Characterisation of Foxp3 splice variants in human CD4+ and CD8+ T cells—Identification of Foxp3Δ7 in human regulatory T cells

Control of Regulatory T Cell Development by the Transcription Factor <i>Foxp3</i>

Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187 · see citing works

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745 · see citing works

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M., Ferguson, P., Whitesell, L., Kelly, T., Saulsbury, F., Chance, P., & Ochs, H. (2001) · Nature Genetics · doi:10.1038/83713 · Cited by 3,576 · see citing works

An essential role for Scurfin in CD4+CD25+ T regulatory cells

Khattri, R., Cox, T., Yasayko, S.-A., & Ramsdell, F. (2003) · Nature Immunology · doi:10.1038/ni909 · Cited by 2,860 · see citing works

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

Brunkow, M. E., Jeffery, E. W., Hjerrild, K. A., Paeper, B. W., Clark, L. B., Yasayko, S.-A., Wilkinson, J. E., Galas, D. J., Ziegler, S. F., & Ramsdell, F. (2001) · Nature Genetics · doi:10.1038/83784 · Cited by 2,628 · see citing works

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

Fontenot, J. D., Rasmussen, J. P., Williams, L. M., Dooley, J., Farr, A. G., & Rudensky, A. Y. (2005) · Immunity · doi:10.1016/j.immuni.2005.01.016 · Cited by 2,255 · see citing works

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

Wildin, R. S., Ramsdell, F., Peake, J., Faravelli, F., Casanova, J., Buist, N. R. M., Levy‐Lahad, E., Mazzella, M., Goulet, O., Perroni, L., et al. (2001) · Nature Genetics · doi:10.1038/83707 · Cited by 1,916 · see citing works

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

Zhou, L., Lopes, J. E., Chong, M. M. W., Ivanov, I. I., Min, R., Victora, G. D., Shen, Y., Du, J., Rubtsov, Y. P., Rudensky, A. Y., et al. (2008) · Nature · doi:10.1038/nature06878 · Cited by 1,859 · see citing works

Epigenetic Control of the foxp3 Locus in Regulatory T Cells

Floess, S., Freyer, J., Siewert, C., Baron, U., Olek, S., Polansky, J. K., Schlawe, K., Chang, H., Bopp, T., Schmitt, E., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050038 · Cited by 1,272 · see citing works

Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells

Walker, M., Kasprowicz, D. J., Gersuk, V. H., Bénard, A., Landeghen, M. V., Buckner, J. H., & Ziegler, S. F. (2003) · Journal of Clinical Investigation · doi:10.1172/jci19441 · Cited by 1,242 · see citing works

FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

Wu, Y., Borde, M., Heissmeyer, V., Feuerer, M., Lapan, A. D., Stroud, J. C., Bates, D. L., Guo, L., Han, A., Ziegler, S. F., et al. (2006) · Cell · doi:10.1016/j.cell.2006.05.042 · Cited by 1,188 · see citing works

Cutting Edge: TGF-β Induces a Regulatory Phenotype in CD4+CD25− T Cells through Foxp3 Induction and Down-Regulation of Smad7

Fantini, M. C., Becker, C., Monteleone, G., Pallone, F., Galle, P. R., & Neurath, M. F. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.9.5149 · Cited by 1,137 · see citing works

Foxp3-dependent programme of regulatory T-cell differentiation

Gavin, M. A., Rasmussen, J. P., Fontenot, J. D., Vasta, V., Manganiello, V. C., Beavo, J. A., & Rudensky, A. Y. (2007) · Nature · doi:10.1038/nature05543 · Cited by 1,127 · see citing works

Transient expression of FOXP3 in human activated nonregulatory CD4 ⁺ T cells

Wang, J., Ioan‐Facsinay, A., van der Voort, E. I. H., Huizinga, T. W. J., & Toes, R. E. M. (2007) · European Journal of Immunology · doi:10.1002/eji.200636435 · Cited by 1,011 · see citing works

Human Cd25+Cd4+ T Regulatory Cells Suppress Naive and Memory T Cell Proliferation and Can Be Expanded in Vitro without Loss of Function

Levings, M. K., Sangregorio, R., & Roncarolo, M. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.11.1295 · Cited by 966 · see citing works

JM2, encoding a fork head–related protein, is mutated in X-linked autoimmunity–allergic disregulation syndrome

