The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy
Open accessAbstract
Summary Metabolism reprogramming is critical for both cancer progression and effective immune responses in the tumor microenvironment. Amino acid metabolism in different cells and their cross-talk shape tumor immunity and therapy efficacy in patients with cancer. In this review, we focus on multiple amino acids and their transporters, solute carriers (SLCs) members. We discuss their involvement in the regulation of the immune responses in the tumor microenvironment, and assess their associations with cancer immunotherapy, chemotherapy, and radiation therapy; as well as review their potential as targets for cancer therapy. We stress the necessity to understand individual amino acids and their transporters in different cell subsets, the molecular intersection between amino acid metabolism, and effective T cell immunity and its relevance in cancer therapies.
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Cites
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Cited by
Amino Acid Depletion Therapies: Starving Cancer Cells to Death
Butler, M., van der Meer, L. T., & van Leeuwen, F. N. (2021) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2021.03.003 · Cited by 268
Metadata
- Authors
- Wang, W., & Zou, W.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 80
- Issue
- 3
- Pages
- 384-395
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W3091364051
- Cited by
- 298
- References
- 96
- FWCI
- 10.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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