mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation
He, Long, Gomes, Ana P., Wang, Xin, Yoon, Sang Oh, Lee, Gina, Nagiec, Michal J., Cho, Sungyun, Chavez, Andre, Islam, Tasnia, Yu, Yonghao, Asara, John M., Kim, Bo Yeon, Blenis, John·2018·Molecular Cell
Cited by (149)
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- mTOR controls ependymal cell differentiation by targeting the alternative cell cycle and centrosomal proteinsAlexia Bankolé, Ayush Srivastava, ASM Shihavuddin, Khaled Tighanimine, Marion Faucourt, Vonda Koka, Solene Weill, Ivan Nemazanyy, Alissa J. Nelson, Matthew P. Stokes et al. · 2025 · EMBO Reports
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- Role of mTORC1 signaling in postnatal microglia activation preceding neurodegeneration in a mouse model for Niemann-Pick disease Type CCaroline E. Murray, David S. Betancourt-Trompa, Michael S. Martinez, Julia M. Carson, Lindsay J. Walsh, Will C. Remillard, Kayla B. Fordyce, Rohan Reddy, Ileana Soto · 2025 · PLoS ONE
- Modulation of the tumor microenvironment by the ubiquitin–proteasome system in colorectal cancerXuan Wang, Yi Ren, Ruihao Song, Jia Liu, Yaojun Zhou, Sihai Yang, Yadong Liu, Yi Lei, Xin Zhao · 2025 · Journal of Translational Medicine
- Hematological and Neurological Expressed 1 Promotes Tumor Progression Through mTOR Signaling in Ovarian CancerPin Li, Li-Heng Qian, Ying-Na Liao, Yan-Zhi Gai, Hong Pan, Long Han, Hui Nie · 2024 · Reproductive Sciences
- FoxK1 and FoxK2 cooperate with ORF45 to promote late lytic replication of Kaposi’s sarcoma-associated herpesvirusQingyang Chen, Xiaojuan Li, Li Quan, Rihong Zhou, Xiangpeng Liu, Lu Cheng, Ronit Sarid, Ersheng Kuang · 2024 · Journal of Virology
- Hyodeoxycholic acid attenuates atherosclerosis by antagonizing FXR and modulating the PD-1/mTORC1 signaling axisFeng Yang, Wenqiong Huang, Zongzhen Meng, Meijun Liu, Aiping Lü, Claudio Mauro, Kenneth C. P. Cheung · 2026 · Redox Biology
- Recombinant human FOXJ1 protein binds DNA, forms higher-order oligomers, has gel-shifting domains and contains intrinsically disordered regionsShashank Arora, Pawan Nagarkar, Jacinta S. D’Souza · 2024 · Protein Expression and Purification
- Forkhead box protein O1 (FoxO1) regulates lipids metabolism and cell proliferation mediated by insulin and PI3K-Akt-mTOR pathway in goose primary hepatocytesRongxue Wei, Chunchun Han, Fengjiang Ye, Shouhai Wei, Fang He, Hehe Liu, Liang Li, Hongyong Xu, Shenqiang Hu, Xianyin Zeng · 2021 · Biocell
- Mammalian-unique eIF4E2 maintains GSK3β proline kinase activity to resist senescence against hypoxiaZhang Min, Lei Sun, Dong He, Jian Chen, Zhiqiang Dong, Huiting Liang, Yu Cao, Bingcheng Cai, Yang He · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Bone Marrow Mesenchymal Stem Cells-Derived Exosomes Upregulate MicroRNA-424-5p to Suppress Hepatocellular Carcinoma Cell Growth by Inhibiting Forkhead Box K1Zewei Lin, Qingqi Ren, Xiaofei Ma, Liu Jikui · 2021 · Research Square
- BAP-1 Inhibits Gastric Cancer Progression via PI3K/AKT Pathway by Suppressing FOXK1 ExpressionChen Mi, Yan Zhao, Li Ren, Dan Zhang · 2021 · Research Square
- Identification of Multi-Omics Cell Signatures of Early Liver InjuryMaciej Migdał, Eugeniusz Tralle, Karim Abu Nahia, Łukasz Bugajski, Katarzyna Kedzierska, Filip Garbicz, Katarzyna Piwocka, Cecilia Lanny Winata, Michał Pawlak · 2021 · Research Square
- Faculty Opinions recommendation of mTOR at the nexus of nutrition, growth, ageing and disease.Shawn M. Ferguson · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Efeito da curcumina na expressão dos componentes da via mTOR no coração de camundongos submetidos a sepse experimentalBruna Amanda da Cruz Rattis · 2022 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
- Phosphorylation of PBX2, a novel downstream target of mTORC1, is determined by GSK3 and PP1Reona Wada, Shun Fujinuma, Hirokazu Nakatsumi, Masaki Matsumoto, Keiichi I. Nakayama · 2022 · The Journal of Biochemistry
