Clinical applications of decellularized extracellular matrices for tissue engineering and regenerative medicine
Open accessAbstract
Decellularization is the process of removing the cellular components from tissues or organs. It is a promising technology for obtaining a biomaterial with a highly preserved extracellular matrix (ECM), which may also act as a biological scaffold for tissue engineering and regenerative therapies. Decellularized products are gaining clinical importance and market space due to their ease of standardized production, constant availability for grafting and mechanical or biochemical superiority against competing clinical options, yielding clinical results ahead of the ones with autografts in some applications. Current drawbacks and limitations of traditional treatments and clinical applications can be overcome by using decellularized or acellular matrices. Several companies are leading the market with versatile acellular products designed for diverse use in the reconstruction of tissues and organs. This review describes ECM-based decellularized and acellular products that are currently in use for different branches of clinic.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Similar ECM scaffolds derived from animals are FDA-approved for clinical applications such as heart valve replacement, facial reconstruction, and osteopathic implants.
“While xenogeneic ECM has the potential to cause immune responses, this risk can be greatly reduced by using proper preparation techniques64; similar ECM scaffolds derived from animals are FDA-approved for clinical applications such as heart valve replacement, facial reconstruction, and osteopathic implants62,65.”
From Towards organoid culture without Matrigel (2021) · cites this paper as [65]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
3 retracted
RETRACTED: Clinical transplantation of a tissue-engineered airway
Macchiarini, P., Jungebluth, P., Go, T., Asnaghi, M. A., Rees, L., Cogan, T. A., Dodson, A., Martorell, J., Bellini, S., Parnigotto, P. P., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61598-6 · Cited by 1,431 · see citing works
RetractedRETRACTED: Engineered whole organs and complex tissues
Badylak, S. F., Weiss, D. J., Caplan, A., & Macchiarini, P. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60073-7 · Cited by 417 · see citing works
RetractedBerg, M., Ejnell, H., Kovács, A., Nayakawde, N. B., Patil, P. B., Joshi, M. G., Aziz, L., Rådberg, G., Hajizadeh, S., Olausson, M., et al. (2013) · Tissue Engineering Part A · doi:10.1089/ten.tea.2012.0514 · Cited by 58 · see citing works
RetractedLanger, R., & Vacanti, J. P. (1993) · Science · doi:10.1126/science.8493529 · Cited by 9,893 · see citing works
Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart
Ott, H. C., Matthiesen, T. S., Goh, S.-K., Black, L. D., Kren, S. M., Netoff, T. I., & Taylor, D. A. (2008) · Nature Medicine · doi:10.1038/nm1684 · Cited by 2,650 · see citing works
Decellularization of tissues and organs
Gilbert, T. W., Sellaro, T. L., & Badylak, S. F. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.02.014 · Cited by 2,222 · see citing works
Stowman, K. (1949) · The Milbank Memorial Fund Quarterly · doi:10.2307/3348165 · Cited by 2,115 · see citing works
Tissue-engineered autologous bladders for patients needing cystoplasty
Atala, A., Bauer, S. B., Söker, S., Yoo, J. J., & Retik, A. B. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68438-9 · Cited by 1,835 · see citing works
Extracellular matrix as a biological scaffold material: Structure and function
BADYLAK, S., FREYTES, D., & GILBERT, T. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2008.09.013 · Cited by 1,671 · see citing works
Uygun, B. E., Soto-Gutierrez, A., Yagi, H., Izamis, M.-L., Guzzardi, M. A., Shulman, C., Milwid, J., Kobayashi, N., Tilles, A., Berthiaume, F., et al. (2010) · Nature Medicine · doi:10.1038/nm.2170 · Cited by 1,370 · see citing works
Bone regenerative medicine: classic options, novel strategies, and future directions
Oryan, A., Alidadi, S., Moshiri, A., & Maffulli, N. (2014) · Journal of Orthopaedic Surgery and Research · doi:10.1186/1749-799x-9-18 · Cited by 1,249 · see citing works
Tissue-Engineered Lungs for in Vivo Implantation
Petersen, T. H., Calle, E. A., Zhao, L., Lee, E. J., Gui, L., Raredon, M. S. B., Gavrilov, K., Yi, T., Zhuang, Z. W., Breuer, C. K., et al. (2010) · Science · doi:10.1126/science.1189345 · Cited by 1,177 · see citing works
Makris, E. A., Hadidi, P., & Athanasiou, K. A. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.06.037 · Cited by 1,127 · see citing works
Regeneration and orthotopic transplantation of a bioartificial lung
Ott, H. C., Clippinger, B., Conrad, C., Schuetz, C., Pomerantseva, I., Ikonomou, L., Kotton, D., & Vacanti, J. P. (2010) · Nature Medicine · doi:10.1038/nm.2193 · Cited by 1,090 · see citing works
Badylak, S. F., Taylor, D., & Uygun, K. (2011) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071910-124743 · Cited by 1,041 · see citing works
Breuing, K. H., Butler, C. E., Ferzoco, S. J., Franz, M., Hultman, C. S., Kilbridge, J. F., Rosen, M. J., Silverman, R. P., & Vargo, D. J. (2010) · Surgery · doi:10.1016/j.surg.2010.01.008 · Cited by 1,031 · see citing works
A Paradigm Shift in U.S. Breast Reconstruction: Increasing Implant Rates
Albornoz, C., Bach, P., Mehrara, B., Disa, J., Pusic, A., McCarthy, C., Cordeiro, P., & Matros, E. (2013) · Plastic and Reconstructive Surgery · doi:10.1097/prs.0b013e3182729cde · Cited by 923 · see citing works
Xenogeneic extracellular matrix as a scaffold for tissue reconstruction
Badylak, S. F. (2004) · Transplant Immunology · doi:10.1016/j.trim.2003.12.016 · Cited by 747 · see citing works
Demographic and socioeconomic aspects of hernia repair in the United States in 2003
Rutkow, I. M. (2003) · Surgical Clinics of North America · doi:10.1016/s0039-6109(03)00132-4 · Cited by 716 · see citing works
The use of whole organ decellularization for the generation of a vascularized liver organoid
Baptista, P. M., Siddiqui, M. M., Lozier, G., Rodriguez, S. R., Atala, A., & Soker, S. (2011) · Hepatology · doi:10.1002/hep.24067 · Cited by 681 · see citing works
Early failure of the tissue engineered porcine heart valve SYNERGRAFT™ in pediatric patients
Simon, P. (2003) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/s1010-7940(03)00094-0 · Cited by 623 · see citing works
Identification of extractable growth factors from small intestinal submucosa
Voytik‐Harbin, S. L., Brightman, A. O., Kraine, M. R., Waisner, B. Z., & Badylak, S. F. (1997) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19971215)67:4 · Cited by 607 · see citing works
Organ engineering based on decellularized matrix scaffolds
Song, J. J., & Ott, H. C. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.03.005 · Cited by 501 · see citing works
Badylak, S. F., Tullius, R. S., Kokini, K., Shelbourne, K. D., Klootwyk, T. E., Voytik, S. L., Kraine, M. R., & Simmons, C. (1995) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820290809 · Cited by 501 · see citing works
Sicari, B. M., Rubin, J., Dearth, C. L., Wolf, M. T., Ambrosio, F., Boninger, M., Turner, N., Weber, D., Simpson, T. W., Wyse, A., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008085 · Cited by 476 · see citing works
Demineralized bone matrix in bone repair: History and use
Gruskin, E. A., Doll, B. A., Futrell, F. W., Schmitz, J. P., & Hollinger, J. O. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.06.008 · Cited by 473 · see citing works
Bladder augmentation using allogenic bladder submucosa seeded with cells
Yoo, J. J., Meng, J., Oberpenning, F., & Atala, A. (1998) · Urology · doi:10.1016/s0090-4295(97)00644-4 · Cited by 456 · see citing works
Mechanisms of Muscle Injury, Repair, and Regeneration
Tidball, J. G. (2011) · Comprehensive physiology · doi:10.1002/cphy.c100092 · Cited by 439 · see citing works
Barber, F. A., Burns, J. P., Deutsch, A. A., Labbé, M. R., & Litchfield, R. B. (2011) · Arthroscopy The Journal of Arthroscopic and Related Surgery · doi:10.1016/j.arthro.2011.06.038 · Cited by 436 · see citing works
Flynn, L. E. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.02.046 · Cited by 433 · see citing works
Gerber, B., Krause, A., Dieterich, M., Kundt, G., & Reimer, T. (2009) · Annals of Surgery · doi:10.1097/sla.0b013e31819a044f · Cited by 395 · see citing works
Surgery for full-thickness rotator-cuff tears.
