Cited by 497RNA modifications and cancerRNA regulation and diseaseMicroRNA in disease regulation

The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.

METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation

Open access

Pandolfini, Luca, Barbieri, Isaia, Bannister, Andrew J., Hendrick, Alan, Andrews, Byron, Webster, Natalie, Murat, Pierre, Mach, Pia, Brandi, Rossella, Robson, Samuel C., Migliori, Valentina, Alendar, Andrej, d’Onofrio, Mara, Balasubramanian, Shankar, Kouzarides, Tony·2019·Molecular Cell

DOI 10.1016/j.molcel.2019.03.040PMC PMC6591002

Open this paper in CoChat — free account Open PDF

Abstract

7-methylguanosine (m7G) is present at mRNA caps and at defined internal positions within tRNAs and rRNAs. However, its detection within low-abundance mRNAs and microRNAs (miRNAs) has been hampered by a lack of sensitive detection strategies. Here, we adapt a chemical reactivity assay to detect internal m7G in miRNAs. Using this technique (Borohydride Reduction sequencing [BoRed-seq]) alongside RNA immunoprecipitation, we identify m7G within a subset of miRNAs that inhibit cell migration. We show that the METTL1 methyltransferase mediates m7G methylation within miRNAs and that this enzyme regulates cell migration via its catalytic activity. Using refined mass spectrometry methods, we map m7G to a single guanosine within the let-7e-5p miRNA. We show that METTL1-mediated methylation augments let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA). These results identify METTL1-dependent N7-methylation of guanosine as a new RNA modification pathway that regulates miRNA structure, biogenesis, and cell migration.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.molcel.2019.03.040

Cites

66 of 66 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · cited 2×
“G Addgene #12259 pMirGlo Promega Cat# E1330 Software and Algorithms Bioconductor https://www.bioconductor.org/ N/A DESeq2 Love et al., 2014 N/A FastQC https://github.com/s-andrews/ FastQC N/A featureCounts Liao et al., 2014 N/A G4Hunter Bedrat et al., 2016 N/A Gage Luo et al., 2009 N/A gbm Freund and Schapire, 1997 N/…”
Influential
Trimmomatic: a flexible trimmer for Illumina sequence data
Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219
A decision-theoretic generalization of on-line learning and an application to boosting
Freund, Y., & Schapire, R. E. (1997) · Journal of Computer and System Sciences · doi:10.1006/jcss.1997.1504 · Cited by 20,466
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068 · cited 1×
“Their specificity is mediated by partial base pairing to sequences predominantly found in the 30 UTR of mRNAs (Bartel, 2009).”
The nuclear RNase III Drosha initiates microRNA processing
Lee, Y., Ahn, C., Han, J., Choi, H., Kim, J., Yim, J., Lee, J., Provost, P., Rådmark, O., Kim, S., et al. (2003) · Nature · doi:10.1038/nature01957 · Cited by 5,292
ViennaRNA Package 2.0
Lorenz, R., Bernhart, S. H., Höner zu Siederdissen, C., Tafer, H., Flamm, C., Stadler, P. F., & Hofacker, I. L. (2011) · Algorithms for Molecular Biology · doi:10.1186/1748-7188-6-26 · Cited by 5,098
miRBase: annotating high confidence microRNAs using deep sequencing data
Kozomara, A., & Griffiths-Jones, S. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1181 · Cited by 5,073
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
Dominissini, D., Moshitch-Moshkovitz, S., Schwartz, S., Salmon-Divon, M., Ungar, L., Osenberg, S., Cesarkas, K., Jacob-Hirsch, J., Amariglio, N., Kupiec, M., et al. (2012) · Nature · doi:10.1038/nature11112 · Cited by 4,884 · cited 2×
“, 2016], N6-methyladenosine [Dominissini et al., 2012], and 5-hydroxymethylcytosine [Delatte et al.”

