The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
C-Reactive Protein Binds to Apoptotic Cells, Protects the Cells from Assembly of the Terminal Complement Components, and Sustains an Antiinflammatory Innate Immune Response
Open accessAbstract
C-reactive protein (CRP) is a serum protein that is massively induced as part of the innate immune response to infection and tissue injury. As CRP has been detected in damaged tissues and is known to activate complement, we assessed whether apoptotic lymphocytes bound CRP and determined the effect of binding on innate immunity. CRP bound to apoptotic cells in a Ca2+-dependent manner and augmented the classical pathway of complement activation but protected the cells from assembly of the terminal complement components. Furthermore, CRP enhanced opsonization and phagocytosis of apoptotic cells by macrophages associated with the expression of the antiinflammatory cytokine transforming growth factor β. The antiinflammatory effects of CRP required C1q and factor H and were not effective once cells had become necrotic. These observations demonstrate that CRP and the classical complement components act in concert to promote noninflammatory clearance of apoptotic cells and may help to explain how deficiencies of the classical pathway and certain pentraxins lead to impaired handling of apoptotic cells and increased necrosis with the likelihood of immune response to self.
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Cites
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“It has been shown that phagocytosis of apoptotic or necrotic cells leads to the synthesis of anti- or proinflammatory cytokines such as TGFb or TNFa , respectively (33, 34).”
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Repeat-induced gene silencing in mammals
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The physiological structure of human C-reactive protein and its complex with phosphocholine
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Regulation of complement activation by C-reactive protein
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Cited by
Complement: a key system for immune surveillance and homeostasis
Ricklin, D., Hajishengallis, G., Yang, K., & Lambris, J. D. (2010) · Nature Immunology · doi:10.1038/ni.1923 · Cited by 3,654
“Early stage effectors are preferentially used because the modified apoptotic cell surface acquires CRP and C1q together with f”
BackgroundC-reactive protein: a critical update
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Metadata
- Authors
- Gershov, D., Kim, S., Brot, N., & Elkon, K. B.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2000-11-06
- Volume
- 192
- Issue
- 9
- Pages
- 1353-1364
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2148045758
- Cited by
- 695
- References
- 6
- FWCI
- 10.35
- Type
- journal article
- Language
- en
- Open access
- green
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- Gershov, D., Kim, S., Brot, N., & Elkon, K. B. (2000). C-Reactive Protein Binds to Apoptotic Cells, Protects the Cells from Assembly of the Terminal Complement Components, and Sustains an Antiinflammatory Innate Immune Response. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.192.9.1353
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