Hawkins, R. J., Misamore, G. W., & Hobeika, P. (1985) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-198567090-00007 · Cited by 390 · see citing works
Mostow, E. N., Haraway, G. D., Dalsing, M. C., Hodde, J. P., & King, D. W. (2005) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2005.01.042 · Cited by 387 · see citing works
Brown, C. M., & Finch, G. (2010) · Annals of The Royal College of Surgeons of England · doi:10.1308/003588410x12664192076296 · Cited by 386 · see citing works
Cortiella, J., Niles, J. A., Cantu, A., Brettler, A. C., Pham, A. N., Vargas, G., Winston, S., Wang, J. P., Walls, S., & Nichols, J. E. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0730 · Cited by 381 · see citing works
Acellular collagen matrix as a possible “off the shelf” biomaterial for urethral repair
Chen, F. J., Yoo, J., & Atala, A. (1999) · Urology · doi:10.1016/s0090-4295(99)00179-x · Cited by 379 · see citing works
Woods, T., & Gratzer, P. F. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.05.066 · Cited by 375 · see citing works
Cheng, C. W., Solorio, L. D., & Alsberg, E. (2014) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.12.012 · Cited by 358 · see citing works
Macrophage Participation in the Degradation and Remodeling of Extracellular Matrix Scaffolds
Valentin, J. E., Stewart-Akers, A. M., Gilbert, T. W., & Badylak, S. F. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0419 · Cited by 356 · see citing works
A Whole-Organ Regenerative Medicine Approach for Liver Replacement
Soto-Gutierrez, A., Zhang, L., Medberry, C., Fukumitsu, K., Faulk, D., Jiang, H., Reing, J., Gramignoli, R., Komori, J., Ross, M., et al. (2011) · Tissue Engineering Part C: Methods · doi:10.1089/ten.tec.2010.0698 · Cited by 311 · see citing works
Badylak, S. F. (2014) · Annals of Biomedical Engineering · doi:10.1007/s10439-013-0963-7 · Cited by 307 · see citing works
Process development of an acellular dermal matrix (ADM) for biomedical applications
Chen, R.-N., Ho, H., Tsai, Y.-T., & Sheu, M. (2003) · Biomaterials · doi:10.1016/j.biomaterials.2003.09.070 · Cited by 298 · see citing works
Mase, V. J., Hsu, J. R., Wolf, S. E., Wenke, J. C., Baer, D. G., Owens, J. G., Badylak, S. F., & Walters, J. (2010) · Orthopedics · doi:10.3928/01477447-20100526-24 · Cited by 291 · see citing works
Hydrogels derived from demineralized and decellularized bone extracellular matrix
Sawkins, M. J., Bowen, W., Dhadda, P., Markides, H., Sidney, L. E., Taylor, A. J., Rose, F. R. A. J., Badylak, S. F., Shakesheff, K. M., & White, L. J. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.04.029 · Cited by 282 · see citing works
Tendon augmentation grafts: a systematic review
Longo, U. G., Lamberti, A., Maffulli, N., & Denaro, V. (2010) · British Medical Bulletin · doi:10.1093/bmb/ldp051 · Cited by 280 · see citing works
Biologic scaffold composed of skeletal muscle extracellular matrix
Wolf, M. T., Daly, K. A., Reing, J. E., & Badylak, S. F. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2011.12.055 · Cited by 259 · see citing works
Bone Grafts in Craniofacial Surgery
Elsalanty, M. E., & Genecov, D. G. (2009) · Craniomaxillofacial Trauma & Reconstruction · doi:10.1055/s-0029-1215875 · Cited by 252 · see citing works
Biaxial strength of multilaminated extracellular matrix scaffolds
Freytes, D. O., Badylak, S. F., Webster, T. J., Geddes, L. A., & Rundell, A. E. (2003) · Biomaterials · doi:10.1016/j.biomaterials.2003.09.015 · Cited by 235 · see citing works
Laparoscopic vs Open Incisional Hernia Repair
Eker, H. H., Hansson, B. M. E., Buunen, M., Janssen, I. M. C., Pierik, R. E. G. J. M., Hop, W. C. J., Bonjer, H. J., Jeekel, J. J., & Lange, J. F. (2013) · JAMA Surgery · doi:10.1001/jamasurg.2013.1466 · Cited by 231 · see citing works
Hernia repair: the search for ideal meshes
Bringman, S., Conze, J., Cuccurullo, D., Deprest, J. A., Junge, K., Klosterhalfen, B., Parra‐Dávila, E., Ramshaw, B., & Schumpelick, V. (2009) · Hernia · doi:10.1007/s10029-009-0587-x · Cited by 227 · see citing works
Transforming growth factor‐β1 in a sterilized tissue derived from the pig small intestine submucosa
McDevitt, C. A., Wildey, G. M., & Cutrone, R. (2003) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.10144 · Cited by 222 · see citing works
Extracellular Matrix Biomaterials for Soft Tissue Repair
Cornwell, K. G., Landsman, A. S., & James, K. S. (2009) · Clinics in Podiatric Medicine and Surgery · doi:10.1016/j.cpm.2009.08.001 · Cited by 215 · see citing works
Use of Decellularized Porcine Liver for Engineering Humanized Liver Organ
Barakat, O., Abbasi, S., Rodriguez, G., Rios, J., Wood, R. P., Ozaki, C., Holley, L. S., & Gauthier, P. K. (2012) · Journal of Surgical Research · doi:10.1016/j.jss.2011.09.033 · Cited by 208 · see citing works
Biomaterial applications in cardiovascular tissue repair and regeneration
Lam, M. T., & Wu, J. C. (2012) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.12.99 · Cited by 203 · see citing works
Tendon Augmentation Grafts: Biomechanical Failure Loads and Failure Patterns
Barber, F. A., Herbert, M. A., & Coons, D. A. (2006) · Arthroscopy The Journal of Arthroscopic and Related Surgery · doi:10.1016/j.arthro.2005.12.021 · Cited by 203 · see citing works
Nelson, D. M., Ma, Z., Fujimoto, K. L., Hashizume, R., & Wagner, W. R. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.06.039 · Cited by 197 · see citing works
Dynamic reciprocity: how do extracellular matrix and hormones direct gene expression?
Bissell, M. J., & Aggeler, J. (1987) · PubMed · Cited by 192 · see citing works
Choi, J. S., Williams, J. K., Greven, M. A., Walter, K. A., Laber, P. W., Khang, G., & Söker, S. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.05.020 · Cited by 190 · see citing works
Bone Grafts Engineered from Human Adipose-Derived Stem Cells in Perfusion Bioreactor Culture
Fröhlich, M., Grayson, W. L., Marolt, D., Gimble, J. M., Kregar‐Velikonja, N., & Vunjak‐Novakovic, G. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0164 · Cited by 183 · see citing works
Acellular dermal matrix in the management of high-risk abdominal wall defects
Kim, H., Bruen, K. J., & Vargo, D. J. (2006) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2006.09.003 · Cited by 180 · see citing works
Small intestinal submucosa: a substrate for in vitro cell growth
Badylak, S. F., Record, R. D., Lindberg, K., Hodde, J. P., & Park, K. (1998) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856298x00208 · Cited by 180 · see citing works
In vivo investigation of tendon responses to mechanical loading.
