The Dual Roles of NRF2 in Cancer

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Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634

The Consensus Coding Sequences of Human Breast and Colorectal Cancers

Sjöblom, T., Jones, S., Wood, L. D., Parsons, D. W., Lin, J., Barber, T. D., Mandelker, D. L., Leary, R. J., Ptak, J., Silliman, N., et al. (2006) · Science · doi:10.1126/science.1133427 · Cited by 3,161

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

Komatsu, M., Kurokawa, H., Waguri, S., Taguchi, K., Kobayashi, A., Ichimura, Y., Sou, Y.-S., Ueno, I., Sakamoto, A., Tong, K. I., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2021 · Cited by 2,288

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

DeNicola, G. M., Karreth, F. A., Humpton, T. J., Gopinathan, A., Wei, C., Frese, K., Mangal, D., Yu, K. H., Yeo, C. J., Calhoun, E. S., et al. (2011) · Nature · doi:10.1038/nature10189 · Cited by 2,277

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Kobayashi, A., Kang, M.-I., Okawa, H., Ohtsuji, M., Zenke, Y., Chiba, T., Igarashi, K., & Yamamoto, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.16.7130-7139.2004 · Cited by 2,224

Nrf2–Keap1 defines a physiologically important stress response mechanism

Motohashi, H., & Yamamoto, M. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.09.003 · Cited by 1,725 · cited 1×

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

Moi, P., Chan, K., Asunis, I., Cao, A., & Kan, Y. W. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.9926 · Cited by 1,607

Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma

Guichard, C., Amaddeo, G., Imbeaud, S., Ladeiro, Y., Pelletier, L., Benmaad, I., Caldéraro, J., Bioulac‐Sage, P., Letexier, M., Degos, F., et al. (2012) · Nature Genetics · doi:10.1038/ng.2256 · Cited by 1,522

Association between glucose‐lowering treatment and cancer metastasis among patients with preexisting type 2 diabetes and incident malignancy

Noh, Y., Jeon, S., & Shin, S. (2018) · International Journal of Cancer · doi:10.1002/ijc.31870 · Cited by 28

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He, J., Zhang, Y., Luo, S., Zhao, Z., Mo, T., Guan, H., Li, H., Bian, Z., Zhang, X., Qiu, S., et al. (2025) · Drug Resistance Updates · doi:10.1016/j.drup.2025.101250 · Cited by 33

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Yen, C., & Hsiao, H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113503 · Cited by 25

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Xia, R. M., Tang, H., Shen, J., Xu, S., Liang, Y., Zhang, Y., Gong, X., Min, Y., Zhang, D., Tao, C., et al. (2021) · Cancer Cell International · doi:10.1186/s12935-021-01857-4 · Cited by 25

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Boonla, C. (2018) · InTech eBooks · doi:10.5772/intechopen.75366 · Cited by 24

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Cai, M., Chen, M., Ma, P., Wu, J., Lu, H., Zhang, S., Liu, J., Zhao, X., Zhuang, G., Yu, Z., et al. (2018) · International Journal of Cancer · doi:10.1002/ijc.31975 · Cited by 25

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Pomatto, L. C. D., Sun, P. Y., Yu, K., Gullapalli, S., Bwiza, C. P., Sisliyan, C., Wong, S., Zhang, H., Forman, H. J., Oliver, P. L., et al. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101194 · Cited by 25

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Lin, W. Y., Wang, X., Diao, M., Wang, Y., Zhao, R., Chen, J., Liao, Y., Long, Q., & Meng, Y. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03418-x · Cited by 26

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Dewanjee, S., Bhattacharya, H., Bhattacharyya, C., Chakraborty, P., Fleishman, J. S., Alexiou, A. T., Papadakis, M., & Jha, S. K. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01878-2 · Cited by 29

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Panigrahi, D. P., Bhol, C. S., Niveta, R., Nagini, S., Patil, S., Maiti, T. K., & Bhutia, S. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.11.079 · Cited by 24

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Li, Y., Qian, W., Wang, D., Meng, Y., Wang, X., Chen, Y., Li, X., Xie, C., Zhong, C., & Fu, S. (2018) · Journal of Applied Toxicology · doi:10.1002/jat.3636 · Cited by 24

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Levings, D. C., Pathak, S. S., Yang, Y., & Slattery, M. G. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102830 · Cited by 23

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El-Mahrouk, S. R., El‐Ghiaty, M. A., & El‐Kadi, A. O. S. (2024) · Journal of Environmental Sciences · doi:10.1016/j.jes.2024.02.027 · Cited by 26

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Rahmani, A. H., Almatroudi, A., Allemailem, K. S., Alharbi, H. O. A., Alwanian, W. M., Alhunayhani, B. A., Algahtani, M., Theyab, A., Almansour, N. M., Algefary, A. N., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11123205 · Cited by 22

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Tunc, R., Ateş, İ., Yılmaz, B., Medoro, A., Davinelli, S., Süzen, S., & Saso, L. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1701249 · Cited by 21

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Smith, R. E. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867326666190517113533 · Cited by 22

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Kobayashi, H., Imanaka, S., & Shigetomi, H. (2022) · Oncology Letters · doi:10.3892/ol.2022.13200 · Cited by 21

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Pan, H., Song, D., Wang, Z., Yang, X., Luo, P., Li, W., Li, Y., Gong, M., & Zhang, C. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2439534 · Cited by 22

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Czogalla, B., Kahaly, M., Mayr, D. C., Schmoeckel, E., Niesler, B., Hester, A., Zeder-Göß, C., Kolben, T., Burges, A., Mahner, S., et al. (2019) · Cancer Management and Research · doi:10.2147/cmar.s210004 · Cited by 21

