The DOI matches its Crossref record; 119 of the 120 references it cites were found in a registry or an index.
Sex differences underlying pancreatic islet biology and its dysfunction
Open accessAbstract
BACKGROUND: The sex of an individual affects glucose homeostasis and the pathophysiology, incidence, and prevalence of diabetes as well as the response to therapy. SCOPE OF THE REVIEW: This review focuses on clinical and experimental sex differences in islet cell biology and dysfunction during development and in adulthood in human and animal models. We discuss sex differences in β-cell and α-cell function, heterogeneity, and dysfunction. We cover sex differences in communication between gonads and islets and islet-cell immune interactions. Finally, we discuss sex differences in β-cell programming by nutrition and other environmental factors during pregnancy. MAJOR CONCLUSIONS: Important sex differences exist in islet cell function and susceptibility to failure. These differences represent sex-related biological factors that can be harnessed for gender-based prevention of and therapy for diabetes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“and thus increased methylation of the DUSP9 gene could act as a risk factor for insulin resistance and T2DM [83].”
From Sex Differences in Response to Treatment with Glucagon-like Peptide 1 Receptor Agonists: Opportunities for a Tailored Approach to Diabetes and Obesity Care (2022) · cites this paper as [83]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity
Markle, J. G. M., Frank, D. N., Mortin-Toth, S., Robertson, C. E., Feazel, L. M., Rolle-Kampczyk, U., von Bergen, M., McCoy, K. D., Macpherson, A. J., & Danska, J. S. (2013) · Science · doi:10.1126/science.1233521 · Cited by 2,025
Kroon, E., Martinson, L. A., Kadoya, K., Bang, A. G., Kelly, O. G., Eliazer, S., Young, H., Richardson, M., Smart, N. G., Cunningham, J., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1393 · Cited by 1,843 · cited 1×
“Information generated from studies of pancreas development and endocrine differentiation from multiple organisms has resulted in multistep directed-differentiation protocols that can convert human embryonic stem cells (hESCs) into pancreatic progenitor cells, which, several months following implantation into immunocom…”
BackgroundInfluentialEpidemiology and estimated population burden of selected autoimmune diseases in the United States
Jacobson, D. L., Gange, S. J., Rose, N. R., & Graham, N. M. H. (1997) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1997.4412 · Cited by 1,667
Diabetes and cardiovascular disease during androgen deprivation therapy for prostate cancer
Keating, N. L., O'Malley, A. J., & Smith, M. R. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.06.2497 · Cited by 1,455
Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring
Ng, S.-F., Lin, R. C. Y., Laybutt, D. R., Barres, R., Owens, J. A., & Morris, M. J. (2010) · Nature · doi:10.1038/nature09491 · Cited by 1,327
Genetics, pathogenesis and clinical interventions in type 1 diabetes
Bluestone, J. A., Herold, K., & Eisenbarth, G. (2010) · Nature · doi:10.1038/nature08933 · Cited by 1,265
Tobi, E. W., Lumey, L. H., Talens, R. P., Kremer, D., Putter, H., Stein, A. D., Slagboom, P. E., & Heijmans, B. T. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp353 · Cited by 1,173
Gender Bias in Autoimmunity Is Influenced by Microbiota
