Life of RISC: Formation, action, and degradation of RNA-induced silencing complex
Open accessAbstract
Small RNAs regulate a wide variety of biological processes by repressing the expression of target genes at the transcriptional and post-transcriptional levels. To achieve these functions, small RNAs form RNA-induced silencing complex (RISC) together with a member of the Argonaute (AGO) protein family. RISC is directed by its bound small RNA to target complementary RNAs and represses their expression through mRNA cleavage, degradation, and/or translational repression. Many different factors fine-tune RISC activity and stability-from guide-target RNA complementarity to the recruitment of other protein partners to post-translational modifications of RISC itself. Here, we review recent progress in understanding RISC formation, action, and degradation, and discuss new, intriguing questions in the field.
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Because miRNAs have imperfect sequence recognition, they may bind to multiple target genes and modulate their expression.
“Because miRNAs have imperfect sequence recognition, they may bind to multiple target genes and modulate their expression.226”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [226]
miRNA sequences guide the RNA-induced silencing complex to target mRNA transcripts, resulting in translational cleavage or repression of mRNA.
“miRNA sequences guide the RISC to target mRNA transcripts, resulting in translational cleavage or repression of mRNA.226”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [226]
Cites
Regulation of microRNA biogenesis
Ha, M., & Kim, V. N. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3838 · Cited by 5,462 · see citing works
MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed Pairing
Grimson, A., Farh, K. K.-H., Johnston, W. K., Garrett-Engele, P., Lim, L. P., & Bartel, D. P. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.06.017 · Cited by 3,766 · see citing works
Bartel, D. P. (2018) · Cell · doi:10.1016/j.cell.2018.03.006 · Cited by 3,751 · see citing works
The impact of microRNAs on protein output
Baek, D., Villén, J., Shin, C., Camargo, F. D., Gygi, S. P., & Bartel, D. P. (2008) · Nature · doi:10.1038/nature07242 · Cited by 3,592 · see citing works
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
Sonenberg, N., & Hinnebusch, A. G. (2009) · Cell · doi:10.1016/j.cell.2009.01.042 · Cited by 3,304 · see citing works
An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
Hammond, S. M., Bernstein, E., Beach, D., & Hannon, G. J. (2000) · Nature · doi:10.1038/35005107 · Cited by 3,006 · see citing works
Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP
Hafner, M., Landthaler, M., Burger, L., Khorshid, M., Hausser, J., Berninger, P., Rothballer, A., Ascano, M., Jungkamp, A.-C., Munschauer, M., et al. (2010) · Cell · doi:10.1016/j.cell.2010.03.009 · Cited by 2,873 · see citing works
Functional siRNAs and miRNAs exhibit strand bias
Khvorova, A., Reynolds, A., & Jayasena, S. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00801-8 · Cited by 2,645 · see citing works
Discrete Small RNA-Generating Loci as Master Regulators of Transposon Activity in Drosophila
Brennecke, J., Aravin, A. A., Stark, A., Dus, M., Kellis, M., Sachidanandam, R., & Hannon, G. J. (2007) · Cell · doi:10.1016/j.cell.2007.01.043 · Cited by 2,524 · see citing works
Argonaute2 is the catalytic engine of mammalian RNAi
Liu, J., Carmell, M. A., Rivas, F. V., Marsden, C. G., Thomson, J. M., Song, J.-J., Hammond, S. M., Joshua-Tor, L., & Hannon, G. J. (2004) · Science · doi:10.1126/science.1102513 · Cited by 2,353 · see citing works
Asymmetry in the Assembly of the RNAi Enzyme Complex
Schwarz, D. S., Hutvágner, G., Du, T., Xu, Z., Aronin, N., & Zamore, P. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00759-1 · Cited by 2,323 · see citing works
microRNA-Directed Phasing during Trans-Acting siRNA Biogenesis in Plants
Allen, E. M., Xie, Z., Gustafson, A. M., & Carrington, J. C. (2005) · Cell · doi:10.1016/j.cell.2005.04.004 · Cited by 2,249 · see citing works
Towards a molecular understanding of microRNA-mediated gene silencing
Jonas, S., & Izaurralde, E. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3965 · Cited by 1,872 · see citing works
Argonaute HITS-CLIP decodes microRNA–mRNA interaction maps
Chi, S. W., Zang, J. B., Mele, A., & Darnell, R. B. (2009) · Nature · doi:10.1038/nature08170 · Cited by 1,791 · see citing works
A MicroRNA as a Translational Repressor of APETALA2 in Arabidopsis Flower Development
Chen, X. (2003) · Science · doi:10.1126/science.1088060 · Cited by 1,762 · see citing works
Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs
Meister, G., Landthaler, M., Patkaniowska, A., Dorsett, Y., Teng, G., & Tuschl, T. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.07.007 · Cited by 1,718 · see citing works
MicroRNA-Directed Cleavage of <i>HOXB8</i> mRNA
Yekta, S., Shih, I.-H., & Bartel, D. P. (2004) · Science · doi:10.1126/science.1097434 · Cited by 1,702 · see citing works
Widespread translational inhibition by plant miRNAs and siRNAs
Brodersen, P., Sakvarelidze-Achard, L., Bruun-Rasmussen, M., Dunoyer, P., Yamamoto, Y. Y., Sieburth, L., & Voinnet, O. (2008) · Science · doi:10.1126/science.1159151 · Cited by 1,477 · see citing works
Crystal Structure of Argonaute and Its Implications for RISC Slicer Activity
Song, J., Smith, S. K., Hannon, G. J., & Joshua‐Tor, L. (2004) · Science · doi:10.1126/science.1102514 · Cited by 1,465 · see citing works
The BioGRID interaction database: 2019 update
