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Structural Basis for Target-Directed MicroRNA Degradation

Sheu-Gruttadauria, Jessica, Pawlica, Paulina, Klum, Shannon M., Wang, Sonia, Yario, Therese A., Schirle Oakdale, Nicole T., Steitz, Joan A., MacRae, Ian J.·2019·Molecular Cell
DOI 10.1016/j.molcel.2019.06.019PMC PMC6754277
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  • TDMD may promote dissociation of the 3' end of the miRNA from the Argonaute protein, thereby exposing the 3' end to modifications that lead to miRNA degradation.

    “TDMD may promote dissociation of the 3′ end of the miRNA from the Argonaute protein, thereby exposing the 3′ end to modifications that lead to miRNA degradation (Sheu‐Gruttadauria et al., 2019; Yang et al., 2020).”

    From microRNA strand selection: Unwinding the rules (2021) · cites this paper as Sheu-Gruttadauria et al., 2019

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Cited by

Sorted by citations

Authors
Sheu-Gruttadauria, J., Pawlica, P., Klum, S. M., Wang, S., Yario, T. A., Schirle Oakdale, N. T., Steitz, J. A., & MacRae, I. J.
Venue
Molecular Cell
Publisher
Elsevier BV
Published
2019-09
Volume
75
Issue
6
Pages
1243-1255.e7
ISSN
1097-2765
DOI
10.1016/j.molcel.2019.06.019
PMC
PMC6754277
Cited by
246
References
4
Language
en
Licence
Funders
  • U.S. Department of Energy (DE-AC02-76SF00515)
  • National Cancer Institute (CA016038)
  • American Cancer Society (PF-18-1124-01-RMC)
  • American Heart Association
  • National Institutes of Health
  • National Institute of General Medical Sciences (K99GM129412, DE-AC02-06CH11357, GM127090, P41GM103393, GM104475, GM115649)
  • Howard Hughes Medical Institute

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