Yurkovetskiy, L., Burrows, M. P., Khan, A. A., Graham, L., Volchkov, P., Becker, L., Antonopoulos, D. A., Umesaki, Y., & Chervonsky, A. V. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.013 · Cited by 943
Sex differences in metabolic homeostasis, diabetes, and obesity
Mauvais-Jarvis, F. (2015) · Biology of Sex Differences · doi:10.1186/s13293-015-0033-y · Cited by 626
Self-citationKeating, N. L., O'Malley, A. J., Freedland, S. J., & Smith, M. R. (2010) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djp404 · Cited by 622
Sharif, S., Arreaza, G., Zucker, P., Mi, Q., Sondhi, J., Naidenko, O. V., Kronenberg, M., Koezuka, Y., Delovitch, T. L., Gombert, J., et al. (2001) · Nature Medicine · doi:10.1038/nm0901-1057 · Cited by 604
Serotonin regulates pancreatic beta cell mass during pregnancy
Kim, H., Toyofuku, Y., Lynn, F. C., Chak, E., Uchida, T., Mizukami, H., Fujitani, Y., Kawamori, R., Miyatsuka, T., Kosaka, Y., et al. (2010) · Nature Medicine · doi:10.1038/nm.2173 · Cited by 586
Hong, S., Wilson, M. T., Serizawa, I., Wu, L., Singh, N., Naidenko, O. V., Miura, T., Haba, T., Scherer, D. C., Wei, J., et al. (2001) · Nature Medicine · doi:10.1038/nm0901-1052 · Cited by 549
Cutting Edge: Estrogen Drives Expansion of the CD4+CD25+ Regulatory T Cell Compartment
Polanczyk, M. J., Carson, B. D., Subramanian, S., Afentoulis, M. E., Vandenbark, A. A., Ziegler, S. F., & Offner, H. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.4.2227 · Cited by 521
Impact of maternal obesity on offspring obesity and cardiometabolic disease risk
Drake, A. J., & Reynolds, R. M. (2010) · Reproduction · doi:10.1530/rep-10-0077 · Cited by 507
Pancreatic islet plasticity: Interspecies comparison of islet architecture and composition
Steiner, D. J., Kim, A., Miller, K. W. P., & Hara, M. (2010) · Islets · doi:10.4161/isl.2.3.11815 · Cited by 492
Khan, D., & Ahmed, S. A. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00635 · Cited by 475
Dunaif, A. E., & Finegood, D. T. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.3.8772555 · Cited by 457
Sex-Specific Differences in Lipid and Glucose Metabolism
Varlamov, O., Bethea, C. L., & Roberts, C. T. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00241 · Cited by 429
Mårtensson, U. E. A., Salehi, A. A., Windahl, S. H., Gomez, M. F., Swärd, K., Daszkiewicz-Nilsson, J., Wendt, A., Andersson, N., Hellstrand, P., Grände, P., et al. (2008) · Endocrinology · doi:10.1210/en.2008-0623 · Cited by 419
Human islets contain four distinct subtypes of β cells
Dorrell, C., Schug, J., Canaday, P. S., Russ, H. A., Tarlow, B., Grompe, M. T., Horton, T., Hebrok, M., Streeter, P. R., Kaestner, K. H., et al. (2016) · Nature Communications · doi:10.1038/ncomms11756 · Cited by 389
Gender differences in glucose homeostasis and diabetes
Mauvais-Jarvis, F. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.08.016 · Cited by 377
Self-citationInduction of regulatory T cells by physiological level estrogen
Tai, P., Wang, J., Jin, H., Song, X., Yan, J., Kang, Y., Zhao, L., An, X., Du, X., Chen, X., et al. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21221 · Cited by 359
Karnik, S. K., Chen, H., McLean, G. W., Heit, J. J., Gu, X., Zhang, A. Y., Fontaine, M., Yen, M. H., & Kim, S. K. (2007) · Science · doi:10.1126/science.1146812 · Cited by 353
Mauvais-Jarvis, F., Manson, J. E., Stevenson, J. C., & Fonseca, V. A. (2017) · Endocrine Reviews · doi:10.1210/er.2016-1146 · Cited by 341