Flagged first, then by citations

Show all 66 references

Sorted by citations

Items 401–497 of 497

The m7G modification: An emerging player in neurological diseases
Song, Y., Zhao, Z., Dai, Y., Li, C., He, X., Wang, Y., Xu, Z.-Q. D., & Yang, Y. (2026) · Pathology - Research and Practice · doi:10.1016/j.prp.2026.156465 · Cited by 1
METTL1/WDR4 Complex: A Novel Epitranscriptomic Target at the Crossroads of RNA Methylation and Drug Discovery
Fabbrizi, E., Hailu, G. S., Mancini, A., Mai, A., Fiorentino, F., & Rotili, D. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6c01379 · Cited by 1
Genetic polymorphisms of pri-let-7f, gene–environment and gene–gene interactions, and associations with ischemic stroke risk in Liaoning Province
Qiu, L., Wang, Y., Liu, F., Deng, S., He, Z., Zheng, W., & Wang, Y. (2023) · Journal of International Medical Research · doi:10.1177/03000605231173578 · Cited by 1
“, methyltransferase 1-mediated methylation regulated the structure of let-7 by changing the structure within the pri-miRNA.(12) Let-7, the first known human miRNA, is related to stem cell division and differentiation.”
Background
Identification of N7-methylguanosine-related miRNAs as potential biomarkers for prognosis and drug response in breast cancer
Dai, D., Zhuang, H., Shu, M., Chen, L., Chen, L., Wu, H., & Chen, B. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e29326 · Cited by 1
“…， miRNAs also play a significant role in regulating drug sensitivity and predicting drug response in BC. Previous studies have demonstrated that the methyltransferase METTL1 mediates m7G modification of specific miRNAs, promoting their maturation and inhibiting lung cancer cell migration [18].”
Background
Neuroblastoma susceptibility and association of N7-methylguanosine modification gene polymorphisms: multi-center case-control study
Lin, H., Liao, F., Liu, J., Yang, Z., Zhang, J., Cheng, J., Zhou, H., Li, S., Li, L., Li, Y., et al. (2024) · Pediatric Research · doi:10.1038/s41390-024-03318-w · Cited by 1
tRNA methylation drives early postnatal cardiomyocyte maturation
Ruiz‐Lozano, P., & Mercola, M. A. (2024) · Nature Cardiovascular Research · doi:10.1038/s44161-024-00572-3 · Cited by 1
Bibliometric analysis and visualization of the research on the relationship between RNA methylation and immune cell infiltration in tumors
Meng, S., Yang, G., Yu, E., & Li, J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1477828 · Cited by 1
“…RNA stability by in ﬂ uencing base pairing (34). m7G is typically found in the 5 ’ cap and internal sites of mRNA, in ﬂ uencing miRNA structure (35) and mRNA nuclear export and translation (36). m3C is a speci ﬁ c modi ﬁ cation of eukaryotic tRNA, crucial for maintaining tRNA structure and…”
Coronavirus NSP14 drives internal m7G modification to rewire host splicing and promote viral replication
Altamirano, E. E. S., Huang, C.-H., Tsai, Y.-L., Tzeng, T. J., Teruel, N., Peñaflor-Téllez, Y., Chatterjee, S., Pandey, I., Oswal, N., Chen, Y. G., et al. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkag829 · Cited by 1
“Mimicking internal m 7 G modification with 7-deaza-deoxyguanosine (DAG) disrupts key hydrogen bonds, leading to rG4 destabilization [ 87 ].”
Systematic analysis of the function and prognostic value of RNA binding proteins in Colon Adenocarcinoma
Qi, X., Liu, Z., Zhang, Q., Yang, M. W., Wan, Y., Huang, J., & Xu, L. (2021) · Journal of Cancer · doi:10.7150/jca.50407 · Cited by 1
“METTL1 mainly regulates the modification of N7-methylguanosine (m7G) and plays an important role in the progression of tumors, such as colon cancer, liver cancer, and lung cancer [50-52].”
Background
Ribonucleotide base-modifying enzymes and diseases
Konno, M., Asai, A., Hirotsu, T., & Ishii, H. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823684-0.00004-9 · Cited by 1
MicroRNAs Regulating Autophagy in Neurodegeneration
Lai, Q., Kovzel, N., Konovalov, R., & Vinnikov, I. A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-16-2830-6_11 · Cited by 1
Differential expression of methyltransferases METTL1, METTL6 and METTL10 is associated with decreased overall survival in pancreatic ductal adenocarcinoma.Preprint
Mamoor, S. (2019) · doi:10.31219/osf.io/wy5te · Cited by 1
Astrocytic IGF-1 and IGF-1R Orchestrate Mitophagy in Traumatic Brain InjuryPreprint
Dabin, R., Chen, W., Liang, S., Ke, C., Wang, Z., & Zheng, P. (2020) · doi:10.21203/rs.3.rs-41602/v1 · Cited by 1
METTL1 Mediated m7G Modification Regulates Ferroptosis and Chemotherapy Resistance via Involvement of pri-miR-26a/FTH1 Axis in OsteosarcomaPreprint