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Orrù, C., Giordano, S., & Columbano, A. (2020) · Cancers · doi:10.3390/cancers12102932 · Cited by 21

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Zhou, J., Fang, F., Qi, J., Li, T., Zhang, L., Liu, H., Lv, J., Xu, T., Wu, F., Song, C., et al. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.10.274 · Cited by 20

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Jiang, Y., Ni, S., Xiao, B., & Jia, L. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.07.019 · Cited by 22

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Wang, C., & Cheng, L. (2017) · Investigational New Drugs · doi:10.1007/s10637-017-0474-8 · Cited by 19

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Grigolon, G., Araldi, E., Erni, R., Wu, J. Y., Thomas, C., Fortezza, M. L., Laube, B., Pöhlmann, D., Stoffel, M., Zarse, K., et al. (2022) · Nature Communications · doi:10.1038/s41467-021-27732-4 · Cited by 21

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Migration and invasion in B16‑F10 mouse melanoma cells are regulated by Nrf2 inhibition during treatment with ionizing radiation

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Selective killing of cancer cells harboring mutant RAS by concomitant inhibition of NADPH oxidase and glutathione biosynthesis

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The Enhanced Inhibitory Effect of Estrogen on PD-L1 Expression Following Nrf2 Deficiency in the AOM/DSS Model of Colitis-Associated Cancer

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SOCS1 Deficiency Promotes Hepatocellular Carcinoma via SOCS3-Dependent CDKN1A Induction and NRF2 Activation

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Research progress on antitumor mechanisms and molecular targets of Inula sesquiterpene lactones

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SOCS1 expression in cancer cells: potential roles in promoting antitumor immunity

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A small molecule targeting glutathione activates Nrf2 and inhibits cancer cell growth through promoting Keap-1 S -glutathionylation and inducing apoptosis

Wang, L., Qu, G., Gao, Y., Su, L., Ye, Q., Jiang, F., Zhao, B., & Miao, J. (2018) · RSC Advances · doi:10.1039/c7ra11935f · Cited by 17

Role of human Keap1 S53 and S293 residues in modulating the binding of Keap1 to Nrf2

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Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors

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Inhibition of Nrf2/HO-1 signaling pathway by Dextran Sulfate suppresses angiogenesis of Gastric Cancer

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Sulforaphane induces colorectal cancer cell proliferation through Nrf2 activation in a p53-dependent manner

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A composition of medicinal plants with an enhanced ability to suppress microsomal lipid peroxidation and a protective activity against carbon tetrachloride-induced hepatotoxicity

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Associations between the Nrf2/Keap1 pathway and mitochondrial functions in colorectal cancer are affected by metastasis

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Gene expression evaluation of antioxidant enzymes in patients with hepatocellular carcinoma: RT-qPCR and bioinformatic analyses

Alves, A. D. F., de Moura, A. C., Andreolla, H. F., da Veiga, A. B. G., Fiegenbaum, M., Giovenardi, M., & Almeida, S. (2021) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2019-0373 · Cited by 16

NRF2 as a ferroptosis gatekeeper in colorectal cancer: implications for therapy

El‐Sehrawy, A. A. M. A., Al-dulaimi, A. A., Alkhathami, A. G., RenukaJyothi, S., Panigrahi, R., Pargaien, A. V., Singh, U., Husseini, A., & Alnajar, M. J. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04324-3 · Cited by 16

NRF2-Driven KEAP1 Transcription in Human Lung Cancer

Tian, Y., Liu, Q., Yu, S., Chu, Q., Chen, Y., Wu, K., & Wang, L. (2020) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0108 · Cited by 15

The Keap1-Nrf2 signaling pathway regulates antioxidant defenses of Ctenopharyngodon idella induced by bacterial infection

Li, Y., Chen, Z., Xiao, Y., Gao, F., Zhan, F., Lu, Z., Huang, Z., Wei, X., Su, F., Shi, F., et al. (2023) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2023.108686 · Cited by 15

Mitophagy in tumor: foe or friend？

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Isoliquiritigenin as a modulator of the Nrf2 signaling pathway: potential therapeutic implications

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Bullous Pemphigoid Associated with the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin in a Patient with Liver Cirrhosis Complicated with Rapidly Progressive Hepatocellular Carcinoma

Harada, M., Yoneda, A., Haruyama, S., Yabuki, K., Honma, Y., Hiura, M., Shibata, M., Matsuoka, H., & Uchiwa, Y. (2017) · Internal Medicine · doi:10.2169/internalmedicine.8703-16 · Cited by 15

PML/RARa Interferes with NRF2 Transcriptional Activity Increasing the Sensitivity to Ascorbate of Acute Promyelocytic Leukemia Cells

Banella, C., Catalano, G., Travaglini, S., Divona, M., Masciarelli, S., Guerrera, G., Fazi, F., Lo‐Coco, F., Voso, M. T., & Noguera, N. I. (2019) · Cancers · doi:10.3390/cancers12010095 · Cited by 15

The anticarcinogenic effect of eugenol on lung cancer induced by diethylnitrosamine/2-acetylaminofluorene in Wistar rats: insight on the mechanisms of action

Morsy, H. M., Ahmed, O. M., Zoheir, K. M. A., & Abdel‐Moneim, A. (2023) · APOPTOSIS · doi:10.1007/s10495-023-01852-2 · Cited by 15

Potential Applications of NRF2 Inhibitors in Cancer Therapy

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Potential Applications of NRF2 Modulators in Cancer Therapy

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Implications of NRF2 in Cancer Progression and Therapeutics

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Balancing Act: NRF2's contradictory roles in cancer progression and therapy

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Cytoprotection “gone astray’’: Nrf2 and its role in cancer

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