Oughtred, R., Stark, C., Breitkreutz, B., Rust, J., Boucher, L., Chang, C., Kolas, N. K., O’Donnell, L., Leung, G. C., McAdam, R. F., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky1079 · Cited by 1,440 · see citing works
Sorting of Small RNAs into Arabidopsis Argonaute Complexes Is Directed by the 5′ Terminal Nucleotide
Mi, S., Cai, T., Hu, Y., Chen, Y., Hodges, E. C., Ni, F., Wu, L., Li, S., Zhou, H., Long, C., et al. (2008) · Cell · doi:10.1016/j.cell.2008.02.034 · Cited by 1,311 · see citing works
Mapping the Human miRNA Interactome by CLASH Reveals Frequent Noncanonical Binding
Helwak, A., Kudla, G., Dudnakova, T., & Tollervey, D. (2013) · Cell · doi:10.1016/j.cell.2013.03.043 · Cited by 1,269 · see citing works
siRNAs can function as miRNAsPreprint
Doench, J. G., Petersen, C. P., & Sharp, P. A. (2003) · Genes & Development · doi:10.1101/gad.1064703 · Cited by 1,262 · see citing works
MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies
Liu, J., Valencia-Sanchez, M. A., Hannon, G. J., & Parker, R. (2005) · Nature Cell Biology · doi:10.1038/ncb1274 · Cited by 1,234 · see citing works
Cellular quality control by the ubiquitin-proteasome system and autophagy
Pohl, C., & Đikić, I. (2019) · Science · doi:10.1126/science.aax3769 · Cited by 1,229 · see citing works
Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5′ UTR as in the 3′ UTR
Lytle, J., Yario, T. A., & STEITZ, J. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703820104 · Cited by 1,196 · see citing works
Baumberger, N., & Baulcombe, D. C. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505461102 · Cited by 1,049 · see citing works
Behm‐Ansmant, I., Rehwinkel, J., Doerks, T., Stark, A., Bork, P., & Izaurralde, E. (2006) · Genes & Development · doi:10.1101/gad.1424106 · Cited by 1,030 · see citing works
A dicer-independent miRNA biogenesis pathway that requires Ago catalysis
Cheloufi, S., Dos Santos, C. O., Chong, M. M. W., & Hannon, G. J. (2010) · Nature · doi:10.1038/nature09092 · Cited by 1,026 · see citing works
A biochemical framework for RNA silencing in plantsPreprint
Tang, G., Reinhart, B. J., Bartel, D. P., & Zamore, P. D. (2003) · Genes & Development · doi:10.1101/gad.1048103 · Cited by 984 · see citing works
Vaucheret, H., Vazquez, F., Crété, P., & Bartel, D. P. (2004) · Genes & Development · doi:10.1101/gad.1201404 · Cited by 982 · see citing works
Passenger-Strand Cleavage Facilitates Assembly of siRNA into Ago2-Containing RNAi Enzyme Complexes
Matranga, C., Tomari, Y., Shin, C., Bartel, D. P., & Zamore, P. D. (2005) · Cell · doi:10.1016/j.cell.2005.08.044 · Cited by 969 · see citing works
Self-citationmiRNA-Mediated Gene Silencing by Translational Repression Followed by mRNA Deadenylation and Decay
Djuranović, S., Nahvi, A., & Green, R. (2012) · Science · doi:10.1126/science.1215691 · Cited by 866 · see citing works
Global identification of microRNA–target RNA pairs by parallel analysis of RNA ends
German, M. A., Pillay, M., Jeong, D., Hetawal, A., Luo, S. J., Janardhanan, P. E., Kannan, V., Rymarquis, L. A., Nobuta, K., German, R., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1417 · Cited by 839 · see citing works
A Human snoRNA with MicroRNA-Like Functions
Ender, C., Krek, A., Friedländer, M. R., Beitzinger, M., Weinmann, L., Chen, W., Pfeffer, S., Rajewsky, N., & Meister, G. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.10.017 · Cited by 837 · see citing works
A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity
Cifuentes, D., Xue, H., Taylor, D. W., Patnode, H., Mishima, Y., Cheloufi, S., Ma, E., Mane, S., Hannon, G. J., Lawson, N. D., et al. (2010) · Science · doi:10.1126/science.1190809 · Cited by 836 · see citing works
Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathwaysPreprint
岡村, 勝., Ishizuka, A., Siomi, H., & Siomi, M. C. (2004) · Genes & Development · doi:10.1101/gad.1210204 · Cited by 833 · see citing works
Endogenous siRNA and miRNA Targets Identified by Sequencing of the Arabidopsis Degradome
Addo‐Quaye, C., Eshoo-Anton, T. W., Bartel, D. P., & Axtell, M. J. (2008) · Current Biology · doi:10.1016/j.cub.2008.04.042 · Cited by 786 · see citing works
Argonaute2 Cleaves the Anti-Guide Strand of siRNA during RISC Activation
Rand, T., Petersen, S., Du, F., & Wang, X. (2005) · Cell · doi:10.1016/j.cell.2005.10.020 · Cited by 784 · see citing works
Montgomery, T. A., Howell, M. D., Cuperus, J. T., Li, D., Hansen, J. E., Alexander, A. L., Chapman, E. J., Fahlgren, N., Allen, E. M., & Carrington, J. C. (2008) · Cell · doi:10.1016/j.cell.2008.02.033 · Cited by 775 · see citing works
RNA-Binding Protein Dnd1 Inhibits MicroRNA Access to Target mRNA
Kedde, M., Strasser, M. J., Boldajipour, B. A., Vrielink, J. A. F. O., Slanchev, K., le Sage, C., Nagel, R., Voorhoeve, P. M., van Duijse, J., Ørom, U. A., et al. (2007) · Cell · doi:10.1016/j.cell.2007.11.034 · Cited by 733 · see citing works
The Functions of MicroRNAs: mRNA Decay and Translational Repression
Iwakawa, H., & Tomari, Y. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.07.011 · Cited by 732 · see citing works
Self-citationRibosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish
Bazzini, A. A., Lee, M. T., & Giraldez, A. J. (2012) · Science · doi:10.1126/science.1215704 · Cited by 709 · see citing works
The Crystal Structure of Human Argonaute2
Schirle, N. T., & MacRae, I. J. (2012) · Science · doi:10.1126/science.1221551 · Cited by 697 · see citing works
Alberti, S. (2017) · Current Biology · doi:10.1016/j.cub.2017.08.069 · Cited by 654 · see citing works
