The Dual Roles of NRF2 in Cancer

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Mutations in the Antioxidant KEAP1/NRF2 Pathway Define an Aggressive Subset of NSCLC Resistant to Conventional Treatments

Nadal, E., Palmero, R., & Muñoz‐Pinedo, C. (2019) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2019.08.005 · Cited by 29

The GTPase KRAS suppresses the p53 tumor suppressor by activating the NRF2-regulated antioxidant defense system in cancer cells

Yang, H., Xiang, S., Kazi, A., & Sebti, S. M. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011930 · Cited by 29

Gain-of-function genetic screen of the kinome reveals BRSK2 as an inhibitor of the NRF2 transcription factor

Tamir, T. Y., Bowman, B. M., Agajanian, M. J., Goldfarb, D., Schrank, T. P., Stohrer, T., Hale, A., Siesser, P. F., Weir, S., Murphy, R. M., et al. (2020) · Journal of Cell Science · doi:10.1242/jcs.241356 · Cited by 29

Interaction of ERα and NRF2 Impacts Survival in Ovarian Cancer Patients

Czogalla, B., Kahaly, M., Mayr, D. C., Schmoeckel, E., Niesler, B., Kolben, T., Burges, A., Mahner, S., Jeschke, U., & Trillsch, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010112 · Cited by 29

Ferroptosis-related signaling pathways in cancer drug resistance

Yang, Y., Yu, S., Liu, W., Zhuo, Y., Qu, C., & Zeng, Y. (2025) · Cancer Drug Resistance · doi:10.20517/cdr.2024.151 · Cited by 32

Gene regulatory effects of disease-associated variation in the NRF2 network

Lacher, S. E., & Slattery, M. G. (2016) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2016.09.001 · Cited by 27

Identification of TC2N as a novel promising suppressor of PI3K-AKT signaling in breast cancer

Hao, X., Gao, L., Deng, X., Han, F., Chen, H., JIANG, X. H., Liu, W., Wang, D., Chen, J.-P., Cui, Z.-H., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1663-5 · Cited by 28

The Taming of Nuclear Factor Erythroid-2-Related Factor-2 (Nrf2) Deglycation by Fructosamine-3-Kinase (FN3K)-Inhibitors-A Novel Strategy to Combat Cancers

Beeraka, N. M., Bovilla, V. R., Doreswamy, S. H., Puttalingaiah, S., Srinivasan, A., & Madhunapantula, S. V. (2021) · Cancers · doi:10.3390/cancers13020281 · Cited by 28

The antioxidant response in Barrett's tumorigenesis: A double-edged sword

Peng, D., Zaika, A. I., Que, J., & El-Rifai, W. M. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101894 · Cited by 28

Nrf2 signaling pathway in trace metal carcinogenesis: A cross-talk between oxidative stress and angiogenesis

Emami, M. H., Sereshki, N., Malakoutikhah, Z., Dehkordi, S. A. E., Fahim, A., Mohammadzadeh, S., & Maghool, F. (2022) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2022.109266 · Cited by 30

Proteomic Analysis of Human Sputum for the Diagnosis of Lung Disorders: Where Are We Today?

D’Amato, M., Iadarola, P., & Viglio, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105692 · Cited by 28

Critical Contribution of Nuclear Factor Erythroid 2-related Factor 2 (NRF2) to Electrophile-induced Interleukin-11 Production

Nishina, T., Deguchi, Y., Miura, R., Yamazaki, S., Shinkai, Y., Kojima, Y., Okumura, K., Kumagai, Y., & Nakano, H. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.744755 · Cited by 28

Chemopreventive Activities of Sulforaphane and Its Metabolites in Human Hepatoma HepG2 Cells

Liu, P., Wang, W., Zhou, Z., Smith, A. J. O., Bowater, R. P., Wormstone, I. M., Chen, Y., & Bao, Y. (2018) · Nutrients · doi:10.3390/nu10050585 · Cited by 27