- CYTL1 induces cell proliferation to modulate gastric cancer progressionWeisong Bai, Lizhi Zhao, Weikun Qian, Peiqiang Shang, Qingyong Ma, Zhenhua Ma · 2023 · Research Square
- p110α-dependent hepatocyte signaling is critical for liver gene expression and its rewiring in MASLDMarion Régnier, Arnaud Polizzi, Tiffany Fougeray, Anne Fougerat, Prunelle Perrier, Karen E. Anderson, Yannick Lippi, Sarra Smati, Céline Lukowicz, Frédéric Lasserre et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Additional file 1 of Using published pathway figures in enrichment analysis and machine learningMin‐Gyoung Shin, Alexander R. Pico · 2023 · Figshare
- Loss of Roquin-1 Enhances CXCR5+PD-1+ Tfh Cell Differentiation by Interfering with Ampkfunction to Enhance Glycolysis in AQP4-IgG–Positive Neuromyelitis Optica Spectrum DisordersHui Li, Peidong Liu, Ruoyu Li, Huiru Hu, Ao Shen, Yanmeng Xing, Wenping Zhu, Hongbo Liu · 2024 · SSRN Electronic Journal
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- FOXK2 gene expression in cancer: Potential regulatory mechanisms and clinical implicationsRenata Ivo Vasconcelos, Luciana da Torre Carneiro, Raquel Ciuvalschi Maia, Thaís Hancio, Gabriela Nestal de Moraes · 2025 · Genes & Diseases
- Additional file 2 of Using published pathway figures in enrichment analysis and machine learningShin, Min-Gyoung, Alexander R. Pico · 2024 · Figshare
- Additional file 3 of Using published pathway figures in enrichment analysis and machine learningShin, Min-Gyoung, Alexander R. Pico · 2024 · Figshare
- pCancer and FOXK2 (Forkhead Box K2): Oncogenic and Tumor-Suppressive Roles of FOXK2 in CancerŞeyda Akın, İbrahim Ozturk, Ceylan Hepokur · 2026 · Biochemical Genetics
- Heat stress-induced condensation of G3BP1 in perinuclear P-bodies in C. elegans’ germlineDiya Zang, Yifan Jing, Xinya Huang, Yan Kuang, Jiewei Cheng, Wenkai Wang, Demin Xu, Chengming Zhu, Di Chen, Zhongying Zhao et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- IKZF3 Promotes Gastric cancer Progression and Oxaliplatin Resistance via PI3K/AKT/mTOR ActivationChunsheng Tsao, Y. Ma, Feng Wang, Hang Yu, Yunlong Cai, Xudong Zhao, Taohua Yue, Long Rong · 2026 · Journal of Gastroenterology and Hepatology
- Connexion des désordres métaboliques à l’émergence tumorale : régulation de l’acide gras synthase (FAS) par O-GlcNAcylation et mTOR au cours de la prolifération cellulaire hépatiqueSadia Raab · 2021 · theses.fr (ABES)
- EVT-701 : targeting electron transport chain complex I as therapeutic approach in cancerRaquel Luna Yolba · 2021 · theses.fr (ABES)
- The role of the GATOR1 complex in mitochondrial function and quality controlHanxiao Zhang · 2025 · theses.fr (ABES)
- SETDB1 promotes gastric cancer progression via UPR and mTOR pathwayJing Qiao, Shijie Lin, Yeju Li, Xiaoyang Yue, Yanyan Liu, Huajian Tian, Jianshuang Li, Junyang Tan · 2026 · Cancer Cell International
- Therapeutic targeting of the PRMT6/FOXK1 axis restores lipid homeostasis and ameliorates hepatic steatosis and steatohepatitis in miceYang Sun, Tao Chen, Lei Zhang, Jinlin Duan, Junyan Xue, Wentao Huang, Jian-Zhong Di, Yonglong Zhang · 2026 · Acta Pharmaceutica Sinica B
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- Heat stress promotes GTBP-1 association with perinuclear P-bodies in the C. elegans germlineDiya Zang, Yifan Jing, Xinya Huang, Yan Kuang, Jiewei Cheng, Wenkai Wang, Demin Xu, Chengming Zhu, Di Chen, Zhongying Zhao et al. · 2026 · PLoS Genetics
- AKT Phosphorylation of FOXK2 at Ser398 Impacts Breast Cancer Cell Growth and ViabilityLuis A. Carneiro, J. M. R. C. Nunes, Giuliana De Gregoriis, Bruna dos Santos Mendonça, Wallace Martins de Araújo, Raquel Ciuvalschi Maia, Eric W.‐F. Lam, Renato Sampaio Carvalho, Marcelo Alex Carvalho, Andrew D Sharrocks et al. · 2026 · The FASEB Journal