The DOI matches its Crossref record; 151 of the 151 references it cites were found in a registry or an index.
DNA Methylation Clocks in Aging: Categories, Causes, and Consequences
Open accessAbstract
Age-associated changes to the mammalian DNA methylome are well documented and thought to promote diseases of aging, such as cancer. Recent studies have identified collections of individual methylation sites whose aggregate methylation status measures chronological age, referred to as the DNA methylation clock. DNA methylation may also have value as a biomarker of healthy versus unhealthy aging and disease risk; in other words, a biological clock. Here we consider the relationship between the chronological and biological clocks, their underlying mechanisms, potential consequences, and their utility as biomarkers and as targets for intervention to promote healthy aging and longevity.
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Cites
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Cited by
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Metadata
- Authors
- Field, A. E., Robertson, N. A., Wang, T., Havas, A., Ideker, T., & Adams, P. D.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 71
- Issue
- 6
- Pages
- 882-895
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2889713233
- Cited by
- 621
- References
- 151
- FWCI
- 18.60
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Field, A. E., Robertson, N. A., Wang, T., Havas, A., Ideker, T., & Adams, P. D. (2018). DNA Methylation Clocks in Aging: Categories, Causes, and Consequences. Molecular Cell. https://doi.org/10.1016/j.molcel.2018.08.008
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