Self-citationEffects of Age and Sex on Postprandial Glucose Metabolism
Basu, R., Dalla Man, C., Campioni, M., Basu, A., Klee, G., Toffolo, G., Cobelli, C., & Rizza, R. A. (2006) · Diabetes · doi:10.2337/db05-1692 · Cited by 334
Færch, K., Torekov, S. S., Vistisen, D., Johansen, N. B., Witte, D. R., Jonsson, A., Pedersen, O., Hansen, T., Lauritzen, T., Sandbæk, A., et al. (2015) · Diabetes · doi:10.2337/db14-1751 · Cited by 321
Influence of gender and menopause on gastric emptying and motility
Hutson, W. R., Roehrkasse, R. L., & Wald, A. M. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)90758-0 · Cited by 304
Ding, G., Wang, F., Shu, J., Tian, S., Jiang, Y., Zhang, D., Wang, N., Luo, Q., Zhang, Y., Jin, F., et al. (2012) · Diabetes · doi:10.2337/db11-1314 · Cited by 295
Ketosis-Prone Type 2 Diabetes in Patients of Sub-Saharan African Origin
Mauvais-Jarvis, F., Sobngwi, E., Porcher, R., Riveline, J.-P., Kevorkian, J.-P., Vaisse, C., Charpentier, G., Guillausseau, P.-J., Vexiau, P., & Gautier, J.-F. (2004) · Diabetes · doi:10.2337/diabetes.53.3.645 · Cited by 294
Self-citationThe role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis
Padgett, L. E., Broniowska, K. A., Hansen, P. A., Corbett, J. A., & Tse, H. M. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06826.x · Cited by 294
Self-citationHolte, J., Bergh, T., Berne, C., Berglund, L., & Lithell, H. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.5.8175959 · Cited by 290
Effect of a diabetic environment in utero on predisposition to type 2 diabetes
Sobngwi, E., Boudou, P., Mauvais‐Jarvis, F., Leblanc, H., Velho, G., Vexiau, P., Porcher, R., Hadjadj, S., Pratley, R. E., Tataranni, P. A., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13505-2 · Cited by 290
Self-citationThe role of androgens in metabolism, obesity, and diabetes in males and females
Navarro, G., Allard, C., Xu, W., & Mauvais‐Jarvis, F. (2015) · Obesity · doi:10.1002/oby.21033 · Cited by 289
Self-citationAlonso-Magdalena, P., Laribi, O., Ropero, A., Fuentes, E., Ripoll, C., Soria, B., & Nadal, A. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.8002 · Cited by 287
A Guide for the Design of Pre-clinical Studies on Sex Differences in Metabolism
Mauvais‐Jarvis, F., Arnold, A. P., & Reue, K. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.033 · Cited by 284
Self-citationHuang, C., Snider, F., & Cross, J. C. (2009) · Endocrinology · doi:10.1210/en.2008-1003 · Cited by 275
Treg suppressive activity involves estrogen-dependent expression of programmed death-1 (PD-1)
Polanczyk, M. J., Hopke, C., Vandenbark, A. A., & Offner, H. (2007) · International Immunology · doi:10.1093/intimm/dxl151 · Cited by 254
Nuutila, P., Knuuti, M. J., Mäki, M., Laine, H., Ruotsalainen, U., Teräs, M., Haaparanta, M., Solin, O., & Yki-Järvinen, H. (1995) · Diabetes · doi:10.2337/diab.44.1.31 · Cited by 253
Hall, E., Volkov, P., Dayeh, T., Esguerra, J. L. S., Salö, S., Eliasson, L., Rönn, T., Bacos, K., & Ling, C. (2014) · Genome Biology · doi:10.1186/s13059-014-0522-z · Cited by 249
Importance of oestrogen receptors to preserve functional β-cell mass in diabetes
Tiano, J. P., & Mauvais‐Jarvis, F. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.242 · Cited by 246
Self-citationDefects in beta-cell function in functional ovarian hyperandrogenism
O’Meara, N., Blackman, J. D., Ehrmann, D. A., Barnes, R. B., Jaspan, J. B., Rosenfield, R. L., & Polonsky, K. S. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.5.8496316 · Cited by 244