Chatila, T. A., Blaeser, F., Ho, N. Y., Lederman, H. M., Voulgaropoulos, C., Helms, C., & Bowcock, A. M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci11679 · Cited by 937 · see citing works

FOXP3: Of Mice and Men

Ziegler, S. F. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090547 · Cited by 921 · see citing works

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

Lahl, K., Loddenkemper, C., Drouin, C. E., Freyer, J., Arnason, J. E., Eberl, G., Hamann, A., Wagner, H., Huehn, J., & Sparwasser, T. D. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061852 · Cited by 918 · see citing works

Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production

Allan, S. E., Crome, S. Q., Crellin, N. K., Passerini, L., Steiner, T. S., Bacchetta, R., Roncarolo, M. G., & Levings, M. K. (2007) · International Immunology · doi:10.1093/intimm/dxm014 · Cited by 872 · see citing works

Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression

Wan, Y. Y., & Flavell, R. A. (2007) · Nature · doi:10.1038/nature05479 · Cited by 855 · see citing works

Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3

Williams, L. M., & Rudensky, A. Y. (2007) · Nature Immunology · doi:10.1038/ni1437 · Cited by 854 · see citing works

IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells

Burchill, M. A., Yang, J., Vogtenhuber, C., Blazar, B. R., & Farrar, M. A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.1.280 · Cited by 836 · see citing works

Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells

Zheng, Y., Josefowicz, S. Z., Kas, A., Chu, T.-T., Gavin, M. A., & Rudensky, A. Y. (2007) · Nature · doi:10.1038/nature05563 · Cited by 835 · see citing works

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

Tone, Y., Furuuchi, K., Kojima, Y., Tykocinski, M. L., Greene, M. I., & Tone, M. (2008) · Nature Immunology · doi:10.1038/ni1549 · Cited by 807 · see citing works

Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells

Yagi, H., Nomura, T., Nakamura, K., Yamazaki, S., Kitawaki, T., Hori, S., Maeda, M., Onodera, M., Uchiyama, T., Fujii, S., et al. (2004) · International Immunology · doi:10.1093/intimm/dxh165 · Cited by 797 · see citing works

Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development

Gavin, M. A., Torgerson, T. R., Houston, E., DeRoos, P. C., Ho, W., Stray‐Pedersen, A., Ocheltree, E., Greenberg, P. D., Ochs, H. D., & Rudensky, A. Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509484103 · Cited by 779 · see citing works

IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo

Zorn, E., Nelson, E. A., Mohseni, M., Porcheray, F., Kim, H. T., Litsa, D., Bellucci, R., Raderschall, E., Canning, C. M., Soiffer, R. J., et al. (2006) · Blood · doi:10.1182/blood-2006-02-004747 · Cited by 740 · see citing works

Induction of FOXP3 expression in naive human CD4+FOXP3− T cells by T-cell receptor stimulation is transforming growth factor-β–dependent but does not confer a regulatory phenotype

Tran, D. Q., Ramsey, H. E., & Shevach, E. M. (2007) · Blood · doi:10.1182/blood-2007-06-094656 · Cited by 738 · see citing works

Foxp3 occupancy and regulation of key target genes during T-cell stimulation

Marson, A., Kretschmer, K., Frampton, G. M., Jacobsen, E. S., Polansky, J. K., MacIsaac, K. D., Levine, S. S., Fraenkel, E., von Boehmer, H., & Young, R. A. (2007) · Nature · doi:10.1038/nature05478 · Cited by 724 · see citing works

Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome

Wildin, R. S., Smyk-Pearson, S., & Filipovich, A. H. (2002) · Journal of Medical Genetics · doi:10.1136/jmg.39.8.537 · Cited by 710 · see citing works

DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3+ conventional T cells

Baron, U., Floess, S., Wieczorek, G., Baumann, K., Grützkau, A., Dong, J., Thiel, A., Boeld, T. J., Hoffmann, P., Edinger, M., et al. (2007) · European Journal of Immunology · doi:10.1002/eji.200737594 · Cited by 694 · see citing works

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

Ono, M., Yaguchi, H., Ohkura, N., Kitabayashi, I., Nagamura, Y., Nomura, T., Miyachi, Y., Tsukada, T., & Sakaguchi, S. (2007) · Nature · doi:10.1038/nature05673 · Cited by 692 · see citing works

Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature.

