Sex differences underlying pancreatic islet biology and its dysfunction

Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity

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Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

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Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

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Genetics, pathogenesis and clinical interventions in type 1 diabetes

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DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific

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Gender Bias in Autoimmunity Is Influenced by Microbiota

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Sex differences in metabolic homeostasis, diabetes, and obesity

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Diabetes and Cardiovascular Disease During Androgen Deprivation Therapy: Observational Study of Veterans With Prostate Cancer

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Sexual dimorphism in cardiometabolic health: the role of adipose tissue, muscle and liver

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Streptozotocin as a tool for induction of rat models of diabetes: a practical guide

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Sex differences in energy metabolism: natural selection, mechanisms and consequences

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Sex Differences in Response to Treatment with Glucagon-like Peptide 1 Receptor Agonists: Opportunities for a Tailored Approach to Diabetes and Obesity Care

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Hepatic sexual dimorphism — implications for non-alcoholic fatty liver disease

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A distinct hypothalamus-to-β cell circuit modulates insulin secretion

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Delineating mouse β-cell identity during lifetime and in diabetes with a single cell atlas

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The Association of Adiponectin and Visceral Fat with Insulin Resistance and β-Cell Dysfunction

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Sex modifies placental gene expression in response to metabolic and inflammatory stress

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Exposure to maternal obesity programs sex differences in pancreatic islets of the offspring in mice

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The β Cell in Diabetes: Integrating Biomarkers With Functional Measures

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Sex differences in islet stress responses support female β cell resilience

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Implantable niche with local immunosuppression for islet allotransplantation achieves type 1 diabetes reversal in rats

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Developmental mechanisms of sex differences: from cells to organisms

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Pancreatic β-cell senescence in diabetes: mechanisms, markers and therapies

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G protein-coupled estrogen receptor activation by bisphenol-A disrupts the protection from apoptosis conferred by the estrogen receptors ERα and ERβ in pancreatic beta cells

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Exposure to Perfluoroalkyl Substances and Glucose Homeostasis in Youth

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Glucose-induced insulin secretion in isolated human islets: Does it truly reflect β-cell function in vivo?

Henquin, J. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101212 · Cited by 48

Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males

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The sex and gender dimensions of COVID-19: A narrative review of the potential underlying factors

Mourosi, J. T., Anwar, S., & Hosen, M. J. (2022) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2022.105338 · Cited by 51

Sex Differences in the Molecular Programs of Pancreatic Cells Contribute to the Differential Risks of Type 2 Diabetes

Yong, H. J., Toledo, M. P., Nowakowski, R. S., & Wang, Y. J. (2022) · Endocrinology · doi:10.1210/endocr/bqac156 · Cited by 45

Sex Differences in Pancreatic β-Cell Physiology and Glucose Homeostasis in C57BL/6J Mice

Jo, S., Beetch, M., Gustafson, E. C., Wong, A., Oribamise, E. I., Chung, G., Vadrevu, S., Satin, L. S., Bernal‐Mizrachi, E., & Alejandro, E. U. (2023) · Journal of the Endocrine Society · doi:10.1210/jendso/bvad099 · Cited by 38

Rising tide: the growing global burden and inequalities of early-onset type 2 diabetes among youths aged 15–34 years (1990–2021)

Zhou, Y., Chen, Y., Tang, Y., Zhang, S., Zhuang, Z., & Ni, Q. (2025) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-025-01673-0 · Cited by 37

Statistical inference of differential RNA-editing sites from RNA-sequencing data by hierarchical modeling

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Adrb2 controls glucose homeostasis by developmental regulation of pancreatic islet vasculature

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Metformin: Sex/Gender Differences in Its Uses and Effects—Narrative Review

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Excitotoxicity and Overnutrition Additively Impair Metabolic Function and Identity of Pancreatic β-Cells

Osipovich, A. B., Stancill, J. S., Cartailler, J., Dudek, K. D., & Magnuson, M. A. (2020) · Diabetes · doi:10.2337/db19-1145 · Cited by 28

Intracrine Testosterone Activation in Human Pancreatic β-Cells Stimulates Insulin Secretion

Xu, W., Schiffer, L., Qadir, M. M. F., Zhang, Y., Hawley, J. M., de Sa, P. M., Keevil, B. G., Wu, H., Arlt, W., & Mauvais‐Jarvis, F. (2020) · Diabetes · doi:10.2337/db20-0228 · Cited by 27

Peripheral mechanisms of acute olanzapine induced metabolic dysfunction: A review of in vivo models and treatment approaches

Shamshoum, H., Medak, K. D., & Wright, D. C. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.113049 · Cited by 27

Intestinal Gpr17 deficiency improves glucose metabolism by promoting GLP-1 secretion

