Cited by 122MicroRNA in disease regulationDevelopmental Biology and Gene RegulationPlant Molecular Biology Research

The roles of microRNAs in mouse development

DeVeale, Brian, Swindlehurst-Chan, Jennifer, Blelloch, Robert·2021·Nature Reviews Genetics

Abstract

Hundreds of microRNAs (miRNAs) are expressed in distinct spatial and temporal patterns during embryonic and postnatal mouse development. The loss of all miRNAs through the deletion of critical miRNA biogenesis factors results in early lethality. The function of each miRNA stems from their cumulative negative regulation of multiple mRNA targets expressed in a particular cell type. During development, miRNAs often coordinate the timing and direction of cell fate transitions. In adults, miRNAs frequently contribute to organismal fitness through homeostatic roles in physiology. Here, we review how the recent dissection of miRNA-knockout phenotypes in mice as well as advances related to their targets, dosage, and interactions have collectively informed our understanding of the roles of miRNAs in mammalian development and adaptive responses.

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Crossref · 10.1038/s41576-020-00309-5

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  • Many miRNAs display tissue-, cell type-, or condition-specific expression patterns and play key roles in the regulation of developmental programs.

    “Many miRNAs also display tissue-, cell type-, or conditionspecific expression patterns and play key roles in the regulation of developmental programs (DeVeale et al., 2021;Manakov et al., 2009).”

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Authors
DeVeale, B., Swindlehurst-Chan, J., & Blelloch, R.
Affiliations
University of California, San Francisco (US)
Corresponding author
Blelloch, Robert
Venue
Nature Reviews Genetics
Published
2021-01-15
Volume
22
Issue
5
Pages
307-323
ISSN
  • 1471-0056 (ISSN-L)
  • 1471-0064
OpenAlex
W3123282374
Cited by
121
References
130
Citations by year
2026: 15 · 2025: 21 · 2024: 23 · 2023: 27 · 2022: 23 · 2021: 12
FWCI
2.59
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Genetics (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Canadian Institutes of Health Research
  • National Institute of General Medical Sciences (R01GM122439, R01GM125089)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R21HD093084, P50HD055764)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Keywords
microRNA, mouse development, microRNA biogenesis, miRNA target genes, cell fate transitions, embryonic development, postnatal development, non-coding RNA, homeostasis, adaptive response
MeSH terms
Animals, Cell Differentiation, Growth, Cell Lineage, MicroRNAs, Embryonic Development, Mice

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