Role of Microglia and Astrocytes in Alzheimer’s Disease: From Neuroinflammation to Ca2+ Homeostasis Dysregulation

Di Benedetto, Giulia; Burgaletto, Chiara; Bellanca, Carlo Maria; Munafò, Antonio; Bernardini, Renato; Cantarella, Giuseppina

doi:10.3390/cells11172728

Cited by 189Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Role of Microglia and Astrocytes in Alzheimer’s Disease: From Neuroinflammation to Ca2+ Homeostasis Dysregulation

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Di Benedetto, Giulia, Burgaletto, Chiara, Bellanca, Carlo Maria, Munafò, Antonio, Bernardini, Renato, Cantarella, Giuseppina·2022·Cells

DOI 10.3390/cells11172728PMC PMC9454513

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Abstract

Alzheimer’s disease (AD) is the most common form of dementia worldwide, with a complex, poorly understood pathogenesis. Cerebral atrophy, amyloid-β (Aβ) plaques, and neurofibrillary tangles represent the main pathological hallmarks of the AD brain. Recently, neuroinflammation has been recognized as a prominent feature of the AD brain and substantial evidence suggests that the inflammatory response modulates disease progression. Additionally, dysregulation of calcium (Ca2+) homeostasis represents another early factor involved in the AD pathogenesis, as intracellular Ca2+ concentration is essential to ensure proper cellular and neuronal functions. Although growing evidence supports the involvement of Ca2+ in the mechanisms of neurodegeneration-related inflammatory processes, scant data are available on its contribution in microglia and astrocytes functioning, both in health and throughout the AD continuum. Nevertheless, AD-related aberrant Ca2+ signalling in astrocytes and microglia is crucially involved in the mechanisms underpinning neuroinflammatory processes that, in turn, impact neuronal Ca2+ homeostasis and brain function. In this light, we attempted to provide an overview of the current understanding of the interactions between the glia cells-mediated inflammatory responses and the molecular mechanisms involved in Ca2+ homeostasis dysregulation in AD.

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In AD and CNS infections, pro- and anti-inflammatory signaling is primarily initiated by CNS resident immune cells, the astrocytes, and microglia.
“In AD and CNS infections, pro- and anti-inflammatory signaling is primarily initiated by CNS resident immune cells, the astrocytes, and microglia (Di Benedetto et al., 2022; Russo and McGavern, 2015).”
From Arbovirus infection increases the risk for the development of neurodegenerative disease pathology in the murine model (2024) · cites this paper as Di Benedetto et al., 2022

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A New Cell-penetrating Peptide That Blocks the Autoinhibitory XIP Domain of NCX1 and Enhances Antiporter Activity
Molinaro, P., Pannaccione, A., Sisalli, M. J., Secondo, A., Cuomo, O., Sirabella, R., Cantile, M., Ciccone, R., Scorziello, A., Renzo, G. D., et al. (2014) · Molecular Therapy · doi:10.1038/mt.2014.231 · Cited by 21 · see citing works
The Plasma Membrane Calcium ATPases in Calcium Signaling Network
Wu, X., Weng, L., Zhang, J., Liu, X., & Huang, J. (2018) · Current Protein and Peptide Science · doi:10.2174/1389203719666180416122745 · Cited by 15 · see citing works
Microglial Store-operated Calcium Signaling in Health and in Alzheimer’s Disease
McLarnon, J. G. (2021) · Current Alzheimer Research · doi:10.2174/1567205018666210119143817 · Cited by 14 · see citing works
Neuron-derived factors negatively modulate ryanodine receptor-mediated calcium release in cultured mouse astrocytes
Skowrońska, K., Kozłowska, H., & Albrecht, J. (2020) · Cell Calcium · doi:10.1016/j.ceca.2020.102304 · Cited by 13 · see citing works
