CoChat
Sign Up
Cited by 10

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

BACE2 suppression in mice aggravates the adverse metabolic consequences of an obesogenic diet

Díaz-Catalán, Daniela, Alcarraz-Vizán, Gema, Castaño, Carlos, de Pablo, Sara, Rodríguez-Comas, Júlia, Fernández-Pérez, Antonio, Vallejo, Mario, Ramírez, Sara, Claret, Marc, Parrizas, Marcelina, Novials, Anna, Servitja, Joan-Marc·2021·Molecular Metabolism
DOI 10.1016/j.molmet.2021.101251PMC PMC8190493
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.molmet.2021.101251

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • BACE2 knockout is associated with an adverse metabolic phenotype, including enhanced weight gain, hyperphagia, hyperinsulinemia, and leptin and insulin resistance.

    “By contrast, BACE2 knockout is associated with an adverse metabolic phenotype, including enhanced weight gain, hyperphagia, hyperinsulinemia, and leptin and insulin resistance.”

    From BACE1: More than just a β‐secretase (2022) · cites this paper as [116]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 42

  1. Ogurtsova, 2017, IDF Diabetes Atlas: global estimates for the prevalence of diabetes for 2015 and 2040, Diabetes Research and Clinical Practice, 128, 40, 10.1016/j.diabres.2017.03.024 · DOI
  2. Nolan, 2019, Insulin resistance and insulin hypersecretion in the metabolic syndrome and type 2 diabetes: time for a conceptual framework shift, Diabetes and Vascular Disease Research, 16, 118, 10.1177/1479164119827611 · DOI · Paper page
  3. Friedman, 2019, Leptin and the endocrine control of energy balance, Nature Metabolism, 1, 754, 10.1038/s42255-019-0095-y · DOI · Paper page
  4. Timper, 2017, Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity, Disease Models & Mechanisms, 10, 679, 10.1242/dmm.026609 · DOI
  5. Turner, 2013, Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding, Diabetologia, 56, 1638, 10.1007/s00125-013-2913-1 · DOI · Paper page
  6. Olofsson, 2013, Modulation of AgRP-neuronal function by SOCS3 as an initiating event in diet-induced hypothalamic leptin resistance, Proceedings of the National Academy of Sciences of the United States of America, 110, 697
  7. Yang, 2014, Variations in body weight, Food Intake and body composition after long-term high-fat diet feeding in C57BL/6J mice, Obesity, 22, 2147, 10.1002/oby.20811 · DOI
  8. Lin, 2000, Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein, Proceedings of the National Academy of Sciences of the United States of America, 97, 1456, 10.1073/pnas.97.4.1456 · DOI
  9. Alcarraz-Vizán, 2017, BACE2 suppression promotes β-cell survival and function in a model of type 2 diabetes induced by human islet amyloid polypeptide overexpression, Cellular and Molecular Life Sciences, 74, 2827, 10.1007/s00018-017-2505-1 · DOI
  10. Esterházy, 2011, Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass, Cell Metabolism, 14, 365, 10.1016/j.cmet.2011.06.018 · DOI · Paper page
  11. Zhao, 2007, β-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis, Journal of Neuroscience, 27, 3639, 10.1523/JNEUROSCI.4396-06.2007 · DOI · Paper page
  12. Vassar, 1999, Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE, Science (New York, N.Y.), 286, 735, 10.1126/science.286.5440.735 · DOI · Paper page
  13. Bennett, 2000, Expression analysis of BACE2 in brain and peripheral tissues, Journal of Biological Chemistry, 275, 20647, 10.1074/jbc.M002688200 · DOI · Paper page
  14. Alcarraz-Vizán, 2015, Inhibition of BACE2 counteracts hIAPP-induced insulin secretory defects in pancreatic β-cells, FASEB Journal, 29, 95, 10.1096/fj.14-255489 · DOI
  15. Voytyuk, 2018, BACE2 distribution in major brain cell types and identification of novel substrates, Life Science Alliance, 1, 10.26508/lsa.201800026 · DOI
  16. Wang, 2019, BACE2, a conditional β-secretase, contributes to Alzheimer's disease pathogenesis, JCI Insight, 4, 10.1172/jci.insight.123431 · DOI
  17. Finzi, 2008, BACE2 is stored in secretory granules of mouse and rat pancreatic β cells, Ultrastructural Pathology, 32, 246, 10.1080/01913120802486217 · DOI
  18. Casas, 2010, BACE2 plays a role in the insulin receptor trafficking in pancreatic β-cells, American Journal of Physiology - Endocrinology and Metabolism, 299, 1087, 10.1152/ajpendo.00420.2010 · DOI
  19. Kennedy, 2016, The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients, Science Translational Medicine, 8, 363, 10.1126/scitranslmed.aad9704 · DOI
  20. Hampel, 2020, The β-secretase BACE1 in Alzheimer's disease, Biological Psychiatry, 11, 1