Hill, J., Feuerer, M., Tash, K., Haxhinasto, S., Perez, J., Melamed, R., Mathis, D., & Benoist, C. (2007) · Immunity · doi:10.1016/j.immuni.2007.09.010 · Cited by 671 · see citing works

Five years on the wings of fork head

Kaufmann, E., & Knöchel, W. (1996) · Mechanisms of Development · doi:10.1016/0925-4773(96)00539-4 · Cited by 660 · see citing works

CREB/ATF-dependent T cell receptor–induced FoxP3 gene expression: a role for DNA methylation

Kim, H., & Leonard, W. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070109 · Cited by 597 · see citing works

Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level

Roncador, G., Brown, P. J., Maestre, L., Hüe, S., Martinez-Torrecuadrada, J. L., Ling, K., Pratap, S., Toms, C., Fox, B. C., Cerundolo, V., et al. (2005) · European Journal of Immunology · doi:10.1002/eji.200526189 · Cited by 592 · see citing works

Nonredundant roles for Stat5a/b in directly regulating Foxp3

Yao, Z., Kanno, Y., Kerenyi, M. A., Stephens, G. L., Durant, L. R., Watford, W. T., Laurence, A. D. J., Robinson, G. W., Shevach, E. M., Moriggl, R., et al. (2007) · Blood · doi:10.1182/blood-2006-11-055756 · Cited by 575 · see citing works

Foxp3 interacts with nuclear factor of activated T cells and NF-κB to repress cytokine gene expression and effector functions of T helper cells

Bettelli, E., Dastrange, M., & Oukka, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501675102 · Cited by 544 · see citing works

Regulatory T cell development in the absence of functional Foxp3

Lin, W. X., Haribhai, D., Relland, L. M., Truong, N., Carlson, M. R. J., Williams, C. B., & Chatila, T. A. (2007) · Nature Immunology · doi:10.1038/ni1445 · Cited by 485 · see citing works

The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs

Allan, S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24685 · Cited by 444 · see citing works

Foxp3 Inhibits RORγt-mediated IL-17A mRNA Transcription through Direct Interaction with RORγt*

Ichiyama, K., Yoshida, H., Wakabayashi, Y., Chinen, T., Saeki, K., Nakaya, M., Takaesu, G., Hori, S., Yoshimura, A., & Kobayashi, T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801286200 · Cited by 438 · see citing works

Human CD25+CD4+ T Suppressor Cell Clones Produce Transforming Growth Factor β, but not Interleukin 10, and Are Distinct from Type 1 T Regulatory Cells

Levings, M. K., Sangregorio, R., Sartirana, C., Moschin, A. L., Battaglia, M., Orban, P. C., & Roncarolo, M. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20021139 · Cited by 429 · see citing works

Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans

Morgan, M. E., van Bilsen, J. H. M., Bakker, A. M., Heemskerk, B., Schilham, M. W., Hartgers, F. C., Elferink, B. G., van der Zanden, L., de Vries, R. R. P., Huizinga, T. W. J., et al. (2004) · Human Immunology · doi:10.1016/j.humimm.2004.05.016 · Cited by 417 · see citing works

FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression

Li, B., Samanta, A., Song, X., Iacono, K. T., Bembas, K., Tao, R. N., Basu, S., Riley, J. L., Hancock, W. W., Shen, Y., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700298104 · Cited by 410 · see citing works

Molecular Mechanisms Underlying FOXP3 Induction in Human T Cells

Mantel, P., Ouaked, N., Rückert, B., Karagiannidis, C., Welz, R., Blaser, K., & Schmidt‐Weber, C. B. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.6.3593 · Cited by 398 · see citing works

X-linked lymphoreticular disease in the scurfy (sf) mutant mouse.

Godfrey, V., Wilkinson, J. E., & Russell, L. B. (1991) · PubMed · Cited by 337 · see citing works

Eos Mediates Foxp3-Dependent Gene Silencing in CD4 + Regulatory T Cells

Pan, F., Yu, H., Dang, E. V., Barbi, J. J., Pan, X., Grosso, J. F., Jinasena, D., Sharma, S. M., McCadden, E., Getnet, D., et al. (2009) · Science · doi:10.1126/science.1176077 · Cited by 335 · see citing works

HIV Infection of Naturally Occurring and Genetically Reprogrammed Human Regulatory T-cells

Oswald-Richter, K. A., Grill, S. M., Shariat, N. W., Leelawong, M., Sundrud, M. S., Haas, D. W., & Unutmaz, D. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020198 · Cited by 296 · see citing works

AP‐1 transcriptional activity requires both T‐cell receptor‐mediated and co‐stimulatory signals in primary T lymphocytes.