Astrocytes and Microglia Exhibit Cell-Specific Ca2+ Signaling Dynamics in the Murine Spinal Cord
Rieder, P., Gobbo, D., Stopper, G., Welle, A., Damo, E., Kirchhoff, F., & Scheller, A. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.840948 · Cited by 12 · see citing works
Quantifying the dose-dependent impact of intracellular amyloid beta in a mathematical model of calcium regulation in xenopus oocyte
Minicucci, J., Alfond, M., Demuro, A., Gerberry, D. J., & Latulippe, J. (2021) · PLoS ONE · doi:10.1371/journal.pone.0246116 · Cited by 11 · see citing works
Calcium signalling in glial cells
Verkhratsky, A. (1997) · Neurophysiology · doi:10.1007/bf02461230 · Cited by 10 · see citing works
Tumor necrosis factor‐related apoptosis‐inducing ligand reduces the expression of the neuroprotective Na+/Ca2+ exchanger isoform NCX 3 in human neuroblastoma SH ‐ SY 5Y cells
Benedetto, G. D., Valerio, O., Lariccia, V., Burgaletto, C., Lempereur, L., Parenti, C., Zanghì, G., Matteucci, A., Amoroso, S., Bernardini, R., et al. (2018) · FEBS Journal · doi:10.1111/febs.14732 · Cited by 6 · see citing works
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Microglia and Alzheimer’s Disease
Merighi, S., Nigro, M., Travagli, A., & Gessi, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112990 · Cited by 236 · see citing works
Lysosomal acidification dysfunction in microglia: an emerging pathogenic mechanism of neuroinflammation and neurodegeneration
Quick, J. D., Silva, C., Wong, J. H., Lim, K. L., Reynolds, R., Barron, A. M., Zeng, J., & Lo, C. H. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02866-y · Cited by 203 · see citing works
The duality of amyloid-β: its role in normal and Alzheimer’s disease states
Azargoonjahromi, A. (2024) · Molecular Brain · doi:10.1186/s13041-024-01118-1 · Cited by 173 · see citing works
Astrocytes as a Therapeutic Target in Alzheimer’s Disease–Comprehensive Review and Recent Developments
Rodríguez-Giraldo, M., González-Reyes, R. E., Ramírez-Guerrero, S., Bonilla-Trilleras, C. E., Guardo-Maya, S., & Nava-Mesa, M. O. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113630 · Cited by 118 · see citing works
Alzheimer's Disease Puzzle: Delving into Pathogenesis Hypotheses
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Microglia and Astroglia—The Potential Role in Neuroinflammation Induced by Pre- and Neonatal Exposure to Lead (Pb)
Gąssowska-Dobrowolska, M., Chlubek, M., Kolasa, A., Tomasiak, P., Korbecki, J., Skowrońska, K., Tarnowski, M., Masztalewicz, M., & Baranowska‐Bosiacka, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24129903 · Cited by 74 · see citing works
JAK2/STAT3 as a new potential target to manage neurodegenerative diseases: An interactive review
Panda, S. P., Kesharwani, A., Datta, S., Prasanth, D., Panda, S. K., & Guru, A. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176490 · Cited by 60 · see citing works
Blood-Based Biomarkers in Alzheimer’s Disease: Advancing Non-Invasive Diagnostics and Prognostics
Dhauria, M., Mondal, R., Deb, S., Shome, G., Chowdhury, D., Sarkar, S., & Benito‐León, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252010911 · Cited by 57 · see citing works
The role of glial autophagy in Alzheimer’s disease
Litwiniuk, A., Juszczak, G. R., Stankiewicz, A. M., & Urbańska, K. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02242-5 · Cited by 54 · see citing works
Biochemical and Molecular Pathways in Neurodegenerative Diseases: An Integrated View
Sanghai, N., & Tranmer, G. K. (2023) · Cells · doi:10.3390/cells12182318 · Cited by 55 · see citing works
Luteolin Mitigates D-Galactose-Induced Brain Ageing in Rats: SIRT1-Mediated Neuroprotection
Younis, R. L., El‐Gohary, R. M., Ghalwash, A. A., Hegab, I. I., Ghabrial, M. M. M., Aboshanady, A. M. M., Mostafa, R. A., El‐Azeem, A. H. A., Farghal, E. E., Belal, A. A. E., et al. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04203-y · Cited by 44 · see citing works