Structural basis for 5′-end-specific recognition of guide RNA by the A. fulgidus Piwi protein
Ma, J., Yuan, Y. A., Meister, G., Pei, Y., Tuschl, T., & Patel, D. J. (2005) · Nature · doi:10.1038/nature03514 · Cited by 649 · see citing works
Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies
Sen, G. L., & Blau, H. M. (2005) · Nature Cell Biology · doi:10.1038/ncb1265 · Cited by 645 · see citing works
MicroRNA Inhibition of Translation Initiation in Vitro by Targeting the Cap-Binding Complex eIF4F
Mathonnet, G., Fabian, M., Svitkin, Y., Parsyan, A., Huck, L., Murata, T., Biffo, S., Merrick, W., Darżynkiewicz, E., Pillai, R., et al. (2007) · Science · doi:10.1126/science.1146067 · Cited by 636 · see citing works
Structural basis for 5′-nucleotide base-specific recognition of guide RNA by human AGO2
Frank, F., Sonenberg, N., & Nagar, B. (2010) · Nature · doi:10.1038/nature09039 · Cited by 625 · see citing works
The Structure of Human Argonaute-2 in Complex with miR-20a
Elkayam, E., Kuhn, C., Tocilj, A., Haase, A. D. D., Greene, E. M., Hannon, G. J., & Joshua‐Tor, L. (2012) · Cell · doi:10.1016/j.cell.2012.05.017 · Cited by 615 · see citing works
A Protein Sensor for siRNA Asymmetry
Tomari, Y., Matranga, C. B., Haley, B., Martinez, N. J., & Zamore, P. D. (2004) · Science · doi:10.1126/science.1102755 · Cited by 601 · see citing works
Self-citationTarget RNA–Directed Trimming and Tailing of Small Silencing RNAs
Ameres, S. L., Horwich, M. D., Hung, J.-H., Xu, J., Ghildiyal, M., Weng, Z., & Zamore, P. D. (2010) · Science · doi:10.1126/science.1187058 · Cited by 597 · see citing works
A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain
Kleaveland, B., Shi, C. Y., Stefano, J., & Bartel, D. P. (2018) · Cell · doi:10.1016/j.cell.2018.05.022 · Cited by 594 · see citing works
PRG-1 and 21U-RNAs Interact to Form the piRNA Complex Required for Fertility in C. elegans
Batista, P. J., Ruby, J. G., Claycomb, J. M., Chiang, R., Fahlgren, N., Kasschau, K. D., Chaves, D. A., Gu, W., Vasale, J. J., Duan, S., et al. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.06.002 · Cited by 588 · see citing works
Song, J., Liu, J., Tolia, N. H., et al. (2003) · Nature Structural & Molecular Biology · doi:10.1038/nsb1016 · Cited by 583 · see citing works
Structural basis for microRNA targeting
Schirle, N. T., Sheu‐Gruttadauria, J., & MacRae, I. J. (2014) · Science · doi:10.1126/science.1258040 · Cited by 563 · see citing works
piRNA-Guided Genome Defense: From Biogenesis to Silencing
Czech, B., Munafò, M., Ciabrelli, F., Eastwood, E. L., Fabry, M., Kneuss, E., & Hannon, G. J. (2018) · Annual Review of Genetics · doi:10.1146/annurev-genet-120417-031441 · Cited by 548 · see citing works
Horwich, M. D., Li, C., Matranga, C. B., Vagin, V. V., Farley, G., Wang, P., & Zamore, P. D. (2007) · Current Biology · doi:10.1016/j.cub.2007.06.030 · Cited by 543 · see citing works
Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes
Wang, Y., Juranek, S., Li, H., Sheng, G., Wardle, G. S., Tuschl, T., & Patel, D. J. (2009) · Nature · doi:10.1038/nature08434 · Cited by 542 · see citing works
Structure of the guide-strand-containing argonaute silencing complex
Wang, Y., Sheng, G., Juranek, S., Tuschl, T., & Patel, D. J. (2008) · Nature · doi:10.1038/nature07315 · Cited by 531 · see citing works
Structural insights into mRNA recognition from a PIWI domain–siRNA guide complex
Parker, J. S., Roe, S. M., & Barford, D. (2005) · Nature · doi:10.1038/nature03462 · Cited by 531 · see citing works
Hsc70/Hsp90 Chaperone Machinery Mediates ATP-Dependent RISC Loading of Small RNA Duplexes
Iwasaki, S., Kobayashi, M., Yoda, M., Sakaguchi, Y., Katsuma, S., Suzuki, T., & Tomari, Y. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.015 · Cited by 507 · see citing works
Self-citationA crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing
Rehwinkel, J., Behm‐Ansmant, I., Gatfield, D., & Izaurralde, E. (2005) · RNA · doi:10.1261/rna.2191905 · Cited by 493 · see citing works
Eichhorn, S. W., Guo, H., McGeary, S. E., Rodríguez‐Mias, R. A., Shin, C., Baek, D., Hsu, S., Ghoshal, K., Villén, J., & Bartel, D. P. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.028 · Cited by 491 · see citing works
Yang, J.-S., Maurin, T., Robine, N., Rasmussen, K. D., Jeffrey, K. L., Chandwani, R., Papapetrou, E. P., Sadelain, M., O’Carroll, D., & Lai, E. C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006432107 · Cited by 481 · see citing works
Down-Regulation of a Host MicroRNA by a <i>Herpesvirus saimiri</i> Noncoding RNA
Cazalla, D., Yario, T., & Steitz, J. A. (2010) · Science · doi:10.1126/science.1187197 · Cited by 474 · see citing works
Kinetic analysis of the RNAi enzyme complex
Haley, B., & Zamore, P. D. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb780 · Cited by 454 · see citing works
Takeda, A., Iwasaki, S., Watanabe, T., Utsumi, M., & Watanabe, Y. (2008) · Plant and Cell Physiology · doi:10.1093/pcp/pcn043 · Cited by 444 · see citing works
Förstemann, K., Horwich, M. D., Wee, L. M., Tomari, Y., & Zamore, P. D. (2007) · Cell · doi:10.1016/j.cell.2007.05.056 · Cited by 440 · see citing works
Self-citationEffective Small RNA Destruction by the Expression of a Short Tandem Target Mimic in Arabidopsis
Yan, J., Gu, Y., Jia, X., Kang, W., Pan, S., Tang, X., Chen, X., & Tang, G. (2012) · The Plant Cell · doi:10.1105/tpc.111.094144 · Cited by 437 · see citing works
Leung, A., Calabrese, J. M., & Sharp, P. (2006) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0608845103 · Cited by 428 · see citing works
Eulálio, A., Huntzinger, E., & Izaurralde, E. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1405 · Cited by 414 · see citing works
