sources and targets of reactive oxygen species (ROS) but their local dynamics and relevance remained elusive since measurement and perturbation of ROS at the organellar interface has proven difficult. Employing drug-inducible synthetic ER-mitochondrial linkers, we overcame this problem and demonstrate that the ER-mitochondrial interface hosts a nanodomain of H2O2, which is induced by cytoplasmic [Ca2+] spikes and exert a positive feedback on calcium oscillations. H2O2 nanodomains originate from the mitochondrial cristae, which are compressed upon calcium signal propagation to the mitochondria, likely due to Ca2+-induced K+ and concomitant water influx to the matrix. Thus, ER-mitochondrial H2O2 nanodomains represent a novel component of inter-organelle communication, regulating calcium signaling and mitochondrial activities.
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Cites
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Cited by
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
Sies, H., & Jones, D. P. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0230-3 · Cited by 5,335
Sies, H. (2017) · Redox Biology · doi:10.1016/j.redox.2016.12.035 · Cited by 2,148
13 reasons why the brain is susceptible to oxidative stress
Cobley, J. N., Fiorello, M. L., & Bailey, D. M. (2018) · Redox Biology · doi:10.1016/j.redox.2018.01.008 · Cited by 1,215
Endoplasmic reticulum-mitochondrial contactology: structure and signaling functions
Csordás, G., Weaver, D., & Hajnóczky, G. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.02.009 · Cited by 625
Self-citationRieusset, J. (2018) · Cell Death & Disease · doi:10.1038/s41419-018-0416-1 · Cited by 248
Metadata
- Authors
- Booth, D. M., Enyedi, B., Geiszt, M., Várnai, P., & Hajnóczky, G.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 63
- Issue
- 2
- Pages
- 240-248
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2469610561
- Cited by
- 308
- References
- 43
- FWCI
- 12.64
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Booth, D. M., Enyedi, B., Geiszt, M., Várnai, P., & Hajnóczky, G. (2016). Redox Nanodomains Are Induced by and Control Calcium Signaling at the ER-Mitochondrial Interface. Molecular Cell. https://doi.org/10.1016/j.molcel.2016.05.040
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