Heinemeier, K. M., & Kjær, M. (2011) · PubMed · Cited by 180 · see citing works
Acellular human heart matrix: A critical step toward whole heart grafts
Sanchez, P. L., Fernández‐Santos, M. E., Costanza, S., Climent, A. M., Moscoso, I., González-Nicolás, M. Á., y, R. S.-R., Rodríguez, H. M., Kren, S. M., Garrido, G., et al. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.04.056 · Cited by 179 · see citing works
Management of Vaginal Erosion of Polypropylene Mesh Slings
Kobashi, K. C., & Govier, F. E. (2003) · The Journal of Urology · doi:10.1097/01.ju.0000060119.43064.f6 · Cited by 176 · see citing works
A Murine Model of Volumetric Muscle Loss and a Regenerative Medicine Approach for Tissue Replacement
Sicari, B. M., Agrawal, V., Siu, B. F., Medberry, C. J., Dearth, C. L., Turner, N. J., & Badylak, S. F. (2012) · Tissue Engineering Part A · doi:10.1089/ten.tea.2012.0475 · Cited by 176 · see citing works
Aurora, A., McCarron, J. A., Iannotti, J. P., & Derwin, K. A. (2007) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2007.03.008 · Cited by 173 · see citing works
Stapleton, T. W., Ingram, J. H., Katta, J., Knight, R., Korossis, S., Fisher, J., & Ingham, E. (2008) · Tissue Engineering Part A · doi:10.1089/tea.2007.0233 · Cited by 171 · see citing works
Kochupura, P. V., Azeloglu, E. U., Kelly, D. J., Doronin, S. V., Badylak, S. F., Krukenkamp, I. B., Cohen, I. S., & Gaudette, G. R. (2005) · Circulation · doi:10.1161/circulationaha.104.524355 · Cited by 168 · see citing works
Akhyari, P., Aubin, H., Gwanmesia, P., Barth, M., Hoffmann, S., Huelsmann, J., Preuß, K., & Lichtenberg, A. (2011) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2011.0210 · Cited by 158 · see citing works
A comparison of commercially available demineralized bone matrix for spinal fusion
Wang, J. C., Alanay, A., Mark, D., Kanim, L. E. A., CAMPBELL, P. A., Dawson, E. G., & Lieberman, J. R. (2007) · European Spine Journal · doi:10.1007/s00586-006-0282-x · Cited by 152 · see citing works
Decellularized matrices for cardiovascular tissue engineering.
Moroni, F., & Mirabella, T. (2014) · Europe PMC (PubMed Central) · Cited by 149 · see citing works
An investigation of the long-term bioactivity of endogenous growth factor in OASIS Wound Matrix
Hodde, J. P., Ernst, D. M. J., & Hiles, M. C. (2005) · Journal of Wound Care · doi:10.12968/jowc.2005.14.1.26721 · Cited by 148 · see citing works
Liao, J., Guo, X., Grande-Allen, K. J., Kasper, F. K., & Mikos, A. G. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.07.110 · Cited by 145 · see citing works
Ventral hernia repair using allogenic acellular dermal matrix in a swine model
Silverman, R. P., Li, E. N., Holton, L. H., Sawan, K. T., & Goldberg, N. H. (2004) · Hernia · doi:10.1007/s10029-004-0241-6 · Cited by 141 · see citing works
Corona, B. T., Ward, C. L., Baker, H. B., Walters, J., & Christ, G. J. (2013) · Tissue Engineering Part A · doi:10.1089/ten.tea.2012.0761 · Cited by 137 · see citing works
Xenotransplantation-The Future of Corneal Transplantation?
Hara, H., & Cooper, D. K. C. (2010) · Cornea · doi:10.1097/ico.0b013e3181f237ef · Cited by 128 · see citing works
Use of Graft Jacket as an Augmentation for Massive Rotator Cuff Tears
Burkhead, W. Z., Schiffern, S. C., & Krishnan, S. G. (2007) · Seminars in Arthroplasty JSES · doi:10.1053/j.sart.2006.11.017 · Cited by 127 · see citing works
Scholl, F. G., Boucek, M. M., Chan, K., Valdes‐Cruz, L. M., & Perryman, R. (2010) · World Journal for Pediatric and Congenital Heart Surgery · doi:10.1177/2150135110362092 · Cited by 126 · see citing works
Peripheral nerve regeneration using acellular nerve grafts
Kim, B., Yoo, J. J., & Atala, A. (2003) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.10045 · Cited by 123 · see citing works
An Injectable Adipose Matrix for Soft-Tissue Reconstruction
Wu, I., Nahas, Z., Kimmerling, K. A., Rosson, G. D., & Elisseeff, J. H. (2012) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0b013e31824ec3dc · Cited by 121 · see citing works
Current Options in the Management of Complex Abdominal Wall Defects
Ghazi, B., Deigni, O., Yezhelyev, M., & Losken, A. (2011) · Annals of Plastic Surgery · doi:10.1097/sap.0b013e31820d18db · Cited by 119 · see citing works
Abdominal wall repair using human acellular dermis
Bellows, C. F., Albo, D., Berger, D. H., & Awad, S. S. (2007) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2006.11.012 · Cited by 111 · see citing works
To mesh or not to mesh: a review of pelvic organ reconstructive surgery
Dällenbach, P. (2015) · International Journal of Women s Health · doi:10.2147/ijwh.s71236 · Cited by 110 · see citing works
Weichman, K. E., Wilson, S. C., Saadeh, P. B., Hazen, A., Levine, J. P., Choi, M., & Karp, N. S. (2013) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0b013e31829fe35b · Cited by 103 · see citing works
Recent developments in tissue engineering and regenerative medicine
Atala, A. (2006) · Current Opinion in Pediatrics · doi:10.1097/01.mop.0000193294.94646.be · Cited by 102 · see citing works
Youngstrom, D. W., Barrett, J. G., Jose, R. R., & Kaplan, D. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064151 · Cited by 102 · see citing works
Cell therapy, 3D culture systems and tissue engineering for cardiac regeneration
Emmert, M. Y., Hitchcock, R. W., & Hoerstrup, S. P. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.12.004 · Cited by 101 · see citing works
Marcos-Campos, I., Marolt, D., Petridis, P. D., Bhumiratana, S., Schmidt, D. F., & Vunjak‐Novakovic, G. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.08.013 · Cited by 101 · see citing works
Keeping an Eye on Decellularized Corneas: A Review of Methods, Characterization and Applications
Wilson, S., Sidney, L., Dunphy, S., Rose, J., & Hopkinson, A. (2013) · Journal of Functional Biomaterials · doi:10.3390/jfb4030114 · Cited by 100 · see citing works
Restoration of elbow function in severe brachial plexus paralysis via muscle transfers
Vekris, M. D., Beris, A. E., Lykissas, M. G., Korompilias, A. V., Vekris, A. D., & Soucacos, P. N. (2008) · Injury · doi:10.1016/j.injury.2008.06.008 · Cited by 97 · see citing works
Comparison of Different ADM Materials in Breast Surgery
