Cited by 637Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stressBioactive Compounds and Antitumor Agents

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The Dual Roles of NRF2 in Cancer

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Menegon, Silvia, Columbano, Amedeo, Giordano, Silvia·2016·Trends in Molecular Medicine

DOI 10.1016/j.molmed.2016.05.002

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Abstract

NRF2 has been traditionally considered as a tumor suppressor because its cytoprotective functions are deemed to be the main cellular defense mechanism against exogenous and endogenous insults, including xenobiotics and oxidative stress. However, several recent studies demonstrate that hyperactivation of the NRF2 pathway creates an environment that favors the survival of normal as well as malignant cells, protecting them against oxidative stress, chemotherapeutic agents, and radiotherapy. In a rapidly advancing field, this review summarizes some of the known mechanisms by which NRF2 can exert its oncogenic functions, and describes the current status of NRF2 inhibitors, providing a clear rationale for the consideration of NRF2 as a powerful putative therapeutic target in cancer treatment.

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“NRF2: Tumor Suppressor or Oncogene? The main function of the transcription factor NRF2 [also known as NFE2L2, nuclear factor (erythroid-derived-2)-like 2] is to activate the cellular antioxidant response by inducing the transcription of several genes to protect cells from the effects of exogenous and endogenous insult…”
Background
Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region
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Authors: Menegon, S., Columbano, A., & Giordano, S.
Affiliations: Candiolo Cancer Institute (IT)
University of Cagliari (IT)
Corresponding author: Menegon, Silvia
Columbano, Amedeo
Giordano, Silvia
ORCID: Menegon, Silvia
Columbano, Amedeo
Giordano, Silvia
Venue: Trends in Molecular Medicine
Publisher: Elsevier BV
Published: 2016-07
Volume: 22
Issue: 7
Pages: 578-593
ISSN: 1471-4914 (ISSN-L)
DOI: 10.1016/j.molmed.2016.05.002
OpenAlex: W2417535489
Cited by: 633
References: 114
Citations by year: 2026: 28 · 2025: 43 · 2024: 64 · 2023: 60 · 2022: 74 · 2021: 75 · 2020: 69 · 2019: 72 · 2018: 73 · 2017: 57 · 2016: 16
FWCI: 6.58
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Molecular Medicine (publishedVersion)
PubMed (publishedVersion)
Institutional Research Information System University of Turin (University of Turin) (submittedVersion, cc-by-nc-nd)
UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
Funders: Associazione Italiana per la Ricerca sul Cancro (15464, 15279, IG-15279)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
Keywords: Nrf2, Nrf2 signaling, oncogenic function, tumor suppressor, oxidative stress, chemoresistance, radioresistance (biology), Nrf2 inhibitors, therapeutic target, cancer
MeSH terms: Kelch-Like ECH-Associated Protein 1, Animals, Antineoplastic Agents, Humans, Mutation, Neoplasms, Signal Transduction, Gene Expression Regulation, Neoplastic, Oxidative Stress, MicroRNAs, Epigenesis, Genetic, NF-E2-Related Factor 2, Drug Discovery, Molecular Targeted Therapy

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The Dual Roles of NRF2 in Cancer

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