Proteostasis disruption and senescence in Alzheimer’s disease pathways to neurodegeneration
Thapa, R., Bhat, A. A., Shahwan, M. J., Ali, H., Padmapriya, G., Bansal, P., Rajotiya, S., Barwal, A., Prasad, G. V. S., Pramanik, A., et al. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149202 · Cited by 44 · see citing works
Immunosenescence and Aging: Neuroinflammation Is a Prominent Feature of Alzheimer’s Disease and Is a Likely Contributor to Neurodegenerative Disease Pathogenesis
Bowirrat, A. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12111817 · Cited by 45 · see citing works
Multi-target approach to Alzheimer’s disease prevention and treatment: antioxidant, anti-inflammatory, and amyloid- modulating mechanisms
Abbas, K., Mustafa, M., Alam, M., Habib, S., Ahmad, W., Adnan, M., Hassan, M. I., & Usmani, N. (2025) · Neurogenetics · doi:10.1007/s10048-025-00821-y · Cited by 44 · see citing works
Glial Perturbation in Metal Neurotoxicity: Implications for Brain Disorders
Ijomone, O. K., Inelo, U. I., Aneke, V. O., Olajide, T. S., Inyang, H. O., Omotosho, O. I., Oyerinde, T. O., Anadu, V. E., Gbayisomore, T. J., Okeowo, O. M., et al. (2025) · Neuroglia · doi:10.3390/neuroglia6010004 · Cited by 40 · see citing works
Microbiome Dysbiosis: A Pathological Mechanism at the Intersection of Obesity and Glaucoma
Pezzino, S., Sofia, M., Greco, L. P., Litrico, G., Filippello, G., Sarvà, I., Greca, G. L., & Latteri, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021166 · Cited by 39 · see citing works
Glutamate: Molecular Mechanisms and Signaling Pathway in Alzheimer’s Disease, a Potential Therapeutic Target
Puranik, N., & Song, M. (2024) · Molecules · doi:10.3390/molecules29235744 · Cited by 45 · see citing works
Modulating Neuroinflammation as a Prospective Therapeutic Target in Alzheimer’s Disease
Lee, E., & Chang, Y. (2025) · Cells · doi:10.3390/cells14030168 · Cited by 38 · see citing works
Recent Progress in Nanomedicine for the Diagnosis and Treatment of Alzheimer’s Diseases
Yang, H., Tan, H., Wen, H., Xin, P., Liu, Y., Deng, Z., Xu, Y., Gao, F., Zhang, L., Ye, Z., et al. (2024) · ACS Nano · doi:10.1021/acsnano.4c11966 · Cited by 37 · see citing works
Quercetin ameliorates neuroinflammatory and neurodegenerative biomarkers in the brain and improves neurobehavioral parameters in a repeated intranasal amyloid-beta exposed model of Alzheimer's disease
Lasure, V., Gautam, A. S., & Singh, R. K. (2024) · Food & Function · doi:10.1039/d4fo02602k · Cited by 35 · see citing works
Cellular and Molecular Interactions in CNS Injury: The Role of Immune Cells and Inflammatory Responses in Damage and Repair
Patel, J. C., Shukla, M., & Shukla, M. (2025) · Cells · doi:10.3390/cells14120918 · Cited by 38 · see citing works
Lactiplantibacillus plantarum HEAL9 attenuates cognitive impairment and progression of Alzheimer's disease and related bowel symptoms in SAMP8 mice by modulating microbiota-gut-inflammasome-brain axis
Salvo, C. D., D’Antongiovanni, V., Benvenuti, L., d’Amati, A., Ippolito, C., Segnani, C., Pierucci, C., Bellini, G., Annese, T., Virgintino, D., et al. (2024) · Food & Function · doi:10.1039/d4fo02075h · Cited by 34 · see citing works
Unravelling neuronal death mechanisms: The role of cytokines and chemokines in immune imbalance in Alzheimer’s disease progression
Kumari, S., Dhapola, R., Sharma, P., Paidlewar, M., Vellingiri, B., Medhi, B., & HariKrishnaReddy, D. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102883 · Cited by 34 · see citing works
Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders
Qiu, Q., Yang, M., Gong, D., Liang, H., & Chen, T. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01766 · Cited by 33 · see citing works