Cheng, A., & Saint‐Cyr, M. (2012) · Clinics in Plastic Surgery · doi:10.1016/j.cps.2012.02.004 · Cited by 97 · see citing works
Dalmau, M. J., González‐Santos, J. M., González, J. A. B., Sastre, J. A., López‐Rodriguez, J., Bueno, M., Castaño, M., & Arribas, A. (2010) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/j.ejcts.2010.11.015 · Cited by 96 · see citing works
Arunkalaivanan, A. S., & Barrington, J. W. (2003) · International Urogynecology Journal · doi:10.1007/s00192-002-1000-9 · Cited by 93 · see citing works
CHOE, J. M., KOTHANDAPANI, R. V., James, L. E., & Bowling, D. (2001) · Urology · doi:10.1016/s0090-4295(01)01205-5 · Cited by 92 · see citing works
Use of demineralized bone matrix in spinal fusion
Tilkeridis, K. E. (2014) · World Journal of Orthopedics · doi:10.5312/wjo.v5.i1.30 · Cited by 90 · see citing works
Stapleton, T. W., Ingram, J., Fisher, J., & Ingham, E. (2010) · Tissue Engineering. Part A · doi:10.1089/ten.tea.2009.0807 · Cited by 88 · see citing works
Byrne, G. W., & McGregor, C. G. A. (2012) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0b013e3283509120 · Cited by 85 · see citing works
Sarig, U., Au-Yeung, G. C. T., Wang, Y., Bronshtein, T., Dahan, N., Boey, F., Venkatraman, S. S., & Machluf, M. (2012) · Tissue Engineering Part A · doi:10.1089/ten.tea.2011.0586 · Cited by 85 · see citing works
Perri, G., Polito, A., Esposito, C., Albanese, S. B., Francalanci, P., Pongiglione, G., & Carotti, A. (2012) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezr221 · Cited by 84 · see citing works
Performance of SynerGraft Decellularized Pulmonary Homograft in Patients Undergoing a Ross Procedure
Brown, J. W., Ruzmetov, M. M., Eltayeb, O. M., Rodefeld, M. D., & Turrentine, M. W. (2011) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2010.10.069 · Cited by 81 · see citing works
Hülsmann, J., Grün, K., Amouri, S. E., Barth, M., Hornung, K., Holzfuß, C., Lichtenberg, A., & Akhyari, P. (2012) · Xenotransplantation · doi:10.1111/j.1399-3089.2012.00719.x · Cited by 81 · see citing works
Reconstructive Urethroplasty Using Porcine Acellular Matrix
Mantovani, F., Trinchieri, A., Castelnuovo, C., Romanò, A. L., & Pisani, E. (2003) · European Urology · doi:10.1016/s0302-2838(03)00212-4 · Cited by 79 · see citing works
Scarring, stem cells, scaffolds and skin repair
Markeson, D., Pleat, J., Sharpe, J. R., Harris, A. L., Seifalian, A. M., & Watt, S. M. (2013) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.1841 · Cited by 77 · see citing works
Macrophage differentiation and polarization on a decellularized pericardial biomaterial
Ariganello, M. B., Simionescu, D. T., Labow, R. S., & Lee, J. M. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.09.004 · Cited by 75 · see citing works
Cardiac xenotransplantation technology provides materials for improved bioprosthetic heart valves
McGregor, C. G. A., Carpentier, A., Lila, N., Logan, J. S., & Byrne, G. W. (2010) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2010.08.064 · Cited by 73 · see citing works
Agrawal, V. (2012) · International Journal of Shoulder Surgery · doi:10.4103/0973-6042.96992 · Cited by 71 · see citing works
Raghavan, S. S., Woon, C. Y. L., Kraus, A., Megerle, K., Choi, M. S. S., Pridgen, B. C., Pham, H., & Chang, J. (2012) · Tissue Engineering Part A · doi:10.1089/ten.tea.2011.0422 · Cited by 71 · see citing works
Localized Angiogenesis Induced by Human Vascular Endothelial Growth Factor-Activated PLGA Sponge
Elçin, A. E., & Elçin, Y. M. (2006) · Tissue Engineering · doi:10.1089/ten.2006.12.959 · Cited by 69 · see citing works
Self-citationCardiac Tissue Engineering and the Bioartificial Heart
Gálvez‐Montón, C., Prat‐Vidal, C., Roura, S., Soler‐Botija, C., & Bayés‐Genís, A. (2013) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2012.11.012 · Cited by 68 · see citing works
β-Adrenergic Blockade in Cardiovascular Disease
Frishman, W. H. (2013) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248413484986 · Cited by 66 · see citing works
Harris, C., & Fliegel, L. (1999) · International Journal of Molecular Medicine · doi:10.3892/ijmm.3.3.315 · Cited by 65 · see citing works
Xenotransplantation of Fetal Porcine Hepatocytes in Rats Using a Tissue Engineering Approach
Elçin, Y. M., Dixit, V., Lewin, K. J., & Gitnick, G. (1999) · Artificial Organs · doi:10.1046/j.1525-1594.1999.06222.x · Cited by 63 · see citing works
Self-citationParmaksız, M., Elçin, A. E., & Elçin, Y. M. (2015) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2071 · Cited by 60 · see citing works
Self-citationTrends in corneal graft surgery in the UK
Keenan, T. D. L., Carley, F. M., Yeates, D., Jones, M. N. A., Rushton, S. N., Goldacre, M. J., & on behalf of the NHSBT Ocular Tissue Advisory Group and contributing ophthalmologists (OTAG Audit Study 8) (2010) · British Journal of Ophthalmology · doi:10.1136/bjo.2010.182329 · Cited by 58 · see citing works
Ferzoco, S. J. (2013) · International Surgery · doi:10.9738/intsurg-d-12-00002.1 · Cited by 57 · see citing works
Dieterich, M., & Faridi, A. (2013) · Geburtshilfe und Frauenheilkunde · doi:10.1055/s-0033-1350930 · Cited by 56 · see citing works
Valdatta, L. A., Cattaneo, A. G., Pellegatta, I., Scamoni, S., Minuti, A., & Cherubino, M. (2014) · Plastic Surgery International · doi:10.1155/2014/472604 · Cited by 47 · see citing works
Initial Experience with Intraventricular Repair Using CorMatrix Extracellular Matrix
Yanagawa, B., Rao, V., Yau, T. M., & Cusimano, R. J. (2013) · Innovations Technology and Techniques in Cardiothoracic and Vascular Surgery · doi:10.1097/imi.0000000000000014 · Cited by 46 · see citing works
Neovascularization by bFGF releasing hyaluronic acid–gelatin microspheres:in vitroandin vivostudies
Demirdögen, B., Elçin, A. E., & Elçin, Y. M. (2010) · Growth Factors · doi:10.3109/08977194.2010.508456 · Cited by 46 · see citing works
Self-citationIngeniería tisular cardiaca y corazón bioartificial
Gálvez‐Montón, C., Prat‐Vidal, C., Roura, S., Soler‐Botija, C., & Bayés‐Genís, A. (2013) · Revista Española de Cardiología · doi:10.1016/j.recesp.2012.11.013 · Cited by 46 · see citing works
A comparison of three methods of decellularization of pig corneas to reduce immunogenicity.