Melanoma in the liver: Oxidative stress and the mechanisms of metastatic cell survival

Obrador, E., Salvador, R., López‐Blanch, R., Jihad-Jebbar, A., Alcácer, J., Benlloch, M., Pellicer, J. A., & Estrela, J. M. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.05.001 · Cited by 27

Catalase Overexpression Drives an Aggressive Phenotype in Glioblastoma

Flor, S., Oliva, C. R., Ali, M. Y., Coleman, K. L., Greenlee, J. D. W., Jones, K. A., Monga, V., & Griguer, C. E. (2021) · Antioxidants · doi:10.3390/antiox10121988 · Cited by 27

BACH1 Orchestrates Lung Cancer Metastasis

Anderson, N. M., & Simon, M. C. (2019) · Cell · doi:10.1016/j.cell.2019.06.020 · Cited by 27

Naturally-derived modulators of the Nrf2 pathway and their roles in the intervention of diseases

Wang, T., Liu, M., Li, X., Zhang, S., Gu, H., Wei, X., Wang, X., Xu, Z., & Shen, T. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.09.035 · Cited by 29

NRF2 level is negatively correlated with TGF-β1-induced lung cancer motility and migration via NOX4-ROS signaling

Ryu, D.-Y., Lee, J., & Kwak, M. (2020) · Archives of Pharmacal Research · doi:10.1007/s12272-020-01298-z · Cited by 27

Changes in Microbial Community Composition Related to Sex and Colon Cancer by Nrf2 Knockout

Song, C., Kim, N., Nam, R. H., Choi, S. I., Yu, J. E., Nho, H., & Surh, Y. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.636808 · Cited by 26

Naked Mole-Rats: Resistant to Developing Cancer or Good at Avoiding It?

Hadi, F., Smith, E. S. J., & Khaled, W. T. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-65943-1_14 · Cited by 26

The nexus between redox state and intermediary metabolism

Zoccarato, A., Nabeebaccus, A., Oexner, R. R., Santos, C. X. C., & Shah, A. M. (2021) · FEBS Journal · doi:10.1111/febs.16191 · Cited by 27

Metformin increases the radiosensitivity of non-small cell lung cancer cells by destabilizing NRF2

Sun, X., Dong, M., Gao, Y., Wang, Y., Du, L., Liu, Y., Wang, Q., Ji, K., He, N., Wang, J., et al. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.114981 · Cited by 26

NFR2/ABC transporter axis in drug resistance of breast cancer cells

Sargazi, Z., Yazdani, Y., Tahavvori, A., Youshanlouei, H. R., Alivirdiloo, V., Beilankouhi, E. A. V., & Valilo, M. (2023) · Molecular Biology Reports · doi:10.1007/s11033-023-08384-7 · Cited by 26

Potential Applications of NRF2 Inhibitors in Cancer Therapy

Panieri, E., & Saso, L. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/8592348 · Cited by 189

Potential Applications of NRF2 Modulators in Cancer Therapy

Panieri, E., Djordjević, A. B., Telkoparan‐Akillilar, P., Cevik, D., Kouretas, D., Veskoukis, A. S., Skaperda, Z., Tsatsakis, A. M., Wallace, D., Süzen, S., et al. (2020) · Antioxidants · doi:10.3390/antiox9030193 · Cited by 167

Implications of NRF2 in Cancer Progression and Therapeutics

Agrawal, M., & Agrawal, S. K. (2022) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-5422-0_79

Balancing Act: NRF2's contradictory roles in cancer progression and therapy

Demirezen, A., & Erbaş, O. (2024) · Demiroglu Science University Florence Nightingale Journal of Medicine · doi:10.5606/fng.btd.2024.160 · Cited by 1

Cytoprotection “gone astray’’: Nrf2 and its role in cancer

Schäfer, H., Geismann, C., Arlt, A., & Sebens, S. (2014) · OncoTargets and Therapy · doi:10.2147/ott.s36624 · Cited by 93