Rincón, M., & Flavell, R. A. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06757.x · Cited by 289 · see citing works

De novo generation of antigen-specific CD4 + CD25 + regulatory T cells from human CD4 + CD25 – cells

Walker, M., Carson, B. D., Nepom, G. T., Ziegler, S. F., & Buckner, J. H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407691102 · Cited by 283 · see citing works

Analysis of FOXP3 Reveals Multiple Domains Required for Its Function as a Transcriptional Repressor

Lopes, J. E., Torgerson, T. R., Schubert, L. A., Anover-Sombke, S. D., Ocheltree, E., Ochs, H. D., & Ziegler, S. F. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.5.3133 · Cited by 274 · see citing works

Alloantigen specific CD8+CD28− FOXP3+ T suppressor cells induce ILT3+ ILT4+ tolerogenic endothelial cells, inhibiting alloreactivity

Manavalan, J. S., Kim‐Schulze, S., Scotto, L., Naiyer, A. J., Vlad, G., Colombo, P. C., Marboe, C. C., MANCINI, D. M., Cortesini, R., & Suciu‐Foca, N. (2004) · International Immunology · doi:10.1093/intimm/dxh107 · Cited by 256 · see citing works

c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells

Isomura, I., Palmer, S. E., Grumont, R. J., Bunting, K., Hoyne, G. F., Wilkinson, N., Banerjee, A., Proietto, A. I., Gugasyan, R., Wu, L., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20091411 · Cited by 253 · see citing works

Isoform-Specific Inhibition of RORα-Mediated Transcriptional Activation by Human FOXP3

Du, J., Huang, C., Zhou, B., & Ziegler, S. F. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.7.4785 · Cited by 234 · see citing works

FOXP3 Promoter Demethylation Reveals the Committed Treg Population in Humans

Janson, P., Winerdal, M. E., Marits, P., Thörn, M., OHLSSON, R. I., & Winqvist, O. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001612 · Cited by 233 · see citing works

Generation of Potent and Stable Human CD4+ T Regulatory Cells by Activation-independent Expression of FOXP3

Allan, S. E., McMurchy, A. N., Mérindol, N., Crellin, N. K., Amendola, M., Bacchetta, R., Naldini, L., Roncarolo, M. G., Soudeyns, H., & Levings, M. K. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300341 · Cited by 233 · see citing works

Runx-CBFβ complexes control expression of the transcription factor Foxp3 in regulatory T cells

Rudra, D., Egawa, T., Chong, M. M. W., Treuting, P. M., Littman, D. R., & Rudensky, A. Y. (2009) · Nature Immunology · doi:10.1038/ni.1795 · Cited by 202 · see citing works

The scurfy mouse mutant has previously unrecognized hematological abnormalities and resembles Wiskott-Aldrich syndrome.

Lyon, M. F., Peters, J., Glenister, P. H., Ball, S., & Wright, E. G. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.7.2433 · Cited by 195 · see citing works

Cutting Edge: Depletion of Foxp3+ Cells Leads to Induction of Autoimmunity by Specific Ablation of Regulatory T Cells in Genetically Targeted Mice

Kim, J. G., Lahl, K., Hori, S., Loddenkemper, C., Chaudhry, A., DeRoos, P. C., Rudensky, A. Y., & Sparwasser, T. D. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804308 · Cited by 180 · see citing works

Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: potential model for thymic education.

