Making new contacts: the mTOR network in metabolism and signalling crosstalk

mTOR Signaling in Growth Control and Disease

Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509 · see citing works

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227 · see citing works

TOR signaling in growth and metabolism

Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787 · see citing works

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Inoki, K., Li, Y., Zhu, T., Wu, J., & Guan, K.-L. (2002) · Nature Cell Biology · doi:10.1038/ncb839 · Cited by 3,083 · see citing works

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

Sancak, Y., Peterson, T. R., Shaul, Y. D., Lindquist, R. A., Thoreen, C. C., Bar-Peled, L., & Sabatini, D. M. (2008) · Science · doi:10.1126/science.1157535 · Cited by 2,773 · see citing works

Notch signalling: a simple pathway becomes complex

Bray, S. J. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2009 · Cited by 2,620 · see citing works

Molecular mechanisms of mTOR-mediated translational control

Ma, X. M., & Blenis, J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2672 · Cited by 2,558 · see citing works

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, A. L., Nada, S., & Sabatini, D. M. (2010) · Cell · doi:10.1016/j.cell.2010.02.024 · Cited by 2,464 · see citing works

Elucidation of a universal size-control mechanism in Drosophila and mammals

Dong, J., Feldmann, G., Huang, J., Wu, S., Zhang, N., Comerford, S. A., Gayyed, M. F., Anders, R. A., Maitra, A., & Pan, D. (2007) · Cell · doi:10.1016/j.cell.2007.07.019 · Cited by 2,370 · see citing works

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

Hosokawa, N., Hara, T., Kaizuka, T., Kishi, C., Takamura, A., Miura, Y., Iemura, S.-I., Natsume, T., Takehana, K., Yamada, N., et al. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1248 · Cited by 2,076 · see citing works

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

Jung, C. H., Jun, C. B., Ro, S.-H., Kim, Y.-M., Otto, N. M., Cao, J., Kundu, M., & Kim, D.-H. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1249 · Cited by 2,025 · see citing works

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

Düvel, K., Yecies, J. L., Menon, S., Raman, P., Lipovsky, A. I., Souza, A. L., Triantafellow, E., Ma, Q., Gorski, R., Cleaver, S., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.022 · Cited by 2,020 · see citing works

A lysosome‐to‐nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

Settembre, C., Zoncu, R., Medina, D. L., Vetrini, F., Erdin, S., Erdin, S. U., Huynh, T., Ferron, M., Karsenty, G., Vellard, M. C., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.32 · Cited by 1,932 · see citing works

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

Thoreen, C. C., Kang, S. A., Chang, J. W., Liu, Q., Zhang, J., Gao, Y., Reichling, L. J., Sim, T., Sabatini, D. M., & Gray, N. S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m900301200 · Cited by 1,803 · see citing works

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H ⁺ -ATPase

Zoncu, R., Bar-Peled, L., Efeyan, A., Wang, S., Sancak, Y., & Sabatini, D. M. (2011) · Science · doi:10.1126/science.1207056 · Cited by 1,673 · see citing works

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

Yu, F.-X., Zhao, B., Panupinthu, N., Jewell, J. L., Lian, I., Wang, L. H., Zhao, J., Yuan, H., Tumaneng, K., Li, H., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.037 · Cited by 1,628 · see citing works

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

Russell, R. C., Tian, Y., Yuan, H., Park, H. W., Chang, Y.-Y., Kim, J., Kim, H., Neufeld, T. P., Dillin, A. G., & Guan, K. (2013) · Nature Cell Biology · doi:10.1038/ncb2757 · Cited by 1,586 · see citing works

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

Ganley, I. G., Lam, D., Wang, J., Ding, X., Chen, S., & Jiang, X. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m900573200 · Cited by 1,559 · see citing works

Termination of autophagy and reformation of lysosomes regulated by mTOR

Yu, L., McPhee, C. K., Zheng, L., Mardones, G. A., Rong, Y., Peng, J., Mi, N., Zhao, Y., Liu, Z., Wan, F., et al. (2010) · Nature · doi:10.1038/nature09076 · Cited by 1,544 · see citing works

The complex world of WNT receptor signalling

Niehrs, C. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3470 · Cited by 1,481 · see citing works

A unifying model for mTORC1-mediated regulation of mRNA translation

Thoreen, C. C., Chantranupong, L., Keys, H. R., Wang, T., Gray, N. S., & Sabatini, D. M. (2012) · Nature · doi:10.1038/nature11083 · Cited by 1,477 · see citing works

SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

Porstmann, T., Santos, C. R., Griffiths, B., Cully, M., Wu, M., Leevers, S., Griffiths, J. R., Chung, Y.-L., & Schulze, A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.07.007 · Cited by 1,413 · see citing works

TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth

Inoki, K., Ouyang, H., Zhu, T., Lindvall, C., Wang, Y., Zhang, X., Yang, Q., Bennett, C., Harada, Y., Stankunas, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.06.055 · Cited by 1,377 · see citing works

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

Martina, J. A., Chen, Y., Guček, M., & Puertollano, R. (2012) · Autophagy · doi:10.4161/auto.19653 · Cited by 1,360 · see citing works

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

Roczniak-Ferguson, A., Petit, C. S. V., Froehlich, F., Qian, S., Ky, J., Angarola, B. L., Walther, T. C., & Ferguson, S. M. (2012) · Science Signaling · doi:10.1126/scisignal.2002790 · Cited by 1,357 · see citing works

Regulation of TORC1 by Rag GTPases in nutrient response

Kim, E., Goraksha-Hicks, P., Li, L., Neufeld, T. P., & Guan, K.-L. (2008) · Nature Cell Biology · doi:10.1038/ncb1753 · Cited by 1,349 · see citing works