Lee, W., Miyagawa, Y., Long, C. E., Cooper, D. K. C., & Hara, H. (2014) · PubMed Central · doi:10.3980/j.issn.2222-3959.2014.04.01 · Cited by 45 · see citing works
Evaluation of Decellularized Extracellular Matrix of Skeletal Muscle for Tissue Engineering
Lin, C., Yang, J.-R., Chiang, N., Ma, H., & Tsay, R.-Y. (2014) · The International Journal of Artificial Organs · doi:10.5301/ijao.5000344 · Cited by 45 · see citing works
Histology of CorMatrix Bioscaffold 5 Years After Pericardial Closure
Stelly, M., & Stelly, T. C. (2013) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2013.06.114 · Cited by 42 · see citing works
Juhász, I., Kiss, B., Lukács, L., Erdei, I., Péter, Z., & Remenyik, É. (2010) · Dermatology Research and Practice · doi:10.1155/2010/210150 · Cited by 40 · see citing works
Tissue Engineered Scaffolds for an Effective Healing and Regeneration: Reviewing Orthotopic Studies
Baiguera, S., Urbani, L., & Gaudio, C. D. (2014) · BioMed Research International · doi:10.1155/2014/398069 · Cited by 39 · see citing works
Olausson, M., Kuna, V. K., Travnikova, G., Bäckdahl, H., Patil, P. B., Saalman, R., Borg, H., Jeppsson, A., & Sumitran–Holgersson, S. (2014) · EBioMedicine · doi:10.1016/j.ebiom.2014.09.001 · Cited by 37 · see citing works
In vitro human tissue models — moving towards personalized regenerative medicine
Schenke‐Layland, K., & Nerem, R. M. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.05.001 · Cited by 33 · see citing works
İnanç, B., Elçin, A. E., & Elçin, Y. M. (2008) · Tissue Engineering Part A · doi:10.1089/tea.2007.0213 · Cited by 33 · see citing works
Self-citationThe Use of Extracellular Matrix Patches in Cardiac Surgery
Holubec, T., Caliskan, E., Sündermann, S., Starck, C. T., Plass, A., Béttex, D., Falk, V., & Maisano, F. (2014) · Journal of Cardiac Surgery · doi:10.1111/jocs.12494 · Cited by 32 · see citing works
Complications of grafts used in female pelvic floor reconstruction: Mesh erosion and extrusion
Kobashi, K. C., & Nazemi, T. M. (2007) · Indian Journal of Urology · doi:10.4103/0970-1591.32067 · Cited by 32 · see citing works
Liu, L., Deng, L., Wang, Y., Xu, H., Ge, L., & Liang, Z. (2010) · International Urogynecology Journal · doi:10.1007/s00192-010-1288-9 · Cited by 31 · see citing works
Vashi, A. V., White, J., McLean, K. M., Neethling, W. M. L., Rhodes, D. I., Ramshaw, J. A. M., & Werkmeister, J. A. (2014) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35335 · Cited by 31 · see citing works
İnanç, B., Elçin, A. E., & Elçin, Y. M. (2008) · Tissue Engineering Part A · doi:10.1089/ten.tea.2007.0213 · Cited by 31 · see citing works
Self-citationClinical challenges in the management of vaginal prolapse
Siddiqui, N. Y., & Edenfield, A. L. (2014) · International Journal of Women s Health · doi:10.2147/ijwh.s54845 · Cited by 30 · see citing works
Reconstruction of Ablated Rat Rectus Abdominis by Muscle Regeneration
Vindigni, V., Mazzoleni, F., Rossini, K., Fabbian, M., Zanin, M. E., Bassetto, F., & Carraro, U. (2004) · Plastic & Reconstructive Surgery · doi:10.1097/01.prs.0000138253.96709.e5 · Cited by 30 · see citing works
Use of Surgisis for Treatment of Anterior and Posterior Vaginal Prolapse
Armitage, S., Šeman, E. I., & Keirse, M. J. N. C. (2012) · Obstetrics and Gynecology International · doi:10.1155/2012/376251 · Cited by 29 · see citing works
Surface chemistry control of monocyte and macrophage adhesion, morphology, and fusion
Collier, T. O., Thomas, C. H., Anderson, J. M., & Healy, K. E. (2000) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(200001)49:1 · Cited by 29 · see citing works
Complex ventral hernia repair with a human acellular dermal matrix
Roth, J. S., BRATHWAITE, C. E. M., Hacker, K., Fisher, K., & King, J. (2014) · Hernia · doi:10.1007/s10029-014-1245-5 · Cited by 28 · see citing works
İnanç, B., Elçin, A. E., & Elçin, Y. M. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0380 · Cited by 28 · see citing works
Self-citationHypoxemia During One-Lung Ventilation for Robot-Assisted Coronary Artery Bypass Graft Surgery
Liu, T.-J., Shih, M.-S., Lee, W.-L., Wang, K., Liu, C.-N., Hung, C.-J., & Lai, H. (2013) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2013.04.017 · Cited by 28 · see citing works
Porcine dermis implants in soft-tissue reconstruction: current status
Smart, N. J., Bryan, N., Hunt, J. A., & Daniels, I. R. (2014) · Biologics · doi:10.2147/btt.s46469 · Cited by 26 · see citing works
van den Heever, J. J., Neethling, W. M. L., Smit, F. E., Litthauer, D., & Joubert, G. (2012) · Cell and Tissue Banking · doi:10.1007/s10561-012-9299-z · Cited by 22 · see citing works
Morticelli, L., Thomas, D., Roberts, N., Ingham, E., & Korossis, S. (2013) · PubMed · Cited by 20 · see citing works
Biomaterials and Stem Cell Therapies for Injuries Associated to Skeletal Muscular Tissues
Pereira, T., Gärtner, A., Amorim, I., Armada-da-, P., Gomes, R., Pereira, C., de Miguel, L., Diana, M. E., Miguel, A., Maria, A., et al. (2013) · InTech eBooks · doi:10.5772/53335 · Cited by 18 · see citing works
Agarwal, C., Kumar, B. T., & Mehta, D. S. (2015) · Journal of Indian Society of Periodontology · doi:10.4103/0972-124x.149938 · Cited by 18 · see citing works
Decellularized bovine reinforced vessels for small-diameter tissue-engineered vascular grafts
Grandi, C. (2011) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2011.720 · Cited by 17 · see citing works
Extracellular Matrix and Regenerative Therapies from the Cardiac Perspective
Doğan, A., Parmaksız, M., Elçin, A. E., & Elçin, Y. M. (2015) · Stem Cell Reviews and Reports · doi:10.1007/s12015-015-9641-5 · Cited by 17 · see citing works
Self-citationA modified tensionless gingival grafting technique using acellular dermal matrix.
Taylor, J. B., Gerlach, R. C., Herold, R. W., Bisch, F. C., & Dixon, D. R. (2010) · PubMed · Cited by 14 · see citing works
Care of the Orthopaedic Trauma Patient
Mamaril, M. E., Childs, S. G., & Sortman, S. (2007) · Journal of PeriAnesthesia Nursing · doi:10.1016/j.jopan.2007.03.008 · Cited by 13 · see citing works
Bioengineered tissues in wound healing: a progress report
Lepow, B. D., Downey, M., Yurgelon, J., Klassen, L., & Armstrong, D. G. (2011) · Expert Review of Dermatology · doi:10.1586/edm.11.27 · Cited by 11 · see citing works
Golla, D., & Russo, C. C. (2014) · International Surgery · doi:10.9738/intsurg-d-13-00170.1 · Cited by 8 · see citing works
Morticelli, L., Thomas, D., Ingham, E., & Korossis, S. (2012) · QScience Proceedings · doi:10.5339/qproc.2012.heartvalve.4.39 · Cited by 7 · see citing works
A Simplified Approach for Arthroscopic Repair of Rotator Cuff Tear with Dermal Patch Augmentation
Levenda, A. C., & Sanders, N. R. (2015) · Advances in Orthopedic Surgery · doi:10.1155/2015/423949 · Cited by 6 · see citing works
Use of Grafts in Pelvic Reconstructive Surgery
Jeon, M. J., & Bai, S. W. (2007) · Yonsei Medical Journal · doi:10.3349/ymj.2007.48.2.147 · Cited by 6 · see citing works
Extracellular matrix for reconstruction of cardiac structures after tumour resections
Sündermann, S., Müggler, O., Caliskan, E., Reser, D., Manka, R., Holubec, T., Czerny, M., & Falk, V. (2014) · Interactive Cardiovascular and Thoracic Surgery · doi:10.1093/icvts/ivu310 · Cited by 6 · see citing works
Cardiac reconstruction with organ specific extracellular matrix
Wainwright, J. (2010) · D-Scholarship@Pitt (University of Pittsburgh) · Cited by 2 · see citing works
Vashi, A. V., White, J. F., McLean, K. M., et al. (2014) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbma.35335 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Extracellular matrix-based materials for regenerative medicine
Hussey, G. S., Dziki, J. L., & Badylak, S. F. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0023-x · Cited by 844 · see citing works
Zhang, X., Chen, X., Hong, H., Hu, R., Liu, J., & Liu, C. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.09.014 · Cited by 680 · see citing works
Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements
Kolimi, P., Narala, S., Nyavanandi, D., Youssef, A. A. A., & Dudhipala, N. R. (2022) · Cells · doi:10.3390/cells11152439 · Cited by 625 · see citing works
Scaffolding Strategies for Tissue Engineering and Regenerative Medicine Applications
