Cited by 76Barrier Structure and Function StudiesNeuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and Treatments

Emerging pathogenic role of peripheral blood factors following BBB disruption in neurodegenerative disease

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Jeon, Min-Tae, Kim, Kyu-Sung, Kim, Eun Seon, Lee, Suji, Kim, Jieun, Hoe, Hyang-Sook, Kim, Do-Geun·2021·Ageing Research Reviews

Abstract

The responses of central nervous system (CNS) cells such as neurons and glia in neurodegenerative diseases (NDs) suggest that regulation of neuronal and glial functions could be a strategy for ND prevention and/or treatment. However, attempts to develop such therapeutics for NDs have been hindered by the challenge of blood-brain barrier (BBB) permeability and continued constitutive neuronal loss. These limitations indicate the need for additional perspectives for the prevention/treatment of NDs. In particular, the disruption of the blood-brain barrier (BBB) that accompanies NDs allows brain infiltration by peripheral factors, which may stimulate innate immune responses involved in the progression of neurodegeneration. The accumulation of blood factors like thrombin, fibrinogen, c-reactive protein (CRP) and complement components in the brain has been observed in NDs and may activate the innate immune system in the CNS. Thus, strengthening the integrity of the BBB may enhance its protective role to attenuate ND progression and functional loss. In this review, we describe the innate immune system in the CNS and the contribution of blood factors to the role of the CNS immune system in neurodegeneration and neuroprotection.

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Authors
Jeon, M.-T., Kim, K.-S., Kim, E. S., Lee, S., Kim, J., Hoe, H.-S., & Kim, D.-G.
Affiliations
  • Korea Brain Research Institute (KR)
  • Daegu Gyeongbuk Institute of Science and Technology (KR)
  • King's College London (GB)
Corresponding author
  • Hoe, Hyang-Sook
  • Kim, Do-Geun
Venue
Ageing Research Reviews
Publisher
Elsevier BV
Published
2021-07
Volume
68
Pages
101333
ISSN
1568-1637 (ISSN-L)
OpenAlex
W3138731251
Cited by
76
References
210
Citations by year
2026: 10 · 2025: 17 · 2024: 15 · 2023: 14 · 2022: 16 · 2021: 4
FWCI
1.43
Type
journal article
Language
en
Open access
Locations
  • Ageing Research Reviews (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
National Research Foundation of Korea
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords
blood-brain barrier disruption, neurodegenerative diseases, innate immunity, thrombin, fibrinogen, C-reactive protein, complement system, neuroinflammation, neuroprotection, glial cells, blood-brain barrier integrity
MeSH terms
Blood-Brain Barrier, Brain, Central Nervous System, Humans, Neuroglia, Neurodegenerative Diseases

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