Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells

Enhancement of Antitumor Immunity by CTLA-4 Blockade

Leach, D. R., Krummel, M. F., & Allison, J. P. (1996) · Science · doi:10.1126/science.271.5256.1734 · Cited by 3,955 · see citing works

RAG-1-deficient mice have no mature B and T lymphocytes

Mombaerts, P., Iacomini, J., Johnson, R. S., Herrup, K., Tonegawa, S., & Papaioannou, V. E. (1992) · Cell · doi:10.1016/0092-8674(92)90030-g · Cited by 2,898 · see citing works

REGULATION OF IMMUNE RESPONSES BY TGF-β

Letterio, J. J., & Roberts, A. B. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.137 · Cited by 1,894 · see citing works

The Central Role of CD4+ T Cells in the Antitumor Immune Response

Hung, K., Hayashi, R., Lafond-Walker, A., Lowenstein, C., Pardoll, D., & Levitsky, H. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.12.2357 · Cited by 1,345 · see citing works

Prostate cancer in a transgenic mouse.

Greenberg, N. M., DeMayo, F. J., Finegold, M. J., Medina, D., Tilley, W. D., Aspinall, J. O., Cunha, G. R., Donjacour, A. A., Matusik, R. J., & Rosen, J. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.8.3439 · Cited by 1,296 · see citing works

Introduction of soluble protein into the class I pathway of antigen processing and presentation

Moore, M. W., Carbone, F. R., & Bevan, M. J. (1988) · Cell · doi:10.1016/s0092-8674(88)91043-4 · Cited by 1,092 · see citing works

Combination Immunotherapy of B16 Melanoma Using Anti–Cytotoxic T Lymphocyte–Associated Antigen 4 (Ctla-4) and Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf)-Producing Vaccines Induces Rejection of Subcutaneous and Metastatic Tumors Accompanied by Autoimmune Depigmentation

van Elsas, A., Hurwitz, A. A., & Allison, J. P. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.3.355 · Cited by 1,020 · see citing works

Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease

Gorelik, L., & Flavell, R. A. (2000) · Immunity · doi:10.1016/s1074-7613(00)80170-3 · Cited by 959 · see citing works

Engagement of Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Induces Transforming Growth Factor β (TGF-β) Production by Murine CD4+ T Cells

Chen, W., Jin, W., & Wahl, S. M. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.10.1849 · Cited by 352 · see citing works

CTLA-4 Blockade Reverses CD8+ T Cell Tolerance to Tumor by a CD4+ T Cell– and IL-2-Dependent Mechanism

Shrikant, P. A., Khoruts, A., & Mescher, M. F. (1999) · Immunity · doi:10.1016/s1074-7613(00)80123-5 · Cited by 284 · see citing works

TGF-β contributes to the shift toward Th2-type responses through direct and IL-10-mediated pathways in tumor-bearing mice

Maeda, H., & Shiraishi, A. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.1.73 · Cited by 277 · see citing works

Cd40-Independent Pathways of T Cell Help for Priming of Cd8+ Cytotoxic T Lymphocytes

Lu, Z., Yuan, L., Zhou, X., Sotomayor, E. M., Levitsky, H. I., & Pardoll, D. M. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.3.541 · Cited by 196 · see citing works

In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance

Sotomayor, E. M., Borrello, I., Tubb, E. E., Allison, J. P., & Levitsky, H. I. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11476 · Cited by 157 · see citing works

Depletion of IL-10- and TGF-beta-producing regulatory gamma delta T cells by administering a daunomycin-conjugated specific monoclonal antibody in early tumor lesions augments the activity of CTLs and NK cells.

Seo, N., Tokura, Y., Takigawa, M., & Egawa, K. (1999) · PubMed · Cited by 144 · see citing works

A soluble divalent class I major histocompatibility complex molecule inhibits alloreactive T cells at nanomolar concentrations.

Porto, J. D., Johansen, T. E., Čatipović, B., et al. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6671 · Cited by 141 · see citing works

Depletion of IL-10- and TGF-β-Producing Regulatory γδ T Cells by Administering a Daunomycin-Conjugated Specific Monoclonal Antibody in Early Tumor Lesions Augments the Activity of CTLs and NK Cells

Seo, N., TOKURA, Y., Takigawa, M., & Egawa, K. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.1.242 · Cited by 129 · see citing works

Immunologically mediated regression of a murine lymphoma after treatment with anti-L3T4 antibody. A consequence of removing L3T4+ suppressor T cells from a host generating predominantly Lyt-2+ T cell-mediated immunity.