The translational landscape of mTOR signalling steers cancer initiation and metastasis

Hsieh, A. C., Liu, Y., Edlind, M. P., Ingolia, N. T., Janes, M. R., Sher, A., Shi, E. Y., Stumpf, C. R., Christensen, C., Bonham, M. J., et al. (2012) · Nature · doi:10.1038/nature10912 · Cited by 1,313 · see citing works

Tor, a Phosphatidylinositol Kinase Homologue, Controls Autophagy in Yeast

Noda, T., & Ohsumi, Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.7.3963 · Cited by 1,308 · see citing works

Lipid signalling in disease

Wymann, M. P., & Schneiter, R. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2335 · Cited by 1,285 · see citing works

mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events

Holz, M. K., Ballif, B. A., Gygi, S. P., & Blenis, J. (2005) · Cell · doi:10.1016/j.cell.2005.10.024 · Cited by 1,262 · see citing works

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

Peterson, T. R., Sengupta, S., Harris, T. E., Carmack, A. E., Kang, S. A. W., Balderas, E., Guertin, D. A., Madden, K. L., Carpenter, A. E., Finck, B. N., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.034 · Cited by 1,233 · see citing works

The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

Zhao, B., Tumaneng, K., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2303 · Cited by 1,205 · see citing works

The mTOR‐regulated phosphoproteome reveals a mechanism of mTORC1‐mediated inhibition of growth factor signaling

Hsu, P. P., Kang, S. A., Rameseder, J., Zhang, Y., Ottina, K. A., Lim, D., Peterson, T. R., Choi, Y., Gray, N. S., Yaffe, M. B., et al. (2011) · Science · doi:10.1126/science.1199498 · Cited by 1,084 · see citing works

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

Bar-Peled, L., Chantranupong, L., Cherniack, A. D., Chen, W. W., Ottina, K. A., Grabiner, B. C., Spear, E. D., Carter, S. L., Meyerson, M., & Sabatini, D. M. (2013) · Science · doi:10.1126/science.1232044 · Cited by 1,080 · see citing works

mTOR kinase structure, mechanism and regulation

Yang, H., Rudge, D. G., Koos, J. D., Vaidialingam, B., Yang, H. J., & Pavletich, N. P. (2013) · Nature · doi:10.1038/nature12122 · Cited by 1,075 · see citing works

Rheb Binds and Regulates the mTOR Kinase

Long, X., Lin, Y., Ortiz-Vega, S., Yonezawa, K., & Avruch, J. (2005) · Current Biology · doi:10.1016/j.cub.2005.02.053 · Cited by 1,005 · see citing works

Rapamycin passes the torch: a new generation of mTOR inhibitors

Benjamin, D., Colombi, M., Moroni, C., & Hall, M. N. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3531 · Cited by 981 · see citing works

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

Bar-Peled, L., Schweitzer, L. D., Zoncu, R., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.07.032 · Cited by 918 · see citing works

Amino acid signalling upstream of mTOR

Jewell, J. L., Russell, R. C., & Guan, K.-L. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3522 · Cited by 894 · see citing works

Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase

Wang, X.-M., Li, W., Williams, M. R., Terada, N., Alessi, D., & Proud, C. G. (2001) · EMBO Journal · doi:10.1093/emboj/20.16.4370 · Cited by 862 · see citing works

Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

Yu, Y., Yoon, S.-O., Poulogiannis, G., Yang, Q., Ma, X. M., Villén, J., Kubica, N., Hoffman, G. R., Cantley, L. C., Gygi, S. P., et al. (2011) · Science · doi:10.1126/science.1199484 · Cited by 855 · see citing works

mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation

Morita, M., Gravel, S.-P., Chénard, V., Sikström, K., Zheng, L., Alain, T., Gandin, V., Avizonis, D., Arguello, M., Zakaria, C., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.10.001 · Cited by 842 · see citing works

Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1

Ben-Sahra, I., Howell, J. J., Asara, J. M., & Manning, B. D. (2013) · Science · doi:10.1126/science.1228792 · Cited by 739 · see citing works

mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs

Dowling, R. J. O., Topisirović, I., Alain, T., Bidinosti, M., Fonseca, B. D., Petroulakis, E., Wang, X., Larsson, O. S., Selvaraj, A., Liu, Y., et al. (2010) · Science · doi:10.1126/science.1187532 · Cited by 726 · see citing works

Glutaminolysis Activates Rag-mTORC1 Signaling

Durán, R. V., Oppliger, W., Robitaille, A. M., Heiserich, L., Skendaj, R., Gottlieb, E., & Hall, M. N. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.05.043 · Cited by 723 · see citing works

Signal integration by mTORC1 coordinates nutrient input with biosynthetic output

Dibble, C. C., & Manning, B. D. (2013) · Nature Cell Biology · doi:10.1038/ncb2763 · Cited by 716 · see citing works

Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes

Blommaart, E. F. C., Luiken, J. J. F. P., Blommaart, P. J. E., van Woerkom, G. M., & Meijer, A. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.5.2320 · Cited by 686 · see citing works

Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

Yecies, J. L., Zhang, H., Menon, S., Liu, S., Yecies, D. W., Lipovsky, A. I., Görgün, C. Z., Kwiatkowski, D. J., Hotamışlıgil, G. S., Lee, C., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.002 · Cited by 662 · see citing works

Activation of mTORC2 by Association with the Ribosome

Zinzalla, V., Stracka, D., Oppliger, W., & Hall, M. N. (2011) · Cell · doi:10.1016/j.cell.2011.02.014 · Cited by 648 · see citing works