RISC is a 5′ phosphomonoester-producing RNA endonucleasePreprint
Martı̂nez, J., & Tuschl, T. (2004) · Genes & Development · doi:10.1101/gad.1187904 · Cited by 407 · see citing works
A Pumilio-induced RNA structure switch in p27-3′ UTR controls miR-221 and miR-222 accessibility
Kedde, M., van Kouwenhove, M., Zwart, W. T., Vrielink, J. A. F. O., Elkon, R., & Agami, R. (2010) · Nature Cell Biology · doi:10.1038/ncb2105 · Cited by 406 · see citing works
Slicer function of Drosophila Argonautes and its involvement in RISC formationPreprint
Miyoshi, K., Tsukumo, H., Nagami, T., Siomi, H., & Siomi, M. C. (2005) · Genes & Development · doi:10.1101/gad.1370605 · Cited by 402 · see citing works
Todesco, M., Rubio‐Somoza, I., Paz‐Ares, J., & Weigel, D. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001031 · Cited by 395 · see citing works
Argonaute Divides Its RNA Guide into Domains with Distinct Functions and RNA-Binding Properties
Wee, L. M., Flores-Jasso, C. F., Salomon, W. E., & Zamore, P. D. (2012) · Cell · doi:10.1016/j.cell.2012.10.036 · Cited by 392 · see citing works
The Polerovirus Silencing Suppressor P0 Targets ARGONAUTE Proteins for Degradation
Baumberger, N., Tsai, C.-H., Lie, M., et al. (2007) · Current Biology · doi:10.1016/j.cub.2007.08.039 · Cited by 391 · see citing works
Mammalian miRNA RISC Recruits CAF1 and PABP to Affect PABP-Dependent Deadenylation
Fabian, M. R., Mathonnet, G., Sundermeier, T. R., Mathys, H., Zipprich, J. T., Svitkin, Y. V., Rivas, F. V., Jínek, M., Wohlschlegel, J. A., Doudna, J. A., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.08.004 · Cited by 388 · see citing works
Sorting of Drosophila Small Silencing RNAs
Tomari, Y., Du, T., & Zamore, P. D. (2007) · Cell · doi:10.1016/j.cell.2007.05.057 · Cited by 383 · see citing works
Self-citationATP-dependent human RISC assembly pathways
Yoda, M., Kawamata, T., Paroo, Z., Ye, X., Iwasaki, S., Liu, Q., & Tomari, Y. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1733 · Cited by 380 · see citing works
Self-citationDistance constraints between microRNA target sites dictate efficacy and cooperativity
Sætrom, P., Heale, B. S. E., Snøve, O., Aagaard, L., Alluin, J. V., & Rossi, J. J. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm133 · Cited by 373 · see citing works
GW182 Proteins Directly Recruit Cytoplasmic Deadenylase Complexes to miRNA Targets
Braun, J. E., Huntzinger, E., Fauser, M., & Izaurralde, E. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.09.007 · Cited by 371 · see citing works
Structure of yeast Argonaute with guide RNA
Nakanishi, K., Weinberg, D. E., Bartel, D. P., & Patel, D. J. (2012) · Nature · doi:10.1038/nature11211 · Cited by 356 · see citing works
Chekulaeva, M., Mathys, H., Zipprich, J. T., Attig, J., Čolić, M., Parker, R., & Filipowicz, W. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2166 · Cited by 353 · see citing works
The Polerovirus F Box Protein P0 Targets ARGONAUTE1 to Suppress RNA Silencing
Bortolamiol, D., Pazhouhandeh, M., Marrocco, K., et al. (2007) · Current Biology · doi:10.1016/j.cub.2007.07.061 · Cited by 347 · see citing works
RNAi-Mediated Allelic trans-Interaction at the Imprinted Rtl1/Peg11 Locus
Davis, E. E., Caiment, F., Tordoir, X., Cavaillé, J., Ferguson‐Smith, A. C., Cockett, N., Georges, M., & Charlier, C. (2005) · Current Biology · doi:10.1016/j.cub.2005.02.060 · Cited by 331 · see citing works
Fabian, M. R., Cieplak-Rotowska, M. K., Frank, F., Morita, M., Green, J., Srikumar, T., Nagar, B., Yamamoto, T. S., Raught, B., Duchaîne, T. F., et al. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2149 · Cited by 329 · see citing works
Harris, A. N., & Macdonald, P. M. (2001) · Development · doi:10.1242/dev.128.14.2823 · Cited by 329 · see citing works
An alternative mode of microRNA target recognition
Chi, S. W., Hannon, G. J., & Darnell, R. B. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2230 · Cited by 328 · see citing works
In Vitro Assembly of Plant RNA-Induced Silencing Complexes Facilitated by Molecular Chaperone HSP90
Iki, T., Yoshikawa, M., Nishikiori, M., Jaudal, M. C., Matsumoto-Yokoyama, E., Mitsuhara, I., Meshi, T., & Ishikawa, M. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.014 · Cited by 325 · see citing works
El‐Shami, M., Pontier, D., Lahmy, S., Braun, L., Picart, C., Véga, D., Hakimi, M., Jacobsen, S. E., Cooke, R., & Lagrange, T. (2007) · Genes & Development · doi:10.1101/gad.451207 · Cited by 321 · see citing works
The N domain of Argonaute drives duplex unwinding during RISC assembly
Kwak, P. B., & Tomari, Y. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2232 · Cited by 315 · see citing works
Self-citationTranscriptome-wide miR-155 Binding Map Reveals Widespread Noncanonical MicroRNA Targeting
Loeb, G. B., Khan, A. A., Canner, D., Hiatt, J. B., Shendure, J., Darnell, R. B., Leslie, C. S., & Rudensky, A. Y. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.10.002 · Cited by 311 · see citing works
Burroughs, A. M., Ando, Y., de Hoon, M., Tomaru, Y., Suzuki, H., Hayashizaki, Y., & Daub, C. O. (2011) · RNA Biology · doi:10.4161/rna.8.1.14300 · Cited by 310 · see citing works
Mathys, H., Basquin, J., Ozgur, S., Czarnocki‐Cieciura, M., Bonneau, F., Aartse, A., Dziembowski, A., Nowotny, M., Conti, E., & Filipowicz, W. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.03.036 · Cited by 308 · see citing works
A C. elegans Piwi, PRG-1, Regulates 21U-RNAs during Spermatogenesis
Wang, G., & Reinke, V. (2008) · Current Biology · doi:10.1016/j.cub.2008.05.009 · Cited by 294 · see citing works