Yuan, Y., He, M., Wang, Y., Pu, J., Shen, Z., Wang, T., Li, G., Mei, Z., Wang, A., Ren, Z., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-1003392/v1 · Cited by 1
Modification of RNAs in natural rG4 (MoRNiNG), A Database of RNA Modification Sites Associated with the Dynamics of RNA Secondary StructuresPreprint
Zhou, Y., Lyu, S., Liew, S. W., Mou, X., Hoffecker, I. T., Yan, J., Li, Y., Kwok, C. K., & Zhang, J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.11.675469 · Cited by 1
Targeting the METTL1/m7G axis as a therapeutic strategy in myeloid leukemia
Ren, L., Zhang, H., Bobiļeva, O., Nai, F., Bi, H., Chan, A., Baker, G., Dong, L., Guarin, D., Hu, W., et al. (2025) · Blood · doi:10.1182/blood-2025-2539 · Cited by 1
Deciphering the Plasmodium epitranscriptome as a mechanism of translational control
Sinha, A. (2019) · doi:10.32657/10356/142964
RNA labelling in live plants reveals single cell transcriptional dynamics: application to phosphate signalingPreprint
Hani, S., Cuyas, L., David, P., Secco, D., Whelan, J., Thibaud, M., Merret, R., Mueller, F., Pochon, N., Javot, H., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.12.439441
The Study of m6A, m5C, m1A, m7G, Adenosine-to-Inosine and Pseudouridine RNA Modification-related Molecules in Peripheral Blood of Rheumatoid ArthritisPreprint
Yu, Z., Tang, J., Xia, J., Xiao, Y., He, Y., Jiang, R., Chen, S., & Lin, J. (2021) · Research Square · doi:10.21203/rs.3.rs-964198/v1
Role of RNA modification in gastrointestinal tumors
Fu, X.-M., Wang, W., & Song, Z. (2021) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v29.i20.1179
A Newly Defined m7G-Related Gene Signature for Overall Survival Prognosis of Kidney Renal Clear Cell CarcinomaPreprint
Yuan, L., Cheng, F., Wu, Z., & Shen, W. (2022) · Research Square · doi:10.21203/rs.3.rs-1415171/v1
M7G-related miRNA biomarkers for predicting overall survival outcomes for colon carcinomaPreprint
Yuan, L., Cheng, F., Wu, Z., & Shen, W. (2022) · Research Square · doi:10.21203/rs.3.rs-1470623/v1
Differential expression of methyltransferase METTL1 associates with death in a cohort of patients with triple negative breast cancer.Preprint
Mamoor, S. (2019) · OSF Preprints (OSF Preprints) · doi:10.31219/osf.io/pncxr
Identification of N7-methylguanosine-related patterns and characterization of the tumor microenvironment in hepatocellular carcinomaPreprint
Yu, J., Wang, S., Shi, R., Yang, L., Lang, Q., & Zhang, Y. (2022) · Research Square · doi:10.21203/rs.3.rs-1732234/v1
A novel N7-methylguanosine(m7G) methylation-associated miRNA signature for prognostic value in patient with carcinoma of colonPreprint
Wang, C., & Liu, S. (2022) · Research Square · doi:10.21203/rs.3.rs-1804453/v1
A Novel N7-Methylguanosine (M7g) Methylation-Associated Mirna Signature for Prognostic Value in Patient with Carcinoma of Colon
(2022) · Journal of Genetic Engineering and Biotechnology Research · doi:10.33140/jgebr.04.02.12
“RNA methyl transferase mettl1 participates in N7 methyl guanosine (m7G) modification of tRNA [20].”
Background
Identification and construction of a prognostic risk model based on multi‐RNA methylation regulators in cervical cancer
Yan, X., Qu, Y., Huang, W., Zhang, H., Zhu, L., & Zhang, L. (2022) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.15421
“modification-dependent chemistries, and is difficult to study by standard sequencing-based technologies.(28)”
Background
Identification and Validation of RNA Methylation-Related Related Alternative Splicing Gene Signature for Low Grade Glioma to Predict Survival and Immune LandscapesPreprint
Ma, C., Bao, Y., Xu, J., Xiao, B., & Li, H. (2022) · Research Square · doi:10.21203/rs.3.rs-2078319/v1
m7G-related miRNA signature for prediction of prognosis in lung adenocarcinomaPreprint
Jiang, S., Shi, Y., Xiao, M., Wang, Y., Xu, Z., & Wang, K. (2022) · Research Square · doi:10.21203/rs.3.rs-1969865/v1
The emerging roles of epitranscriptomic marks in cancer
Ilieva, M. S., Kauppinen, S., & Uchida, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91367-6.00018-0
Mettl1-dependent m 7 G tRNA modification is essential for maintaining spermatogenesis and fertility in Drosophila melanogasterPreprint
Kaneko, S., Miyoshi, K., Tomuro, K., Terauchi, M., Kondo, S., Tani, N., Ishiguro, K., Toyoda, A., Noguchi, H., Iwasaki, S., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.04.555845
Novel defined N7-methylguanosine modification-related lncRNAs for predicting the prognosis of laryngeal squamous cell carcinoma
YAO, Z., MA, H., Liu, L., ZHAO, Q., QIN, L., REN, X., WU, C., & SUN, K. (2023) · Biocell · doi:10.32604/biocell.2023.030796