Yan, S., Conley, J. M., Reilly, A. M., Stull, N. D., Abhyankar, S. D., Ericsson, A. C., Kono, T., Molosh, A. I., Kubal, C. A., Evans‐Molina, C., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2021.110179 · Cited by 26

Wnt4 is heterogeneously activated in maturing β-cells to control calcium signaling, metabolism and function

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Proteomic pathways to metabolic disease and type 2 diabetes in the pancreatic islet

Yau, B., Naghiloo, S., Díaz‐Vegas, A., Carr, A. V., van Gerwen, J., Needham, E. J., Jevon, D., Chen, S.-Y., Hoehn, K. L., Brandon, A. E., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103099 · Cited by 24

Developmental Timing of High-Fat Diet Exposure Impacts Glucose Homeostasis in Mice in a Sex-Specific Manner

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Transgene-associated human growth hormone expression in pancreatic β-cells impairs identification of sex-based gene expression differences

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Sex-specific regulatory architecture of pancreatic islets from subjects with and without type 2 diabetes

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Exercise mode influences post‐exercise glucose sensitivity and insulin clearance in young, healthy males and females in a sex‐dependent manner: A randomized control trial

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Metabolic Messengers: oestradiol

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Diabetes mellitus risk after hysterectomy

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Offspring of Obese Dams Exhibit Sex-Differences in Pancreatic Heparan Sulfate Glycosaminoglycans and Islet Insulin Secretion

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Heterogeneous enhancer states orchestrate β cell responses to metabolic stress

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Impaired Glucose Homeostasis in a Tau Knock-In Mouse Model

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A New Hypothesis for Type 1 Diabetes Risk: The At-Risk Allele at rs3842753 Associates With Increased Beta-Cell INS Messenger RNA in a Meta-Analysis of Single-Cell RNA-Sequencing Data

Wang, S., Flibotte, S., Camuñas-Soler, J., MacDonald, P. E., & Johnson, J. D. (2021) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2021.03.007 · Cited by 21

Human and molecular genetics shed lights on fatty liver disease and diabetes conundrum

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Sex differences feed into nuclear receptor signaling along the digestive tract

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Galectin-1 impacts on glucose homeostasis by modulating pancreatic insulin release

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Deconstructing the origins of sexual dimorphism in sensory modulation of pancreatic β cells

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Prolonged Islet Allograft Function is Associated With Female Sex in Patients After Islet Transplantation

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Aging of human endocrine pancreatic cell types is heterogeneous and sex-specificPreprint

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GLP-1 agonists and changes in body mass and composition in adults with overweight or obesity with or without type 2 diabetes mellitus: a systematic review and meta-analysis

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Towards the development of a female animal model of T1DM using hyaluronic acid nanocoated cell transplantation: refinements and considerations for future protocols

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Autocrine IGF2 programmes β-cell plasticity under conditions of increased metabolic demand

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Multipollutant, longitudinal analysis of the association between urinary tungsten and incident diabetes in a rural population

Riseberg, E., James, K. A., Woodin, M., Melamed, R., Alderete, T. L., & Corlin, L. (2021) · Environmental Epidemiology · doi:10.1097/ee9.0000000000000173 · Cited by 13

Molecular mechanism responsible for sex differences in electrical activity of mouse pancreatic β cells

Jacobo-Piqueras, N., Theiner, T., Geisler, S. M., & Tuluc, P. (2024) · JCI Insight · doi:10.1172/jci.insight.171609 · Cited by 13

Sex differences impact the pancreatic response to chronic immobilization stress in rats

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Investigating the protective effects of estrogen on β-cell health and the progression of hyperglycemia-induced atherosclerosis

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Species-specific roles for the MAFA and MAFB transcription factors in regulating islet β cell identity

Cha, J., Tong, X., Walker, E. M., Dahan, T., Cochrane, V. A., Ashe, S., Russell, R., Osipovich, A. B., Mawla, A. M., Guo, M. A., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.166386 · Cited by 12

Non-glucose modulators of insulin secretion in healthy humans: (dis)similarities between islet and in vivo studies

Henquin, J. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154821 · Cited by 13

Anti-obesity and anti-diabetic effects of L-citrulline are sex-dependent

Bagheripour, F., Jeddi, S., Kashfi, K., & Ghasemi, A. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122432 · Cited by 12

Novel secreted regulators of glucose and lipid metabolism in the development of metabolic diseases

Wat, L. W., & Svensson, K. J. (2024) · Diabetologia · doi:10.1007/s00125-024-06253-x · Cited by 13

