Organ engineering based on decellularized matrix scaffolds
Abstract
End-organ failure is one of the major healthcare challenges in the Western world. Yet, donor organ shortage and the need for immunosuppression limit the impact of transplantation. The regeneration of whole organs could theoretically overcome these hurdles. Early milestones have been met by combining stem and progenitor cells with increasingly complex scaffold materials and culture conditions. Because the native extracellular matrix (ECM) guides organ development, repair and physiologic regeneration, it provides a promising alternative to synthetic scaffolds and a foundation for regenerative efforts. Perfusion decellularization is a novel technology that generates native ECM scaffolds with intact 3D anatomical architecture and vasculature. This review summarizes achievements to date and discusses the role of native ECM scaffolds in organ regeneration.
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The maintenance of intrinsic biochemical and biophysical cues within the natural ECM yields structural and chemical signaling cues that support cell adhesion, migration, proliferation, and differentiation.
“The maintenance of intrinsic biochemical and biophysical cues within the natural ECM yields structural and chemical signaling cues that support cell adhesion, migration, proliferation, and differentiation.”
From Bioactive scaffolds for tissue engineering: A review of decellularized extracellular matrix applications and innovations (2025) · cites this paper as [8]
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- Authors
- Song, J. J., & Ott, H. C.
- Affiliations
- Harvard University (US)
- Corresponding author
- Ott, Harald C.
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 17
- Issue
- 8
- Pages
- 424-432
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W2032856345
- Cited by
- 501
- References
- 2
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 31 · 2023: 18 · 2022: 19 · 2021: 39 · 2020: 33 · 2019: 45 · 2018: 40 · 2017: 44 · 2016: 44 · 2015: 49 · 2014: 49 · 2013: 48 · 2012: 18
- FWCI
- 6.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- organ engineering, decellularization, extracellular matrix scaffolds, perfusion decellularization, organ regeneration, stem cells, progenitor cells, organ shortage, transplantation
- MeSH terms
- Animals, Extracellular Matrix, Humans, Kidney, Lung, Pancreas, Perfusion, Regeneration, Organ Transplantation, Tissue Engineering, Myocytes, Cardiac, Tissue Scaffolds
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