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

Sengupta, S., Peterson, T. R., Laplante, M., Oh, S., & Sabatini, D. M. (2010) · Nature · doi:10.1038/nature09584 · Cited by 646 · see citing works

mTOR, translation initiation and cancer

Mamane, Y., Petroulakis, E., LeBacquer, O., & Sonenberg, N. (2006) · Oncogene · doi:10.1038/sj.onc.1209888 · Cited by 607 · see citing works

The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4

Csibi, A., Fendt, S.-M., Li, C., Poulogiannis, G., Choo, A. Y., Chapski, D. J., Jeong, S. M., Dempsey, J. M., Parkhitko, A., Morrison, T., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.023 · Cited by 586 · see citing works

The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

Tsun, Z.-Y., Bar-Peled, L., Chantranupong, L., Zoncu, R., Wang, T., Kim, C., Spooner, E., & Sabatini, D. M. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.09.016 · Cited by 565 · see citing works

Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c

Hagiwara, A., Cornu, M., Cybulski, N., Polak, P., Betz, C., Trapani, F., Terracciano, L., Heim, M. H., Rüegg, M. A., & Hall, M. N. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.015 · Cited by 551 · see citing works

Where is mTOR and what is it doing there?

Betz, C., & Hall, M. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201306041 · Cited by 529 · see citing works

Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis

Robitaille, A. M., Christen, S., Shimobayashi, M., Cornu, M., Fava, L. L., Moes, S., Prescianotto-Baschong, C., Sauer, U., Jenoe, P., & Hall, M. N. (2013) · Science · doi:10.1126/science.1228771 · Cited by 525 · see citing works

Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases

Raught, B., Peiretti, F., Gingras, A., Livingstone, M., Shahbazian, D., Mayeur, G. L., Polakiewicz, R. D., Sonenberg, N., & Hershey, J. W. B. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600193 · Cited by 473 · see citing works

Regulation of TFEB and V‐ATPases by mTORC1

Peña‐Llopis, S., Vega-Rubín-de-Celis, S., Schwartz, J. C., Wolff, N. C., Tran, T. A. T., Zou, L., Xie, X., Corey, D. R., & Brugarolas, J. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.257 · Cited by 456 · see citing works

YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29

Tumaneng, K., Schlegelmilch, K., Russell, R. C., Yimlamai, D., Basnet, H., Mahadevan, N., Fitamant, J., Bardeesy, N., Camargo, F. D., & Guan, K.-L. (2012) · Nature Cell Biology · doi:10.1038/ncb2615 · Cited by 453 · see citing works

mTOR in aging, metabolism, and cancer

Cornu, M., Albert, V., & Hall, M. N. (2013) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2012.12.005 · Cited by 446 · see citing works

mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin

Kang, S. A. W., Pacold, M. E., Cervantes, C., Lim, D., Lou, H. J., Ottina, K. A., Gray, N. S., Turk, B. E., Yaffe, M. B., & Sabatini, D. M. (2013) · Science · doi:10.1126/science.1236566 · Cited by 432 · see citing works

WNT-LRP5 Signaling Induces Warburg Effect through mTORC2 Activation during Osteoblast Differentiation

Esen, E., Chen, J., Karner, C. M., Okunade, A. L., Patterson, B. W., & Long, F. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.017 · Cited by 367 · see citing works

A Central Role for mTOR in Lipid Homeostasis

Lamming, D. W., & Sabatini, D. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.002 · Cited by 361 · see citing works

Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases

Petit, C. S., Roczniak-Ferguson, A., & Ferguson, S. M. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201307084 · Cited by 355 · see citing works

Rag GTPases mediate amino acid–dependent recruitment of TFEB and MITF to lysosomes

Martina, J. A., & Puertollano, R. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201209135 · Cited by 350 · see citing works

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

Oh, W. J., Wu, C. C., Kim, S. J., Facchinetti, V., Julien, L.-A., Finlan, M., Roux, P. P., Su, B., & Jacinto, E. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.271 · Cited by 333 · see citing works

Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy

Sparks, C. A., & Guertin, D. A. (2010) · Oncogene · doi:10.1038/onc.2010.139 · Cited by 298 · see citing works

Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy

Yuan, H., Russell, R. C., & Guan, K. (2013) · Autophagy · doi:10.4161/auto.26058 · Cited by 292 · see citing works

Amino Acid Deprivation Inhibits TORC1 Through a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr1

Panchaud, N., Gulli, M., & VIRGILIO, C. D. (2013) · Science Signaling · doi:10.1126/scisignal.2004112 · Cited by 290 · see citing works

The multifaceted role of mTORC1 in the control of lipid metabolism

Ricoult, S. J. H., & Manning, B. D. (2013) · EMBO Reports · doi:10.1038/embor.2013.5 · Cited by 287 · see citing works

Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program

Chauvin, C., Koka, V., Nouschi, A., Mieulet, V., Hoareau‐Aveilla, C., Dreazen, A., Cagnard, N., Carpentier, W., Kiss, T., Meyuhas, O., et al. (2013) · Oncogene · doi:10.1038/onc.2012.606 · Cited by 279 · see citing works

TOR complex 2: a signaling pathway of its own

Cybulski, N., & Hall, M. N. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2009.09.004 · Cited by 264 · see citing works

Identification of Serum-Derived Sphingosine-1-Phosphate as a Small Molecule Regulator of YAP

Miller, E., Yang, J., DeRan, M., Wu, C., Su, A. I., Bonamy, G. M. C., Liu, J., Peters, E. C., & Wu, X. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.07.005 · Cited by 247 · see citing works

Metabolic Stress Controls mTORC1 Lysosomal Localization and Dimerization by Regulating the TTT-RUVBL1/2 Complex

