Cited by 90Redox biology and oxidative stressNeutrophil, Myeloperoxidase and Oxidative MechanismsLipid Membrane Structure and Behavior

The Plasma Membrane: A Platform for Intra- and Intercellular Redox Signaling

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Nordzieke, Daniela E., Medraño-Fernandez, Iria·2018·Antioxidants

Abstract

Membranes are of outmost importance to allow for specific signal transduction due to their ability to localize, amplify, and direct signals. However, due to the double-edged nature of reactive oxygen species (ROS)—toxic at high concentrations but essential signal molecules—subcellular localization of ROS-producing systems to the plasma membrane has been traditionally regarded as a protective strategy to defend cells from unwanted side-effects. Nevertheless, specialized regions, such as lipid rafts and caveolae, house and regulate the activated/inhibited states of important ROS-producing systems and concentrate redox targets, demonstrating that plasma membrane functions may go beyond acting as a securing lipid barrier. This is nicely evinced by nicotinamide adenine dinucleotide phosphate (NADPH)-oxidases (NOX), enzymes whose primary function is to generate ROS and which have been shown to reside in specific lipid compartments. In addition, membrane-inserted bidirectional H2O2-transporters modulate their conductance precisely during the passage of the molecules through the lipid bilayer, ensuring time-scaled delivery of the signal. This review aims to summarize current evidence supporting the role of the plasma membrane as an organizing center that serves as a platform for redox signal transmission, particularly NOX-driven, providing specificity at the same time that limits undesirable oxidative damage in case of malfunction. As an example of malfunction, we explore several pathological situations in which an inflammatory component is present, such as inflammatory bowel disease and neurodegenerative disorders, to illustrate how dysregulation of plasma-membrane-localized redox signaling impacts normal cell physiology.

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Crossref · 10.3390/antiox7110168

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  • NOX2 is predominantly expressed in phagocytes and produces a relatively large amount of superoxide in order to kill bacteria within phagosomes in an inflamed area.

    “NOX2 is predominantly expressed in phagocytes and produces a relatively large amount of superoxide in order to kill bacteria within phagosomes in an inflamed area [33,34], Figure 13.”

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Authors
Nordzieke, D. E., & Medraño-Fernandez, I.
Affiliations
  • University of Göttingen (DE)
  • Protein Transport and Secretion Unit, Division of Genetics and Cell Biology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale San Raffaele, Università Vita-Salute San Raffaele, 20132 Milan, Italy
Corresponding author
Nordzieke, Daniela E.
Venue
Antioxidants
Publisher
MDPI AG
Published
2018-11-20
Volume
7
Issue
11
Pages
168
ISSN
2076-3921 (ISSN-L)
OpenAlex
W2901436247
Cited by
90
References
319
Citations by year
2026: 9 · 2025: 9 · 2024: 8 · 2023: 17 · 2022: 14 · 2021: 11 · 2020: 10 · 2019: 12
FWCI
0.81
Type
journal article
Language
en
Open access
Locations
  • Antioxidants (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
Funders
  • Deutsche Forschungsgemeinschaft (NO 1230/2-1)
  • Associazione Italiana per la Ricerca sul Cancro (IG 2016-18824)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
Keywords
plasma membrane, redox signaling, reactive oxygen species, NADPH oxidase, lipid rafts, caveolae, oxidative stress, inflammatory bowel disease, neurodegenerative diseases, signal transduction

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