Godfrey, V., Wilkinson, J. E., Rinchik, E. M., & Russell, L. B. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.13.5528 · Cited by 179 · see citing works

The Amount of Scurfin Protein Determines Peripheral T Cell Number and Responsiveness

Khattri, R., Kasprowicz, D. J., Cox, T., Mortrud, M. T., Appleby, M. W., Brunkow, M. E., Ziegler, S. F., & Ramsdell, F. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.11.6312 · Cited by 148 · see citing works

FOXP3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human XLAAD/IPEX autoimmune disease

Li, B., Samanta, A., Song, X., Iacono, K. T., Brennan, P. J., Chatila, T. A., Roncador, G., Banham, A. H., Riley, J. L., Wang, Q., et al. (2007) · International Immunology · doi:10.1093/intimm/dxm043 · Cited by 134 · see citing works

Regulatory T cell-like activity of Foxp3+ adult T cell leukemia cells

Chen, S., Ishii, N., Ine, S., Ikeda, S., Fujimura, T., Ndhlovu, L. C., Soroosh, P., Tada, K., Harigae, H., Kameoka, J., et al. (2005) · International Immunology · doi:10.1093/intimm/dxh366 · Cited by 122 · see citing works

FOXP3 and NFAT: Partners in Tolerance

Rudensky, A. Y., Gavin, M. A., & Zheng, Y. (2006) · Cell · doi:10.1016/j.cell.2006.07.005 · Cited by 113 · see citing works

CARMA1 Controls an Early Checkpoint in the Thymic Development of FoxP3+ Regulatory T Cells

Molinero, L. L., Yang, J., Gajewski, T. F., Abraham, C., Farrar, M. A., & Alegre, M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900498 · Cited by 108 · see citing works

Commitment to the Regulatory T Cell Lineage Requires CARMA1 in the Thymus but Not in the Periphery

Barnes, M. J., Krebs, P., Harris, N. L., Eidenschenk, C., González‐Quintial, R., Arnold, C. N., Crozat, K., Sovath, S., Moresco, E. M. Y., Theofilopoulos, A. N., et al. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000051 · Cited by 106 · see citing works

Forced overexpression of either of the two common human Foxp3 isoforms can induce regulatory T cells from CD4 + CD25 – cells

Aarts‐Riemens, T., Emmelot, M. E., Verdonck, L. F., & Mutis, T. (2008) · European Journal of Immunology · doi:10.1002/eji.200737590 · Cited by 101 · see citing works

Autoreactive human peripheral blood CD8+ T cells with a regulatory phenotype and function

Jarvis, L. B., Matyszak, M. K., Duggleby, R. C., GOODALL, J. C., Hall, F. C., & Gaston, H. (2005) · European Journal of Immunology · doi:10.1002/eji.200526162 · Cited by 89 · see citing works

Splice variants of human FOXP3 are functional inhibitors of human CD4+ T‐cell activation

Smith, E., Finney, H. M., Nesbitt, A. M., Ramsdell, F., & Robinson, M. K. (2006) · Immunology · doi:10.1111/j.1365-2567.2006.02425.x · Cited by 87 · see citing works

Acquisition of Suppressive Function by Activated Human CD4+CD25− T Cells Is Associated with the Expression of CTLA-4 Not FoxP3

Zheng, Y., Manzotti, C. N., Burke, F., Dussably, L., Qureshi, O., Walker, L. S. K., & Sansom, D. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.3.1683 · Cited by 86 · see citing works

FOXP3 Actively Represses Transcription by Recruiting the HAT/HDAC Complex

Li, B., & Greene, M. I. (2007) · Cell Cycle · doi:10.4161/cc.6.12.4421 · Cited by 69 · see citing works

Domain Requirements and Sequence Specificity of DNA Binding for the Forkhead Transcription Factor FOXP3

Koh, K. P., Sundrud, M. S., & Rao, A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008109 · Cited by 67 · see citing works

Human leukocyte antigen class I-restricted immunosuppression by human CD8+ regulatory T cells requires CTLA-4-mediated interaction with dendritic cells

Jarvis, L. B., GOODALL, J. C., & Gaston, H. (2008) · Human Immunology · doi:10.1016/j.humimm.2008.08.277 · Cited by 9 · see citing works

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Cossarizza, A., Chang, H., Radbruch, A., Acs, A., Adam, D., Adam‐Klages, S., Agace, W. W., Aghaeepour, N., Akdiş, M., Allez, M., et al. (2019) · European Journal of Immunology · doi:10.1002/eji.201970107 · Cited by 982 · see citing works

The regulation of immune tolerance by FOXP3

Lu, L., Barbi, J., & Pan, F. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.75 · Cited by 580 · see citing works

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531 · see citing works

Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants

Rosa, V. D., Galgani, M., Porcellini, A., Colamatteo, A., Santopaolo, M., Zuchegna, C., Romano, A., Simone, S. D., Procaccini, C., Rocca, C. L., et al. (2015) · Nature Immunology · doi:10.1038/ni.3269 · Cited by 399 · see citing works