Pina, S., Ribeiro, V. P., Marques, C. F., Maia, F. R., Silva, T. H., Reis, R. L., & Oliveira, J. M. (2019) · Materials · doi:10.3390/ma12111824 · Cited by 492 · see citing works
Towards organoid culture without Matrigel
Kozlowski, M. T., Crook, C. J., & Ku, H. T. (2021) · Communications Biology · doi:10.1038/s42003-021-02910-8 · Cited by 409 · see citing works
Mendibil, U., Ruiz-Hernández, R., Retegi-Carrión, S., García‐Urkía, N., Olalde, B., & Abarrategi, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155447 · Cited by 302 · see citing works
Revete, A., Aparicio, A., Cisterna, B. A., Revete, J., Luis, L., Ibarra, E., González, E. A. S., Molino, J. J., & Reginensi, D. (2022) · International Journal of Biomaterials · doi:10.1155/2022/3606765 · Cited by 235 · see citing works
Xu, X., Li, X., Wang, J., He, X., Sun, H., & Chen, F. (2018) · Stem Cells Translational Medicine · doi:10.1002/sctm.18-0181 · Cited by 233 · see citing works
Recent Trends in Decellularized Extracellular Matrix Bioinks for 3D Printing: An Updated Review
Dzobo, K., Motaung, K. S., & Adesida, A. B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184628 · Cited by 236 · see citing works
Decellularized Extracellular Matrix Materials for Cardiac Repair and Regeneration
Bejleri, D., & Davis, M. E. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801217 · Cited by 215 · see citing works
Extracellular Matrix‐Based Strategies for Immunomodulatory Biomaterials Engineering
Rowley, A. T., Nagalla, R. R., Wang, S., & Liu, W. F. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801578 · Cited by 193 · see citing works
Recent development and biomedical applications of decellularized extracellular matrix biomaterials
Yao, Q., Zheng, Y., Lan, Q.-H., Kou, L., Xu, H., & Zhao, Y. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.109942 · Cited by 176 · see citing works
3D cell-printing of biocompatible and functional meniscus constructs using meniscus‐derived bioink
Chae, S., Lee, S., Choi, Y., Hong, D. H., Gao, G., Wang, J. H., & Cho, D. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120466 · Cited by 148 · see citing works
Microfluidic Skin‐on‐a‐Chip Models: Toward Biomimetic Artificial Skin
Sutterby, E., Thurgood, P., Baratchi, S., Khoshmanesh, K., & Pirogova, E. (2020) · Small · doi:10.1002/smll.202002515 · Cited by 142 · see citing works
Biocompatibility Evolves: Phenomenology to Toxicology to Regeneration
Crawford, L., Wyatt, M., Bryers, J. D., & Ratner, B. D. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202002153 · Cited by 138 · see citing works
Liao, J., Xu, B., Zhang, R., Fan, Y., Xie, H., & Li, X. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb01534b · Cited by 129 · see citing works
Chasing the Paradigm: Clinical Translation of 25 Years of Tissue Engineering
Hoffman, T., Khademhosseini, A., & Langer, R. (2019) · Tissue Engineering Part A · doi:10.1089/ten.tea.2019.0032 · Cited by 118 · see citing works
Functional acellular matrix for tissue repair
Wang, B., Qinglai, T., Yang, Q., Li, M., Zeng, S., Yang, X., Xiao, Z., Tong, X., Lei, L., & Li, S. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100530 · Cited by 111 · see citing works
Heath, D. E. (2019) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-018-0080-0 · Cited by 108 · see citing works
Willemse, J., van Tienderen, G., van Hengel, E., Schurink, I., van der Ven, D., Kan, Y., de Ruiter, P., Rosmark, O., Westergren-Thorsson G, G., Schneeberger, K., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121473 · Cited by 106 · see citing works
Cao, G., Huang, Y., Li, K., Fan, Y., Xie, H., & Li, X. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb00530g · Cited by 101 · see citing works
Kočí, Z., Výborný, K., Dubišová, J., Vacková, I., Jäger, A., Lunov, O., Jiráková, K., & Kubinová, Š. (2017) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2017.0089 · Cited by 96 · see citing works
Decellularized tissues as platforms for in vitro modeling of healthy and diseased tissues
McCrary, M. W., Bousalis, D., Mobini, S., Song, Y. H., & Schmidt, C. E. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.05.031 · Cited by 96 · see citing works
Strategies for improving the 3D printability of decellularized extracellular matrix bioink
Zhang, H., Wang, Y., Zheng, Z., Wei, X., Chen, L., Wu, Y., Huang, W., & Yang, L. (2023) · Theranostics · doi:10.7150/thno.81785 · Cited by 94 · see citing works
Yang, X., Ma, Y., Wang, X., Yuan, S., Huo, F., Yi, G., Zhang, J., Yang, B., & Tian, W. (2022) · Advanced Science · doi:10.1002/advs.202205041 · Cited by 92 · see citing works
3D Bioprinting with Live Cells
Persaud, A., Maus, A., Strait, L., & Zhu, D. (2022) · Engineered Regeneration · doi:10.1016/j.engreg.2022.07.002 · Cited by 91 · see citing works
Hyldig, K., Riis, S., Pennisi, C., Zachar, V., & Fink, T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061167 · Cited by 80 · see citing works
Rao, Z., Lin, T., Qiu, S., Zhou, J., Liu, S., Chen, S., Wang, T., Liu, X., Zhu, Q., Bai, Y., et al. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111791 · Cited by 87 · see citing works
Pruett, L. J., Jenkins, C. H., Singh, N. S., Catallo, K. J., & Griffin, D. R. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202104337 · Cited by 87 · see citing works
Feng, B., Ji, T.-J., Wang, X., Fu, W. E., Ye, L., Zhang, H., & Li, F. (2020) · Materials & Design · doi:10.1016/j.matdes.2020.108773 · Cited by 86 · see citing works
Artificial Scaffolds in Cardiac Tissue Engineering
Roacho-Pérez, J. A., Garza-Treviño, E. N., Moncada-Saucedo, N. K., Carriquiry-Chequer, P. A., Valencia-Gómez, L. E., Matthews, E. R., Flores, V. G., Simental-Mendía, M. A., González, P. D., Delgado-Gallegos, J. L., et al. (2022) · Life · doi:10.3390/life12081117 · Cited by 81 · see citing works
Rijal, G., & Li, W. (2018) · Journal of Biological Engineering · doi:10.1186/s13036-018-0114-7 · Cited by 80 · see citing works
Cartilage extracellular matrix as a biomaterial for cartilage regeneration
Kiyotake, E. A., Beck, E. C., & Detamore, M. S. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13278 · Cited by 78 · see citing works
Baptista, L. S., Kronemberger, G. S., Côrtes, I., Charelli, L. E., Matsui, R. A. M., Palhares, T. N., Sohier, J., Rossi, A. M., & Granjeiro, J. M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051285 · Cited by 77 · see citing works
Jorgensen, A. M., Chou, Z., Gillispie, G. J., Lee, S. J., Yoo, J. J., Söker, S., & Atala, A. (2020) · Nanomaterials · doi:10.3390/nano10081484 · Cited by 74 · see citing works
Vermeulen, M., Del Vento, F., De Michele, F., Poels, J., & Wyns, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010227 · Cited by 72 · see citing works
van der Merwe, Y., Faust, A. E., Sakalli, E. T., Westrick, C. C., Hussey, G. S., Chan, K. C., Conner, I. P., Fu, V. L. N., Badylak, S. F., & Steketee, M. B. (2019) · Scientific Reports · doi:10.1038/s41598-019-39861-4 · Cited by 70 · see citing works
Li, Y., Xu, Y., Liu, Y., Wang, Z., Chen, W., Duan, L., & Gu, D. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.110139 · Cited by 69 · see citing works
Innovative approaches to wound healing: insights into interactive dressings and future directions
Yadav, R., Kumar, R., Kathpalia, M., Ahmed, B., Dua, K., Gulati, M., Singh, S. K., Singh, P. J., Kumar, S., Shah, R., et al. (2024) · Journal of Materials Chemistry B · doi:10.1039/d3tb02912c · Cited by 72 · see citing works
Decellularized human amniotic membrane: From animal models to clinical trials
Milan, P. B., Amini, N., Joghataei, M. T., Ebrahimi, L., Amoupour, M., Sarveazad, A., Kargozar, S., & Mozafari, M. (2019) · Methods · doi:10.1016/j.ymeth.2019.07.018 · Cited by 69 · see citing works
Biodegradable and Non-Biodegradable Biomaterials and Their Effect on Cell Differentiation
Geevarghese, R., Sajjadi, S. S., Hudecki, A., Sajjadi, S., Jalal, N. R., Madrakian, T., Ahmadi, M., Włodarczyk‐Biegun, M. K., Ghavami, S., Likus, W., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232416185 · Cited by 63 · see citing works
Mao, Y., Block, T., Singh-Varma, A., Sheldrake, A., Leeth, R., Griffey, S., & Kohn, J. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.12.006 · Cited by 63 · see citing works
