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Cited by 815Ion Channels and ReceptorsCalcium signaling and nucleotide metabolismIon channel regulation and function

Intracellular Ca2+ Sensing: Its Role in Calcium Homeostasis and Signaling

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Bagur, Rafaela, Hajnóczky, György·2017·Molecular Cell
DOI 10.1016/j.molcel.2017.05.028PMC PMC5657234
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Abstract

Ca 2+ is a ubiquitous intracellular messenger that controls diverse cellular functions but can become toxic and cause cell death. Selective control of specific targets depends on spatiotemporal patterning of the calcium signal and decoding it by multiple, tunable, and often strategically positioned Ca 2+-sensing elements. Ca 2+ is detected by specialized motifs on proteins that have been biochemically characterized decades ago. However, the field of Ca 2+ sensing has been reenergized by recent progress in fluorescent technology, genetics, and cryo-EM. These approaches exposed local Ca 2+-sensing mechanisms inside organelles and at the organellar interfaces, revealed how Ca 2+ binding might work to open some channels, and identified human mutations and disorders linked to a variety of Ca 2+-sensing proteins. Here we attempt to place these new developments in the context of intracellular calcium homeostasis and signaling.

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  • Cytosolic Ca2+ fluctuations play a pivotal role in maintaining the structure and function of intracellular organelles.

    “Cytosolic Ca²⁺ fluctuations also play a pivotal role in maintaining the structure and function of intracellular organelles88,89.”

    From CYFIP1 governs the development of cortical axons by modulating calcium availability (2025) · cites this paper as [89]

    The Calcium Homeostasis and Signaling section says cytosolic Ca2+ signals may regulate organelle-specific functions, including nuclear gene regulation and mitochondrial metabolism. Localization and compartmentalization also describes Ca2+-dependent mitochondrial positioning. These passages support a role in organelle function and distribution, but do not establish that cytosolic fluctuations maintain organelle structure generally; page numbers are unavailable in our copy. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

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Authors
Bagur, R., & Hajnóczky, G.
Affiliations
Thomas Jefferson University (US)
Corresponding author
Hajnóczky, György
ORCID
Hajnóczky, György
Venue
Molecular Cell
Publisher
Elsevier BV
Published
2017-06
Volume
66
Issue
6
Pages
780-788
ISSN
1097-2765 (ISSN-L)
DOI
10.1016/j.molcel.2017.05.028
PMC
PMC5657234
OpenAlex
W2624937154
Cited by
815
References
3
Citations by year
2026: 95 · 2025: 107 · 2024: 137 · 2023: 106 · 2022: 117 · 2021: 105 · 2020: 64 · 2019: 57 · 2018: 24 · 2017: 3
FWCI
6.13
Type
journal article
Language
en
Open access
Licence
Locations
  • Molecular Cell (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • The Medicine Forum (submittedVersion, cc-by-nc-nd)
Funders
National Institutes of Health (DK051526)
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Keywords
calcium homeostasis, calcium signaling, calcium-binding proteins, calcium channels, calcium-binding motif
MeSH terms
Protein Domains, Animals, Calcium, Homeostasis, Humans, Mutation, Phenotype, Structure-Activity Relationship, Calcium Channels, Ion Channel Gating, Calcium Signaling, Genetic Predisposition to Disease, Cryoelectron Microscopy, Amino Acid Motifs, Intracellular Calcium-Sensing Proteins

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