CoChat
Sign Up
Cited by 233Fibroblast Growth Factor ResearchDiet, Metabolism, and DiseaseDietary Effects on Health

The DOI matches its Crossref record; 45 of the 47 references it cites were found in a registry or an index.

Fructose ingestion acutely stimulates circulating FGF21 levels in humans

Open access
Dushay, Jody R., Toschi, Elena, Mitten, Emilie K., Fisher, Ffolliott M., Herman, Mark A., Maratos-Flier, Eleftheria·2015·Molecular Metabolism
DOI 10.1016/j.molmet.2014.09.008PMC PMC4314524
Open this paper in CoChat — free account

Abstract

OBJECTIVE: Fibroblast growth factor 21 (FGF21) is a hormone with pleiotropic metabolic activities which, in rodents, is robustly regulated by fasting and ketogenic diets. In contrast, similar dietary interventions have either no or minimal effects on circulating FGF21 in humans. Moreover, no intervention or dietary challenge has been shown to acutely stimulate circulating FGF21 in either humans or animals. Recent animal data suggest that the transcription factor Carbohydrate Responsive-Element Binding Protein (ChREBP) stimulates hepatic FGF21 expression and that fructose may activate hepatic ChREBP more robustly than glucose. Here, we examined whether fructose ingestion can acutely stimulate FGF21 in humans. METHODS: We measured serum FGF21, glucose, insulin, and triglyceride levels in ten lean, healthy adults and eleven adults with the metabolic syndrome following oral ingestion of 75 g of glucose, fructose, or a combination of the two sugars. RESULTS: FGF21 levels rose rapidly following fructose ingestion, achieved a mean 3.4-fold increase at two hours (P < 0.01), and returned to baseline levels within five hours. In contrast, FGF21 did not increase in the first two hours following ingestion of a glucose load, although more modest increases were observed after three to four hours. Both baseline and fructose-stimulated FGF21 levels were 2-3 fold elevated in subjects with metabolic syndrome. CONCLUSIONS: Fructose ingestion acutely and robustly increases serum FGF21 levels in humans in a pattern consistent with a hormonal response. While FGF21 appears to be critical for the adaptive response to fasting or starvation in rodents, these findings suggest that in humans, FGF21 may play an important role in fructose metabolism.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.molmet.2014.09.008

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Show all 47 references

2 of the 47 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Items 101–200 of 233

Related

See all

Metadata

Authors
Dushay, J. R., Toschi, E., Mitten, E. K., Fisher, F. M., Herman, M. A., & Maratos-Flier, E.
Affiliations
  • Beth Israel Deaconess Medical Center (US)
  • Broad Institute (US)
Corresponding author
Herman, Mark A.
ORCID
Venue
Molecular Metabolism
Publisher
Elsevier BV
Published
2015-01
Volume
4
Issue
1
Pages
51-57
ISSN
2212-8778 (ISSN-L)
DOI
10.1016/j.molmet.2014.09.008
PMC
PMC4314524
OpenAlex
W2048578282
Cited by
233
References
47
Citations by year
2026: 12 · 2025: 17 · 2024: 19 · 2023: 16 · 2022: 22 · 2021: 22 · 2020: 14 · 2019: 28 · 2018: 20 · 2017: 29 · 2016: 22 · 2015: 11
FWCI
8.60
Type
journal article
Language
en
Open access
Licence
Locations
  • Molecular Metabolism (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DukeSpace (Duke University) (submittedVersion, cc-by-nc-nd)
Funders
  • JPB Foundation (8UL1TR000170-05)
  • Harvard Catalyst/Harvard Clinical and Translational Science Center (1UL1 TR001102-01)
  • EMF (R01DK028082)
  • MAH (P30DK057521, R01DK100425)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
Keywords
fructose, FGF21, glucose, carbohydrate-responsive element-binding protein, ChREBP, metabolic syndrome, fructose metabolism, insulin, triglycerides, fasting response

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review