Kim, S. G., Hoffman, G. R., Poulogiannis, G., Buel, G. R., Jang, Y. J., Lee, K. W., Kim, B.-Y., Erikson, R. L., Cantley, L. C., Choo, A. Y., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.003 · Cited by 215 · see citing works

Distinct perturbation of the translatome by the antidiabetic drug metformin

Larsson, O. S., Morita, M., Topisirović, I., Alain, T., Blouin, M., Pollak, M., & Sonenberg, N. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201689109 · Cited by 199 · see citing works

DAP1, a Novel Substrate of mTOR, Negatively Regulates Autophagy

Koren, I., Reem, E., & Kimchi, A. (2010) · Current Biology · doi:10.1016/j.cub.2010.04.041 · Cited by 178 · see citing works

Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability

Pajvani, U. B., Qiang, L., Kangsamaksin, T., Kitajewski, J., Ginsberg, H. N., & Accili, D. (2013) · Nature Medicine · doi:10.1038/nm.3259 · Cited by 168 · see citing works

Identification of Akt-independent Regulation of Hepatic Lipogenesis by Mammalian Target of Rapamycin (mTOR) Complex 2

Yuan, M., Pino, E. C., Wu, L., Kacergis, M. C., & Soukas, A. A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.386854 · Cited by 154 · see citing works

Molecular and Genetic Crosstalks between mTOR and ERRα Are Key Determinants of Rapamycin-Induced Nonalcoholic Fatty Liver

Chaveroux, C., Eichner, L. J., Dufour, C. R., Shatnawi, A. A., Khoutorsky, A., Bourque, G., Sonenberg, N., & Giguère, V. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.003 · Cited by 153 · see citing works

HIF-independent role of prolyl hydroxylases in the cellular response to amino acids

Durán, R. V., MacKenzie, E. D., Boulahbel, H., Frezza, C., Heiserich, L., Tardito, S., Bussolati, O., Rocha, S., Hall, M. N., & Gottlieb, E. (2013) · Oncogene · doi:10.1038/onc.2012.465 · Cited by 139 · see citing works

S6 kinase inactivation impairs growth and translational target phosphorylation in muscle cells maintaining proper regulation of protein turnover

Mieulet, V., Roceri, M., Espeillac, C., Sotiropoulos, A., Ohanna, M., Oorschot, V., Klumperman, J., Sandri, M., & Pende, M. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00499.2006 · Cited by 99 · see citing works

mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblastsPreprint

Dai, N., Christiansen, J., Nielsen, F. C., & Avruch, J. (2013) · Genes & Development · doi:10.1101/gad.209130.112 · Cited by 99 · see citing works

Tuberous Sclerosis Complex-1 Deficiency Attenuates Diet-Induced Hepatic Lipid Accumulation

Kenerson, H. L., Yeh, M. M., & Yeung, R. S. W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018075 · Cited by 70 · see citing works

Tuberous sclerosis complex: linking cancer to metabolism

Mieulet, V., & Lamb, R. F. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.05.001 · Cited by 51 · see citing works

Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1)in mice and zebrafish

Valvezan, A. J., Huang, J. Y., Lengner, C. J., Pack, M. A., & Klein, P. S. (2013) · Disease Models & Mechanisms · doi:10.1242/dmm.012625 · Cited by 29 · see citing works

Oxidative stress and autophagy: The clash between damage and metabolic needs

Filomeni, G., De Zio, D., & Cecconi, F. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.150 · Cited by 2,195 · see citing works

MTOR: a pharmacologic target for autophagy regulation

Kim, Y. C., & Guan, K.-L. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73939 · Cited by 2,126 · see citing works

The functions and regulation of the PTEN tumour suppressor: new modes and prospects

Lee, Y.-R., Chen, M., & Pandolfi, P. P. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0015-0 · Cited by 917 · see citing works

Metabolic control of autophagy

Galluzzi, L., Pietrocola, F., Levine, B., & Kroemer, G. (2014) · Cell · doi:10.1016/j.cell.2014.11.006 · Cited by 855 · see citing works

Regulation of innate immune cell function by mTOR

Weichhart, T., Hengstschläger, M., & Linke, M. (2015) · Nature reviews. Immunology · doi:10.1038/nri3901 · Cited by 836 · see citing works

AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control

González, A., Hall, M. N., Lin, S.-C., & Hardie, D. G. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.01.015 · Cited by 797 · see citing works

Metabolic Control of Longevity

López-Otín, C., Galluzzi, L., Freije, J. M. P., Madeo, F., & Kroemer, G. (2016) · Cell · doi:10.1016/j.cell.2016.07.031 · Cited by 753 · see citing works

ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway

Zhao, Y., Hu, X., Liu, Y., Dong, S., Wen, Z., He, W., Zhang, S., Huang, Q., & Shi, M. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0648-1 · Cited by 735 · see citing works

Nutrient sensing and TOR signaling in yeast and mammals

González, A., & Hall, M. (2017) · EMBO Journal · doi:10.15252/embj.201696010 · Cited by 684 · see citing works

Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications

Tuo, Q., Zhang, S., & Lei, P. (2021) · Medicinal Research Reviews · doi:10.1002/med.21817 · Cited by 747 · see citing works

The interplay between cell signalling and the mevalonate pathway in cancer

Mullen, P., Yu, R., Longo, J., Archer, M. C., & Penn, L. Z. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.76 · Cited by 697 · see citing works

Reciprocal Regulation of the TOR Kinase and ABA Receptor Balances Plant Growth and Stress Response

Wang, P., Zhao, Y., Li, Z., Hsu, C., Liu, X., Fu, L., Hou, Y., Du, Y., Xie, S., Zhang, C., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.12.002 · Cited by 597 · see citing works

mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy

Tian, T., Li, X., & Zhang, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030755 · Cited by 581 · see citing works