Degradation of the antiviral component ARGONAUTE1 by the autophagy pathway
Derrien, B., Baumberger, N., Schepetilnikov, M. V., Viotti, C., Cillia, J. D., Ziegler‐Graff, V., Isono, E., Schumacher, K., & Genschik, P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209487109 · Cited by 288 · see citing works
Chen, Y., Boland, A., Kuzuoğlu‐Öztürk, D., Bawankar, P., Loh, B., Chang, C.-T., Weichenrieder, O., & Izaurralde, E. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.03.034 · Cited by 284 · see citing works
Grosswendt, S., Filipchyk, A., Manzano, M., Klironomos, F., Schilling, M., Herzog, M., Gottwein, E., & Rajewsky, N. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.03.049 · Cited by 282 · see citing works
Molecular mechanisms of Dicer: endonuclease and enzymatic activity
Song, M.-S., & Rossi, J. J. (2017) · Biochemical Journal · doi:10.1042/bcj20160759 · Cited by 281 · see citing works
Designing siRNA That Distinguish between Genes That Differ by a Single Nucleotide
Schwarz, D. S., Ding, H., Kennington, L. A., Moore, J. T., Schelter, J. M., Burchard, J., Linsley, P. S., D, N. A. M., Xu, Z., & Zamore, P. D. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020140 · Cited by 271 · see citing works
Structural determinants of miRNAs for RISC loading and slicer-independent unwinding
Kawamata, T., Seitz, H., & Tomari, Y. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1630 · Cited by 269 · see citing works
Self-citationSalomon, W. E., Jolly, S. M., Moore, M. J., Zamore, P. D., & Serebrov, V. (2015) · Cell · doi:10.1016/j.cell.2015.06.029 · Cited by 266 · see citing works
Molecular Insights into microRNA-Mediated Translational Repression in Plants
Iwakawa, H., & Tomari, Y. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.10.033 · Cited by 263 · see citing works
Self-citationAn Argonaute phosphorylation cycle promotes microRNA-mediated silencing
Golden, R. J., Chen, B., Li, T., Braun, J., Manjunath, H., Chen, X., Wu, J., Schmid, V., Chang, T.-C., Kopp, F. B., et al. (2017) · Nature · doi:10.1038/nature21025 · Cited by 259 · see citing works
Phase Transitions in the Assembly and Function of Human miRISC
Sheu‐Gruttadauria, J., & MacRae, I. J. (2018) · Cell · doi:10.1016/j.cell.2018.02.051 · Cited by 258 · see citing works
Selective autophagy degrades DICER and AGO2 and regulates miRNA activity
Gibbings, D., Mostowy, S., Jay, F., Schwab, Y., Cossart, P., & Voinnet, O. (2012) · Nature Cell Biology · doi:10.1038/ncb2611 · Cited by 249 · see citing works
Characterization of endogenous human Argonautes and their miRNA partners in RNA silencing
Azuma-Mukai, A., Oguri, H., Mitsuyama, T., Qian, Z. R., Asai, K., Siomi, H., & Siomi, M. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800334105 · Cited by 249 · see citing works
Structural Basis for Target-Directed MicroRNA Degradation
Sheu-Gruttadauria, J., Pawlica, P., Klum, S. M., Wang, S., Yario, T. A., Schirle Oakdale, N. T., Steitz, J. A., & MacRae, I. J. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.06.019 · Cited by 246 · see citing works
A Dynamic Search Process Underlies MicroRNA Targeting
Chandradoss, S. D., Schirle, N. T., Szczepaniak, M., MacRae, I. J., & Joo, C. (2015) · Cell · doi:10.1016/j.cell.2015.06.032 · Cited by 244 · see citing works
Functional Analysis of Three Arabidopsis ARGONAUTES Using Slicer-Defective Mutants
Carbonell, A., Fahlgren, N., García-Ruíz, H., Gilbert, K. B., Montgomery, T. A., Nguyen, T., Cuperus, J. T., & Carrington, J. C. (2012) · The Plant Cell · doi:10.1105/tpc.112.099945 · Cited by 239 · see citing works
The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation
Shi, C. Y., Kingston, E. R., Kleaveland, B., Lin, D. H., Stubna, M. W., & Bartel, D. P. (2020) · Science · doi:10.1126/science.abc9359 · Cited by 239 · see citing works
A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming
Han, J., LaVigne, C. A., Jones, B. T., Zhang, H., Gillett, F. A., & Mendell, J. T. (2020) · Science · doi:10.1126/science.abc9546 · Cited by 235 · see citing works
Liu, Q., Wang, F., & Axtell, M. J. (2014) · The Plant Cell · doi:10.1105/tpc.113.120972 · Cited by 230 · see citing works
Winter, J. J., & Diederichs, S. (2011) · RNA Biology · doi:10.4161/rna.8.6.17665 · Cited by 224 · see citing works
Marcinowski, L., Tanguy, M., Krmpotić, A., Rädle, B., Lisnić, V. J., Tuddenham, L., Chane-Woon-Ming, B., Ruzsics, Z., Erhard, F., Benkartek, C., et al. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002510 · Cited by 201 · see citing works
Kinetic analysis reveals successive steps leading to miRNA‐mediated silencing in mammalian cells
Béthune, J., Artus-Revel, C. G., & Filipowicz, W. (2012) · EMBO Reports · doi:10.1038/embor.2012.82 · Cited by 201 · see citing works
Potent degradation of neuronal miRNAs induced by highly complementary targets
de la Mata, M., Gaidatzis, D., Vitanescu, M., Stadler, M. B., Wentzel, C., Scheiffele, P., Filipowicz, W., & Großhans, H. (2015) · The EMBO Reports · doi:10.15252/embr.201540078 · Cited by 201 · see citing works
Ago–TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps
Chen, C. A., Zheng, D., Xia, Z., & Shyu, A. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1709 · Cited by 194 · see citing works
CRD-BP Protects the Coding Region of βTrCP1 mRNA from miR-183-Mediated Degradation
Elcheva, I. A., Goswami, S., Noubissi, F. K., & Spiegelman, V. S. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.06.007 · Cited by 192 · see citing works
Csorba, T., Lózsa, R., Hutvágner, G., et al. (2010) · The Plant Journal · doi:10.1111/j.1365-313x.2010.04163.x · Cited by 192 · see citing works