Mohiuddin, O. A., Campbell, B., Poche, J. N., Thomas‐Porch, C., Hayes, D., Bunnell, B. A., & Gimble, J. M. (2019) · Advances in experimental medicine and biology · doi:10.1007/5584_2019_371 · Cited by 63 · see citing works
Dong, Q., Zu, D., Kong, L., Chen, S., Yao, J., Lin, J., Lü, L., Wu, B., & Fang, B. (2022) · Biomaterials Research · doi:10.1186/s40824-022-00281-7 · Cited by 62 · see citing works
Clinical translation of personalized bioengineered implant scaffolds
Xu, C., & Ivanovski, S. (2025) · Nature Reviews Bioengineering · doi:10.1038/s44222-024-00269-z · Cited by 62 · see citing works
Membranous Extracellular Matrix-Based Scaffolds for Skin Wound Healing
Da, L., Huang, Y., Xie, H., Zheng, B., Huang, Y., & Du, S. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13111796 · Cited by 59 · see citing works
Krishtul, S., Baruch, L., & Machluf, M. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201900386 · Cited by 57 · see citing works
Tognetti, L., Pianigiani, E., Ierardi, F., Lorenzini, G., Casella, D., Liso, F. G., Pascalis, A. D., Cinotti, É., & Rubegni, P. (2021) · Dermatologic Therapy · doi:10.1111/dth.14987 · Cited by 56 · see citing works
Biomaterial approaches for cardiovascular tissue engineering
Theus, A. S., Tomov, M. L., Cetnar, A. C., Lima, B., Nish, J., McCoy, K., Mahmoudi, M., & Serpooshan, V. (2019) · Emergent Materials · doi:10.1007/s42247-019-00039-3 · Cited by 56 · see citing works
Update on the main use of biomaterials and techniques associated with tissue engineering
Steffens, D., Braghirolli, D. I., Maurmann, N., & Pranke, P. H. L. (2018) · Drug Discovery Today · doi:10.1016/j.drudis.2018.03.013 · Cited by 54 · see citing works
3D Structure and Processing Methods Direct the Biological Attributes of ECM-Based Cardiac Scaffolds
Efraim, Y., Schoen, B., Zahran, S., Davidov, T., Vasilyev, G. B., Baruch, L., Zussman, E., & Machluf, M. (2019) · Scientific Reports · doi:10.1038/s41598-019-41831-9 · Cited by 54 · see citing works
Ibsirlioglu, T., Elçin, A. E., & Elçin, Y. M. (2019) · Methods · doi:10.1016/j.ymeth.2019.04.020 · Cited by 53 · see citing works
Self-citationExosome-loaded scaffolds for regenerative medicine in hard tissues
Rahmati, S., Khazaei, M., Nadi, A., Alizadeh, M., & Rezakhani, L. (2023) · Tissue and Cell · doi:10.1016/j.tice.2023.102102 · Cited by 50 · see citing works
Chiti, M. C., Vanacker, J., Ouni, E., Tatic, N., Viswanath, A., Rieux, A. D., Dolmans, M., White, L. J., & Amorim, C. A. (2021) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.34974 · Cited by 48 · see citing works
Urinary Tissue Engineering: Challenges and Opportunities
Singh, A., Bivalacqua, T. J., & Sopko, N. A. (2017) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2017.08.004 · Cited by 46 · see citing works
Parmaksız, M., Elçin, A. E., & Elçin, Y. M. (2018) · Materials Science and Engineering C · doi:10.1016/j.msec.2018.10.011 · Cited by 46 · see citing works
Self-citationErgun, C., Parmaksiz, M., Vurat, M. T., Elçin, A. E., & Elçin, Y. M. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.12.086 · Cited by 45 · see citing works
Self-citationAswathy, S. H., Mohan, C. C., Unnikrishnan, P. S., Krishnan, A. G., & Nair, M. B. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111500 · Cited by 44 · see citing works
CARDIOVASCULAR DISEASE, SIGNALING, GENE/CELL THERAPY AND ADVANCED NANOBIOMATERIALS
Erdil, N. (2024) · Advances in Biology & Earth Sciences · doi:10.62476/abes9s58 · Cited by 43 · see citing works
Şeker, Ş., Elçin, A. E., & Elçin, Y. M. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.110703 · Cited by 42 · see citing works
Self-citationA pH-driven genipin gelator to engineer decellularized extracellular matrix-based tissue adhesives
Nishiguchi, A., & Taguchi, T. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.06.033 · Cited by 42 · see citing works
Savitri, C., Ha, S. S., Kwon, J. W., Kim, S. H., Kim, Y., Park, H. M., Kwon, H., Ji, M. J., & Park, K. (2024) · Advanced Science · doi:10.1002/advs.202305852 · Cited by 42 · see citing works
Milan, P. B., Masoumi, F., Biazar, E., Jalise, S. Z., & Mehrabi, A. (2024) · Macromolecular Bioscience · doi:10.1002/mabi.202400322 · Cited by 41 · see citing works
Crosslinking strategies of decellularized extracellular matrix in tissue regeneration
Qiao, S., Peijie, T., & Jiang, N. (2023) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37650 · Cited by 39 · see citing works
Desai, S. U., Srinivasan, S. S., Kumbar, S. G., & Moss, I. L. (2024) · Gels · doi:10.3390/gels10010062 · Cited by 39 · see citing works
Cicuéndez, M., Casarrubios, L., Feito, M. J., Madarieta, I., Garcia-Urkia, N., Murua, O., Olalde, B., Briz, N., Diez-Orejas, R., & Portolés, M. T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083847 · Cited by 39 · see citing works
Tavakoli, S., Kisiel, M., Biedermann, T., & Klar, A. S. (2022) · Biomedicines · doi:10.3390/biomedicines10010118 · Cited by 35 · see citing works
Host macrophage response to injectable hydrogels derived from ECM and α-helical peptides.
Mehrban, N., Molina, C., Quijano, L. M., Bowen, J., Johnson, S., Bartolacci, J., Chang, J. T., Scott, D., Woolfson, D., Birchall, M., et al. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.05.022 · Cited by 30 · see citing works
Decellularized Cell Culture ECMs Act as Cell Differentiation Inducers
Parmaksız, M., Elçin, A. E., & Elçin, Y. M. (2020) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-09963-y · Cited by 35 · see citing works
Self-citationDecellularized extracellular matrix for organoid and engineered organ culture
Guo, X., Liu, B., Zhang, Y., Cheong, S., Xu, T., Lu, F., & He, Y. (2024) · Journal of Tissue Engineering · doi:10.1177/20417314241300386 · Cited by 38 · see citing works
Decellularized extracellular matrices for tissue engineering applications
Elmashhady, H., Kraemer, B. A., Patel, K. H., Sell, S. A., & Garg, K. (2017) · Electrospinning · doi:10.1515/esp-2017-0005 · Cited by 34 · see citing works
Rat lung decellularization using chemical detergents for lung tissue engineering
Tebyanian, H., Karami, A., Motavallian, E., Samadikuchaksaraei, A., Arjmand, B., & Nourani, M. R. (2018) · Biotechnic & Histochemistry · doi:10.1080/10520295.2018.1544376 · Cited by 34 · see citing works
Role of Region-Specific Brain Decellularized Extracellular Matrix on In Vitro Neuronal Maturation
Reginensi, D., Ortiz, D. A., Pravia, A., Burillo, A., Morales, F. L., Morgan, C., Jimenez, L., Dave, K. R., Pérez‐Pinzón, M. A., & Gittens, R. A. (2020) · Tissue Engineering Part A · doi:10.1089/ten.tea.2019.0277 · Cited by 34 · see citing works
Importance of Matrix Cues on Intervertebral Disc Development, Degeneration, and Regeneration
Kibble, M. J., Domingos, M. A. N., Hoyland, J. A., & Richardson, S. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23136915 · Cited by 33 · see citing works
Heuschkel, M. A., Leitolis, A., Roderjan, J. G., Suss, P. H., Luzia, C., da Costa, F. D. A., Correa, A., & Stimamiglio, M. A. (2018) · Xenotransplantation · doi:10.1111/xen.12464 · Cited by 33 · see citing works
Biomaterials for repair and regeneration of the cartilage tissue
Ansari, M., & Eshghanmalek, M. (2018) · Bio-Design and Manufacturing · doi:10.1007/s42242-018-0031-0 · Cited by 32 · see citing works
Xie, X., Wang, W., Cheng, J. Q., Liang, H., Lin, Z., Zhang, T., Lu, Y., & Li, Q. (2020) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2020.110903 · Cited by 32 · see citing works
Parmaksız, M., Lalegül‐Ülker, Ö., Vurat, M. T., Elçin, A. E., & Elçin, Y. M. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.112065 · Cited by 32 · see citing works
Self-citationA multifunctional decellularized gut suture platform
Lee, J. S., Kim, H., Carroll, G., Liu, G. W., Kirtane, A. R., Hayward, A. M., Wentworth, A. J., Lopes, A., Collins, J. E., Tamang, S., et al. (2023) · Matter · doi:10.1016/j.matt.2023.04.015 · Cited by 31 · see citing works
Tavakoli, S., Kisiel, M. A., Biedermann, T., & Klar, A. S. (2022) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-213624 · Cited by 31 · see citing works
Zhu, D., Jiang, Z., Li, N., Wang, X., Ren, L., Ye, Y., Pan, Y., & Yang, G. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114413 · Cited by 31 · see citing works
The Study of the Extracellular Matrix in Chronic Inflammation: A Way to Prevent Cancer Initiation?
