Cited by 135Pancreatic function and diabetesDiabetes and associated disordersSex and Gender in Healthcare

The DOI matches its Crossref record; 119 of the 120 references it cites were found in a registry or an index.

Sex differences underlying pancreatic islet biology and its dysfunction

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Gannon, Maureen, Kulkarni, Rohit N., Tse, Hubert M., Mauvais-Jarvis, Franck·2018·Molecular Metabolism

Abstract

BACKGROUND: The sex of an individual affects glucose homeostasis and the pathophysiology, incidence, and prevalence of diabetes as well as the response to therapy. SCOPE OF THE REVIEW: This review focuses on clinical and experimental sex differences in islet cell biology and dysfunction during development and in adulthood in human and animal models. We discuss sex differences in β-cell and α-cell function, heterogeneity, and dysfunction. We cover sex differences in communication between gonads and islets and islet-cell immune interactions. Finally, we discuss sex differences in β-cell programming by nutrition and other environmental factors during pregnancy. MAJOR CONCLUSIONS: Important sex differences exist in islet cell function and susceptibility to failure. These differences represent sex-related biological factors that can be harnessed for gender-based prevention of and therapy for diabetes.

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Crossref · 10.1016/j.molmet.2018.05.017

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Figure 1 Summary of sex differences in islet biology and failure.
Figure 1 Summary of sex differences in islet biology and failure.CC BY-NC-ND · PubMed Central

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Metadata

Authors
Gannon, M., Kulkarni, R. N., Tse, H. M., & Mauvais-Jarvis, F.
Affiliations
  • VA Tennessee Valley Healthcare System (US)
  • Joslin Diabetes Center (US)
  • University of Alabama at Birmingham (US)
Venue
Molecular Metabolism
Publisher
Elsevier BV
Published
2018-09
Volume
15
Pages
82-91
ISSN
2212-8778 (ISSN-L)
OpenAlex
W2806507802
Cited by
133
References
120
Citations by year
2026: 13 · 2025: 18 · 2024: 14 · 2023: 17 · 2022: 23 · 2021: 27 · 2020: 10 · 2019: 7 · 2018: 3
FWCI
2.61
Type
journal article
Language
en
Open access
Locations
  • Molecular Metabolism (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Juvenile Diabetes Research Foundation United States of America (BX003725, 2 -SRA-2016-270-S-B, R01 DK107444, R01 DK074970, 2-PNF-2016-322-S-B)
  • National Institutes of Health (R01 DK105689, 2R24 DK090964-06)
  • U.S. Department of Veterans Affairs (BX003744, R01 DK099550, R01 DK103215, R01 DK67536)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
Keywords
sex differences, pancreatic islets, beta-cell dysfunction, alpha-cell dysfunction, islet heterogeneity, pregnancy, nutrition, diabetes susceptibility, glucose homeostasis
MeSH terms
Animals, Diabetes Mellitus, Humans, Islets of Langerhans, Sex Characteristics, Gonadal Hormones

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