Awwad, M., & North, R. J. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.168.6.2193 · Cited by 114 · see citing works

Soluble Antigen and CD40 Triggering Are Sufficient to Induce Primary and Memory Cytotoxic T Cells

Lefrançois, L., Altman, J. D., Williams, K., & Olson, S. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.2.725 · Cited by 103 · see citing works

Immunosuppressive activity of cloned natural killer (NK1.1+) T cells established from murine tumor-infiltrating lymphocytes

Tamada, K., Harada, M., Abe, K., Li, T., Tada, H., Onoe, Y., & Nomoto, K. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.10.4846 · Cited by 65 · see citing works

Lack of a role for transforming growth factor-β in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation

Sullivan, T. J., Letterio, J. J., van Elsas, A., Mamura, M., van Amelsfort, J., Sharpe, S., Metzler, B., Chambers, C. A., & Allison, J. P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051632398 · Cited by 58 · see citing works

Insight into the mechanism(s) through which TNF promotes the generation of T cell-mediated antitumor cytotoxicity by tumor bearer splenic cells

Gorelik, L., Bar-Dagan, Y., & MOKYR, M. B. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.11.4298 · Cited by 57 · see citing works

Pregnancy Ameliorates Induction and Expression of Experimental Autoimmune Uveitis

Agarwal, R. K., Chan, C., Wiggert, B. O., & Caspi, R. R. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.5.2648 · Cited by 50 · see citing works

Transforming growth factor beta secretion from primary breast cancer fibroblasts

van Roozendaal, C. E. P., Klijn, J. G. M., Ooijen, B. V., Claassen, C., Eggermont, A. M. M., Henzen-Logmans, S. C., & Foekens, J. A. (1995) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(95)03539-j · Cited by 39 · see citing works

Expression and secretion of TGF-beta isoforms and expression of TGF-beta-receptors I, II and III in normal and neoplastic human breast.

Chakravarthy, D., Green, A. R., Green, V. L., Kerin, M. J., & Speirs, V. (1999) · International Journal of Oncology · doi:10.3892/ijo.15.1.187 · Cited by 32 · see citing works

Stimulation of GATA-2 as a mechanism of hydrogen peroxide suppression in hypoxia-induced erythropoietin gene expression

Tabata, M., Tarumoto, T., Ohmine, K., Furukawa, Y., Hatake, K., Ozawa, K., Hasegawa, Y., Mukai, H. Y., Yamamoto, M. P., & Imagawa, S. (2001) · Journal of Cellular Physiology · doi:10.1002/1097-4652(200002)186:2 · Cited by 31 · see citing works

Interleukin-2 suppresses activated macrophage intracellular killing activity by inducing macrophages to secrete TGF-β

Nelson, B. J., Danielpour, D., Rossio, J. L., Turpin, J. A., & Nacy, C. A. (1994) · Journal of Leukocyte Biology · doi:10.1002/jlb.55.1.81 · Cited by 19 · see citing works

New functions for the matrix metalloproteinases in cancer progression

Egeblad, M., & Werb, Z. (2002) · Nature Reviews Cancer · doi:10.1038/nrc745 · Cited by 6,108 · see citing works

Transforming Growth Factor-β Signaling in Immunity and Cancer

Batlle, E., & Massagué, J. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.024 · Cited by 2,366 · see citing works

Targeting the TGFβ signalling pathway in disease

Akhurst, R. J., & Hata, A. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3810 · Cited by 1,466 · see citing works

TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

Thomas, D. A., & Massagué, J. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.10.012 · Cited by 1,355 · see citing works

Role of tissue stroma in cancer cell invasion

De Wever, O., & Mareel, M. (2003) · The Journal of Pathology · doi:10.1002/path.1398 · Cited by 1,042 · see citing works

TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression

Yang, L., Pang, Y., & Moses, H. L. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.04.002 · Cited by 1,023 · see citing works

TGFβ biology in cancer progression and immunotherapy

Derynck, R., Turley, S. J., & Akhurst, R. J. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0403-1 · Cited by 944 · see citing works

Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signals <i>in vivo</i>

Chen, M.-L., Pittet, M. J., Gorelik, L., Flavell, R. A., Weissleder, R., von Boehmer, H., & Khazaie, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408197102 · Cited by 806 · see citing works

