The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity
Open accessAbstract
Canonically, GSDMD cleavage by caspase-1 through inflammasome signaling triggers immune cell pyroptosis (ICP) as a host defense against pathogen infection. However, cancer cell pyroptosis (CCP) was recently discovered to be activated by distinct molecular mechanisms in which GSDMB, GSDMC and GSDME, rather than GSDMD, are the executioners. Moreover, instead of inflammatory caspases, apoptotic caspases and granzymes are required for gasdermin protein cleavage to induce CCP. Sufficient accumulation of protease-cleaved gasdermin proteins is the prerequisite for CCP. Inflammation induced by ICP or CCP results in diametrically opposite effect on antitumor immunity due to the differential duration and released cellular contents, leading to contrary impacts on therapeutic outcomes. Here, we focus on the distinct mechanisms of ICP and CCP, and discuss the roles of ICP and CCP in inflammation and antitumor immunity representing actionable targets.
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Cites
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Cited by
Tong, X., Tang, R., Xiao, M., Xu, J., Wang, W., Zhang, B., Liu, J., Yu, X., & Shi, S. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01392-3 · Cited by 883
Pyroptosis in inflammatory diseases and cancer
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Metadata
- Authors
- Hou, J., Hsu, J.-M., & Hung, M.-C.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2021-11
- Volume
- 81
- Issue
- 22
- Pages
- 4579-4590
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W3201800866
- Cited by
- 301
- References
- 30
- FWCI
- 14.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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