Lamins: Nuclear Intermediate Filament Proteins with Fundamental Functions in Nuclear Mechanics and Genome Regulation

Gruenbaum, Y., & Foisner, R. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-034115 · Cited by 536 · see citing works

Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy

Roberts, D. J., & Miyamoto, S. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.173 · Cited by 507 · see citing works

mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy

Zhao, J., Zhai, B., Gygi, S. P., & Goldberg, A. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521919112 · Cited by 471 · see citing works

Targeting PI3K/AKT/mTOR pathway in non small cell lung cancer

Fumarola, C., Bonelli, M. A., Petronini, P. G., & Alfieri, R. R. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.05.011 · Cited by 463 · see citing works

The utilization of extracellular proteins as nutrients is suppressed by mTORC1

Palm, W., Park, Y., Wright, K., Pavlova, N. N., Tuveson, D. A., & Thompson, C. B. (2015) · Cell · doi:10.1016/j.cell.2015.06.017 · Cited by 457 · see citing works

A systems study reveals concurrent activation of AMPK and mTOR by amino acids

Pezze, P. D., Ruf, S., Sonntag, A. G., Langelaar-Makkinje, M., Hall, P., Heberle, A., Navas, P., van Eunen, K., Tölle, R. C., Schwarz, J. J., et al. (2016) · Nature Communications · doi:10.1038/ncomms13254 · Cited by 315 · see citing works

Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer

Liu, G., Pei, F., Yang, F., Li, L., Amin, A. D., Liu, S., Buchan, J. R., & Cho, W. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020367 · Cited by 424 · see citing works

mTORC1 Regulates Mitochondrial Integrated Stress Response and Mitochondrial Myopathy Progression

Khan, N. A., Nikkanen, J., Yatsuga, S., Jackson, C. B., Wang, L., Pradhan, S., Kivelä, R., Pessia, A., Velagapudi, V., & Suomalainen, A. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.07.007 · Cited by 391 · see citing works

mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1

Morita, M., Prudent, J., Basu, K., Goyon, V., Katsumura, S., Hulea, L., Pearl, D., Siddiqui, N., Strack, S., McGuirk, S., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.08.013 · Cited by 368 · see citing works

PP2A as a master regulator of the cell cycle

Wlodarchak, N., & Xing, Y. (2016) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2016.1143913 · Cited by 366 · see citing works

Architecture of human mTOR complex 1

Aylett, C. H. S., Sauer, E., Imseng, S., Boehringer, D., Hall, M. N., Ban, N., & Maier, T. (2016) · Science · doi:10.1126/science.aaa3870 · Cited by 344 · see citing works

Pitfalls of the MTT assay: Direct and off-target effects of inhibitors can result in over/underestimation of cell viability

Stepanenko, A. A., & Dmitrenko, V. V. (2015) · Gene · doi:10.1016/j.gene.2015.08.009 · Cited by 321 · see citing works

Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time

Crosby, P., Hamnett, R., Putker, M., Hoyle, N. P., Reed, M., Karam, C. J., Maywood, E. S., Stangherlin, A., Chesham, J. E., Hayter, E. A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.02.017 · Cited by 309 · see citing works

Growing knowledge of the mTOR signaling network

Huang, K., & Fingar, D. C. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.09.011 · Cited by 301 · see citing works

mTOR signaling in cellular and organismal energetics

Albert, V., & Hall, M. N. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.12.001 · Cited by 304 · see citing works

Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes

Takahara, T., Amemiya, Y., Sugiyama, R., Maki, M., & Shibata, H. (2020) · Journal of Biomedical Science · doi:10.1186/s12929-020-00679-2 · Cited by 300 · see citing works

The role of mammalian target of rapamycin (mTOR) in insulin signaling

Yoon, M.-S. (2017) · Nutrients · doi:10.3390/nu9111176 · Cited by 300 · see citing works

mTOR Pathways in Cancer and Autophagy

Paquette, M., El–Houjeiri, L., & Pause, A. (2018) · Cancers · doi:10.3390/cancers10010018 · Cited by 296 · see citing works

The lysosome as a command-and-control center for cellular metabolism

Lim, C.-Y., & Zoncu, R. (2016) · Journal of Cell Biology · doi:10.1083/jcb.201607005 · Cited by 274 · see citing works

GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2Preprint

Ye, J., Palm, W., Peng, M., King, B., Lindsten, T., Li, M. O., Koumenis, C., & Thompson, C. B. (2015) · Genes & Development · doi:10.1101/gad.269324.115 · Cited by 289 · see citing works

The Upstream Pathway of mTOR-Mediated Autophagy in Liver Diseases

Wang, H., Liu, Y., Wang, D., Xu, Y., Dong, R., Yang, Y., Lv, Q., Chen, X., & Zhang, Z. (2019) · Cells · doi:10.3390/cells8121597 · Cited by 281 · see citing works

Current treatment strategies for inhibiting mTOR in cancer.