Transforming growth factor-β in T-cell biology

Gorelik, L., & Flavell, R. A. (2002) · Nature Reviews Immunology · doi:10.1038/nri704 · Cited by 792 · see citing works

Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication

Kloss, C. C., Lee, J., Zhang, A., Chen, F., Melenhorst, J. J., Lacey, S. F., Maus, M. V., Fraietta, J. A., Zhao, Y., & June, C. H. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.05.003 · Cited by 648 · see citing works

Immune resistance orchestrated by the tumor microenvironment

Gajewski, T. F., Meng, Y., Blank, C., Brown, I., Kacha, A., Kline, J., & Harlin, H. (2006) · Immunological Reviews · doi:10.1111/j.1600-065x.2006.00442.x · Cited by 437 · see citing works

Transforming growth factor‐β in stem cells and tissue homeostasis

Xu, X., Zheng, L., Yuan, Q., Zhen, G., Crane, J. L., Zhou, X., & Cao, X. (2018) · Bone Research · doi:10.1038/s41413-017-0005-4 · Cited by 414 · see citing works

Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects

Yang, Y.-A., Dukhanina, O., Tang, B., Mamura, M., Letterio, J. J., MacGregor, J., Patel, S. C., Khozin, S., Liu, Z.-Y., Green, J., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200215333 · Cited by 404 · see citing works

Overcoming TGFβ-mediated immune evasion in cancer

Tauriello, D. V. F., Sancho, E., & Batlle, E. (2022) · Nature Reviews Cancer · doi:10.1038/s41568-021-00413-6 · Cited by 377 · see citing works

Induction of regular cytolytic T cell synapses by bispecific single-chain antibody constructs on MHC class I-negative tumor cells

Offner, S., Hofmeister, R., Romaniuk, A., Kufer, P., & Baeuerle, P. A. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2005.03.007 · Cited by 365 · see citing works

Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy

Ravi, R., Noonan, K. A., Pham, V., Bedi, R., Zhavoronkov, A., Ozerov, I. V., Makarev, E., V. Artemov, A., Wysocki, P. T., Mehra, R., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02696-6 · Cited by 325 · see citing works

TGFβ1-Mediated SMAD3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer

Park, B. V., Freeman, Z. T., Ghasemzadeh, A., Chattergoon, M. A., Rutebemberwa, A., Steigner, J., Winter, M. E., Huynh, T. V., Sebald, S. M., Lee, S.-J., et al. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-1347 · Cited by 287 · see citing works

Tumour-infiltrating lymphocytes in melanoma prognosis and cancer immunotherapy

Lee, N., Zakka, L. R., Mihm, M. C., & Schatton, T. (2016) · Pathology · doi:10.1016/j.pathol.2015.12.006 · Cited by 250 · see citing works

BiTEs: bispecific antibody constructs with unique anti-tumor activity

Wolf, E., Hofmeister, R., Kufer, P., Schlereth, B., & Baeuerle, P. A. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(05)03554-3 · Cited by 260 · see citing works

Transforming growth factor β as regulator of cancer stemness and metastasis

Bellomo, C., Caja, L., & Moustakas, A. (2016) · British Journal of Cancer · doi:10.1038/bjc.2016.255 · Cited by 235 · see citing works

Targeting TGF-β signaling in cancer

Katz, L. H., Li, Y., Chen, J.-S., Muñoz, N. M., Majumdar, A., Chen, J., & Mishra, L. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.782287 · Cited by 212 · see citing works

Impairment of NKG2D-Mediated Tumor Immunity by TGF-β

Lazarova, M., & Steinle, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02689 · Cited by 149 · see citing works

Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β

Metelli, A., Wu, B. X., Riesenberg, B., Guglietta, S., Huck, J. D., Mills, C., Li, A., Rachidi, S., Krieg, C., Rubinstein, M. P., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay4860 · Cited by 139 · see citing works

T Cell Surveillance of Oncogene-Induced Prostate Cancer Is Impeded by T Cell-Derived TGF-β1 Cytokine

Donkor, M. K., Sarkar, A., Savage, P. A., Franklin, R. A., Johnson, L. K., Jungbluth, A. A., Allison, J. P., & Li, M. O. (2011) · Immunity · doi:10.1016/j.immuni.2011.04.019 · Cited by 130 · see citing works

Anti–Transforming Growth Factor β Receptor II Antibody Has Therapeutic Efficacy against Primary Tumor Growth and Metastasis through Multieffects on Cancer, Stroma, and Immune Cells