Regulatory T‐cell physiology and application to treat autoimmunity
Tang, Q., & Bluestone, J. A. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00421.x · Cited by 233
Liu, S., May, C. L., Wong, W. P. S., Ward, R. D., Clegg, D. J., Marcelli, M., Korach, K. S., & Mauvais‐Jarvis, F. (2009) · Diabetes · doi:10.2337/db09-0257 · Cited by 198
Self-citationEndocrine and metabolic programming during intrauterine development
Fowden, A. L., Giussani, D. A., & Forhead, A. J. (2005) · Early Human Development · doi:10.1016/j.earlhumdev.2005.06.007 · Cited by 196
Influence of Maternal Obesity on Insulin Sensitivity and Secretion in Offspring
Mingrone, G., Manco, M., Mora, M. E. V., Guidone, C., Iaconelli, A., Gniuli, D., Leccesi, L., Chiellini, C., & Ghirlanda, G. (2008) · Diabetes Care · doi:10.2337/dc08-0432 · Cited by 182
Impact of islet architecture on β-cell heterogeneity, plasticity and function
Roscioni, S. S., Migliorini, A., Gegg, M., & Lickert, H. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.147 · Cited by 181
Kondegowda, N. G., Fenutría, R., Pollack, I., Orthofer, M., García-Ocaña, A., Penninger, J. M., & Vasavada, R. C. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.021 · Cited by 176
Navarro, G., Xu, W., Jacobson, D. A., Wicksteed, B. L., Allard, C., Zhang, G., Gendt, K. D., Kim, S. H., Wu, H., Zhang, H., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.03.015 · Cited by 172
Self-citationBisphenol A Exposure Disrupts Metabolic Health Across Multiple Generations in the Mouse
Susiarjo, M., Xin, F., Bansal, A., Stefaniak, M., Li, C., Simmons, R. A., & Bartolomei, M. S. (2015) · Endocrinology · doi:10.1210/en.2014-2027 · Cited by 159
Sicree, R. A., Zimmet, P. Z., Dunstan, D. W., Cameron, A. J., Welborn, T. A., & Shaw, J. E. (2008) · Diabetic Medicine · doi:10.1111/j.1464-5491.2007.02362.x · Cited by 155
Branum, A. M., Kirmeyer, S., & Gregory, E. C. W. (2016) · PubMed · Cited by 152
New Understanding of β-Cell Heterogeneity and In Situ Islet Function
Benninger, R. K. P., & Hodson, D. J. (2018) · Diabetes · doi:10.2337/dbi17-0040 · Cited by 152
Gourdy, P., Araujo, L. M. M., Zhu, R., Garmy-Susini, B. H., Diem, S., Laurell, H., Leite‐de‐Moraes, M., Dy, M., Arnal, J., Bayard, F., et al. (2004) · Blood · doi:10.1182/blood-2004-07-2819 · Cited by 150
Yokomizo, H., Inoguchi, T., Sonoda, N., Sakaki, Y., Maeda, Y., Inoue, T., Hirata, E., Takei, R., Ikeda, N., Fujii, M., et al. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00688.2013 · Cited by 141
Stein, A. D., Ravelli, A. C. J., & Lumey, L. H. (1995) · PubMed · Cited by 141
Sexual Function and Endocrine Profile in Fertile Women With Type 1 Diabetes
Salonia, A., Lanzi, R., Scavini, M., Pontillo, M., Gatti, E., Petrella, G., Licata, G., Nappi, R. E., Bosi, E., Briganti, A., et al. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1067 · Cited by 137
Demirci, C., Ernst, S., Álvarez-Pérez, J. C., Rosa, T. C., Valle, S. R., Shridhar, V., Casinelli, G. P., Alonso, L. C., Vasavada, R. C., & Garcı́a-Ocaña, A. (2012) · Diabetes · doi:10.2337/db11-1154 · Cited by 123
Role of Sex Steroids in β Cell Function, Growth, and Survival
Mauvais‐Jarvis, F. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.08.008 · Cited by 122
Self-citationBansal, A., Rashid, C. S., Xin, F., Li, C., Polyák, E., Duemler, A., van der Meer, T., Stefaniak, M., Wajid, S., Doliba, N. M., et al. (2017) · Environmental Health Perspectives · doi:10.1289/ehp1674 · Cited by 121