Chiarini, F., Evangelisti, C., McCubrey, J., & Martelli, A. (2015) · TIPS - Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.11.004 · Cited by 262 · see citing works

mTORC 1 and mTORC 2 as regulators of cell metabolism in immunity

Linke, M., Fritsch, S. D., Sukhbaatar, N., Hengstschläger, M., & Weichhart, T. (2017) · FEBS Letters · doi:10.1002/1873-3468.12711 · Cited by 271 · see citing works

Application of Metabolomics in Alzheimer’s Disease

Wilkins, J. M., & Trushina, E. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2017.00719 · Cited by 268 · see citing works

MTOR inhibitors in cancer therapy

Xie, J., Wang, X., & Proud, C. G. (2016) · F1000Research · doi:10.12688/f1000research.9207.1 · Cited by 266 · see citing works

Emerging roles of aerobic glycolysis in breast cancer

Wu, Z., Wu, J., Zhao, Q., Fu, S., & Jin, J. (2019) · Clinical & Translational Oncology · doi:10.1007/s12094-019-02187-8 · Cited by 260 · see citing works

AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3

Paquette, M., El–Houjeiri, L., Zirden, L. C., Puustinen, P., Blanchette, P., Jeong, H., Dejgaard, K., Siegel, P. M., & Pause, A. (2021) · Autophagy · doi:10.1080/15548627.2021.1898748 · Cited by 260 · see citing works

Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity

Romero, R., Erez, O., Hüttemann, M., Maymon, E., Panaitescu, B., Conde-Agudelo, A., Pacora, P., Yoon, B. H., & Grossman, L. I. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.06.003 · Cited by 253 · see citing works

Spatial colocalization and functional link of purinosomes with mitochondria

French, J. B., Jones, S. A., Deng, H., Pedley, A. M., Kim, D., Chan, C. Y., Hu, H., Pugh, R. J., Zhao, H., Zhang, Y., et al. (2016) · Science · doi:10.1126/science.aac6054 · Cited by 241 · see citing works

Tunable and reversible drug control of protein production via a self-excising degron

Chung, H. K., Jacobs, C. L., Huo, Y., Yang, J., Krumm, S. A., Plemper, R. K., Tsien, R. Y., & Lin, M. Z. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1869 · Cited by 233 · see citing works

Mitochondria in the signaling pathways that control longevity and health span

Akbari, M., Kirkwood, T. B. L., & Bohr, V. A. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100940 · Cited by 232 · see citing works

Targeting immune cells for cancer therapy

Gun, S. Y., Lee, S. W. L., Sieow, J. L., & Wong, S. C. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101174 · Cited by 229 · see citing works

Immunosuppressive Medications

Wiseman, A. C. (2015) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.08570814 · Cited by 230 · see citing works

Targeting mTOR and Metabolism in Cancer: Lessons and Innovations

Magaway, C., Kim, E., & Jacinto, E. (2019) · Cells · doi:10.3390/cells8121584 · Cited by 225 · see citing works

Multiple amino acid sensing inputs to mTORC1

Shimobayashi, M., & Hall, M. (2015) · Cell Research · doi:10.1038/cr.2015.146 · Cited by 216 · see citing works

Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling

Lee, G., Zheng, Y., Cho, S., Jang, C., England, C., Dempsey, J. M., Yu, Y., Liu, X., He, L., Cavaliere, P. M., et al. (2017) · Cell · doi:10.1016/j.cell.2017.10.037 · Cited by 222 · see citing works

Klippel–Trenaunay syndrome belongs to the PIK3CA‐related overgrowth spectrum (PROS)

Vahidnezhad, H., Youssefian, L., & Uitto, J. (2015) · Experimental Dermatology · doi:10.1111/exd.12826 · Cited by 217 · see citing works

Key proteins and pathways that regulate lifespan

Pan, H., & Finkel, T. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.r116.771915 · Cited by 218 · see citing works

NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer

Karki, R., Man, S. M., Malireddi, R. K. S., Kesavardhana, S., Zhu, Q., Burton, A. R., Sharma, B. R., Qi, X., Pelletier, S. W., Vogel, P., et al. (2016) · Nature · doi:10.1038/nature20597 · Cited by 215 · see citing works

Regulation of mTORC2 Signaling

Fu, W., & Hall, M. N. (2020) · Genes · doi:10.3390/genes11091045 · Cited by 213 · see citing works

The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1

Hansen, C. G., Ng, Y. L. D., Lam, W.-L. M., Plouffe, S. W., & Guan, K.-L. (2015) · Cell Research · doi:10.1038/cr.2015.140 · Cited by 212 · see citing works

Roles of mTOR complexes in the kidney: implications for renal disease and transplantation

Fantus, D., Rogers, N. M., Grahammer, F., Huber, T. B., & Thomson, A. W. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.108 · Cited by 208 · see citing works

mTOR signaling regulates central and peripheral circadian clock function

Ramanathan, C., Kathale, N. D., Liu, D., Lee, C., Freeman, D. A., Hogenesch, J. B., Cao, R., & Liu, A. C. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007369 · Cited by 206 · see citing works

nanoCAGE reveals 5′ UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAsPreprint

Gandin, V., Masvidal, L., Hulea, L., Gravel, S., Cargnello, M., McLaughlan, S., Cai, Y., Balanathan, P., Morita, M., Rajakumar, A., et al. (2016) · Genome Research · doi:10.1101/gr.197566.115 · Cited by 200 · see citing works

Organelle-Specific Initiation of Autophagy

Sica, V., Galluzzi, L., Bravo-San Pedro, J. M., Izzo, V., Maiuri, M. C., & Kroemer, G. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.07.021 · Cited by 205 · see citing works

Metabolic strategies of melanoma cells: Mechanisms, interactions with the tumor microenvironment, and therapeutic implications

Fischer, G. M., Gopal, Y. N. V., McQuade, J. L., Peng, W., DeBerardinis, R. J., & Davies, M. A. (2017) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12661 · Cited by 195 · see citing works

Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation

Tan, H. W. S., Sim, A. Y. L., & Long, Y. C. (2017) · Nature Communications · doi:10.1038/s41467-017-00369-y · Cited by 193 · see citing works

SZT2 dictates GATOR control of mTORC1 signalling

Peng, M., Yin, N., & Li, M. O. (2017) · Nature · doi:10.1038/nature21378 · Cited by 192 · see citing works

GTPase ROP2 binds and promotes activation of target of rapamycin, TOR, in response to auxin

Schepetilnikov, M. V., Makarian, J., Srour, O., Geldreich, A., Yang, Z., Chicher, J., Hammann, P., & Ryabova, L. A. (2017) · The EMBO Journal · doi:10.15252/embj.201694816 · Cited by 186 · see citing works

A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma

Fan, Q.-W., Aksoy, O., Wong, R. A., Ilkhanizadeh, S., Novotny, C. J., Gustafson, W. C., Truong, A. Y.-Q., Cayanan, G., Simonds, E. F., Haas-Kogan, D. A., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.01.014 · Cited by 184 · see citing works

Metabolic and hypoxic adaptation to anti‐angiogenic therapy: a target for induced essentiality

McIntyre, A., & Harris, A. L. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201404271 · Cited by 185 · see citing works

Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?