Marangio, A., Biccari, A., D’Angelo, E., Sensi, F., Spolverato, G., Pucciarelli, S., & Agostini, M. (2022) · Cancers · doi:10.3390/cancers14235903 · Cited by 32 · see citing works
Preconditioning process for dermal tissue decellularization using electroporation with sonication
Koo, M., Jeong, H., Hong, S. H., Seon, G. M., Lee, M. H., & Park, J. (2021) · Regenerative Biomaterials · doi:10.1093/rb/rbab071 · Cited by 30 · see citing works
Boriani, F., Fazio, N., Fotia, C., Savarino, L., Aldini, N. N., Martini, L., Zini, N., Bernardini, M., & Baldini, N. (2017) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36090 · Cited by 30 · see citing works
Comparison of two decellularized dermal equivalents
Kuo, S., Kim, H. M., Wang, Z., Bingham, E. L., Miyazawa, A., Marcelo, C. L., & Feinberg, S. E. (2017) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2530 · Cited by 29 · see citing works
Sládková, M., Cheng, J., Pujari‐Palmer, M., Chen, S., Lin, C., Xia, W., Yu, Y. E., Zhou, B., Engqvist, H., & de Peppo, G. M. (2018) · Tissue Engineering Part A · doi:10.1089/ten.tea.2018.0149 · Cited by 28 · see citing works
Han, X., Liao, L., Zhu, T., Xu, Y., Bi, F., Li, X., Li, H., Huo, F., Tian, W., & Guo, W. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111224 · Cited by 28 · see citing works
Chen, S., Yao, J., Huo, S., Xu, C., Yang, R., Tao, D., Fang, B., Ma, G., Zhu, Z., Ye, Z., et al. (2024) · Nano Convergence · doi:10.1186/s40580-024-00447-0 · Cited by 27 · see citing works
Yu, H., Chen, Y., Kong, H., He, Q., Sun, H., Bhugul, P. A., Zhang, Q., Chen, B., & Zhou, M. (2018) · Journal of Biological Engineering · doi:10.1186/s13036-018-0096-5 · Cited by 27 · see citing works
Regenerative Potential of A Bovine ECM-Derived Hydrogel for Biomedical Applications
Francesco, D. D., Bertani, F., Fusaro, L., Clemente, N., Carton, F., Talmon, M., Fresu, L. G., & Boccafoschi, F. (2022) · Biomolecules · doi:10.3390/biom12091222 · Cited by 28 · see citing works
Cardiac organoids: a new tool for disease modeling and drug screening applications
Yaqinuddin, A., Jabri, A., Mhannayeh, A., Taftafa, B., Alsharif, M., Abbad, T., Khan, J. A., Elsalti, A., Chinnappan, R., Alshehri, E. A., et al. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1537730 · Cited by 27 · see citing works
Eren, A. D., Sinha, R., Eren, E. D., Yuan, H., İz, S. G., Valster, H., Moroni, L., Foolen, J., & de Boer, J. (2020) · Journal of Immunology and Regenerative Medicine · doi:10.1016/j.regen.2020.100027 · Cited by 26 · see citing works
Mokhtarinia, K., & Masaeli, E. (2023) · Biomaterials Science · doi:10.1039/d2bm02111k · Cited by 26 · see citing works
Klabukov, I., Atiakshin, D., Kogan, E. A., Ignatyuk, M. A., Крашенинников, М. Е., Zharkov, N. V., Yakimova, A. O., Grinevich, V. N., Pryanikov, P. D., Parshin, V. D., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242316783 · Cited by 26 · see citing works
Decellularization Concept in Regenerative Medicine
Somuncu, O. (2019) · Advances in experimental medicine and biology · doi:10.1007/5584_2019_338 · Cited by 26 · see citing works
New Insights into the Pros and Cons of Cross-Linking Decellularized Bioartificial Organs
Hussein, K. H., Park, K., Lee, Y., Woo, J.-S., Kang, B., Choi, K., Kang, K., & Woo, H. (2017) · The International Journal of Artificial Organs · doi:10.5301/ijao.5000541 · Cited by 26 · see citing works
Wang, Z., Liu, R., Liu, Y., Zhao, Y., Wang, Y., Lu, B., Li, H., Ju, C., Wu, W., Gao, X., et al. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c00067 · Cited by 25 · see citing works
Decellularization of fish tissues for tissue engineering and regenerative medicine applications
Chen, W., Chen, M., Chen, S., Wang, S., Huang, Z., Zhang, L., Wu, J., Peng, W., Li, H., & Wen, F. (2024) · Regenerative Biomaterials · doi:10.1093/rb/rbae138 · Cited by 25 · see citing works
Wang, Z., Sun, F., Lu, Y., Zhang, B., Zhang, G., & Shi, H. (2021) · ACS Omega · doi:10.1021/acsomega.0c06247 · Cited by 25 · see citing works
Francés‐Herrero, E., Lopez, R., Campo, H., de Miguel–Gómez, L., Rodríguez‐Eguren, A., Faus, A., Pellicer, A., & Cervelló, I. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213480 · Cited by 25 · see citing works
- Authors
- Parmaksiz, M., Dogan, A., Odabas, S., Elçin, A. E., & Elçin, Y. M.
- Affiliations
- Ankara University Faculty of Science, and Ankara University Stem Cell Institute
- Ankara University (TR)
- Corresponding author
- Elçin, A Eser
- Elçin, Y Murat
- Venue
- Biomedical Materials
- Publisher
- IOP Publishing
- Published
- 2016-03-17
- Volume
- 11
- Issue
- 2
- Pages
- 022003
- ISSN
- 1748-6041 (ISSN-L)
- 1748-605X
- OpenAlex
- W2314454902
- Cited by
- 268
- References
- 155
- Citations by year
- 2026: 12 · 2025: 23 · 2024: 30 · 2023: 30 · 2022: 29 · 2021: 38 · 2020: 32 · 2019: 27 · 2018: 27 · 2017: 15 · 2016: 4
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biomedical Materials (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- decellularized extracellular matrix, tissue engineering scaffolds, regenerative medicine, clinical application, biomaterials, tissue grafting, autograft alternative, tissue reconstruction
- MeSH terms
- Animals, Biocompatible Materials, Extracellular Matrix, Humans, Plastic Surgery Procedures, Tissue Engineering, Regenerative Medicine, Tissue Scaffolds
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review