Regulatory T cell proliferative potential is impaired in human autoimmune disease

Carbone, F., Rosa, V. D., Carrieri, P. B., Montella, S., Bruzzese, D., Porcellini, A., Procaccini, C., Cava, A. L., & Matarese, G. (2013) · Nature Medicine · doi:10.1038/nm.3411 · Cited by 214 · see citing works

Control of alternative splicing in immune responses: many regulators, many predictions, much still to learn

Martínez, N. M., & Lynch, K. W. (2013) · Immunological Reviews · doi:10.1111/imr.12047 · Cited by 191 · see citing works

Role of Metabolism in the Immunobiology of Regulatory T Cells

Galgani, M., Rosa, V. D., Cava, A. L., & Matarese, G. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600242 · Cited by 116 · see citing works

Subcellular localization of FOXP 3 in human regulatory and nonregulatory T cells

Magg, T., Mannert, J., Ellwart, J. W., Schmid, I., & Albert, M. H. (2012) · European Journal of Immunology · doi:10.1002/eji.201141838 · Cited by 95 · see citing works

Alternative Splicing of FOXP3—Virtue and Vice

Mailer, R. K. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00530 · Cited by 71 · see citing works

The expression of FOXP3 and its role in human cancers

Hao, J., Qi, H., Gong, Z., Yang, S., Ren, J., Liu, Y., Li, M., & Chen, G. G. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.12.004 · Cited by 69 · see citing works

The Impact of Dietary Components on Regulatory T Cells and Disease

Hornero, R. A., Hamad, I., Côrte‐Real, B. F., & Kleinewietfeld, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00253 · Cited by 57 · see citing works

Metabolic pressure and the breach of immunological self-tolerance

Rosa, V. D., Cava, A. L., & Matarese, G. (2017) · Nature Immunology · doi:10.1038/ni.3851 · Cited by 53 · see citing works

Epigenetics: An opportunity to shape innate and adaptive immune responses

Liotti, A., Ferrara, A. L., Loffredo, S., Galdiero, M. R., Varricchi, G., Rella, F. D., Maniscalco, G. T., Belardo, M., Vastano, R., Prencipe, R., et al. (2022) · Immunology · doi:10.1111/imm.13571 · Cited by 47 · see citing works

All creatures great and small: regulatory T cells in mice, humans, dogs and other domestic animal species

Garden, O. A., Pinheiro, D., & Cunningham, F. M. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.11.003 · Cited by 47 · see citing works

Foxp3 lacking exons 2 and 7 is unable to confer suppressive ability to regulatory T cells in vivo

Joly, A.-L., Liu, S., Dahlberg, C. I. M., Mailer, R. K., Westerberg, L. S., & Andersson, J. (2015) · Journal of Autoimmunity · doi:10.1016/j.jaut.2015.06.009 · Cited by 42 · see citing works

Age as a risk factor in vasculitis

Gloor, A. D., Berry, G. J., Goronzy, J. J., & Weyand, C. M. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00911-1 · Cited by 43 · see citing works

Towards gene therapy for IPEX syndrome

Borna, Š., Lee, E., Sato, Y., & Bacchetta, R. (2022) · European Journal of Immunology · doi:10.1002/eji.202149210 · Cited by 36 · see citing works

Inactivation of X-Linked Tumor Suppressor Genes in Human Cancer

Liu, R., Kain, M., & Wang, L. (2012) · Future Oncology · doi:10.2217/fon.12.26 · Cited by 34 · see citing works

One, No One, and One Hundred Thousand: T Regulatory Cells' Multiple Identities in Neuroimmunity

Sambucci, M., Gargano, F., Guerrera, G., Battistini, L., & Borsellino, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02947 · Cited by 31 · see citing works

TL1A, a novel alarmin in airway, intestinal, and autoimmune disorders

Varricchi, G., Poto, R., Criscuolo, G., Strisciuglio, C., Nair, P., & Marone, G. (2025) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2025.02.018 · Cited by 28 · see citing works

Metabolism of murine TH17 cells: Impact on cell fate and function

Wang, R., & Solt, L. A. (2016) · European Journal of Immunology · doi:10.1002/eji.201545788 · Cited by 27 · see citing works