The potential prognostic and immunological roles of N7-methylguanosine (m7G) in uveal melanomaPreprint
Zheng, Y., Yao, Y., Yang, L., Ge, T., Jia, R., Ge, S., Song, X., & Zhuang, A. (2023) · Research Square · doi:10.21203/rs.3.rs-3625755/v1
A Novel N7-Methylguanosine (M7g) Methylation-Associated Mirna Signature for Prognostic Value in Patient with Carcinoma of Colon
(2022) · Journal of Genetic Engineering and Biotechnology Research · doi:10.33140/jgebr.04.02.012
Khdc3 Regulates Metabolism Across Generations in a DNA-Independent MannerPreprint
Senaldi, L., Hassan, N. A., Cullen, S. M., Balaji, U., Trigg, N. A., Gu, J., Finkelstein, H., Phillips, K. L., Conine, C. C., & Smith-Raska, M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.27.582278
Additional file 1 of N7-methylguanosine modification of lncRNAs in a rat model of hypoxic pulmonary hypertension: a comprehensive analysis
Wang, H., Chen, R. B., Zhang, S. N., & Zhang, R. F. (2022) · Figshare · doi:10.6084/m9.figshare.18070769
Additional file 3 of M7G methylated core genes (METTL1 and WDR4) and associated RNA risk signatures are associated with prognosis and immune escape in HCC
Li, R., Liu, X., Deng, K., & Wang, X. (2023) · Figshare · doi:10.6084/m9.figshare.23819839
Additional file 2 of N7-methylguanosine modification of lncRNAs in a rat model of hypoxic pulmonary hypertension: a comprehensive analysis
Wang, H., Chen, R. B., Zhang, S. N., & Zhang, R. F. (2022) · Figshare · doi:10.6084/m9.figshare.18070772
Khdc3 Regulates Metabolism Across Generations in a DNA-Independent MannerPreprint
Senaldi, L., Hassan, N. A., Cullen, S. M., Balaji, U., Trigg, N. A., Gu, J., Finkelstein, H., Phillips, K. L., Conine, C. C., & Smith-Raska, M. (2024) · eLife · doi:10.7554/elife.96849
Khdc3 Regulates Metabolism Across Generations in a DNA-Independent MannerPreprint
Senaldi, L., Hassan, N. A., Cullen, S. M., Balaji, U., Trigg, N. A., Gu, J., Finkelstein, H., Phillips, K. L., Conine, C. C., & Smith-Raska, M. (2024) · eLife · doi:10.7554/elife.96849.1
Effects of METTL3-METTL14 on primary microRNA processing by Drosha-DGCR8Preprint
Khadgi, B. B., & Nam, Y. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.15.618347
“Another modification, internal N 7 - methylguanosine (m 7 G), can be added by the METTL1-WDR4 complex. m 7 G has been implicated in promoting the maturation of key pri-miRs such as those of the let-7 family of tumor-suppressive microRNAs (24).”
BackgroundMethod
m7G gene expression and disease risk model construction in patients with herpes zoster
Lu, L., Cai, F., & Luo, Y. (2025) · Scientific Reports · doi:10.1038/s41598-025-88664-3
“The m7G modification has been shown to play a significant role in the development of many human diseases by participating in various RNA metabolic processes and has attracted great attention in recent years 7 .”
M7G Methylation-Regulated Genes Coordinate Gastric Cancer Proliferation and Immune Evasion: Functional Characterization of WDR4 and BUD23Preprint
Zhang, Y., Zhang, W., Zhou, J., Zhang, Y., Cai, L., Chen, X., Xiao, J., Li, Y., Zheng, J., & Feng, H. (2025) · Research Square · doi:10.21203/rs.3.rs-6389159/v1
Integrated Analysis of Single‐Cell and Bulk RNA ‐Sequencing Defines N7 ‐Methylguanosine ( m7G )‐Mediated Modifications' Role in Prognosis and the Tumor Immune Microenvironment in Hepatocellular Carcinoma
Liang, J., Ma, M., Xu, B., Zhong, C., Zeng, G., Lu, H., Lai, J., & Chen, J. (2025) · Cancer Medicine · doi:10.1002/cam4.70992
“Mounting studies have revealed that m7G alteration has a broad influence on tRNA, rRNA, and mRNA, and is required for various biological activities, including transcription elongation, pre-mRNA splicing, and mRNA translation [4, 29, 30].”
7-Methylguanosine lncRNA Signature: Prognostic Validation and Therapy Guidance in Colon AdenocarcinomaPreprint
Zhao, Z., Wang, X., Liu, Y., Xiao, J., & Wang, J. (2025) · Research Square · doi:10.21203/rs.3.rs-6812043/v1
Identification of hub genes predicting sensitivity to neoadjuvant chemoradiation in locally advanced rectal cancer
Zhao, Q., Zhang, C., Zhang, X., Liu, Y., & Cui, B. (2025) · Radiology and Oncology · doi:10.2478/raon-2025-0005 · Cited by 1
“48,49 Upregulation of METTL1 expression has recently been found to increase oncogenic activity and alter anticancer treatment resistance.”
The functional and therapeutic potential of epitranscriptomics in breast cancer
Thompson, R. L., Lothion‐Roy, J. H., Bellows, E., Woodcock, C. L., Jackson-Oxley, J., Haque, M., Varun, D., Kumari, A. A., Alsaleem, M. A., de Brot, S., et al. (2025) · Epigenomics · doi:10.1080/17501911.2025.2542113