  21. Probst, 2012, Small-molecule BACE1 inhibitors: a patent literature review (2006 - 2011), Expert Opinion on Therapeutic Patents, 22, 511, 10.1517/13543776.2012.681302 · DOI
  22. Meakin, 2012, Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice, Biochemical Journal, 441, 285, 10.1042/BJ20110512 · DOI · Paper page
  23. Meakin, 2018, Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice, Scientific Reports, 8, 55, 10.1038/s41598-017-18388-6 · DOI · Paper page
  24. Ghosh, 2019, Highly selective and potent human β-secretase 2 (BACE2) inhibitors against type 2 diabetes: design, synthesis, X-ray structure and structure–activity relationship studies, ChemMedChem, 14, 545, 10.1002/cmdc.201800725 · DOI
  25. Dominguez, 2005, Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice, Journal of Biological Chemistry, 280, 30797, 10.1074/jbc.M505249200 · DOI
  26. Cui, 2017, Optimized analysis of In vivo and In vitro hepatic steatosis, Journal of Visualized Experiments, 10.3791/55178 · DOI
  27. Moreno-Asso, 2013, Glucose regulation of a cell cycle gene module is selectively lost in mouse pancreatic islets during ageing, Diabetologia, 56, 1761, 10.1007/s00125-013-2930-0 · DOI
  28. Rueden, 2017, ImageJ2: ImageJ for the next generation of scientific image data, BMC Bioinformatics, 18, 529, 10.1186/s12859-017-1934-z · DOI
  29. Winzell, 2007, Temporal and dietary fat content-dependent islet adaptation to high-fat feeding-induced glucose intolerance in mice, Metabolism: Clinical and Experimental, 56, 122, 10.1016/j.metabol.2006.09.008 · DOI
  30. Mosser, 2015, High-fat diet-induced β-cell proliferation occurs prior to insulin resistance in C57Bl/6J male mice, American Journal of Physiology-Endocrinology and Metabolism, 308, E573, 10.1152/ajpendo.00460.2014 · DOI
  31. Kwon, 2016, Leptin signalling pathways in hypothalamic neurons, Cellular and Molecular Life Sciences, 73, 1457, 10.1007/s00018-016-2133-1 · DOI
  32. Stützer, 2013, Systematic proteomic analysis identifies β-site amyloid precursor protein cleaving enzyme 2 and 1 (BACE2 and BACE1) substrates in pancreatic β-cells, Journal of Biological Chemistry, 288, 10536, 10.1074/jbc.M112.444703 · DOI · Paper page
  33. Ramírez, 2017, Mitochondrial dynamics mediated by mitofusin 1 is required for POMC neuron glucose-sensing and insulin release control, Cell Metabolism, 25, 1390, 10.1016/j.cmet.2017.05.010 · DOI
  34. Alonge, 2021, Brain control of blood glucose levels: implications for the pathogenesis of type 2 diabetes, Diabetologia, 64, 5, 10.1007/s00125-020-05293-3 · DOI
  35. Rosario, 2016, The brain-to-pancreatic islet neuronal map reveals differential glucose regulation from distinct hypothalamic regions, Diabetes, 65, 2711, 10.2337/db15-0629 · DOI
  36. Rulifson, 2016, Identification of human islet amyloid polypeptide as a BACE2 substrate, PloS One, 11, 10.1371/journal.pone.0147254 · DOI
  37. Blüher, 2003, Extended longevity in mice lacking the insulin receptor in adipose tissue, Science, 299, 572, 10.1126/science.1078223 · DOI · Paper page
  38. Page, 2018, Mild suppression of hyperinsulinemia to treat obesity and insulin resistance, Trends in Endocrinology and Metabolism, 29, 389, 10.1016/j.tem.2018.03.018 · DOI · Paper page
  39. Vetterli, 2016, The amplifying pathway of the β-cell contributes to diet-induced obesity, Journal of Biological Chemistry, 291, 13063, 10.1074/jbc.M115.707448 · DOI
  40. Lee, 2011, PWD/PhJ and WSB/EiJ mice are resistant to diet-induced obesity but have abnormal insulin secretion, Endocrinology, 152, 3005, 10.1210/en.2011-0060 · DOI
  41. Chen, 2017, Hypothalamic insulin resistance in obesity: effects on glucose homeostasis, Neuroendocrinology, 104, 364, 10.1159/000455865 · DOI
  42. Ono, 2019, Molecular mechanisms of hypothalamic insulin resistance, International Journal of Molecular Sciences, 20, 1317, 10.3390/ijms20061317 · DOI

Cited by

Sorted by citations

Metadata

Authors
Díaz-Catalán, D., Alcarraz-Vizán, G., Castaño, C., de Pablo, S., Rodríguez-Comas, J., Fernández-Pérez, A., Vallejo, M., Ramírez, S., Claret, M., Parrizas, M., Novials, A., & Servitja, J.-M.
ORCID
Venue
Molecular Metabolism
Publisher
Elsevier BV
Published
2021-11
Volume
53
Pages
101251
ISSN
2212-8778
DOI
10.1016/j.molmet.2021.101251
PMC
PMC8190493
Cited by
10
References
1
Language
en
Licence
Funders
  • Ministerio de Ciencia e Innovación
  • European Regional Development Fund
  • Generalitat de Catalunya (2014_SGR_520)
  • Ministerio de Economía y Competitividad (BFU2017-89336-R)
  • Comisión Nacional de Investigación Científica y Tecnológica
  • Instituto de Salud Carlos III (PI17/00879)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review