Contreras, J. L., Smyth, C. A., Bilbao, G., Young, C. J., Thompson, J. A., & Eckhoff, D. E. (2002) · Transplantation · doi:10.1097/00007890-200211150-00010 · Cited by 118
MAFA missense mutation causes familial insulinomatosis and diabetes mellitus
Iacovazzo, D., Flanagan, S. E., Walker, E. M., Quezado, R., Barros, F. A. D. S., Caswell, R. C., Johnson, M. B., Wakeling, M. N., Brändle, M., Guo, M. A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1712262115 · Cited by 118
Emanuelli, B., Eberlé, D., Suzuki, R., & Kahn, C. R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712275105 · Cited by 114
Kautzky‐Willer, A., Kosi, L., Lin, J., & Mihaljevic, R. (2015) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12449 · Cited by 113
Gender differences in counterregulation to hypoglycaemia
Amiel, S. A., Maran, A., Powrie, J. K., Umpleby, A. M., & Macdonald, I. A. (1993) · Diabetologia · doi:10.1007/bf00402284 · Cited by 113
Mandour, T. M., Kissebah, A. H., & Wynn, V. (1977) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1977.tb01595.x · Cited by 108
T Regulatory Cells in Autoimmune Diabetes: Past Challenges, Future Prospects
Bluestone, J. A., Tang, Q., & Sedwick, C. E. (2008) · Journal of Clinical Immunology · doi:10.1007/s10875-008-9242-z · Cited by 108
Stabilization of Plasma Glucose during Fasting
Merimee, T. J., & Tyson, J. E. (1974) · New England Journal of Medicine · doi:10.1056/nejm197412122912404 · Cited by 107
Wei, J., Sun, X., Chen, Y.-J., Li, Y.-Y., Song, L., Zhou, Z., Xu, B., Lin, Y., & Xu, S. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0356 · Cited by 100
β-Cell Function: A Key Pathological Determinant in Polycystic Ovary Syndrome
Goodarzi, M. O., Erickson, S. W., Port, S. C., Jennrich, R. I., & Korenman, S. G. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1006 · Cited by 99
Theys, N., Bouckenooghe, T., Ahn, M., Remacle, C., & Reusens, B. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00280.2009 · Cited by 94
Havel, P. J., & Åhrén, B. (1997) · Diabetes · doi:10.2337/diab.46.5.801 · Cited by 91
Song, L., Xia, W., Zhao, Z., Li, Y., Lin, Y., Wei, J., Wei, Z., Xu, B., Shen, J., Li, W., et al. (2012) · Journal of Endocrinology · doi:10.1530/joe-12-0219 · Cited by 86
Balhuizen, A., Kumar, R., Amisten, S., Lundquist, I., & Salehi, A. A. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.01.030 · Cited by 85
Effects of ageing and senescence on pancreatic β‐cell function
Helman, A., Avrahami, D., Klochendler, A., Gläser, B., Kaestner, K. H., Ben‐Porath, I., & Dor, Y. (2016) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12719 · Cited by 83
Androgen Excess in Pancreatic β Cells and Neurons Predisposes Female Mice to Type 2 Diabetes
Navarro, G., Allard, C., Morford, J. J., Xu, W., Liu, S., Molinas, A. J. R., Butcher, S. M., Fine, N. H. F., Blandino-Rosano, M., Sure, V. N., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.98607 · Cited by 80
Self-citationRobert, T., Mesmaeker, I. D., Stangé, G. M., Suenens, K. G., Ling, Z., KROON, E. J., & PIPELEERS, D. G. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.01.040 · Cited by 79
Gender influences counterregulatory hormone responses to hypoglycemia
Diamond, M. P., Jones, T. W., Caprio, S., Hallarman, L., Connolly-Diamond, M., Addabbo, M., Tamborlane, W. V., & Sherwin, R. S. (1993) · Metabolism · doi:10.1016/0026-0495(93)90152-e · Cited by 78
