Differential Content of Proteins, mRNAs, and miRNAs Suggests that MDSC and Their Exosomes May Mediate Distinct Immune Suppressive Functions
Open accessAbstract
Myeloid-derived suppressor cells (MDSC) are immature myeloid cells that accumulate in the circulation and the tumor microenvironment of most cancer patients. There, MDSC suppress both adaptive and innate immunity, hindering immunotherapies. The inflammatory milieu often present in cancers facilitates MDSC suppressive activity, causing aggressive tumor progression and metastasis. MDSC from tumor-bearing mice release exosomes, which carry biologically active proteins and mediate some of the immunosuppressive functions characteristic of MDSC. Studies on other cell types have shown that exosomes may also carry RNAs which can be transferred to local and distant cells, yet the mRNA and microRNA cargo of MDSC-derived exosomes has not been studied to date. Here, the cargo of MDSC and their exosomes was interrogated with the goal of identifying and characterizing molecules that may facilitate MDSC suppressive potency. Because inflammation is an established driving force for MDSC suppressive activity, we used the well-established 4T1 mouse mammary carcinoma system, which includes "conventional" as well as "inflammatory" MDSC. We provide evidence that MDSC-derived exosomes carry proteins, mRNAs, and microRNAs with different quantitative profiles than those of their parental cells. Several of these molecules have known or predicted functions consistent with MDSC suppressive activity, suggesting a potential mechanistic redundancy.
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Nucleic acids (mRNA, miRNA, siRNA, piRNA, etc.) have been reported as a potential method for cancer treatment.
“In addition to proteins, nucleic acids (mRNA, miRNA, siRNA, piRNA, etc.) have also been reported as a potential method for cancer treatment [47,48].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [47]
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- Authors
- Geis-Asteggiante, L., Belew, A. T., Clements, V. K., Edwards, N. J., Ostrand-Rosenberg, S., El-Sayed, N. M., & Fenselau, C.
- Affiliations
- Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, United States
- University of Maryland, College Park (US)
- University of Maryland, Baltimore County (US)
- Georgetown University Medical Center (US)
- Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland 21250, United States
- Venue
- Journal of Proteome Research
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-11-27
- Volume
- 17
- Issue
- 1
- Pages
- 486-498
- ISSN
- 1535-3893 (ISSN-L)
- 1535-3907
- PMC
- PMC6200353
- OpenAlex
- W2768796960
- Cited by
- 104
- References
- 85
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 8 · 2023: 14 · 2022: 14 · 2021: 15 · 2020: 20 · 2019: 11 · 2018: 8
- FWCI
- 4.35
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Proteome Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Maryland Shared Open Access Repository (USMAI Consortium) (submittedVersion)
- Digital Repository at the University of Maryland (University of Maryland College Park)
- Funders
- NIH Office of the Director (OD019938)
- National Institute of Allergy and Infectious Diseases (AI094773)
- University of Maryland
- National Institute of General Medical Sciences (GM021248)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- myeloid-derived suppressor cells, exosomes, immunosuppression, microRNA cargo, protein cargo, tumor microenvironment, inflammation, 4T1 mammary carcinoma, cancer immunotherapy resistance
- MeSH terms
- Myeloid-Derived Suppressor Cells, Animals, Immunity, Inflammation, Proteins, RNA, Messenger, MicroRNAs, Mice, Exosomes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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