“Conflicting evidence has been described as to whether METTL1 may also mediate m 7 G in miRNA [176,194].”
Identification of ALKBH6 as a nucleotide demethylase with a distinct substrate preference
Das, S., Rankawat, S., Shaji, U. P., Tuti, N., Shahnaz, N., Ray, S., & Anindya, R. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110638 · Cited by 1
“…N-methylated bases can occur in RNA as well, either as reversible posttranscriptional modification or following exposure to methylating agents, such as MMS. Guanosine N7 methylation is present in the 5 ′ -caps and also occurs internally in mRNAs and miRNAs (4, 5), tRNAs and 18S rRNAs (6).”
Comprehensive analysis of MGLL as a novel diagnostic and prognostic biomarker for clear cell renal cell carcinoma
Chen, C., Hu, Z., Zhao, W., Ma, Y., & Xia, Q. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1594540
m7G-related gene signatures determine prognosis in triple-negative breast cancer
Li, Y., Lan, X., Dong, J., Li, J., Wang, B., Wang, Y., & Jia, H. (2025) · Scientific Reports · doi:10.1038/s41598-025-21622-1
MicroRNA-Mediated Regulatory Mechanisms in the Etiopathogenesis of Congenital Heart Disease
Durmuş, S. (2025) · IGI Global eBooks · doi:10.4018/979-8-3373-3735-7.ch007
Additional file 2 of M7G methylated core genes (METTL1 and WDR4) and associated RNA risk signatures are associated with prognosis and immune escape in HCC
Li, R., Liu, X., Deng, K., & Wang, X. (2023) · Figshare · doi:10.6084/m9.figshare.23819836
Additional file 5 of Comprehensive analysis of the prognosis and immune infiltration landscape of RNA methylation-related subtypes in pancreatic cancer
Lu, S., Hua, J., Liu, J., Wei, M., Liang, C., Meng, Q., Zhang, B., Yu, X., Wang, W., & Xu, J. (2022) · Figshare · doi:10.6084/m9.figshare.20356464
Additional file 3 of HIF1A-repressed PUS10 regulates NUDC/Cofilin1 dependent renal cell carcinoma migration by promoting the maturation of miR-194-5p
Luo, W., Xu, Z., Wang, H., Lu, Z., Ding, L., Wang, R., Xie, H., Zheng, Q., Lin, Y., Zhou, Z., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26611487
Additional file 8 of Comprehensive analysis of the prognosis and immune infiltration landscape of RNA methylation-related subtypes in pancreatic cancer
Lu, S., Hua, J., Liu, J., Wei, M., Liang, C., Meng, Q., Zhang, B., Yu, X., Wang, W., & Xu, J. (2022) · Figshare · doi:10.6084/m9.figshare.20356473
Additional file 3 of Comprehensive analysis of the prognosis and immune infiltration landscape of RNA methylation-related subtypes in pancreatic cancer
Lu, S., Hua, J., Liu, J., Wei, M., Liang, C., Meng, Q., Zhang, B., Yu, X., Wang, W., & Xu, J. (2022) · Figshare · doi:10.6084/m9.figshare.20356458
Additional file 9 of Comprehensive analysis of the prognosis and immune infiltration landscape of RNA methylation-related subtypes in pancreatic cancer
Lu, S., Hua, J., Liu, J., Wei, M., Liang, C., Meng, Q., Zhang, B., Yu, X., Wang, W., & Xu, J. (2022) · Figshare · doi:10.6084/m9.figshare.20356476
Additional file 6 of Comprehensive analysis of the prognosis and immune infiltration landscape of RNA methylation-related subtypes in pancreatic cancer
Lu, S., Hua, J., Liu, J., Wei, M., Liang, C., Meng, Q., Zhang, B., Yu, X., Wang, W., & Xu, J. (2022) · Figshare · doi:10.6084/m9.figshare.20356467
Additional file 13 of Integrative analyses of the RNA modification machinery reveal tissue- and cancer-specific signatures
Begik, O., Lucas, M. C., Liu, H., Ramírez, J. M., Mattick, J. S., & Novoa, E. M. (2020) · Figshare · doi:10.6084/m9.figshare.12262577
Additional file 1 of M7G methylated core genes (METTL1 and WDR4) and associated RNA risk signatures are associated with prognosis and immune escape in HCC
Li, R., Liu, X., Deng, K., & Wang, X. (2023) · Figshare · doi:10.6084/m9.figshare.23819833
Additional file 1 of HIF1A-repressed PUS10 regulates NUDC/Cofilin1 dependent renal cell carcinoma migration by promoting the maturation of miR-194-5p
Luo, W., Xu, Z., Wang, H., Lu, Z., Ding, L., Wang, R., Xie, H., Zheng, Q., Lin, Y., Zhou, Z., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26611481
Additional file 1 of Comprehensive analysis of the prognosis and immune infiltration landscape of RNA methylation-related subtypes in pancreatic cancer
Lu, S., Hua, J., Liu, J., Wei, M., Liang, C., Meng, Q., Zhang, B., Yu, X., Wang, W., & Xu, J. (2022) · Figshare · doi:10.6084/m9.figshare.20356452
Additional file 10 of Comprehensive analysis of the prognosis and immune infiltration landscape of RNA methylation-related subtypes in pancreatic cancer
