The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Structure-Mediated RNA Decay by UPF1 and G3BP1
Open accessAbstract
SUMMARY Post-transcriptional mechanisms regulate the stability and hence expression of coding and noncoding RNAs. Sequence-specific features within the 3’-untranslated region (3’UTR) often direct mRNAs for decay. Here we characterize a genome-wide RNA decay pathway that reduces the half-lives of mRNAs based on overall 3’UTR structure formed by base-pairing. The decay pathway is independent of specific single-stranded sequences, as regulation is maintained in both the original and reverse complement orientation. Regulation can be compromised by reducing the overall structure by fusing the 3’UTR with an unstructured sequence. Mutating base-paired RNA regions can also compromise this structure-mediated regulation, which can be restored by re-introducing base-paired structures of different sequences. The decay pathway requires the RNA-binding proteins UPF1 and its associated protein G3BP1. Depletion of either protein increased steady-state levels of mRNAs with highly-structured 3’UTRs as well as highly-structured circular RNAs. This structure-dependent mechanism therefore enables cells to selectively regulate coding and noncoding RNAs.
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1 retracted
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Metadata
- Authors
- Fischer, J. W., Busa, V. F., Shao, Y., & Leung, A. K. L.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 78
- Issue
- 1
- Pages
- 70-84.e6
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W3004193861
- Cited by
- 267
- References
- 64
- FWCI
- 9.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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