Zhong, Z., Carroll, K. D., Policarpio, D., Osborn, C., Gregory, M., Bassi, R., Jimenez, X., Prewett, M., Liebisch, G., Persaud, K., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1634 · Cited by 123 · see citing works

Integrin-Mediated TGFβ Activation Modulates the Tumour Microenvironment

Brown, N. F., & Marshall, J. F. (2019) · Cancers · doi:10.3390/cancers11091221 · Cited by 116 · see citing works

A Novel Small-Molecule Inhibitor of Transforming Growth Factor β Type I Receptor Kinase (SM16) Inhibits Murine Mesothelioma Tumor Growth <i>In vivo</i> and Prevents Tumor Recurrence after Surgical Resection

Suzuki, E., Kim, S., Cheung, H.-K., Corbley, M. J., Zhang, X., Sun, L., Shan, F., Singh, J., Lee, W.-C., Albelda, S. M., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2389 · Cited by 113 · see citing works

Beyond the biomarker role: prostate-specific antigen (PSA) in the prostate cancer microenvironment

Moradi, A., Srinivasan, S., Clements, J., & Batra, J. (2019) · Cancer and Metastasis Reviews · doi:10.1007/s10555-019-09815-3 · Cited by 114 · see citing works

Integrin αvβ8 on T cells is responsible for suppression of anti-tumor immunity in multiple syngeneic models and is a promising target for tumor immunotherapy

Dodagatta-Marri, E., Ma, H.-Y., Liang, B., Li, J., Meyer, D. S., Sun, K.-H., Ren, X., Zivak, B., Rosenblum, M. D., Headley, M. B., et al. (2020) · doi:10.1101/2020.05.14.084913 · Cited by 70 · see citing works

Soluble Type II Transforming Growth Factor-β Receptor Inhibits Established Murine Malignant Mesothelioma Tumor Growth by Augmenting Host Antitumor Immunity

Suzuki, E., Kapoor, V., Cheung, H.-K., Ling, L. E., DeLong, P. A., Kaiser, L. R., & Albelda, S. M. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0611 · Cited by 65 · see citing works

Baseline T cell dysfunction by single cell network profiling in metastatic breast cancer patients

Formenti, S. C., Hawtin, R. E., Dixit, N., Evensen, E., Lee, P., Goldberg, J. D., Li, X., Vanpouille-Box, C., Schaue, D., McBride, W. H., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0633-x · Cited by 53 · see citing works

Tgf-β1 produced by activated CD4 ⁺ T Cells Antagonizes T Cell Surveillance of Tumor Development

Donkor, M. K., Sarkar, A., & Li, M. O. (2012) · OncoImmunology · doi:10.4161/onci.1.2.18481 · Cited by 48 · see citing works

TGF-beta: a master switch in tumor immunity

Gigante, M., Gesualdo, L., & Ranieri, E. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212802430378 · Cited by 45 · see citing works

Tgf-beta in the natural history of prostate cancer

Ahel, J. (2019) · Acta Clinica Croatica · doi:10.20471/acc.2019.58.01.17 · Cited by 30 · see citing works

Site-directed mutagenesis of glycosylation sites in the transforming growth factor-beta 1 (TGF beta 1) and TGF beta 2 (414) precursors and of cysteine residues within mature TGF beta 1: effects on secretion and bioactivity

Brunner, A. M. (1992) · Molecular Endocrinology · doi:10.1210/me.6.10.1691 · Cited by 27 · see citing works

The Progress in Researches on TGF-β and its Receptor in Marfan Syndrome

Yan-a, W. (2008) · Medical Recapitulate

Short-or long-term effects of a low-protein diet on fibronectin and transforming growth factor-β synthesis in Adriamycin-induced nephropathy(アドリアマイシン腎症における短期および長期の低蛋白食投与の効果 -フィブロネクチンおよびtransforming growth factor(TGF)-β産生について)

中山勝 (1997) · Institutional Repositories DataBase (IRDB) · doi:10.11501/3130923

Effect of Transforming Growth Factor-beta (TGF-β) on Mammary Development

Plaut, K. I., Dean, A. J., Patnode, T. A., & Casey, T. (2003) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(03)74036-3 · Cited by 11 · see citing works

Transforming growth factor type beta(TGF—β1 )can increase IL—2R expression and suppress the proliferation of immature(CD~(4-)CD~(8-))thymocytes

Qin, G. S. L. H.-Y. L. J. T. F.-R. Y. (1992) · Zhongguo mianyixue zazhi