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Cited by 432

The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.

RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay

Open access
Yang, Ying, Wang, Lu, Han, Xiao, Yang, Wen-Lan, Zhang, Mengmeng, Ma, Hai-Li, Sun, Bao-Fa, Li, Ang, Xia, Jun, Chen, Jing, Heng, Jian, Wu, Baixing, Chen, Yu-Sheng, Xu, Jia-Wei, Yang, Xin, Yao, Huan, Sun, Jiawei, Lyu, Cong, Wang, Hai-Lin, Huang, Ying, Sun, Ying-Pu, Zhao, Yong-Liang, Meng, Anming, Ma, Jinbiao, Liu, Feng, Yang, Yun-Gui·2019·Molecular Cell
DOI 10.1016/j.molcel.2019.06.033
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Abstract

The maternal-to-zygotic transition (MZT) is a conserved and fundamental process during which the maternal environment is converted to an environment of embryonic-driven development through dramatic reprogramming. However, how maternally supplied transcripts are dynamically regulated during MZT remains largely unknown. Herein, through genome-wide profiling of RNA 5-methylcytosine (m5C) modification in zebrafish early embryos, we found that m5C-modified maternal mRNAs display higher stability than non-m5C-modified mRNAs during MZT. We discovered that Y-box binding protein 1 (Ybx1) preferentially recognizes m5C-modified mRNAs through π-π interactions with a key residue, Trp45, in Ybx1's cold shock domain (CSD), which plays essential roles in maternal mRNA stability and early embryogenesis of zebrafish. Together with the mRNA stabilizer Pabpc1a, Ybx1 promotes the stability of its target mRNAs in an m5C-dependent manner. Our study demonstrates an unexpected mechanism of RNA m5C-regulated maternal mRNA stabilization during zebrafish MZT, highlighting the critical role of m5C mRNA modification in early development.

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Metadata

Authors
Yang, Y., Wang, L., Han, X., Yang, W.-L., Zhang, M., Ma, H.-L., Sun, B.-F., Li, A., Xia, J., Chen, J., Heng, J., Wu, B., Chen, Y.-S., Xu, J.-W., Yang, X., Yao, H., Sun, J., Lyu, C., Wang, H.-L., Huang, Y., Sun, Y.-P., Zhao, Y.-L., Meng, A., Ma, J., Liu, F., & Yang, Y.-G.
Venue
Molecular Cell
Publisher
Elsevier BV
Published
2019-09
Volume
75
Issue
6
Pages
1188-1202.e11
ISSN
1097-2765 (ISSN-L)
DOI
10.1016/j.molcel.2019.06.033
OpenAlex
W2964888213
Cited by
432
References
88
FWCI
13.11
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay. https://app.cochat.ai/papers/10.1016/j.molcel.2019.06.033
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Yang, Y., Wang, L., Han, X., Yang, W.-L., Zhang, M., Ma, H.-L., Sun, B.-F., Li, A., Xia, J., Chen, J., Heng, J., Wu, B., Chen, Y.-S., Xu, J.-W., Yang, X., Yao, H., Sun, J., Lyu, C., Wang, H.-L., . . . Yang, Y.-G. (2019). RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay. Molecular Cell. https://doi.org/10.1016/j.molcel.2019.06.033

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.