Light modulates glucose and lipid homeostasis via the sympathetic nervous system

Chen, X., Lin, E., Haghighatian, M. M., Shepard, L. W., Hattar, S. S., Kuruvilla, R., & Zhao, H. (2024) · Science Advances · doi:10.1126/sciadv.adp3284 · Cited by 11

Sex-based impact of pancreatic islet stressors in GluCreERT2/Rosa26-eYFP mice

Tanday, N., Coulter‐Parkhill, A., Moffett, R. C., Suruli, K., Dubey, V., Flatt, P. R., & Irwin, N. (2023) · Journal of Endocrinology · doi:10.1530/joe-23-0174 · Cited by 10

Consideration of sex as a biological variable in diabetes research across twenty years

Cherian, C. M., Reeves, H., Silva, D. D., Tsao, S., Marshall, K. E., & Rideout, E. J. (2024) · Biology of Sex Differences · doi:10.1186/s13293-024-00595-2 · Cited by 13

Pancreatic islet β-cell subtypes are derived from biochemically-distinct and nutritionally-regulated islet progenitors

Brown, M. E., Miranda, V. E., Nevills, S., Hu, R., Dadi, P. K., Simmons, A. J., Xu, Y., Yang, Y., Yagan, M., Najam, S., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60831-0 · Cited by 10

Birth Order, Caesarean Section, or Daycare Attendance in Relation to Child- and Adult-Onset Type 1 Diabetes: Results from the German National Cohort

Tanoey, J., Bächle, C., Brenner, H., Deckert, A., Fricke, J., Günther, K., Karch, A., Keil, T. O. P., Kluttig, A., Leitzmann, M. F., et al. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191710880 · Cited by 11

Hedgehog Interacting Protein (Hhip) Regulates Insulin Secretion in Mice Fed High Fat Diets

Nchienzia, H., Liao, M.-C., Zhao, X. C., Chang, S., Lo, C., Chénier, I., Ingelfinger, J. R., Chan, J. S. D., & Zhang, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-47633-3 · Cited by 9

The Effects of Photobiomodulation Therapy on Porcine Islet Insulin Secretion

Huang, H.-H., Stillman, T. J., Branham, L. A., & Williams, S. (2022) · Photobiomodulation Photomedicine and Laser Surgery · doi:10.1089/photob.2022.0022 · Cited by 9

Use of c-peptide as a measure of cephalic phase insulin release in humans

Pullicin, A. J., Newsom, S. A., Robinson, M. M., & Lim, J. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113940 · Cited by 9

Renalase inhibition defends against acute and chronic β cell stress by regulating cell metabolism

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Identification and validation of reference genes for RT-qPCR analysis in fetal rat pancreas

Dai, Y., Kou, H., Guo, X.-L., Gong, Z., Liu, H., Liu, Y., Wang, H., & Guo, Y. (2021) · Reproductive Toxicology · doi:10.1016/j.reprotox.2021.09.009 · Cited by 8

More than meets the islet: aligning nutrient and paracrine inputs with hormone secretion in health and disease

Morriseau, T. S., Doucette, C. A., & Dolinsky, V. W. (2022) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00411.2021 · Cited by 9

DC-SIGN+ macrophages alleviate metabolic dysfunction-associated steatotic liver disease via fine-tuning TLR4 signaling and inflammatory secretory profiles

Liu, J., Wu, H., Zhou, L., Jin, Q., Ji, H., Hu, B., Wu, H., Chen, T., Wang, X., Hong, J., et al. (2026) · Metabolism · doi:10.1016/j.metabol.2025.156453 · Cited by 7

The MODY-associated KCNK16 L114P mutation increases islet glucagon secretion and limits insulin secretion resulting in transient neonatal diabetes and glucose dyshomeostasis in adults

Nakhe, A. Y., Dadi, P. K., Kim, J., Dickerson, M. T., Behera, S., Dobson, J. R., Shrestha, S., Cartailler, J., Sampson, L. L., Magnuson, M. A., et al. (2023) · eLife · doi:10.7554/elife.89967 · Cited by 8

Loss of mitogen‐activated protein kinase phosphate‐5 aggravates islet dysfunction in mice with type 1 and type 2 diabetes

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The flavonoid resokaempferol improves insulin secretion from healthy and dysfunctional pancreatic β‐cells

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Loss of growth hormone signaling in the mouse germline or in adulthood reduces islet mass and alters islet function with notable sex differences

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Steroidogenic factor 1 protects mice from obesity-induced glucose intolerance via improving glucose-stimulated insulin secretion by beta cells

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Sex differences in islet stress responses support female beta cell resiliencePreprint

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Sex differences in islet stress responses support female β cell resilience

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Biological sex affects human islet gene expression and mitochondrial function in type 2 diabetes

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