The DOI matches its Crossref record; 119 of the 120 references it cites were found in a registry or an index.
Sex differences underlying pancreatic islet biology and its dysfunction
Open accessAbstract
BACKGROUND: The sex of an individual affects glucose homeostasis and the pathophysiology, incidence, and prevalence of diabetes as well as the response to therapy. SCOPE OF THE REVIEW: This review focuses on clinical and experimental sex differences in islet cell biology and dysfunction during development and in adulthood in human and animal models. We discuss sex differences in β-cell and α-cell function, heterogeneity, and dysfunction. We cover sex differences in communication between gonads and islets and islet-cell immune interactions. Finally, we discuss sex differences in β-cell programming by nutrition and other environmental factors during pregnancy. MAJOR CONCLUSIONS: Important sex differences exist in islet cell function and susceptibility to failure. These differences represent sex-related biological factors that can be harnessed for gender-based prevention of and therapy for diabetes.
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“and thus increased methylation of the DUSP9 gene could act as a risk factor for insulin resistance and T2DM [83].”
From Sex Differences in Response to Treatment with Glucagon-like Peptide 1 Receptor Agonists: Opportunities for a Tailored Approach to Diabetes and Obesity Care (2022) · cites this paper as [83]
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Cites
Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity
Markle, J. G. M., Frank, D. N., Mortin-Toth, S., Robertson, C. E., Feazel, L. M., Rolle-Kampczyk, U., von Bergen, M., McCoy, K. D., Macpherson, A. J., & Danska, J. S. (2013) · Science · doi:10.1126/science.1233521 · Cited by 2,025
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“Information generated from studies of pancreas development and endocrine differentiation from multiple organisms has resulted in multistep directed-differentiation protocols that can convert human embryonic stem cells (hESCs) into pancreatic progenitor cells, which, several months following implantation into immunocom…”
BackgroundInfluentialEpidemiology and estimated population burden of selected autoimmune diseases in the United States
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Diabetes and cardiovascular disease during androgen deprivation therapy for prostate cancer
Keating, N. L., O'Malley, A. J., & Smith, M. R. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.06.2497 · Cited by 1,455
Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring
Ng, S.-F., Lin, R. C. Y., Laybutt, D. R., Barres, R., Owens, J. A., & Morris, M. J. (2010) · Nature · doi:10.1038/nature09491 · Cited by 1,327
Genetics, pathogenesis and clinical interventions in type 1 diabetes
Bluestone, J. A., Herold, K., & Eisenbarth, G. (2010) · Nature · doi:10.1038/nature08933 · Cited by 1,265
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Gender Bias in Autoimmunity Is Influenced by Microbiota
Yurkovetskiy, L., Burrows, M. P., Khan, A. A., Graham, L., Volchkov, P., Becker, L., Antonopoulos, D. A., Umesaki, Y., & Chervonsky, A. V. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.013 · Cited by 943
Sex differences in metabolic homeostasis, diabetes, and obesity
Mauvais-Jarvis, F. (2015) · Biology of Sex Differences · doi:10.1186/s13293-015-0033-y · Cited by 626
Self-citationKeating, N. L., O'Malley, A. J., Freedland, S. J., & Smith, M. R. (2010) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djp404 · Cited by 622
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Goossens, G. H., Jocken, J. W. E., & Blaak, E. E. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-00431-8 · Cited by 359
Streptozotocin as a tool for induction of rat models of diabetes: a practical guide
Ghasemi, A., & Jeddi, S. (2022) · EXCLI journal · doi:10.17179/excli2022-5720 · Cited by 273
Sex differences in energy metabolism: natural selection, mechanisms and consequences
Mauvais‐Jarvis, F. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00781-2 · Cited by 174
Self-citationRentzeperi, E., Pegiou, S., Koufakis, T., Grammatiki, M., & Kotsa, K. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12030454 · Cited by 140
Hepatic sexual dimorphism — implications for non-alcoholic fatty liver disease
Lefèbvre, P., & Staels, B. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00538-6 · Cited by 121
Metadata
- Authors
- Gannon, M., Kulkarni, R. N., Tse, H. M., & Mauvais-Jarvis, F.
- Affiliations
- VA Tennessee Valley Healthcare System (US)
- Joslin Diabetes Center (US)
- University of Alabama at Birmingham (US)
- Venue
- Molecular Metabolism
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 15
- Pages
- 82-91
- ISSN
- 2212-8778 (ISSN-L)
- PMC
- PMC6066785
- OpenAlex
- W2806507802
- Cited by
- 133
- References
- 120
- Citations by year
- 2026: 13 · 2025: 18 · 2024: 14 · 2023: 17 · 2022: 23 · 2021: 27 · 2020: 10 · 2019: 7 · 2018: 3
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecular Metabolism (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Juvenile Diabetes Research Foundation United States of America (BX003725, 2 -SRA-2016-270-S-B, R01 DK107444, R01 DK074970, 2-PNF-2016-322-S-B)
- National Institutes of Health (R01 DK105689, 2R24 DK090964-06)
- U.S. Department of Veterans Affairs (BX003744, R01 DK099550, R01 DK103215, R01 DK67536)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
- Keywords
- sex differences, pancreatic islets, beta-cell dysfunction, alpha-cell dysfunction, islet heterogeneity, pregnancy, nutrition, diabetes susceptibility, glucose homeostasis
- MeSH terms
- Animals, Diabetes Mellitus, Humans, Islets of Langerhans, Sex Characteristics, Gonadal Hormones
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