The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures
Open accessAbstract
Double-strand breaks (DSBs) are extremely detrimental DNA lesions that can lead to cancer-driving mutations and translocations. Non-homologous end joining (NHEJ) and homologous recombination (HR) represent the two main repair pathways operating in the context of chromatin to ensure genome stability. Despite extensive efforts, our knowledge of DSB-induced chromatin still remains fragmented. Here, we describe the distribution of 20 chromatin features at multiple DSBs spread throughout the human genome using ChIP-seq. We provide the most comprehensive picture of the chromatin landscape set up at DSBs and identify NHEJ- and HR-specific chromatin events. This study revealed the existence of a DSB-induced monoubiquitination-to-acetylation switch on histone H2B lysine 120, likely mediated by the SAGA complex, as well as higher-order signaling at HR-repaired DSBs whereby histone H1 is evicted while ubiquitin and 53BP1 accumulate over the entire γH2AX domains.
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Cites
A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping
Rao, S. S. P., Huntley, M. H., Durand, N. C., Stamenova, E. K., Bochkov, I. D., Robinson, J. T., Sanborn, A. L., Machol, I., Omer, A. D., Lander, E. S., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.021 · Cited by 9,212
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S., & Bonner, W. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5858 · Cited by 5,438
Double-strand break repair: 53BP1 comes into focus
Panier, S., & Boulton, S. J. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3719 · Cited by 1,098
Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast
Sun, Z.-W., & Allis, C. D. (2002) · Nature · doi:10.1038/nature00883 · Cited by 1,072
Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks
Huyen, Y., Zgheib, O., DiTullio Jr, R. A., Gorgoulis, V. G., Zacharatos, P., Petty, T. J., Sheston, E. A., Mellert, H. S., Stavridi, E. S., & Halazonetis, T. D. (2004) · Nature · doi:10.1038/nature03114 · Cited by 884 · cited 1×
“Conversely, we observed a clear loss of H3K79me2 and H2BK120ub, two histone modifications that were found, respectively, unchanged and increased at sites of breaks (Huyen et al., 2004; Moyal et al., 2011; Nakamura et al., 2011).”
The control of DNA repair by the cell cycle
Hustedt, N., & Durocher, D. (2017) · Nature Cell Biology · doi:10.1038/ncb3452 · Cited by 738
53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark
Fradet-Turcotte, A., Canny, M. D., Escribano-Díaz, C., Orthwein, A., Leung, C. C. Y., Huang, H., Landry, M.-C., Kitevski-LeBlanc, J., Noordermeer, S. M., Sicheri, F., et al. (2013) · Nature · doi:10.1038/nature12318 · Cited by 686
Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks
Aymard, F., Bugler, B., Schmidt, C. K., Guillou, E., Caron, P., Briois, S., Iacovoni, J. S., Daburon, V., Miller, K. M., Jackson, S. P., et al. (2014) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2796 · Cited by 668
Self-citationHuman HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining
Miller, K. M., Tjeertes, J. V., Coates, J., Legube, G., Polo, S. E., Britton, S., & Jackson, S. P. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1899 · Cited by 629
Self-citationvan Attikum, H., Fritsch, O., Hohn, B., & Gasser, S. M. (2004) · Cell · doi:10.1016/j.cell.2004.11.033 · Cited by 613
Cited by
Loop extrusion as a mechanism for formation of DNA damage repair foci
Arnould, C., Rocher, V., Finoux, A.-L., Clouaire, T., Li, K., Zhou, F., Caron, P., Mangeot, P. E., Ricci, E. P., Mourad, R., et al. (2021) · Nature · doi:10.1038/s41586-021-03193-z · Cited by 341
Self-citationRadiation-induced DNA damage and repair effects on 3D genome organization
Sanders, J. T., Freeman, T. F., Xu, Y., Golloshi, R., Stallard, M. A., Hill, A. M., San Martin, R., Balajee, A. S., & McCord, R. P. (2020) · Nature Communications · doi:10.1038/s41467-020-20047-w · Cited by 134
Nuclear actin filaments in DNA repair dynamics
Caridi, C. P., Plessner, M., Grosse, R., & Chiolo, I. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0379-1 · Cited by 127
Profiling DNA break sites and transcriptional changes in response to contextual fear learning
Stott, R. T., Kritsky, O., & Tsai, L.-H. (2021) · PLOS ONE · doi:10.1371/journal.pone.0249691 · Cited by 62
Metadata
- Authors
- Clouaire, T., Rocher, V., Lashgari, A., Arnould, C., Aguirrebengoa, M., Biernacka, A., Skrzypczak, M., Aymard, F., Fongang, B., Dojer, N., Iacovoni, J. S., Rowicka, M., Ginalski, K., Côté, J., & Legube, G.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 72
- Issue
- 2
- Pages
- 250-262.e6
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2892569542
- Cited by
- 298
- References
- 73
- FWCI
- 9.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Clouaire, T., Rocher, V., Lashgari, A., Arnould, C., Aguirrebengoa, M., Biernacka, A., Skrzypczak, M., Aymard, F., Fongang, B., Dojer, N., Iacovoni, J. S., Rowicka, M., Ginalski, K., Côté, J., & Legube, G. (2018). Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures. Molecular Cell. https://doi.org/10.1016/j.molcel.2018.08.020
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