Adurthi, S., Kumar, M. M., Vinodkumar, H. S., Mukherjee, G., Krishnamurthy, H., Kshitish, A. K., Bafna, U. D., Uma, D. K., Basavarajegowda, A., Krishna, S., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-17102-w · Cited by 78
17-β Estradiol regulates proglucagon-derived peptide secretion in mouse and human α- and L cells
Handgraaf, S., Dusaulcy, R., Visentin, F., Philippé, J., & Gosmain, Y. (2018) · JCI Insight · doi:10.1172/jci.insight.98569 · Cited by 76
Chamson-Reig, A., Thyssen, S. M., Arany, E. J., & Hill, D. J. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06754 · Cited by 73
Liu, S., Kilic, G., Meyers, M. S., Navarro, G., Wang, Y., Oberholzer, J., & Mauvais‐Jarvis, F. (2012) · Diabetologia · doi:10.1007/s00125-012-2764-1 · Cited by 72
Self-citationCoxsackievirus infection as an environmental factor in the etiology of type 1 diabetes
Richer, M. J., & Horwitz, M. S. (2009) · Autoimmunity Reviews · doi:10.1016/j.autrev.2009.02.006 · Cited by 70
Effects of insulin on the counterregulatory response to equivalent hypoglycemia in normal females
Davis, S. N., Cherrington, A. D., Goldstein, R. E., Jacobs, J. K., & Price, L. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.265.5.e680 · Cited by 69
Maternal malnutrition programs pancreatic islet mitochondrial dysfunction in the adult offspring
Theys, N., Ahn, M., Bouckenooghe, T., Reusens, B., & Remacle, C. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.08.015 · Cited by 68
The physiology and pathophysiology of the neural control of the counterregulatory response
Beall, C., Ashford, M. L., & McCrimmon, R. J. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00531.2011 · Cited by 63
Conrad, E., Dai, C., Spaeth, J. M., Guo, M. A., Cyphert, H. A., Scoville, D. W., Carroll, J. M., Yu, W.-M., Goodrich, L. V., Harlan, D. M., et al. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00285.2015 · Cited by 62
Horie, I., Abiru, N., Eto, M., Sako, A., Akeshima, J., Nakao, T., Nakashima, Y., Niri, T., Ito, A., Nozaki, A., et al. (2018) · Journal of Diabetes Investigation · doi:10.1111/jdi.12829 · Cited by 59
Samuelsson, U., Lindblad, B., Carlsson, A., Forsander, G., Ivarsson, S. A., Kockum, I. S., Lernmark, Å., Marcus, C., Ludvigsson, J., & Better Diabetes Diagnosis (BDD) study group (2012) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2365 · Cited by 50
Sex Differences in Maturation of Human Embryonic Stem Cell–Derived β Cells in Mice
Saber, N., Bruin, J. E., O’Dwyer, S. M., Schuster, H., Rezania, A., & Kieffer, T. J. (2018) · Endocrinology · doi:10.1210/en.2018-00048 · Cited by 49
Kristiansen, O. P. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg132 · Cited by 48
Epigenetic modifiers of islet function and mass
Jesus, D. F. D., & Kulkarni, R. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.08.006 · Cited by 45
Self-citationPancreatic inflammation and increased islet macrophages in insulin-resistant juvenile primates
Nicol, L. E., Grant, W. F., Comstock, S. M., Nguyen, M. L., Smith, M. S., Grove, K. L., & Marks, D. L. (2013) · Journal of Endocrinology · doi:10.1530/joe-12-0424 · Cited by 44
Stereological analyses of the whole human pancreas
Poudel, A., Fowler, J. L., Zielinski, M. C., Kilimnik, G., & Hara, M. (2016) · Scientific Reports · doi:10.1038/srep34049 · Cited by 42
Exploring inter-organ crosstalk to uncover mechanisms that regulate β-cell function and mass
