The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Reciprocal Regulation of the TOR Kinase and ABA Receptor Balances Plant Growth and Stress Response
Open accessAbstract
SUMMARY As sessile organisms, plants must adapt to variations in the environment. Environmental stress triggers various responses, including growth inhibition, mediated by the plant hormone abscisic acid (ABA). The mechanisms that integrate stress responses with growth are poorly understood. Here, we discovered that the Target of Rapamycin (TOR) kinase phosphorylates PYL ABA receptors at a conserved serine residue to prevent activation of the stress response in unstressed plants. This phosphorylation disrupts PYL association with ABA and with PP2C phosphatase effectors, leading to inactivation of SnRK2 kinases. Under stress, ABA-activated SnRK2s phosphorylate Raptor, a component of the TOR complex, triggering TOR complex dissociation and inhibition. Thus, TOR signaling represses ABA signaling and stress responses in unstressed conditions, whereas ABA signaling represses TOR signaling and growth during times of stress. Plants utilize this conserved phospho-regulatory feedback mechanism to optimize the balance of growth and stress responses.
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Cites
Cox, J., & Mann, M. (2008) · Nature Biotechnology · doi:10.1038/nbt.1511 · Cited by 14,855
AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., Vasquez, D. S., Turk, B. E., & Shaw, R. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.003 · Cited by 3,849
Making new contacts: the mTOR network in metabolism and signalling crosstalk
Shimobayashi, M., & Hall, M. N. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3757 · Cited by 1,053
A gate–latch–lock mechanism for hormone signalling by abscisic acid receptors
Melcher, K., Ng, L.-M., Zhou, X. E., Soon, F.-F., Xu, Y., Suino-Powell, K. M., Park, S.-Y., Weiner, J. J., Fujii, H., Chinnusamy, V., et al. (2009) · Nature · doi:10.1038/nature08613 · Cited by 731
Self-citationERK1/2 Phosphorylate Raptor to Promote Ras-dependent Activation of mTOR Complex 1 (mTORC1)
Carriere, A., Romeo, Y., Acosta-Jaquez, H. A., Moreau, J., Bonneil, E., Thibault, P., Fingar, D. C., & Roux, P. P. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.159046 · Cited by 268
Cited by
Signaling mechanisms in abscisic acid-mediated stomatal closure
Hsu, P., Dubeaux, G., Takahashi, Y., & Schroeder, J. I. (2021) · The Plant Journal · doi:10.1111/tpj.15067 · Cited by 546
Revisiting the Basal Role of ABA – Roles Outside of Stress
Yoshida, T., Christmann, A., Yamaguchi-Shinozaki, K., Grill, E., & Fernie, A. R. (2019) · Trends in Plant Science · doi:10.1016/j.tplants.2019.04.008 · Cited by 268
Miao, J., Li, X., Li, X., Tan, W., You, A., Wu, S., Tao, Y., Chen, C., Wang, J., Zhang, D., et al. (2020) · New Phytologist · doi:10.1111/nph.16670 · Cited by 110
Regulation of vacuole fusion in stomata by dephosphorylation of the HOPS subunit VPS39
Pullen, A., Billings, G., Hodgens, C., White, G., Akpa, B. S., & Rojas‐Pierce, M. (2025) · The Plant Journal · doi:10.1111/tpj.70640 · Cited by 1
Metadata
- Authors
- Wang, P., Zhao, Y., Li, Z., Hsu, C.-C., Liu, X., Fu, L., Hou, Y.-J., Du, Y., Xie, S., Zhang, C., Gao, J., Cao, M., Huang, X., Zhu, Y., Tang, K., Wang, X., Tao, W. A., Xiong, Y., & Zhu, J.-K.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 69
- Issue
- 1
- Pages
- 100-112.e6
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2778077257
- Cited by
- 591
- References
- 5
- FWCI
- 40.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wang, P., Zhao, Y., Li, Z., Hsu, C.-C., Liu, X., Fu, L., Hou, Y.-J., Du, Y., Xie, S., Zhang, C., Gao, J., Cao, M., Huang, X., Zhu, Y., Tang, K., Wang, X., Tao, W. A., Xiong, Y., & Zhu, J.-K. (2018). Reciprocal Regulation of the TOR Kinase and ABA Receptor Balances Plant Growth and Stress Response. Molecular Cell. https://doi.org/10.1016/j.molcel.2017.12.002
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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