The dual role of the X‐linked FoxP3 gene in human cancers

Redpath, M., Xu, B., van Kempen, L. C. L. T., & Spatz, A. (2011) · Molecular Oncology · doi:10.1016/j.molonc.2011.03.001 · Cited by 26 · see citing works

ChIP-on-chip analysis identifies IL-22 as direct target gene of ectopically expressed FOXP3 transcription factor in human T cells

Jeron, A., Hansen, W., Ewert, F., Buer, J., Geffers, R., & Bruder, D. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-705 · Cited by 19 · see citing works

IPEX due to an exon 7 skipping FOXP3 mutation with autoimmune diabetes mellitus cured by selective TReg cell engraftment

Magg, T., Wiebking, V., Conca, R., Krebs, S., Arens, S., Schmid, I., Klein, C., Albert, M. H., & Hauck, F. H. (2018) · Clinical Immunology · doi:10.1016/j.clim.2018.03.008 · Cited by 18 · see citing works

A splice of life: the discovery, function, and clinical implications of FOXP3 isoforms in autoimmune disease

Weinstein, K. N., Domeier, P. P., & Ziegler, S. F. (2024) · International Immunology · doi:10.1093/intimm/dxae049 · Cited by 16 · see citing works

Dissecting the role of the foxp3 gene in the joint genetic susceptibility to autoimmune thyroiditis and diabetes: A genetic and functional analysis

Li, C. W., Concepcion, E., & Tomer, Y. (2014) · Gene · doi:10.1016/j.gene.2014.11.064 · Cited by 15 · see citing works

C‐Terminal Cleavage of Human Foxp3 at a Proprotein Convertase Motif Abrogates its Suppressive Function

Elhage, R., Cheraï, M., Levacher, B., Darrasse-Jèze, G., Baillou, C., Zhao, X., Khatib, A., Piaggio, E., & Klatzmann, D. (2015) · Scandinavian Journal of Immunology · doi:10.1111/sji.12275 · Cited by 13 · see citing works

Metabolic regulation of forkhead box P3 alternative splicing isoforms and their impact on health and disease

Luo, Z., Zhang, Y., Saleh, Q. W., Zhang, J., Zhu, Z., & Tepel, M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1278560 · Cited by 10 · see citing works

Expression landscape of cancer-FOXP3 and its prognostic value in pancreatic adenocarcinoma

Gong, R., Wang, J., Xing, Y., Wang, J., Chen, X., Lei, K., Yu, Q., Zhao, C., Li, S., Zhang, Y., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216838 · Cited by 10 · see citing works

Therapeutic opportunities to modulate immune tolerance through the metabolism-chromatin axis

Ferrara, A. L., Liotti, A., Pezone, A., & Rosa, V. D. (2022) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2022.04.002 · Cited by 9 · see citing works

The frequency of Treg subsets distinguishes disease activity in ANCA vasculitis

Agosto‐Burgos, C., Wu, E. Y., Iannone, M. A., Hu, Y., Hogan, S. L., Henderson, C. D., Kennedy, K. B., Blazek, L. N., Herrera, C. A., Munson, D., et al. (2022) · Clinical & Translational Immunology · doi:10.1002/cti2.1428 · Cited by 9 · see citing works

ACTUAL CONCEPTION OF ALLERGEN-SPECIFIC IMMUNOTHERAPY MECHANISMS, POTENTIAL BIOMARKERS OF EFFICACY AND WAYS OF ENHANCEMENT

Pavlova, K. S., Kurbacheva, O. M., Galitskaya, M. A., & Smirnov, D. S. (2017) · Russian Journal of Allergy · doi:10.36691/rja290 · Cited by 7 · see citing works

Immunological Profiling of Haemodialysis Patients and Young Healthy Individuals with Implications for Clinical Regulatory T Cell Sorting

Bergström, M., Joly, A.-L., Seiron, P., Isringhausen, S., Modig, E., Fellström, B., Andersson, J., & Berglund, D. (2015) · Scandinavian Journal of Immunology · doi:10.1111/sji.12287 · Cited by 6 · see citing works

FOXP3 Isoforms Expression in Cervical Cancer: Evidence about the Cancer-Related Properties of FOXP3Δ2Δ7 in Keratinocytes

