The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Visfatin: the missing link between intra-abdominal obesity and diabetes?
Open accessAbstract
Human obesity-related diabetes and the accompanying metabolic disorders have been specifically linked to increased visceral adipose tissue mass. Understanding the differences in biology of the two human fat depots (visceral and subcutaneous) might hold the key to therapeutic strategies aimed at reducing obesity-induced insulin resistance and alleviating symptoms of the metabolic syndrome. Visfatin (pre-B-cell colony-enhancing factor, PBEF) is a novel adipokine that appears to be preferentially produced by visceral adipose tissue and has insulin-mimetic actions. Could this molecule hold the keytofuture treatments for type 1 and 2 diabetes? This article discusses the pros and cons of visfatin action and how it might affect future therapeutic strategies.
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Citations
Cites
1 retracted
Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin
Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., Matsuki, Y., Murakami, M., Ichisaka, T., Murakami, H., et al. (2005) · Science · doi:10.1126/science.1097243 · Cited by 1,906
RetractedAdipose tissue, adipokines, and inflammation
Fantuzzi, G. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.02.023 · Cited by 2,606 · cited 1×
“Therefore, the adipose tissue, in addition to being a specialized organ for fat storage, should be considered the largest endocrine gland in the body, capable of synthesizing and secreting hormones (adipokines) that can modulate insulin sensitivity locally and in other organs [3].”
Background
Cited by
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
Visfatin, an Adipocytokine with Proinflammatory and Immunomodulating Properties
Moschen, A. R., Kaser, A., Enrich, B., Mosheimer, B., Theurl, M., Niederegger, H., & Tilg, H. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.3.1748 · Cited by 933
Dahl, T. B., Yndestad, A., Skjelland, M., Øie, E., Dahl, A., Michelsen, A., Damås, J. K., Tunheim, S. H., Ueland, T., Smith, C., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.665893 · Cited by 465
The regulation of nicotinamide adenine dinucleotide biosynthesis by Nampt/PBEF/visfatin in mammals
Revollo, J. R., Grimm, A. A., & Imai, S.-I. (2007) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32801b3c8f · Cited by 310
Turgeon, J. L., Carr, M. C., Maki, P. M., Mendelsohn, M. E., & Wise, P. M. (2006) · Endocrine Reviews · doi:10.1210/er.2005-0020 · Cited by 264
Metadata
- Authors
- Sethi, J. K., & Vidal-Puig, A.
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2005-08
- Volume
- 11
- Issue
- 8
- Pages
- 344-347
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W2023178691
- Cited by
- 266
- References
- 2
- FWCI
- 14.61
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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