The DOI matches its Crossref record; 209 of the 209 references it cites were found in a registry or an index.
The brain as an insulin-sensitive metabolic organ
Open accessAbstract
BACKGROUND: The brain was once thought of as an insulin-insensitive organ. We now know that the insulin receptor is present throughout the brain and serves important functions in whole-body metabolism and brain function. Brain insulin signaling is involved not only in brain homeostatic processes but also neuropathological processes such as cognitive decline and Alzheimer's disease. SCOPE OF REVIEW: In this review, we provide an overview of insulin signaling within the brain and the metabolic impact of brain insulin resistance and discuss Alzheimer's disease, one of the neurologic diseases most closely associated with brain insulin resistance. MAJOR CONCLUSIONS: While brain insulin signaling plays only a small role in central nervous system glucose regulation, it has a significant impact on the brain's metabolic health. Normal insulin signaling is important for mitochondrial functioning and normal food intake. Brain insulin resistance contributes to obesity and may also play an important role in neurodegeneration.
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“Because astrocytes contribute to neuronal metabolic homeostasis and respond to neuronal firing by releasing lactate [56,105,109], these findings may have implications for astrocyte insulin signaling in maintaining neuronal metabolism and brain metabolic defects observed in insulin-resistant conditions.”
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The physiological control of eating: signals, neurons, and networks
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Incretin and insulin signaling as novel therapeutic targets for Alzheimer’s and Parkinson’s disease
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Piccialli, I., Tedeschi, V., Caputo, L., D’Errico, S., Ciccone, R., De Feo, V., Secondo, A., & Pannaccione, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.876614 · Cited by 73
State of the science on brain insulin resistance and cognitive decline due to Alzheimer's disease
Rhea, E. M., Leclerc, M., Yassine, H. N., Capuano, A. W., Tong, H., Petyuk, V. A., Macauley, S. L., Fioramonti, X., Carmichael, O., Calon, F., et al. (2023) · Aging and disease · doi:10.14336/ad.2023.0814 · Cited by 70
Yue, Q., Leng, X., Xie, N., Zhang, Z., Yang, D., & Hoi, M. P. M. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70079 · Cited by 48
Metadata
- Authors
- Milstein, J. L., & Ferris, H. A.
- Venue
- Molecular Metabolism
- Publisher
- Elsevier BV
- Published
- 2021-10
- Volume
- 52
- Pages
- 101234
- ISSN
- 2212-8778 (ISSN-L)
- OpenAlex
- W3153955578
- Cited by
- 259
- References
- 209
- FWCI
- 12.99
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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