Shirakawa, J., Jesus, D. F. D., & Kulkarni, R. (2017) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2017.13 · Cited by 42
Self-citationMarchese, E., Rodeghier, C., Monson, R. S., McCracken, B., Shi, T., Schrock, W., Martellotto, J., Oberholzer, J., & Danielson, K. K. (2015) · Diabetes Care · doi:10.2337/dc15-0723 · Cited by 41
Avrahami, D., Wang, Y. J., Klochendler, A., Dor, Y., Gläser, B., & Kaestner, K. H. (2017) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13019 · Cited by 39
Men Are from Mars, Women Are from Venus: Sex Differences in Insulin Action and Secretion
Basu, A., Dube, S., & Basu, R. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-70178-3_4 · Cited by 38
Zimmet, P., Elliott, R. B., Mackay, I. R., Tuomi, T., Rowley, M. J., Pilcher, C. C., & Knowles, W. J. (1994) · Diabetic Medicine · doi:10.1111/j.1464-5491.1994.tb00370.x · Cited by 36
Havel, P. J., Parry, S. J., CURRY, D. L., Stern, J. S., Akpan, J. O., & Gingerich, R. L. (1992) · Endocrinology · doi:10.1210/endo.130.4.1347741 · Cited by 35
Gourdy, P., Bourgeois, E. A., Levescot, A., Pham, L., Riant, É., Ahui, M. L. B., Damotte, D., Gombert, J., Bayard, F., Ohlsson, C., et al. (2015) · Endocrinology · doi:10.1210/en.2015-1313 · Cited by 35
Sexual dimorphism in transmission of expression of islet autoantibodies to offspring
Yu, L., Chase, H. P., Falorni, A., Rewers, M., Lernmark, Å., & Eisenbarth, G. S. (1995) · Diabetologia · doi:10.1007/bf00401769 · Cited by 32
Gender difference in the glucagon response to glucopenic stress in mice
Karlsson, S., Scheurink, A. J. W., & Åhrén, B. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2002.282.1.r281 · Cited by 32
Coppieters, K. T., Amirian, N., Pagni, P. P., Jones, C. B., Wiberg, A., Lasch, S., Hintermann, E., Christen, U., & von Herrath, M. G. (2013) · Diabetes · doi:10.2337/db12-1370 · Cited by 31
Modulation of innate immunity in human pancreatic islets infected with enterovirus in vitro
Skog, O., Korsgren, O., & Frisk, G. (2011) · Journal of Medical Virology · doi:10.1002/jmv.21924 · Cited by 29
Gender and neurogenin3 influence the pathogenesis of ketosis‐prone diabetes
Louet, J. ‐., Smith, S. B., Gautier, J. ‐., Molokhia, M., Virally, M. ‐., Kevorkian, J. ‐., Guillausseau, P. ‐., Vexiau, P., Charpentier, G., German, M. S., et al. (2008) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2007.00830.x · Cited by 26
Self-citationLi, T., Jiao, W., Li, W., & Li, H. (2016) · Endocrine Research · doi:10.3109/07435800.2015.1124437 · Cited by 24
Innate Viral Receptor Signaling Determines Type 1 Diabetes Onset
Morse, Z. J., & Horwitz, M. S. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00249 · Cited by 24
Experimental diets affect pancreatic insulin and glucagon differently in male and female mice
Bonnevie‐Nielsen, V. (1980) · Metabolism · doi:10.1016/0026-0495(80)90014-1 · Cited by 22
Dimitriadis, G. K., Randeva, H. S., Aftab, S., Ali, A., Hattersley, J. G., Pandey, S., Grammatopoulos, D. K., Valsamakis, G., Mastorakos, G., Jones, T. H., et al. (2018) · Endocrine · doi:10.1007/s12020-017-1516-x · Cited by 17
Bonnevie-Nielsen, V. (1982) · PubMed · Cited by 16
Androgen-deprivation therapy and pancreatic β-cell dysfunction in men
Mauvais‐Jarvis, F. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.01.007 · Cited by 15
Self-citationDevelopmental programming of the pancreatic islet by in utero overnutrition.
