The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1
Open accessAbstract
R loop, a transcription intermediate containing RNA:DNA hybrids and displaced single-stranded DNA (ssDNA), has emerged as a major source of genomic instability. RNaseH1, which cleaves the RNA in RNA:DNA hybrids, plays an important role in R loop suppression. Here, we show that replication protein A (RPA), a ssDNA-binding protein, interacts with RNaseH1 and colocalizes with both RNaseH1 and R loops in cells. In vitro, purified RPA directly enhances the association of RNaseH1 with RNA:DNA hybrids and stimulates the activity of RNaseH1 on R loops. An RPA binding-defective RNaseH1 mutant is not efficiently stimulated by RPA in vitro, fails to accumulate at R loops in cells, and loses the ability to suppress R loops and associated genomic instability. Thus, in addition to sensing DNA damage and replication stress, RPA is a sensor of R loops and a regulator of RNaseH1, extending the versatile role of RPA in suppression of genomic instability.
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UCSF Chimera—A visualization system for exploratory research and analysis
Pettersen, E. F., Goddard, T. D., Huang, C. C., Couch, G. S., Greenblatt, D. M., Meng, E. C., & Ferrin, T. E. (2004) · Journal of Computational Chemistry · doi:10.1002/jcc.20084 · Cited by 45,828
Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes
Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693
Self-citationCauses and consequences of replication stress
Zeman, M. K., & Cimprich, K. A. (2014) · Nature Cell Biology · doi:10.1038/ncb2897 · Cited by 2,079
R-Loop Formation Is a Distinctive Characteristic of Unmethylated Human CpG Island Promoters
Ginno, P. A., Lott, P. L., Christensen, H. C., Korf, I., & Chédin, F. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.01.017 · Cited by 910
Skourti-Stathaki, K., Proudfoot, N. J., & Gromak, N. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.04.026 · Cited by 819
Ribonuclease H: the enzymes in eukaryotes
Cerritelli, S. M., & Crouch, R. J. (2009) · The FEBS Journal · doi:10.1111/j.1742-4658.2009.06908.x · Cited by 814
R loops: new modulators of genome dynamics and function
Santos-Pereira, J. M., & Aguilera, A. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3961 · Cited by 775
Inactivation of the SR Protein Splicing Factor ASF/SF2 Results in Genomic Instability
Li, X., & Manley, J. L. (2005) · Cell · doi:10.1016/j.cell.2005.06.008 · Cited by 769
Huertas, P., & Aguilera, A. (2003) · Molecular Cell · doi:10.1016/j.molcel.2003.08.010 · Cited by 746
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells
Yu, K., Chedin, F., Hsieh, C.-L., Wilson, T. E., & Lieber, M. R. (2003) · Nature Immunology · doi:10.1038/ni919 · Cited by 746
Cited by
m5C modification of mRNA serves a DNA damage code to promote homologous recombination
Chen, H., Yang, H., Zhu, X., Yadav, T., Ouyang, J., Truesdell, S. S., Tan, J., Wang, Y., Duan, M., Wei, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16722-7 · Cited by 179
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Metadata
- Authors
- Nguyen, H. D., Yadav, T., Giri, S., Saez, B., Graubert, T. A., & Zou, L.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 65
- Issue
- 5
- Pages
- 832-847.e4
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2594603678
- Cited by
- 267
- References
- 61
- FWCI
- 9.03
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Nguyen, H. D., Yadav, T., Giri, S., Saez, B., Graubert, T. A., & Zou, L. (2017). Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1. Molecular Cell. https://doi.org/10.1016/j.molcel.2017.01.029
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