Garcia-Becerra, N., Aguila-Estrada, M. U., Palafox-Mariscal, L. A., Hernández‐Flores, G., Aguilar‐Lemarroy, A., & Jave‐Suárez, L. F. (2023) · Cancers · doi:10.3390/cancers15020347 · Cited by 5 · see citing works

Alternative Splicing as a Modulator of the Interferon-Gamma Pathway

Suri, P., Badalov, A., & Ruggiu, M. (2025) · Cancers · doi:10.3390/cancers17040594 · Cited by 4 · see citing works

Activation-dependent mitochondrial translocation of Foxp3 in human hepatocytes

Rojas, J., Terán‐Ángel, G., Barbosa, L., Peterson, D. L., Berrueta, L., & Salmen, S. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2016.04.008 · Cited by 4 · see citing works

Get Spliced: Uniting Alternative Splicing and Arthritis

van Haaren, M. J. H., Steller, L. B., Vastert, S. J., Calis, J. J. A., & van Loosdregt, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158123 · Cited by 3 · see citing works

Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes

Dudina, G. A., Дмитриевна, Д. А., Litvina, M. M., Mitin, A. N., Mitina, T. A., & Polyakov, S. A. (2018) · Advances in Hematology · doi:10.1155/2018/8487403 · Cited by 3 · see citing works

Expression of FOXP3 isoforms by peripheral blood regulatory T cells in allergic and lymphoproliferative disorders

Дмитриевна, Д. А., Litvina, M. M., Smirnov, D. S., Kurbacheva, O. M., Mitina, T. A., Белоусов, К. А., & Mitin, A. N. (2020) · Russian Medical Inquiry · doi:10.32364/2587-6821-2020-4-1-4-9 · Cited by 2 · see citing works

Prospects for studying of FOXP3 and its isoforms expression in allergic diseases

Smirnov, D. S., Kurbacheva, O. M., Polner, S. A., & Pavlova, K. S. (2017) · Russian Journal of Allergy · doi:10.36691/rja320 · Cited by 1 · see citing works

FoxP3 mRNA splice forms in arthritis patients

Ryder, L. R. (2011) · Cited by 1 · see citing works

The molecular regulation of Forkhead box P3

Jochems, S. P. (2011) · Utrecht University Repository (Utrecht University)

FOXP3 and CTLA-4 : how isoforms regulate immunological tolerance

Liu, S. (2015) · Figshare

Whole-exome sequencing as a diagnostic tool for ipex syndrome

Linh, D. A., Liên, N. T. K., Tung, N. V., Anh, N. T. V., Phuong, N. T., Tien, N. M., Hạnh, T. T. M., & Hoang, N. H. (2022) · TAP CHI SINH HOC · doi:10.15625/2615-9023/16305

Precision Over Prednisone: Innovative Treatment Strategies for Giant Cell Arteritis

Gloor, A. D., Sørensen, M., Muratore, F., Villiger, P. M., & Christ, L. (2025) · Current Treatment Options in Rheumatology · doi:10.1007/s40674-025-00230-0

Cell Receptor-Ligand Interaction, Signalling, Activation and Apoptosis [216-220]

(2008) · Lara D. Veeken · doi:10.1093/rheumatology/kem518

Forced overexpression of either of the two common human Foxp3 isoforms can induce regulatory T cells from CD4 + CD25 – cells

Aarts‐Riemens, T., Emmelot, M. E., Verdonck, L. F., & Mutis, T. (2008) · European Journal of Immunology · doi:10.1002/eji.200737590 · Cited by 101 · see citing works

Splice variants of human FOXP3 are functional inhibitors of human CD4+ T‐cell activation

Smith, E., Finney, H. M., Nesbitt, A. M., Ramsdell, F., & Robinson, M. K. (2006) · Immunology · doi:10.1111/j.1365-2567.2006.02425.x · Cited by 87 · see citing works

Generation of CD4+ Regulatory T Cells by Retroviral Transduction of CD4+CD25− T Cells Either with the Full-Length or with a Common Exon-2 Negative Variant of Human Foxp3.

Mutis, T., Verdonck, L. F., Aarts‐Riemens, T., & Emmelot, M. E. (2005) · Blood · doi:10.1182/blood.v106.11.3315.3315 · Cited by 1 · see citing works

Funktion natürlicher Isoformen des Transkriptionsfaktors FOXP3 in regulatorischen CD4+ T-Zellen

Mailer, R. K. (2009) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-13397