The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress
Open accessAbstract
SUMMARY Cells respond to nutrient stress by trafficking cytosolic contents to lysosomes for degradation via macroautophagy. The endoplasmic reticulum (ER) serves as an initiation site for autophagosomes and is also remodeled in response to nutrient stress through ER-phagy, a form of selective autophagy. Quantitative proteome analysis during nutrient stress identified an unstudied single-pass transmembrane ER protein TEX264 as a ER-phagy receptor. TEX264 uses an LC3-interacting region (LIR) to traffic into ATG8-positive puncta that often initiate from 3-way ER tubule junctions and subsequently fuse with lysosomes. Interaction and proximity biotinylation proteomics identified a cohort of autophagy regulatory proteins and cargo adaptors located nearby TEX264 in a LIR-dependent manner. Global proteomics and ER-phagy flux analysis revealed stabilization of a cohort of ER proteins in TEX264−/− cells during nutrient stress. This work reveals TEX264 as an unrecognized ER-phagy receptor that acts independently of other candidate ER-phagy receptors to remodel the ER during nutrient stress.
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Metadata
- Authors
- An, H., Ordureau, A., Paulo, J. A., Shoemaker, C. J., Denic, V., & Harper, J. W.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2019-06
- Volume
- 74
- Issue
- 5
- Pages
- 891-908.e10
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2940118858
- Cited by
- 292
- References
- 39
- FWCI
- 24.18
- Type
- journal article
- Language
- en
- Open access
- bronze
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- An, H., Ordureau, A., Paulo, J. A., Shoemaker, C. J., Denic, V., & Harper, J. W. (2019). TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress. Molecular Cell. https://doi.org/10.1016/j.molcel.2019.03.034
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