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MUC1: a multifaceted oncoprotein with a key role in cancer progression
Open accessAbstract
The transmembrane glycoprotein Mucin 1 (MUC1) is aberrantly glycosylated and overexpressed in a variety of epithelial cancers, and plays a crucial role in progression of the disease. Tumor-associated MUC1 differs from the MUC1 expressed in normal cells with regard to its biochemical features, cellular distribution, and function. In cancer cells, MUC1 participates in intracellular signal transduction pathways and regulates the expression of its target genes at both the transcriptional and post-transcriptional levels. This review highlights the structural and functional differences that exist between normal and tumor-associated MUC1. We also discuss the recent advances made in the use of MUC1 as a biomarker and therapeutic target for cancer.
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Lakshminarayanan, V., Thompson, P., Wolfert, M. A., Buskas, T., Bradley, J. M., Pathangey, L. B., Madsen, C. S., Cohen, P. A., Gendler, S. J., & Boons, G.-J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115166109 · Cited by 301
Cited by
Zhong, Q., Xiao, X., Qiu, Y., Xu, Z., Chen, C., Chong, B., Zhao, X., Hai, S., Li, S., An, Z., et al. (2023) · MedComm · doi:10.1002/mco2.261 · Cited by 442
An overview of mammographic density and its association with breast cancer
Nazari, S. S., & Mukherjee, P. (2018) · Breast Cancer · doi:10.1007/s12282-018-0857-5 · Cited by 298
Self-citationTrial watch: TLR3 agonists in cancer therapy
Le Naour, J., Galluzzi, L., Zitvogel, L., Kroemer, G., & Vacchelli, E. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1771143 · Cited by 239
Magnetic Resonance Imaging and Iron-oxide Nanoparticles in the era of Personalized Medicine
Rahman, M. (2023) · Nanotheranostics · doi:10.7150/ntno.86467 · Cited by 244
MUC1 (CD227): a multi-tasked molecule
Apostolopoulos, V., Stojanovska, L., & Gargosky, S. E. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2014-z · Cited by 138
Metadata
- Authors
- Nath, S., & Mukherjee, P.
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 20
- Issue
- 6
- Pages
- 332-342
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W1978739865
- Cited by
- 837
- References
- 6
- FWCI
- 2.72
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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