Burke, John E.

Accurate prediction of protein structures and interactions using a 3-track network

Baek, M., DiMaio, F., Anishchenko, I., Dauparas, J., Ovchinnikov, S., Lee, G. R., Wang, J., Cong, Q., Kinch, L. N., Schaeffer, R. D., et al. (2021) · Science

Protein Structure and DynamicsMachine Learning in Bioinformatics

Cited by 5,549

Phospholipase A2 structure/function, mechanism, and signaling

Burke, J. E., & Dennis, E. A. (2009) · Journal of Lipid Research

Lipid metabolism and biosynthesisSphingolipid Metabolism and Signaling

Cited by 933

Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α ( PIK3CA )

Burke, J. E., Perisic, O., Masson, G. R., Vadas, O., & Williams, R. L. (2012) · Proceedings of the National Academy of Sciences

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 300

Structural Basis for Activation and Inhibition of Class I Phosphoinositide 3-Kinases

Vadas, O., Burke, J. E., Zhang, X., Berndt, A., & Williams, R. L. (2011) · Science Signaling

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 299

Structural Basis for Regulation of Phosphoinositide Kinases and Their Involvement in Human Disease

Burke, J. E. (2018) · Molecular Cell

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 276

Synergy in activating class I PI3Ks

Burke, J. E., & Williams, R. L. (2015) · Trends in Biochemical Sciences

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 216

Novel roles of phosphoinositides in signaling, lipid transport, and disease

Hammond, G. R. V., & Burke, J. E. (2020) · Current Opinion in Cell Biology

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 203

Beyond PI3Ks: targeting phosphoinositide kinases in disease

Burke, J. E., Triscott, J., Emerling, B. M., & Hammond, G. R. V. (2023) · Nature Reviews Drug Discovery

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 156

Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS)

Burke, J. E., & Williams, R. L. (2013) · Advances in Biological Regulation

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 102

Expanding the scope of electrophiles capable of targeting K-Ras oncogenes

McGregor, L. M., Jenkins, M. L., Kerwin, C., Burke, J. E., & Shokat, K. M. (2017) · Biochemistry

Protein Kinase Regulation and GTPase SignalingClick Chemistry and Applications

Cited by 97

Recognition of protein-linked glycans as a determinant of peptidase activity

Noach, I., Ficko-Blean, E., Pluvinage, B., Stuart, C., Jenkins, M. L., Brochu, D., Buenbrazo, N., Wakarchuk, W., Burke, J. E., Gilbert, M., et al. (2017) · Proceedings of the National Academy of Sciences

Glycosylation and Glycoproteins ResearchProtease and Inhibitor Mechanisms

Cited by 89

Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation

Choi, Y. M., Ajjaji, D., Fleming, K. D., Borbat, P. P., Jenkins, M. L., Moeller, B. E., Fernando, S., Bhatia, S. R., Freed, J. H., Burke, J. E., et al. (2023) · Nature Communications

Lipid metabolism and biosynthesisLipid Membrane Structure and Behavior

Cited by 57

Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation

Choi, Y. M., Ajjaji, D., Fleming, K. D., Borbat, P. P., Jenkins, M. L., Moeller, B. E., Fernando, S., Bhatia, S. R., Freed, J. H., Burke, J. E., et al. (2022) · Nature Communications

Lipid metabolism and biosynthesisLipid Membrane Structure and Behavior

Cited by 57

Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs

Rathinaswamy, M. K., Jenkins, M. L., Duewell, B. R., Zhang, X., Harris, N. J., Evans, J. T., Stariha, J. T. B., Dalwadi, U., Fleming, K. D., Ranga-Prasad, H., et al. (2023) · Cell Reports

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 28

Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs

Rathinaswamy, M. K., Jenkins, M. L., Zhang, X., Stariha, J. T., Ranga-Prasad, H., Dalwadi, U., Fleming, K. D., Yip, C. K., Williams, R. L., & Burke, J. E. (2022) · Cell Reports

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 28

Spartin-mediated lipid transfer facilitates lipid droplet turnover

Wan, N., Hong, Z., Parson, M. A. H., Korfhage, J. L., Burke, J. E., Melia, T. J., & Reinisch, K. M. (2024) · Proceedings of the National Academy of Sciences

Lipid metabolism and biosynthesisAutophagy in Disease and Therapy

Cited by 22

Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes

Siraliev-Perez, E., Stariha, J. T., Hoffmann, R. M., Temple, B. R., Zhang, Q., Hajicek, N., Jenkins, M. L., Burke, J. E., & Sondek, J. (2022) · eLife

Protein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancer

Cited by 18

PKD autoinhibition in trans regulates activation loop autophosphorylation in cis

Reinhardt, R., Hirzel, K., Link, G., Eisler, S. A., Hägele, T., Parson, M. A. H., Burke, J. E., Hausser, A., & Leonard, T. A. (2023) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancer

Cited by 13

Structure of Calcineurin bound to PI4KA reveals dual interface in both PI4KA and FAM126A

Shaw, A. L., Suresh, S., Parson, M. A., Harris, N. J., Jenkins, M. L., Yip, C. K., & Burke, J. E. (2024) · Structure

Cellular transport and secretionSignaling Pathways in Disease

Cited by 8

Structure of calcineurin bound to PI4KA reveals dual interface in both PI4KA and FAM126A

Shaw, A. L., Suresh, S., Parson, M. A. H., Harris, N. J., Jenkins, M. L., Yip, C. K., & Burke, J. E. (2024) · Structure

Cellular transport and secretionSignaling Pathways in Disease

Cited by 8

SH2-mediated steric occlusion of the C2 domain regulates autoinhibition of SHIP1 inositol 5-phosphatase

Drew, E. E., Nyvall, H. G., Parson, M. A. H., Talus, R. K., Burke, J. E., & Hansen, S. D. (2025) · Journal of Biological Chemistry

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 6

SH2-mediated steric occlusion of the C2 domain regulates autoinhibition of SHIP1 inositol 5-phosphatase

Drew, E. E., Nyvall, H. G., Parson, M. A. H., Talus, R. K., Burke, J. E., & Hansen, S. D. (2025) · Journal of Biological Chemistry

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 6

Unconventional binding of Calmodulin to CHK2 kinase inhibits catalytic activity

Horne, C. R., Wang, T., Young, S. N., Dite, T. A., Nyvall, H. G., Suresh, S., Davies, K. A., Mather, L. J., Dagley, L. F., Manning, G., et al. (2024) · Biochemical Journal

Protein Kinase Regulation and GTPase SignalingProtein Structure and Dynamics

Cited by 4