State of the science on brain insulin resistance and cognitive decline due to Alzheimer's disease

Tissue-based map of the human proteome

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Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition

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NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease

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Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019

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An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

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Insulin signalling and the regulation of glucose and lipid metabolism

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Use and Abuse of HOMA Modeling

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Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

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Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

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Impact of sleep debt on metabolic and endocrine function

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The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

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Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

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A molecular atlas of cell types and zonation in the brain vasculature

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Drug Transport across the Blood–Brain Barrier

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Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

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The role of apolipoprotein E in Alzheimer's disease

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Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

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Bidirectional associations between COVID-19 and psychiatric disorder: retrospective cohort studies of 62 354 COVID-19 cases in the USA.

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Insulin Receptor Signaling in Normal and Insulin-Resistant StatesPreprint

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Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo

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Participation in Cognitively Stimulating Activities and Risk of Incident Alzheimer Disease

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Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function

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Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment: A Pilot Clinical Trial

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Massively parallel single-nucleus RNA-seq with DroNc-seq

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Insulin and insulin resistance.

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Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

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Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

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Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways

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Adverse Metabolic Consequences in Humans of Prolonged Sleep Restriction Combined with Circadian Disruption

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Glucose Levels and Risk of Dementia

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Insulin Receptor Isoform A, a Newly Recognized, High-Affinity Insulin-Like Growth Factor II Receptor in Fetal and Cancer Cells

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β-Amyloid accumulation in the human brain after one night of sleep deprivation

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Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches

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Intranasal insulin improves cognition and modulates β-amyloid in early AD

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New-onset diabetes in Covid-19

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A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk

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Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer’s disease

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Brain insulin and insulin receptors in aging and sporadic Alzheimer’s disease

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Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease

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Biochemical and cellular properties of insulin receptor signalling

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Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector

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Intranasal insulin improves memory in humans

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Insulin Action in AgRP-Expressing Neurons Is Required for Suppression of Hepatic Glucose Production

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Alzheimer’s disease drug development pipeline: 2022

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Proteogenomic and metabolomic characterization of human glioblastoma

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Diet‐induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease

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Hypothalamic KATP channels control hepatic glucose production

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Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes

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What is resilience? An integrative review of the empirical literature.

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Effects of intranasal insulin on cognition in memory-impaired older adults: Modulation by APOE genotype

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Sleep Restriction for 1 Week Reduces Insulin Sensitivity in Healthy Men

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Proteogenomic characterization of pancreatic ductal adenocarcinoma

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Insulin in the brain: There and back again

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Self-reported sleep and β-amyloid deposition in community-dwelling older adults

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Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: Relationship to severity of dementia and apolipoprotein E genotype

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Memory improvement following induced hyperinsulinemia in Alzheimer’s disease

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Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults

Reger, M. A., Watson, G. S., Green, P. S., Baker, L. D., Cholerton, B., Fishel, M. A., Plymate, S. R., Cherrier, M. M., Schellenberg, G. D., Frey, W. H., et al. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-13309 · Cited by 521 · see citing works

Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability

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CSF, blood-brain barrier, and brain drug delivery

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Insulin/Insulin-like Growth Factor I Hybrid Receptors Have Different Biological Characteristics Depending on the Insulin Receptor Isoform Involved

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Obesity and diabetes as high‐risk factors for severe coronavirus disease 2019 ( Covid ‐19)

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Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats

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Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain.

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Insulin resistance in brain alters dopamine turnover and causes behavioral disorders

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Long-Acting Intranasal Insulin Detemir Improves Cognition for Adults with Mild Cognitive Impairment or Early-Stage Alzheimer's Disease Dementia

Claxton, A., Baker, L. D., Hanson, A., Trittschuh, E. H., Cholerton, B., Morgan, A., Callaghan, M., Arbuckle, M., Behl, C., & Craft, S. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-141791 · Cited by 467 · see citing works

High-throughput phosphoproteomics reveals in vivo insulin signaling dynamics

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The insulin receptor: structure, function, and signaling

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Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle

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How insulin engages its primary binding site on the insulin receptor

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Blood-Based Protein Biomarkers for Diagnosis of Alzheimer Disease

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Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle–Aged Adults at Risk for Alzheimer Disease

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The Catabolic Action of Insulin in the Brain Is Mediated by Melanocortins

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Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types

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Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance

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Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia: A Randomized Clinical Trial

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Insulin Receptor Isoforms in Physiology and Disease: An Updated View

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A proteogenomic portrait of lung squamous cell carcinoma

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Functionally distinct insulin receptors generated by tissue‐specific alternative splicing.

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Intracerebroventricular Streptozotocin Injections as a Model of Alzheimer’s Disease: in Search of a Relevant Mechanism

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The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance

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