Singh, S. S. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i43.12261 · Cited by 181 · see citing works

Pathological Roles of Iron in Cardiovascular Disease

Kobayashi, M., Suhara, T., Baba, Y., Kawasaki, N. K., Higa, J. K., & Matsui, T. (2018) · Current Drug Targets · doi:10.2174/1389450119666180605112235 · Cited by 179 · see citing works

Accumulation of autophagosomes confers cytotoxicity

Button, R. W., Roberts, S. L., Willis, T. L., Hanemann, C. O., & Luo, S. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.782276 · Cited by 179 · see citing works

mTORC1 Phosphorylates Acetyltransferase p300 to Regulate Autophagy and Lipogenesis

Wan, W., You, Z., Xu, Y., Zhou, L., Guan, Z., Peng, C., Wong, C. C. L., Su, H., Zhou, T., Xia, H., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.09.020 · Cited by 175 · see citing works

Autophagy Maintains the Function of Bone Marrow Mesenchymal Stem Cells to Prevent Estrogen Deficiency-Induced Osteoporosis

Qi, M., Zhang, L., Ma, Y., Shuai, Y., Li, L., Luo, K., Liu, W., & Jin, Y. J. (2017) · Theranostics · doi:10.7150/thno.17949 · Cited by 175 · see citing works

Getting ready for building: signaling and autophagosome biogenesis

Abada, A., & Elazar, Z. (2014) · EMBO Reports · doi:10.15252/embr.201439076 · Cited by 171 · see citing works

Repair, Reuse, Recycle: The Expanding Role of Autophagy in Genome Maintenance

Hewitt, G., & Korolchuk, V. I. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.11.011 · Cited by 168 · see citing works

Autophagy in the presynaptic compartment in health and disease

Vijayan, V., & Verstreken, P. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201611113 · Cited by 167 · see citing works

mTORC1 signaling in hepatic lipid metabolism

Han, J., & Wang, Y. (2017) · Protein & Cell · doi:10.1007/s13238-017-0409-3 · Cited by 168 · see citing works

Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva

Hino, K., Horigome, K., Nishio, M., Komura, S., Nagata, S., Zhao, C., Jin, Y., Kawakami, K., Yamada, Y., Ohta, A., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci93521 · Cited by 169 · see citing works

Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing

Blandino-Rosano, M., Barbaresso, R., Jiménez-Palomares, M., Bozadjieva-Kramer, N., Werneck‐de‐Castro, J. P., Hatanaka, M., Mirmira, R. G., Sonenberg, N., Liu, M. R., Rüegg, M. A., et al. (2017) · Nature Communications · doi:10.1038/ncomms16014 · Cited by 162 · see citing works

mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate

Marat, A. L., Wallroth, A., Lo, W., Müller, R., Norata, G. D., Falasca, M., Schultz, C., & Haucke, V. (2017) · Science · doi:10.1126/science.aaf8310 · Cited by 160 · see citing works

Targeting the PI3K/AKT/mTOR Pathway in Bladder Cancer

Sathe, A., & Nawroth, R. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7234-0_23 · Cited by 158 · see citing works

The Mevalonate Pathway, a Metabolic Target in Cancer Therapy

Guerra, B., Recio, C., Aranda-Tavío, H., Guerra-Rodríguez, M., García-Castellano, J. M., & Fernández‐Pérez, L. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.626971 · Cited by 160 · see citing works

Regulation of Glucose Metabolism – A Perspective From Cell Bioprocessing

Mulukutla, B. C., Yongky, A., Le, T. S., Mashek, D. G., & Hu, W. (2016) · Trends in biotechnology · doi:10.1016/j.tibtech.2016.04.012 · Cited by 160 · see citing works

Microglia promote glioblastoma via mTOR‐mediated immunosuppression of the tumour microenvironment

Dumas, A. A., Pomella, N., Rosser, G., Guglielmi, L., Vinel, C., Millner, T. O., Rees, J. H., Aley, N., Sheer, D., Wei, J., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2019103790 · Cited by 156 · see citing works

The Arabidopsis TOR Kinase Specifically Regulates the Expression of Nuclear Genes Coding for Plastidic Ribosomal Proteins and the Phosphorylation of the Cytosolic Ribosomal Protein S6

Dobrenel, T., Mancera-Martínez, E., Forzani, C., Azzopardi, M., Davanture, M., Moreau, M., Schepetilnikov, M. V., Chicher, J., Langella, O., Zivy, M., et al. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.01611 · Cited by 153 · see citing works

mTORC1 pathway in DNA damage response.