Bronevetsky, Y., Villarino, A. V., Eisley, C. J., Barbeau, R., Barczak, A. J., Heinz, G. A., Kremmer, E., Heissmeyer, V., McManus, M. T., Erle, D. J., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20111717 · Cited by 189 · see citing works
Moretti, F., Thermann, R., & Hentze, M. (2010) · RNA: A publication of the RNA Society · doi:10.1261/rna.2384610 · Cited by 183 · see citing works
Plant 22-nt siRNAs mediate translational repression and stress adaptation
Wu, H., Li, B., Iwakawa, H., et al. (2020) · Nature · doi:10.1038/s41586-020-2231-y · Cited by 178 · see citing works
Self-citationSelective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis
Ding, H., Schwarz, D. S., Keene, A. C., Affar, E. B., Fenton, L., Xia, X., Shi, Y., Zamore, P. D., & Xu, Z. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00054.x · Cited by 172 · see citing works
MicroRNA degradation by a conserved target RNA regulates animal behavior
Bitetti, A., Mallory, A. C., Golini, E., Carrieri, C., Gutiérrez, H. C., Perlas, E., Perez-Rico, Y. A., Tocchini‐Valentini, G. P., Enright, A. J., Norton, W., et al. (2018) · Nature Structural & Molecular Biology · doi:10.1038/s41594-018-0032-x · Cited by 168 · see citing works
A direct role for Hsp90 in pre-RISC formation in Drosophila
Miyoshi, T., Takeuchi, A., Siomi, H., et al. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1875 · Cited by 166 · see citing works
High-Throughput Analysis Reveals Rules for Target RNA Binding and Cleavage by AGO2
Becker, W. R., Ober-Reynolds, B., Jouravleva, K., Jolly, S. M., Zamore, P. D., & Greenleaf, W. J. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.06.012 · Cited by 161 · see citing works
Pontier, D., Picart, C., Roudier, F., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.07.027 · Cited by 148 · see citing works
Mechanistic Insights into MicroRNA-Mediated Gene SilencingPreprint
Duchaîne, T. F., & Fabian, M. R. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a032771 · Cited by 146 · see citing works
Beyond the seed: structural basis for supplementary microRNA targeting by human Argonaute2
Sheu‐Gruttadauria, J., Xiao, Y., Gebert, L. F. R., & MacRae, I. J. (2019) · The EMBO Journal · doi:10.15252/embj.2018101153 · Cited by 146 · see citing works
Argonaute protein identity and pairing geometry determine cooperativity in mammalian RNA silencing
Broderick, J. A., Salomon, W. E., Ryder, S., D, N. A. M., & Zamore, P. D. (2011) · RNA · doi:10.1261/rna.2778911 · Cited by 145 · see citing works
Defining fundamental steps in the assembly of the Drosophila RNAi enzyme complex
Iwasaki, S., Sasaki, H. M., Sakaguchi, Y., Suzuki, T., Tadakuma, H., & Tomari, Y. (2015) · Nature · doi:10.1038/nature14254 · Cited by 138 · see citing works
Self-citationMicroRNAs Trigger Dissociation of eIF4AI and eIF4AII from Target mRNAs in Humans
Fukao, A., Mishima, Y., Takizawa, N., Oka, S., Imataka, H., Pelletier, J., Sonenberg, N., Thoma, C., & Fujiwara, T. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.09.005 · Cited by 137 · see citing works
Degrauwe, N., Schlumpf, T. B., Janiszewska, M., Martin, P., Cauderay, A., Provero, P., Riggi, N., Suvà, M.-L., Paro, R., & Stamenkovic, I. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.04.086 · Cited by 136 · see citing works
Human DDX6 effects miRNA-mediated gene silencing via direct binding to CNOT1
Rouya, C., Siddiqui, N., Morita, M., Duchaine, T., Fabian, M., & Sonenberg, N. (2014) · RNA: A publication of the RNA Society · doi:10.1261/rna.045302.114 · Cited by 133 · see citing works
The Making of a Slicer: Activation of Human Argonaute-1
Faehnle, C. R., Elkayam, E., Haase, A. D. D., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.033 · Cited by 131 · see citing works
The DDX6–4E-T interaction mediates translational repression and P-body assembly
Kamenska, A., Simpson, C. E., Vindry, C., Broomhead, H. E., Bénard, M., Ernoult‐Lange, M., Lee, B. P., Harries, L. W., Barbieri-Weill, D., & Standart, N. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw565 · Cited by 128 · see citing works
Argonaute2 expression is post-transcriptionally coupled to microRNA abundance
Martinez, N. J., & Gregory, R. I. (2013) · RNA · doi:10.1261/rna.036434.112 · Cited by 126 · see citing works
MicroRNAs Block Assembly of eIF4F Translation Initiation Complex in Drosophila
Fukaya, T., Iwakawa, H., & Tomari, Y. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.09.004 · Cited by 120 · see citing works
Self-citationRocca, G. L., Olejniczak, S. H., González, A. J., Briskin, D., Vidigal, J. A., Spraggon, L., Dematteo, R. G., Radler, M. R., Lindsten, T., Ventura, A., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1424217112 · Cited by 117 · see citing works
Cap-binding protein 4EHP effects translation silencing by microRNAs
Chapat, C., Jafarnejad, S. M., Matta‐Camacho, E., Hesketh, G. G., Gelbart, I. A., Attig, J., Gkogkas, C. G., Alain, T., Stern‐Ginossar, N., Fabian, M. R., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1701488114 · Cited by 116 · see citing works
Structural basis for piRNA targeting
Anzelon, T. A., Chowdhury, S., Hughes, S. M., Xiao, Y., Lander, G. C., & MacRae, I. J. (2021) · Nature · doi:10.1038/s41586-021-03856-x · Cited by 113 · see citing works
Crystal structure and ligand binding of the MID domain of a eukaryotic Argonaute protein
Boland, A., Tritschler, F., Heimstädt, S., et al. (2010) · EMBO Reports · doi:10.1038/embor.2010.81 · Cited by 109 · see citing works
Small-RNA asymmetry is directly driven by mammalian Argonautes