Lu, S., Hua, J., Liu, J., Wei, M., Liang, C., Meng, Q., Zhang, B., Yu, X., Wang, W., & Xu, J. (2022) · Figshare · doi:10.6084/m9.figshare.20356440
Additional file 2 of Comprehensive analysis of the prognosis and immune infiltration landscape of RNA methylation-related subtypes in pancreatic cancer
Lu, S., Hua, J., Liu, J., Wei, M., Liang, C., Meng, Q., Zhang, B., Yu, X., Wang, W., & Xu, J. (2022) · Figshare · doi:10.6084/m9.figshare.20356455
Additional file 13 of Comprehensive analysis of the prognosis and immune infiltration landscape of RNA methylation-related subtypes in pancreatic cancer
Lu, S., Hua, J., Liu, J., Wei, M., Liang, C., Meng, Q., Zhang, B., Yu, X., Wang, W., & Xu, J. (2022) · Figshare · doi:10.6084/m9.figshare.20356449
Additional file 12 of Comprehensive analysis of the prognosis and immune infiltration landscape of RNA methylation-related subtypes in pancreatic cancer
Lu, S., Hua, J., Liu, J., Wei, M., Liang, C., Meng, Q., Zhang, B., Yu, X., Wang, W., & Xu, J. (2022) · Figshare · doi:10.6084/m9.figshare.20356446
Additional file 7 of Comprehensive analysis of the prognosis and immune infiltration landscape of RNA methylation-related subtypes in pancreatic cancer
Lu, S., Hua, J., Liu, J., Wei, M., Liang, C., Meng, Q., Zhang, B., Yu, X., Wang, W., & Xu, J. (2022) · Figshare · doi:10.6084/m9.figshare.20356470
Additional file 4 of Comprehensive analysis of the prognosis and immune infiltration landscape of RNA methylation-related subtypes in pancreatic cancer
Lu, S., Hua, J., Liu, J., Wei, M., Liang, C., Meng, Q., Zhang, B., Yu, X., Wang, W., & Xu, J. (2022) · Figshare · doi:10.6084/m9.figshare.20356461
Additional file 1 of P300/SP1 complex mediating elevated METTL1 regulates CDK14 mRNA stability via internal m7G modification in CRPC
Zhang, M., Kan, D., Zhang, B., Chen, X., Wang, C., Chen, S., Gao, W., Yang, Z., Li, Y., Chen, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26611646
Additional file 1 of Selection of M7G-related lncRNAs in kidney renal clear cell carcinoma and their putative diagnostic and prognostic role
Zhong, S., Chen, S., Lin, H., Luo, Y., & He, J. (2023) · Figshare · doi:10.6084/m9.figshare.24571861
Additional file 14 of Integrative analyses of the RNA modification machinery reveal tissue- and cancer-specific signatures
Begik, O., Lucas, M. C., Liu, H., Ramírez, J. M., Mattick, J. S., & Novoa, E. M. (2020) · Figshare · doi:10.6084/m9.figshare.12262589
Additional file 2 of HIF1A-repressed PUS10 regulates NUDC/Cofilin1 dependent renal cell carcinoma migration by promoting the maturation of miR-194-5p
Luo, W., Xu, Z., Wang, H., Lu, Z., Ding, L., Wang, R., Xie, H., Zheng, Q., Lin, Y., Zhou, Z., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26611484
Additional file 11 of Comprehensive analysis of the prognosis and immune infiltration landscape of RNA methylation-related subtypes in pancreatic cancer
Lu, S., Hua, J., Liu, J., Wei, M., Liang, C., Meng, Q., Zhang, B., Yu, X., Wang, W., & Xu, J. (2022) · Figshare · doi:10.6084/m9.figshare.20356443
Additional file 4 of HIF1A-repressed PUS10 regulates NUDC/Cofilin1 dependent renal cell carcinoma migration by promoting the maturation of miR-194-5p
Luo, W., Xu, Z., Wang, H., Lu, Z., Ding, L., Wang, R., Xie, H., Zheng, Q., Lin, Y., Zhou, Z., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26611490
Unsupervised classification based on m7G-related lncRNAs reveals molecular subtypes of patients with hepatocellular carcinoma
Yang, Y., Xu, Z., Zhang, Z., Chen, F., & Zhang, N. (2025) · Biomedical Analysis · doi:10.1016/j.bioana.2025.09.002
Khdc3 Regulates Metabolism Across Generations in a DNA-Independent MannerPreprint
Senaldi, L., Hassan, N., Cullen, S. M., Balaji, U., Trigg, N. A., Gu, J., Finkelstein, H., Phillips, K. L., Conine, C. C., & Smith-Raska, M. (2026) · eLife · doi:10.7554/elife.96849.2
Glioblastome multiforme et épigénétique : de la prévention au développement de nouveaux traitements
Briand, J. (2019) · theses.fr (ABES) · doi:10.70675/6e5954ddz97e2z4cb8zb9ddza267e0081ca8
Comprendre le rôle des complexes de modification de l’ARNt ADAT3/ADAT2 & WDR4/METTL1 pendant le développement du cortex cérébral
Del-Pozo-Rodríguez, J. (2020) · theses.fr (ABES) · doi:10.70675/c4e031efz0a8bz4cfaz93abza990eb954d53
Rôle des microARNs dérégulés par l'alcool dans l'établissement des réseaux neuronaux murins
Altounian, M. (2021) · theses.fr (ABES) · doi:10.70675/a0e0a626zc6c5z4276z9eefz3417c53aea21
Biochemical, biophysical and structural study of proteins associated to human diseases : tcDAC2 and ADAT complex
Ramos‐Morales, E. (2021) · theses.fr (ABES) · doi:10.70675/c6b28473zf6b6z4024z99bfz05629f0484d7