Ma, Y.-X., Vassetzky, Y., & Dokudovskaya, S. (2018) · Biochimica et biophysica acta. Molecular cell research · doi:10.1016/j.bbamcr.2018.06.011 · Cited by 42 · see citing works

Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21

Cornu, M., Oppliger, W., Albert, V., Robitaille, A. M., Trapani, F., Quagliata, L., Fuhrer, T., Sauer, U., Terracciano, L., & Hall, M. N. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412047111 · Cited by 148 · see citing works

High mTORC1 activity drives glycolysis addiction and sensitivity to G6PD inhibition in acute myeloid leukemia cells

Poulain, L., Sujobert, P., Zylbersztejn, F., Barreau, S., Stuani, L., Lambert, M., Palama, T. L., Chesnais, V, Birsen, R., Vergez, F., et al. (2017) · Leukemia · doi:10.1038/leu.2017.81 · Cited by 145 · see citing works

Glucose uptake in brown fat cells is dependent on mTOR complex 2–promoted GLUT1 translocation

Olsen, J. M., Sato, M., Dallner, O. S., Sandström, A. L., Pisani, D. F., Chambard, J., Amri, E., Hutchinson, D. S., & Bengtsson, T. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201403080 · Cited by 151 · see citing works

Eosinophilic Solid and Cystic Renal Cell Carcinoma (ESC RCC)

Trpkov, K., Abou–Ouf, H., Hes, O., Lopez, J. I., Nesi, G., Compérat, É., Sibony, M., Osunkoya, A. O., Zhou, M., Gökden, N., et al. (2017) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000000838 · Cited by 151 · see citing works

Glutaminolysis and autophagy in cancer

Villar, V. H., Merhi, F., Djavaheri-Mergny, M., & Durán, R. V. (2015) · Autophagy · doi:10.1080/15548627.2015.1053680 · Cited by 143 · see citing works

Novel links in the plant TOR kinase signaling network

Xiong, Y., & Sheen, J. (2015) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2015.09.006 · Cited by 148 · see citing works

Transforming Growth Factor-β and Interleukin-10 Synergistically Regulate Humoral Immunity via Modulating Metabolic Signals

Komai, T., Inoue, M., Okamura, T., Morita, K., Iwasaki, Y., Sumitomo, S., Shoda, H., Yamamoto, K., & Fujio, K. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01364 · Cited by 147 · see citing works

Dysfunction of autophagy in high-fat diet-induced non-alcoholic fatty liver disease

Ren, Q., Sun, Q., & Fu, J. (2023) · Autophagy · doi:10.1080/15548627.2023.2254191 · Cited by 147 · see citing works

The opposing actions of target of rapamycin and AMP-activated protein kinase in cell growth control.Preprint

Hindupur, S., González, A., & Hall, M. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019141 · Cited by 137 · see citing works

Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects

Cai, H., Dong, L., & Liu, F. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.11.011 · Cited by 142 · see citing works

LncRNA MEG3 downregulation mediated by DNMT3b contributes to nickel malignant transformation of human bronchial epithelial cells via modulating PHLPP1 transcription and HIF-1α translation

Zhou, C., Huang, C., Wang, J., Huang, H., Li, J., Xie, Q., Liu, Y., Zhu, J., Li, Y., Zhang, D., et al. (2017) · Oncogene · doi:10.1038/onc.2017.14 · Cited by 139 · see citing works

Lysosomal control of senescence and inflammation through cholesterol partitioning

Roh, K., Noh, J., Kim, Y., Jang, Y., Kim, J., Choi, H., Lee, Y., Ji, M., Kang, D., Kim, M.-S., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00747-5 · Cited by 142 · see citing works

Retinoic acid regulates Kit translation during spermatogonial differentiation in the mouse

Busada, J. T., Chappell, V. A., Niedenberger, B. A., Kaye, E. P., Keiper, B. D., Hogarth, C. A., & Geyer, C. B. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.10.020 · Cited by 137 · see citing works

Effects of Interferons and Viruses on Metabolism

Fritsch, S. D., & Weichhart, T. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00630 · Cited by 134 · see citing works

Exploration of age-related mitochondrial dysfunction and the anti-aging effects of resveratrol in zebrafish retina

Wang, N., Luo, Z., Jin, M., Sheng, W., Wang, H.-T., Long, X., Wu, Y., Hu, P., Xu, H. A., & Zhang, X. (2019) · Aging · doi:10.18632/aging.101966 · Cited by 148 · see citing works

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Wei, X., Luo, L., & Chen, J.-Z. (2019) · Cells · doi:10.3390/cells8091075 · Cited by 132 · see citing works

mTORC2 sustains thermogenesis via Akt‐induced glucose uptake and glycolysis in brown adipose tissue

Albert, V., Svensson, K., Shimobayashi, M., Colombi, M., MUÑOZ, S. A., Jiménez, V., Handschin, C., Bosch, F., & Hall, M. N. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201505610 · Cited by 133 · see citing works

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Zhang, L., Tschumi, B., López‐Mejía, I. C., Oberle, S. G., Meyer, M., Samson, G. P. B., Rüegg, M. A., Hall, M. N., Lluis Fajas, A., Zehn, D., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2015.12.095 · Cited by 132 · see citing works

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Chen, J. (2004) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-18930-2_14 · Cited by 35 · see citing works

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Corradetti, M. N., & Guan, K.-L. (2006) · Oncogene · doi:10.1038/sj.onc.1209885 · Cited by 387 · see citing works

The mammalian target of rapamycin-signaling pathway in regulating metabolism and growth1,2

Yang, X., Yang, C. B., Farberman, A., Rideout, T. C., de Lange, C. F. M., France, J., & Fan, M. Z. (2007) · Journal of Animal Science · doi:10.2527/jas.2007-0567 · Cited by 128 · see citing works

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Zhang, H.-X., Xiao, X., Pan, Z.-R., & Dokudovskaya, S. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02493-4 · Cited by 90 · see citing works

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Dunlop, E. A., & Tee, A. R. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.01.012 · Cited by 257 · see citing works