Suzuki, H. I., Katsura, A., Yasuda, T., Ueno, T., Mano, H., Sugimoto, K., & Miyazono, K. (2015) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3050 · Cited by 108 · see citing works
Turning catalytically inactive human Argonaute proteins into active slicer enzymes
Hauptmann, J., Dueck, A., Harlander, S., et al. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2577 · Cited by 108 · see citing works
PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding
Moretti, F., Kaiser, C., Zdanowicz-Specht, A., & Hentze, M. W. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2309 · Cited by 107 · see citing works
Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation
Jínek, M., Fabian, M. R., Coyle, S. M., Sonenberg, N., & Doudna, J. A. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1768 · Cited by 106 · see citing works
Kozlov, G., Safaee, N., Rosenauer, A., & Gehring, K. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.089540 · Cited by 105 · see citing works
Human Argonaute3 has slicer activity
Park, M. S., Phan, H., Büsch, F., Hinckley, S. H., Brackbill, J. A., Wysocki, V. H., & Nakanishi, K. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx916 · Cited by 105 · see citing works
Convergent Evolution of Argonaute-2 Slicer Antagonism in Two Distinct Insect RNA Viruses
van Mierlo, J. T., Bronkhorst, A. W., Overheul, G. J., et al. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002872 · Cited by 103 · see citing works
Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets
Schirle, N. T., Sheu‐Gruttadauria, J., Chandradoss, S. D., Joo, C., & MacRae, I. J. (2015) · eLife · doi:10.7554/elife.07646 · Cited by 101 · see citing works
Multivalent Recruitment of Human Argonaute by GW182
Elkayam, E., Faehnle, C. R., Morales, M., Sun, J., Li, H., & Joshua‐Tor, L. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.07.007 · Cited by 101 · see citing works
Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity
Léveillé, N., Elkon, R., Dávalos, V., Manoharan, V., Hollingworth, D., Vrielink, J. A. F. O., le Sage, C., Melo, C. A., Horlings, H. M., Wesseling, J., et al. (2011) · Nature Communications · doi:10.1038/ncomms1519 · Cited by 98 · see citing works
FUS Regulates Activity of MicroRNA-Mediated Gene Silencing
Zhang, T., Wu, Y., Mullane, P., Ji, Y. J., Liu, H., He, L., Arora, A., Hwang, H., Alessi, A. F., Niaki, A. G., et al. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.02.001 · Cited by 92 · see citing works
The biochemical basis for the cooperative action of microRNAs
Briskin, D., Wang, P. Y., & Bartel, D. P. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1920404117 · Cited by 92 · see citing works
An endogenous F-box protein regulates ARGONAUTE1 in Arabidopsis thaliana
Earley, K. W., Smith, M., Weber, R. A., et al. (2010) · Silence · doi:10.1186/1758-907x-1-15 · Cited by 89 · see citing works
Pircs, K., Petri, R., Madsen, S., Brattås, P. L., Vuono, R., Ottosson, D. R., St‐Amour, I., Hersbach, B. A., Matusiak-Brückner, M., Lundh, S. H., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.017 · Cited by 88 · see citing works
Garcia, D., Garcia, S., Pontier, D., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.07.028 · Cited by 85 · see citing works
Huberdeau, M. Q., Zeitler, D. M., Hauptmann, J., Bruckmann, A., Fressigné, L., Danner, J., Piquet, S., Strieder, N., Engelmann, J. C., Jannot, G., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201696386 · Cited by 84 · see citing works
Tsuboyama, K., Tadakuma, H., & Tomari, Y. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.04.010 · Cited by 83 · see citing works
Self-citationSlicing-Independent RISC Activation Requires the Argonaute PAZ Domain
Gu, S., Jin, L. S., Huang, Y., et al. (2012) · Current Biology · doi:10.1016/j.cub.2012.06.040 · Cited by 82 · see citing works
Molecular dissection of human Argonaute proteins by DNA shuffling
Schürmann, N., Trabuco, L. G., Bender, C., et al. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2607 · Cited by 81 · see citing works
A non-canonical site reveals the cooperative mechanisms of microRNA-mediated silencing
Flamand, M. N., Gan, H. H., Mayya, V. K., Gunsalus, K. C., & Duchaîne, T. F. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx340 · Cited by 68 · see citing works
Jee, D. I. H., Yang, J.-S., Park, S., Farmer, D. T., Wen, J., Chou, T., Chow, A., McManus, M. T., Kharas, M. G., & Lai, E. C. (2018) · Molecular Cell · doi:10.1016/j.molcel.2017.12.027 · Cited by 65 · see citing works
Ameres, S. L., Hung, J., Xu, J. L., et al. (2010) · RNA · doi:10.1261/rna.2498411 · Cited by 63 · see citing works
A guide to micro RNA ‐mediated gene silencing
Huberdeau, M. Q., & Simard, M. J. (2018) · FEBS Journal · doi:10.1111/febs.14666 · Cited by 62 · see citing works
Derrien, B., Clavel, M., Baumberger, N., Iki, T., Sarazin, A., Hacquard, T., Ponce, M. R., Ziegler‐Graff, V., Vaucheret, H., Micol, J. L., et al. (2018) · The Plant Cell · doi:10.1105/tpc.18.00111 · Cited by 60 · see citing works
Dallaire, A., Frédérick, P., & Simard, M. J. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.08.022 · Cited by 58 · see citing works
Iwakawa, H., Lam, A. Y. W., Mine, A., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109300 · Cited by 58 · see citing works
Self-citationAutophagy modulates miRNA‐mediated gene silencing and selectively degrades AIN‐1/GW182 in C. elegans
Zhang, P., & Zhang, H. (2013) · EMBO Reports · doi:10.1038/embor.2013.53 · Cited by 57 · see citing works
Human Argonaute2 and Argonaute3 are catalytically activated by different lengths of guide RNA
