Cited by 429Autophagy in Disease and TherapyUbiquitin and proteasome pathwaysCellular transport and secretion

Mechanisms of Selective Autophagy

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Lamark, Trond, Johansen, Terje·2021·Annual Review of Cell and Developmental Biology

Abstract

Selective autophagy is the lysosomal degradation of specific intracellular components sequestered into autophagosomes, late endosomes, or lysosomes through the activity of selective autophagy receptors (SARs). SARs interact with autophagy-related (ATG)8 family proteins via sequence motifs called LC3-interacting region (LIR) motifs in vertebrates and Atg8-interacting motifs (AIMs) in yeast and plants. SARs can be divided into two broad groups: soluble or membrane bound. Cargo or substrate selection may be independent or dependent of ubiquitin labeling of the cargo. In this review, we discuss mechanisms of mammalian selective autophagy with a focus on the unifying principles employed in substrate recognition, interaction with the forming autophagosome via LIR-ATG8 interactions, and the recruitment of core autophagy components for efficient autophagosome formation on the substrate.

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Crossref · 10.1146/annurev-cellbio-120219-035530

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Authors
Lamark, T., & Johansen, T.
Affiliations
UiT The Arctic University of Norway (NO)
Venue
Annual Review of Cell and Developmental Biology
Published
2021-10-06
Volume
37
Issue
1
Pages
143-169
ISSN
  • 1081-0706 (ISSN-L)
  • 1530-8995
OpenAlex
W3176556289
Cited by
429
References
183
Citations by year
2026: 81 · 2025: 112 · 2024: 110 · 2023: 74 · 2022: 41 · 2021: 11
FWCI
9.03
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Annual Review of Cell and Developmental Biology (publishedVersion)
  • PubMed (publishedVersion)
  • NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords
selective autophagy, autophagy receptors, LC3-interacting region, Atg8-family proteins, autophagosome formation, substrate recognition, cargo selection, lysosomal degradation
MeSH terms
Autophagosomes, Autophagy-Related Protein 8 Family, Animals, Autophagy, Mammals, Microtubule-Associated Proteins, Apoptosis Regulatory Proteins

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