Real-time imaging of transcription to study phosphate sensing in plants
Hani, S. (2022) · theses.fr (ABES) · doi:10.70675/5461667cz5fd4z47f2zb3a4zd5d54c2ea194
Identification of an m7G-Related lncRNA Signature for Prognostic Prediction and Immune Landscape Characterization in Early Gastric Cancer
Zhang, Y., Cai, H. F., Yin, K., Liu, L., Yang, M., & Ji, C. (2026) · OncoTargets and Therapy · doi:10.2147/ott.s582487
“12,13 Pertinently, emerging studies have also suggested that aberrant expression of m7G-related genes is associated with clinical outcomes and tumor behaviors in GC, 14,15 highlighting the potential relevance of m7G-associated regulators in GC pathophysiology.”
The role of methylation in pituitary neuroendocrine tumors current insights and emerging perspectives
Wang, Y., Hu, T., Jia, J., Chen, W., & Zhang, C. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-11789-9
Mitochondrial RNA Modifications in Pancreatic β-Cells: A Novel Axis in Early Diabetes Pathogenesis
Butar, N. F. B., Regitamadari, S. P., Mulyadi, A., Modesty, K., Sutopo, S. E., Sitepu, B. E., Harbuwono, D. S., Santini, A., & Nurkolis, F. (2026) · Sci · doi:10.3390/sci8050104
Nanopore sequencing for RNA modification detection: current algorithm development and future applications
TingTing, L. U. O., MoPing, X. U., Miao, W. A. N. G., FaYing, C. H. E. N., & JieJun, S. H. I. (2026) · Scientia Sinica Vitae · doi:10.1360/ssv-2025-0377
Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment
Zhang, C., Lu, J., Yan, S., Wang, Y., Li, Z., Chen, W., Han, Y., Zhang, Z., Yu, Y., Zhen, Q., et al. (2026) · Advanced Science · doi:10.1002/advs.75970
N7-Methylguanosine Modification in Colorectal Cancer: Molecular Insights and Clinical Implications
Zhang, Q., Li, C., Zhu, Y., Yu, M., Liu, Y., Xie, Y., & Cao, J. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27125228
“In the miRNA let-7e-5p, m7G methylation at the G11 site antagonizes G-quadruplex structures in the pri-miRNA, facilitating its processing and maturation [32].”
Reading between the bases: technological advances in RNA modification detection
Bouvet, M., & Barbieri, I. (2026) · Frontiers in RNA Research · doi:10.3389/frnar.2026.1872456
“Indeed, studies have shown that identical modifications (e.g., m 6 A) can exert distinct regulatory effects depending on context, underscoring the need for transcript-resolved approaches to capture functional epitranscriptomic regulation (Pandolfini et al., 2019).”
InfluentialSelf-citation
JAK–STAT3–MYC axis defines pathogenic stem cell-like memory CD4+ T cells in rheumatoid arthritis
Yang, S., Kim, M., Park, K.-L., Kim, H., Park, J. W., Park, J. K., & Lee, E. B. (2026) · Clinical Immunology · doi:10.1016/j.clim.2026.110733
RNA Modifications in Tumor Microenvironment: A New Dimension for Cancer Treatment
Li, Q., Sun, Y. W., Lin, S., & Yuan, Q. (2026) · MedComm · doi:10.1002/mco2.70816
“Recent studies have revealed the presence of m 7 G at various internal positions across multiple types of RNAs [ 46–48 ].”
METTL1 regulates glioma proliferation through internal m7G methylation of EPHA2Preprint
Xu, T., Yu, P., Sun, Y., Huang, J., Fang, X., Lv, J., Yang, S., & Li, G. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.05.736545
Epigenetics and the kidney
Wei, Q., & Dong, Z. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-34069-7.00008-2
Ribonucleases targeting noncoding RNAs
Li, J. R. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-27312-4.00001-8
RNabel─A Standalone Software Tool for Annotating Tandem Mass Spectra of Modified Ribonucleic Acids
Song, G., Du, Y.-J. N., Sun, R., & Dong, M. (2026) · Analytical Chemistry · doi:10.1021/acs.analchem.6c02176
Molecular mechanisms regulating differential expression of individual miRNAs within polycistronic clusters
Maltseva, D. V., & Tonevitsky, A. (2026) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2026.1913118
“Suppression of METTL1 reduces expression of several other miRNAs, including clustered miRNAs miR-125a, let-7a, let-7b, let-7c, and miR-23b (Pandolfini et al., 2019), suggesting that this mechanism regulates maturation of these miRNAs.”
BindingDB Entry 50015427: 1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors.
BindingDB (2023) · UC San Diego · doi:10.7270/q2pk0m21
Pharmacological inhibition of METTL1 as a therapy against solid and blood cancers
Yankova, E., Sapetschnig, A., Thomas, B. A., Evans, S., Eleftheriou, M., Gozdecka, M., Fischl, H., Brevini, T., Wilson, R., Bucknell, S. J., et al. (2026) · Nature · doi:10.1038/s41586-026-11178-z
Self-citation