Park, M. S., Sim, G., Kehling, A. C., & Nakanishi, K. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2015026117 · Cited by 55 · see citing works
Translational control of ERK signaling through miRNA/4EHP-directed silencing
Jafarnejad, S. M., Chapat, C., Matta‐Camacho, E., Gelbart, I. A., Hesketh, G. G., Arguello, M., Garzia, A., Kim, S., Attig, J., Shapiro, M., et al. (2018) · eLife · doi:10.7554/elife.35034 · Cited by 53 · see citing works
Wang, Z., Hou, Y., Guo, X., van der Voet, M., Boxem, M., Dixon, J. E., Chisholm, A. D., & Jin, Y. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.035 · Cited by 51 · see citing works
Slicer-independent mechanism drives small-RNA strand separation during human RISC assembly
Park, J. H., & Shin, C. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv937 · Cited by 50 · see citing works
mRNA structural dynamics shape Argonaute-target interactions
Ruijtenberg, S., Sonneveld, S., Cui, T.-J., Logister, I., de Steenwinkel, D., Xiao, Y., MacRae, I., Joo, C., & Tanenbaum, M. (2019) · Nature Structural & Molecular Biology · doi:10.1038/s41594-020-0461-1 · Cited by 46 · see citing works
Iruka Eliminates Dysfunctional Argonaute by Selective Ubiquitination of Its Empty State
Kobayashi, H., Shoji, K., Kiyokawa, K., Negishi, L., & Tomari, Y. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.10.033 · Cited by 44 · see citing works
Self-citationLin, X., Yang, B., Liu, W., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.6869 · Cited by 42 · see citing works
microRNA-mediated translation repression through GYF-1 and IFE-4 in C. elegans development
Mayya, V. K., Flamand, M. N., Lambert, A. M., Jafarnejad, S. M., Wohlschlegel, J. A., Sonenberg, N., & Duchaîne, T. F. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab162 · Cited by 40 · see citing works
Structural and biochemical insights into small RNA 3′ end trimming by Arabidopsis SDN1
Chen, J., Liu, L., You, C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05942-7 · Cited by 38 · see citing works
In vitro reconstitution of chaperone-mediated human RISC assembly
Naruse, K., Matsuura-Suzuki, E., Watanabe, M., Iwasaki, S., & Tomari, Y. (2018) · RNA: A publication of the RNA Society · doi:10.1261/rna.063891.117 · Cited by 32 · see citing works
Self-citationVCP Machinery Mediates Autophagic Degradation of Empty Argonaute
Kobayashi, H., Shoji, K., Kiyokawa, K., Negishi, L., & Tomari, Y. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.003 · Cited by 31 · see citing works
Self-citationNovel functional small RNAs are selectively loaded onto mammalian Ago1
Yamakawa, N., Okuyama, K., Ogata, J., Kanai, A., Helwak, A., Takamatsu, M., Imadome, K., 高倉, 光., Chanda, B., Kurosaki, N., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku137 · Cited by 30 · see citing works
Generation of catalytic human Ago4 identifies structural elements important for RNA cleavage
Hauptmann, J., Kater, L., Löffler, P., Merkl, R., & Meister, G. (2014) · RNA · doi:10.1261/rna.045203.114 · Cited by 30 · see citing works
Mei, J., Jiang, N., & Ren, G. (2018) · Journal of Integrative Plant Biology · doi:10.1111/jipb.12761 · Cited by 28 · see citing works
Suen, K. M., Braukmann, F., Butler, R., Bensaddek, D., Akay, A., Lin, C., Milonaitytė, D., Doshi, N., Sapetschnig, A., Lamond, A. I., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18089-1 · Cited by 27 · see citing works
Sibony, M., Abdullah, M., Greenfield, L. K., Raju, D., Wu, T., Rodrigues, D. M., Galindo‐Mata, E., Mascarenhas, H., Philpott, D. J., Silverberg, M. S., et al. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000553 · Cited by 20 · see citing works
Iki, T., Takami, M., & Kai, T. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108380 · Cited by 11 · see citing works
Kingston, E. R., & Bartel, D. P. (2021) · RNA · doi:10.1261/rna.078961.121 · Cited by 1 · see citing works
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Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246 · see citing works
Xu, Z., Sziraki, A., Lee, J., Zhou, W., & Cao, J. (2024) · Nature Biotechnology · doi:10.1038/s41587-023-01948-9 · Cited by 52 · see citing works
Histopathology and molecular pathology of pediatric pineal parenchymal tumors
Vasiljevic, A. (2023) · Child's Nervous System · doi:10.1007/s00381-022-05637-x · Cited by 18 · see citing works
- Authors
- Iwakawa, H.-O., & Tomari, Y.
- Affiliations
- Institute for Quantitative Biosciences, The University of Tokyo (JP)
- Corresponding author
- Iwakawa, Hiro-oki
- Tomari, Yukihide
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2022-01
- Volume
- 82
- Issue
- 1
- Pages
- 30-43
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W4200304551
- Cited by
- 488
- References
- 190
- Citations by year
- 2026: 97 · 2025: 151 · 2024: 115 · 2023: 91 · 2022: 34
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 370 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (18H05271)
- Japan Science and Technology Agency
- Precursory Research for Embryonic Science and Technology (JPMJPR18K2)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Keywords
- RNA-induced silencing complex, Argonaute proteins, small RNA, RNA interference, post-transcriptional gene silencing, mRNA degradation, protein synthesis inhibition, post-translational modification
- MeSH terms
- Animals, Humans, Protein Binding, RNA, RNA, Messenger, RNA Stability, RNA, Small Interfering, RNA-Induced Silencing Complex, MicroRNAs, Protein Stability, Proteolysis, Argonaute Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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