The role of estrogen in Alzheimer’s disease pathogenesis and therapeutic potential in women
Wang, X., Feng, S., Deng, Q., Wu, C., Duan, R., & Yang, L. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05071-4 · Cited by 33 · see citing works
Inflammatory proteins associated with Alzheimer’s disease reduced by a GLP1 receptor agonist: a post hoc analysis of the EXSCEL randomized placebo controlled trial
Koychev, I. G., Reid, G., Nguyen, M., Mentz, R. J., Joyce, D. W., Shah, S. H., & Holman, R. R. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01573-x · Cited by 35 · see citing works
Dual impact of neuroinflammation on cognitive and motor impairments in Alzheimer's disease
Fakorede, S., Lateef, O. M., Garuba, W. A., Akosile, P. O., Okon, D. A., & Aborode, A. T. (2025) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823251341870 · Cited by 33 · see citing works
An Appraisal of the Oleocanthal-Rich Extra Virgin Olive Oil (EVOO) and Its Potential Anticancer and Neuroprotective Properties
Infante, R., Infante, M., Pastore, D., Pacifici, F., Chiereghin, F., Malatesta, G., Donadel, G., Tesauro, M., & Della‐Morte, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417323 · Cited by 33 · see citing works
Zebrafish: A Model Deciphering the Impact of Flavonoids on Neurodegenerative Disorders
Mhalhel, K., Sicari, M., Pansera, L., Chen, J., Levanti, M. B., Diotel, N., Rastegar, S., Germanà, A., & Montalbano, G. (2023) · Cells · doi:10.3390/cells12020252 · Cited by 36 · see citing works
Role of P2Y receptors in astrocyte physiology and pathophysiology
Lohr, C. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109311 · Cited by 29 · see citing works
Revolutionizing neurotherapeutics: Nanocarriers unveiling the potential of phytochemicals in Alzheimer's disease
Kamath, A. P., Nayak, P. G., John, J., Mutalik, S., Balaraman, A. K., & Nandakumar, K. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110096 · Cited by 31 · see citing works
Alzheimer's Disease: A Review of Pathology, Current Treatments, and the Potential Therapeutic Effect of Decreasing Oxidative Stress by Combined Vitamin D and l -Cysteine Supplementation
Jain, S. K., Stevens, C. M., Margret, J. J., & Levine, S. N. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0245 · Cited by 27 · see citing works
Glial cell nutrient sensing: mechanisms of nutrients regulating Alzheimer’s pathogenesis and precision intervention
Yan, Q., Qin, Q., Zhang, S., Chen, F., Ru, Y., Zhong, Y., & Wu, G. (2025) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2025.2568606 · Cited by 27 · see citing works
Potential Therapeutic Targets to Modulate the Endocannabinoid System in Alzheimer’s Disease
Kanwal, H., Sangineto, M., Ciarnelli, M., Castaldo, P., Villani, R., Romano, A. D., Serviddio, G., & Cassano, T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25074050 · Cited by 26 · see citing works
The Alteration of Microglial Calcium Homeostasis in Central Nervous System Disorders: A Comprehensive Review
Hasan, A. R., Tasnim, F., Aktaruzzaman, M., Islam, M. T., Rayhan, R., Brishti, A., Hur, J., Porter, J. E., & Raihan, M. O. (2024) · Neuroglia · doi:10.3390/neuroglia5040027 · Cited by 25 · see citing works
Glial Cells as Emerging Therapeutic Targets in Neurodegenerative Diseases: Mechanistic Insights and Translational Perspectives
Vishnumukkala, T., Nassir, C. M. N. C. M., Hein, Z. M., Gopalakrishna, P. K., Karikalan, B., Alkatiri, A., Jagadeesan, S., Naik, V. R., Thomas, W., Moklas, M. A. M., et al. (2025) · Cells · doi:10.3390/cells14191497 · Cited by 27 · see citing works
Synthesis, characterization, in-silico, and pharmacological evaluation of new 2-amino-6‑trifluoromethoxy benzothiazole derivatives