Authors: Pandolfini, L., Barbieri, I., Bannister, A. J., Hendrick, A., Andrews, B., Webster, N., Murat, P., Mach, P., Brandi, R., Robson, S. C., Migliori, V., Alendar, A., d’Onofrio, M., Balasubramanian, S., & Kouzarides, T.
Affiliations: University of Cambridge (GB)
European Brain Research Institute (IT)
Istituto di Farmacologia Traslazionale (IT)
Corresponding author: Kouzarides, Tony
ORCID: Pandolfini, Luca
Barbieri, Isaia
Bannister, Andrew J.
Hendrick, Alan
Andrews, Byron
Webster, Natalie
Murat, Pierre
Mach, Pia
Brandi, Rossella
Robson, Samuel C.
Migliori, Valentina
Alendar, Andrej
d’Onofrio, Mara
Balasubramanian, Shankar
Kouzarides, Tony
Venue: Molecular Cell
Publisher: Elsevier BV
Published: 2019-06
Volume: 74
Issue: 6
Pages: 1278-1290.e9
ISSN: 1097-2765 (ISSN-L)
DOI: 10.1016/j.molcel.2019.03.040
PMC: PMC6591002
OpenAlex: W2941132662
Cited by: 491
References: 66
Citations by year: 2026: 32 · 2025: 68 · 2024: 76 · 2023: 95 · 2022: 101 · 2021: 68 · 2020: 37 · 2019: 14
FWCI: 18.36
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Molecular Cell (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
Apollo (University of Cambridge) (submittedVersion, cc-by-nc-nd)
Apollo
Funders: European Research Council (268569)
Cancer Research UK (RG72100)
Horizon 2020 (732678)
Wellcome Trust (WT203144, C6946/A24843)
Kay Kendall Leukaemia Fund (337778, RG86786, RG88664)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Keywords: METTL1, let-7 microRNA, 7-methylguanosine, RNA methylation, microRNA biogenesis, cell migration, RNA modification
MeSH terms: A549 Cells, Base Sequence, Biological Assay, Cell Movement, Guanosine, Humans, Methylation, Methyltransferases, Nucleic Acid Conformation, RNA Processing, Post-Transcriptional, Caco-2 Cells, MicroRNAs, Cell Proliferation, HEK293 Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks