Controlling the biodistribution and clearance of nanomedicines
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
PDA-mediated oral tumor therapy faces unresolved issues including limited NIR penetration, possible thermal injury to adjacent normal tissues, biodistribution, clearance, and long-term safety.
“Issues such as limited NIR penetration, possible thermal injury to adjacent normal tissues, biodistribution, clearance, and long-term safety still require systematic evaluation before clinical translation.85”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [85]
In vitro tumor cell studies and selected animal tumor models support NIR-mediated photothermal therapy, drug loading, controlled release, and chemo-photothermal synergistic effects for PDA-based oral tumor therapy.
“In vitro tumor cell studies and selected animal tumor models support NIR-mediated photothermal therapy, drug loading, controlled release, and chemo-photothermal synergistic effects.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [85]
Cites
Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
Jain, R. K. (2005) · Science · doi:10.1126/science.1104819 · Cited by 5,527 · cited 2× · see citing works
“Repairing the structure and function of the vascular network can improve tumour perfusion and oxygenation 223 , thereby enhancing drug delivery and decreasing tumour hypoxia, which in turn can decrease tumour malignancy, set an immunostimulatory microenvironment 223,224 and improve the therapeutic…”
Tensional homeostasis and the malignant phenotype
Paszek, M. J., Zahir, N., Johnson, K. R., Lakins, J. N., Rozenberg, G. I., Gefen, A., Reinhart-King, C. A., Margulies, S. S., Dembo, M., Boettiger, D., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.010 · Cited by 3,941 · cited 1× · see citing works
“…CAFs) and acellular (ECM) components of the stroma 234,235 ; for example, during tumour progression, CAFs overproduce ECM proteins (collagen I, elastin, fibronectin and hyaluronan), secrete growth factors and modify the tumour tissue through contractile forces, thereby building up stress 236,237 .”
Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size
Cabral, H., Matsumoto, Y., Mizuno, K., Chen, Q., Murakami, M., Kimura, M., Terada, Y., Kano, M. R., Miyazono, K., Uesaka, M., et al. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.166 · Cited by 2,429 · see citing works
Self-citationThe Tumour Microenvironment after Radiotherapy: Mechanisms of Resistance and Recurrence
Barker, H. E., Paget, J. T. E., Khan, A. A., & Harrington, K. J. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3958 · Cited by 2,144 · see citing works
Clinical trial of blood-brain barrier disruption by pulsed ultrasound
Carpentier, A., Canney, M., Vignot, A., Reina, V., Beccaria, K., Horodyckid, C., Karachi, C., Leclercq, D., Lafon, C., Chapelon, J.-Y., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf6086 · Cited by 757 · see citing works
Gunaydin, G., Gedik, M. E., & Ayan, S. (2021) · Frontiers in Chemistry · doi:10.3389/fchem.2021.686303 · Cited by 402 · see citing works
A review of magnet systems for targeted drug delivery
Liu, Y.-L., Chen, D., Shang, P., & Yin, D.-C. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.03.031 · Cited by 298 · see citing works
Wilson, M. W., Kerlan, R. K., Fidelman, N. A., Venook, A. P., LaBerge, J. M., Koda, J., & Gordon, R. L. (2004) · Radiology · doi:10.1148/radiol.2301021493 · Cited by 190 · see citing works
Role of the methoxy group in immune responses to mPEG-protein conjugates
Sherman, M. R., Williams, L. D., Sobczyk, M. A., Michaels, S. J., & Saifer, M. G. P. (2012) · Bioconjugate Chemistry · doi:10.1021/bc200551b · Cited by 185 · see citing works
Evaluation of nanomedicines: stick to the basics
McNeil, S. E. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.73 · Cited by 126 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Clinical translation of nanomedicines for brain diseases: Current challenges and future directions
Wang, G., Wang, N., Xia, X., Ismail, M., & Shi, B. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114426 · Cited by 33 · see citing works
Yang, Z., Song, W., Lv, L., Zhai, S., Liu, Y., Cui, H., Li, X., Gao, F., & Chu, S. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s611922
“85”
- Authors
- Cabral, H., Li, J., Miyata, K., & Kataoka, K.
- Affiliations
- The University of Tokyo (JP)
- Kyushu University (JP)
- Innovation Center of NanoMedicine (JP)
- Corresponding author
- Cabral, Horacio
- Kataoka, Kazunori
- Venue
- Nature Reviews Bioengineering
- Published
- 2023-12-20
- Volume
- 2
- Issue
- 3
- Pages
- 214-232
- ISSN
- 2731-6092 (ISSN-L)
- OpenAlex
- W4389992857
- Cited by
- 303
- References
- 10
- Citations by year
- 2026: 144 · 2025: 97 · 2024: 61 · 2023: 1
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature Reviews Bioengineering (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (23K28429)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- nanomedicine, tissue distribution, pharmacokinetics, clearance, blood circulation, clinical translation, size tuning, active targeting, transcytosis, stimuli-responsive nanocarriers, COVID-19 vaccines, drug delivery barriers
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