Malik, S., Miana, G. A., Ata, A., Kanwal, M., Maqsood, S., Malik, I., & Kazmi, Z. (2022) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.106175 · Cited by 23 · see citing works
Inhibition of GluN2B pathway is involved in the neuroprotective effect of silibinin on streptozotocin-induced Alzheimer's disease models
Liu, P., Wang, C., Chen, W., Kang, Y., Liu, W., Qiu, Z., Hayashi, T., Mizuno, K., Hattori, S., Fujisaki, H., et al. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154594 · Cited by 23 · see citing works
An updated and comprehensive review of the health benefits and pharmacological activities of hesperidin
Ogunro, O. B. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.151974 · Cited by 22 · see citing works
Innovative treatments for obesity and NAFLD: A bibliometric study on antioxidants, herbs, phytochemicals, and natural compounds
Pezzino, S., Sofia, M., Mazzone, C., Litrico, G., Greco, L. P., Gallo, L., Greca, G. L., & Latteri, S. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e35498 · Cited by 23 · see citing works
The Therapeutic Potential of Butyrate and Lauric Acid in Modulating Glial and Neuronal Activity in Alzheimer’s Disease
Wtpsk, S., Oikari, L. E., Bharadwaj, P., Jayasena, V., Martins, R. N., & Fernando, W. M. A. D. B. (2025) · Nutrients · doi:10.3390/nu17142286 · Cited by 21 · see citing works
Bringing synapses into focus: Recent advances in synaptic imaging and mass-spectrometry for studying synaptopathy
Hindley, N., Avila, A. S., & Henstridge, C. M. (2023) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2023.1130198 · Cited by 18 · see citing works
Contribution of Axon Initial Segment Structure and Channels to Brain Pathology
Garrido, J. J. (2023) · Cells · doi:10.3390/cells12081210 · Cited by 19 · see citing works
Thyroid Hormone Supplementation Restores Cognitive Deficit, Insulin Signaling, and Neuroinflammation in the Hippocampus of a Sporadic Alzheimer’s-like Disease Rat Model
Sepúlveda, P., Ferreira, A. F. F., Sandoval, C., Bergoc, G. G., Moreno, A. C. R., Nunes, M. T., & Torrão, A. D. S. (2024) · Cells · doi:10.3390/cells13211793 · Cited by 18 · see citing works
Tau and Amyloid beta causes microglial activation in Alzheimer’s disease
Chinnathambi, S., Adithyan, A., Chandrashekar, M., & Rangappa, N. (2025) · Advances in clinical chemistry · doi:10.1016/bs.acc.2025.06.002 · Cited by 18 · see citing works
Roles of Astrocytic Endothelin ETB Receptor in Traumatic Brain Injury
Michinaga, S., Hishinuma, S., & Kōyama, Y. (2023) · Cells · doi:10.3390/cells12050719 · Cited by 18 · see citing works
Molecular mechanisms of Alzheimer’s disease: From therapeutic targets to promising drugs
Alan, E., Kerry, Z., & Sevin, G. (2023) · Fundamental & Clinical Pharmacology · doi:10.1111/fcp.12861 · Cited by 17 · see citing works
Spatiotemporal Dysregulation of Neuron–Glia Related Genes and Pro-/Anti-Inflammatory miRNAs in the 5xFAD Mouse Model of Alzheimer’s Disease
Ianni, M., Corraliza-Gómez, M., Costa-Coelho, T., Ferreira-Manso, M., Inteiro-Oliveira, S., Alemãn-Serrano, N., Sebastião, A. M., Garcia, G., Diógenes, M. J., & Brites, D. M. T. O. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179475 · Cited by 17 · see citing works
Bacterial Membrane Vesicles: The Missing Link Between Bacterial Infection and Alzheimer Disease
Butler, C. A., Ciccotosto, G. D., Rygh, N., Bijlsma, E., Dashper, S. G., & Brown, A. C. (2024) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiae228 · Cited by 17 · see citing works
Exosomal non-coding RNAs: gatekeepers of inflammation in autoimmune disease
Saadh, M. J., Allela, O. Q. B., Al-Hussainy, A. F., Baldaniya, L., Rekha, M. M., Nathiya, D., Kaur, P., Aminov, Z., Sameer, H. N., Hameed, H. G., et al. (2025) · Journal of Inflammation · doi:10.1186/s12950-025-00443-z · Cited by 18 · see citing works
Astrocytes and Microglia in Alzheimer's Disease: Friends, Foes, or Both?
Sharma, A., Parekh, B. K., Patil, V., Renuka Jyothi, S., Nayak, P. P., Janney, J. B., Singh, G., & Al-Hasnaawei, S. (2025) · Developmental Neurobiology · doi:10.1002/dneu.23015 · Cited by 17 · see citing works
American Ginseng for the Treatment of Alzheimer’s Disease: A Review
Shan, M., Bai, Y., Fang, X., Lan, X., Zhang, Y., Cao, Y., Zhu, D., & Luo, H. (2023) · Molecules · doi:10.3390/molecules28155716 · Cited by 15 · see citing works
Unlocking therapeutic potential of siRNA-based drug delivery system for treatment of Alzheimer's disease
Jain, S., Bhushan, B., Mishra, A. K., & Singh, R. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.106413 · Cited by 15 · see citing works
Microglial Modulation in Alzheimer’s Disease: Central Players in Neuroinflammation and Pathogenesis
Hussain, M. S., Khan, Y., Fatima, R., Maqbool, M., Ramalingam, P. S., Khan, M. G., & Bisht, A. S. (2025) · Current Alzheimer Research · doi:10.2174/0115672050364292250113063513 · Cited by 15 · see citing works
Mind the Gap: Unraveling the Intricate Dance Between Alzheimer’s Disease and Related Dementias and Bone Health
Karnik, S. J., Margetts, T. J., Wang, H. S., Movilă, A., Oblak, A. L., Fehrenbacher, J. C., Kacena, M. A., & Plotkin, L. I. (2024) · Current Osteoporosis Reports · doi:10.1007/s11914-023-00847-x · Cited by 15 · see citing works
Supplementation of Seaweed Extracts to the Diet Reduces Symptoms of Alzheimer’s Disease in the APPswePS1ΔE9 Mouse Model
Martens, N., Zhan, N., Yam, S. C., Leijten, F. P. J., Palumbo, M., Caspers, M. P. M., Tiane, A., Friedrichs, S., Li, Y., der Zee, L. V. V., et al. (2024) · Nutrients · doi:10.3390/nu16111614 · Cited by 14 · see citing works
Activation of Gq-Coupled Receptors in Astrocytes Restores Cognitive Function in Alzheimer’s Disease Mice Model
Gerasimov, E., Борисович, Б. И., & Власова, О. Л. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24129969 · Cited by 13 · see citing works
Another Use for a Proven Drug: Experimental Evidence for the Potential of Artemisinin and Its Derivatives to Treat Alzheimer’s Disease
Kiss, E., Kins, S., Gorgas, K., Szakács, K. H. V., Kirsch, J., & Kuhse, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084165 · Cited by 14 · see citing works
Pharmacological enhancement of cholinergic neurotransmission alleviates neuroinflammation and improves functional outcomes in a triple transgenic mouse model of Alzheimer’s disease
Munafò, A., Cantone, A. F., Benedetto, G. D., Torrisi, S. A., Burgaletto, C., Bellanca, C. M., Gaudio, G., Broggi, G., Caltabiano, R., Leggio, G. M., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1386224 · Cited by 12 · see citing works
Self-citation
Neuroimmunology of Cardiovascular Disease
Zarate, S. M., Kirabo, A., Hinton, A. O., Jr., & Santisteban, M. M. (2024) · Current Hypertension Reports · doi:10.1007/s11906-024-01301-8 · Cited by 13 · see citing works
Therapeutic potential of chrysin in regulation of interleukin-17 signaling in a repeated intranasal amyloid-beta-induced Alzheimer's disease model
Gautam, A. S., Panda, E. S., Balki, S., Pandey, S. K., Tiwari, A., & Singh, R. K. (2024) · Food & Function · doi:10.1039/d4fo05278a · Cited by 12 · see citing works
The Role of Probiotics in Modulating the Gut Microbiome in Alzheimer’s Disease: A Review
Dong, Y., Wu, X., Zhang, Y., Hu, A., Zhou, Q., Yue, X., Liu, Z., & Li, M. (2025) · Foods · doi:10.3390/foods14091531 · Cited by 14 · see citing works
Recent advances in diagnostic and therapeutic strategies for canine cognitive dysfunction.
Kim, S. H., & Hao, J. (2025) · American Journal of Veterinary Research · doi:10.2460/ajvr.25.02.0053 · Cited by 19 · see citing works
Aβ1-42 Accumulation Accompanies Changed Expression of Ly6/uPAR Proteins, Dysregulation of the Cholinergic System, and Degeneration of Astrocytes in the Cerebellum of Mouse Model of Early Alzheimer Disease
Bychkov, M. L., Isaev, A. B., Andreev-Andrievskiy, A. A., Petrov, K. A., Paramonov, A. S., Kirpichnikov, M. P., & Lyukmanova, E. N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914852 · Cited by 11 · see citing works
Chondroitin sulphate modified MoS2 nanoenzyme with multifunctional activities for treatment of Alzheimer's disease
Tian, J., Peng, Q., Shen, Y., Liu, X., Li, D., Li, J., Guo, S., Meng, C., & Xiao, Y. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.131425 · Cited by 11 · see citing works
The potential link between the development of Alzheimer’s disease and osteoporosis
Nasme, F., Behera, J., Tyagi, P., Debnath, N., Falcone, J. C., & Tyagi, N. (2025) · Biogerontology · doi:10.1007/s10522-024-10181-z · Cited by 12 · see citing works
IL-17 A Exacerbated Neuroinflammatory and Neurodegenerative Biomarkers in Intranasal Amyloid-Beta Model of Alzheimer’s Disease
Gautam, A. S., Pandey, S. K., Balki, S., Panda, E. S., & Singh, R. K. (2025) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-025-10192-8 · Cited by 10 · see citing works
Endogenous Aβ and Exogenous Wheat Gluten Nanostructures: Understanding Peptide Self-Assembly in Disease
Herrera, M. G., Ciccone, L., Moleiro, L. H., Tonali, N., & Dodero, V. I. (2025) · ACS Nano · doi:10.1021/acsnano.5c01662 · Cited by 11 · see citing works
Alterations of mRNAs and Non-coding RNAs Associated with Neuroinflammation in Alzheimer’s Disease
Hernández-Contreras, K. A., Martínez-Díaz, J. A., Hernández‐Aguilar, M. E., Herrera‐Covarrubias, D., Rojas-Durán, F., Chi-Castañeda, D., García, L. I., & Aranda-Abreu, G. E. (2024) · Molecular Neurobiology · doi:10.1007/s12035-023-03908-5 · Cited by 11 · see citing works
Aging-Related Protein Alterations in the Brain
Syed, R. A., Hayat, M., Qaiser, H., Uzair, M., Al-Regaiey, K., Khallaf, R. A., Kaleem, I., & Bashir, S. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-230801 · Cited by 10 · see citing works
Arbovirus infection increases the risk for the development of neurodegenerative disease pathology in the murine model
Fongsaran, C., Jirakanwisal, K., Peng, B.-H., Fracassi, A., Taglialatela, G., Dineley, K. T., Paessler, S., & Cisneros, I. E. (2024) · Brain, Behavior, & Immunity - Health · doi:10.1016/j.bbih.2024.100780 · Cited by 9 · see citing works
Effects of Probiotics on Colitis-Induced Exacerbation of Alzheimer’s Disease in AppNL-G-F Mice
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Authors: Di Benedetto, G., Burgaletto, C., Bellanca, C. M., Munafò, A., Bernardini, R., & Cantarella, G.
Affiliations: Department of Biomedical and Biotechnological Sciences, Section of Pharmacology, University of Catania, 95123 Catania, Italy
University of Catania (IT)
Corresponding author: Bernardini, Renato
ORCID: Di Benedetto, Giulia
Burgaletto, Chiara
Bellanca, Carlo Maria
Munafò, Antonio
Bernardini, Renato
Cantarella, Giuseppina
Venue: Cells
Publisher: MDPI AG
Published: 2022-09-01
Volume: 11
Issue: 17
Pages: 2728
ISSN: 2073-4409 (ISSN-L)
DOI: 10.3390/cells11172728
PMC: PMC9454513
OpenAlex: W4294151542
Cited by: 189
References: 187
Citations by year: 2026: 53 · 2025: 63 · 2024: 46 · 2023: 19 · 2022: 8
FWCI: 3.48
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Cells (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: the Italian Ministry of Research (2017YH3SXK)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: Alzheimer's disease, microglia, astrocytes, neuroinflammation, calcium homeostasis, calcium signaling, glial interactions, amyloid plaques, neurofibrillary tangles, neurodegeneration, glial inflammation
MeSH terms: Neuroinflammatory Diseases, Alzheimer Disease, Astrocytes, Homeostasis, Humans, Microglia, Plaque, Amyloid

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Role of Microglia and Astrocytes in Alzheimer’s Disease: From Neuroinflammation to Ca2+ Homeostasis Dysregulation

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