Elsakr, J. M., & GANNON, M. A. (2017) · PubMed · Cited by 15
Self-citationvan der Kroon, I., der Weg, W. W.-V., Brom, M., Joosten, L., Frielink, C., Konijnenberg, M., Visser, E. P., & Gotthardt, M. (2017) · Scientific Reports · doi:10.1038/srep39800 · Cited by 11
Understanding Autoimmune Diabetes through the Prism of the Tri-Molecular Complex
Bettini, M. L., & Bettini, M. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00351 · Cited by 11
Effect of sex on histomorphometric properties of Langerhans islets in native chickens.
Parchami, A., & Kusha, S. (2015) · Europe PMC (PubMed Central) · Cited by 10
Sex Difference In the Effect of Fetal Exposure to Maternal Diabetes on Insulin Secretion
Gautier, J., Fetita, L.-S., Riveline, J., Ibrahim, F., Porcher, R., Khalil, C. A., Velho, G., Choukem, S. P., Hadjadj, S., Larger, É., et al. (2018) · Journal of the Endocrine Society · doi:10.1210/js.2017-00482 · Cited by 9
Self-citationAre estrogens promoting immune modulation and islet protection in type 1 diabetes?
Mauvais‐Jarvis, F. (2017) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2017.07.015 · Cited by 6
Self-citationAdrenal interference of insulin secretion after 14-days oestradiol treatment in female rats
Faure, A., Billaudel, B. J. L., & Sutter, B. C. J. (1984) · Diabetologia · doi:10.1007/bf00252268 · Cited by 5
Cited by
Sorted by citations
Sexual dimorphism in cardiometabolic health: the role of adipose tissue, muscle and liver
Goossens, G. H., Jocken, J. W. E., & Blaak, E. E. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-00431-8 · Cited by 359
Streptozotocin as a tool for induction of rat models of diabetes: a practical guide
Ghasemi, A., & Jeddi, S. (2022) · EXCLI journal · doi:10.17179/excli2022-5720 · Cited by 273
Sex differences in energy metabolism: natural selection, mechanisms and consequences
Mauvais‐Jarvis, F. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00781-2 · Cited by 174
Self-citationRentzeperi, E., Pegiou, S., Koufakis, T., Grammatiki, M., & Kotsa, K. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12030454 · Cited by 140
Hepatic sexual dimorphism — implications for non-alcoholic fatty liver disease
Lefèbvre, P., & Staels, B. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00538-6 · Cited by 121
Metadata
- Authors
- Gannon, M., Kulkarni, R. N., Tse, H. M., & Mauvais-Jarvis, F.
- Affiliations
- VA Tennessee Valley Healthcare System (US)
- Joslin Diabetes Center (US)
- University of Alabama at Birmingham (US)
- Venue
- Molecular Metabolism
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 15
- Pages
- 82-91
- ISSN
- 2212-8778 (ISSN-L)
- PMC
- PMC6066785
- OpenAlex
- W2806507802
- Cited by
- 133
- References
- 120
- Citations by year
- 2026: 13 · 2025: 18 · 2024: 14 · 2023: 17 · 2022: 23 · 2021: 27 · 2020: 10 · 2019: 7 · 2018: 3
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecular Metabolism (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Juvenile Diabetes Research Foundation United States of America (BX003725, 2 -SRA-2016-270-S-B, R01 DK107444, R01 DK074970, 2-PNF-2016-322-S-B)
- National Institutes of Health (R01 DK105689, 2R24 DK090964-06)
- U.S. Department of Veterans Affairs (BX003744, R01 DK099550, R01 DK103215, R01 DK67536)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
- Keywords
- sex differences, pancreatic islets, beta-cell dysfunction, alpha-cell dysfunction, islet heterogeneity, pregnancy, nutrition, diabetes susceptibility, glucose homeostasis
- MeSH terms
- Animals, Diabetes Mellitus, Humans, Islets of Langerhans, Sex Characteristics, Gonadal Hormones
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
