The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Progression from ductal carcinoma in situ to invasive breast cancer: Revisited
Open accessAbstract
Ductal carcinoma in situ (DCIS) is an intraductal neoplastic proliferation of epithelial cells that is separated from the breast stroma by an intact layer of basement membrane and myoepithelial cells. DCIS is a non‐obligate precursor of invasive breast cancer, and up to 40% of these lesions progress to invasive disease if untreated. Currently, it is not possible to predict accurately which DCIS would be more likely to progress to invasive breast cancer as neither the significant drivers of the invasive transition have been identified, nor has the clinical utility of tests predicting the likelihood of progression been demonstrated. Although molecular studies have shown that qualitatively, synchronous DCIS and invasive breast cancers are remarkably similar, there is burgeoning evidence to demonstrate that intra‐tumor genetic heterogeneity is observed in a subset of DCIS, and that the process of progression to invasive disease may constitute an ‘evolutionary bottleneck’, resulting in the selection of subsets of tumor cells with specific genetic and/or epigenetic aberrations. Here we review the clinical challenge posed by DCIS, the contribution of the microenvironment and genetic aberrations to the progression from in situ to invasive breast cancer, the emerging evidence of the impact of intra‐tumor genetic heterogeneity on this process, and strategies to combat this heterogeneity.
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Cites
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Cited by
Multiclonal Invasion in Breast Tumors Identified by Topographic Single Cell Sequencing
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Ductal carcinoma in situ: to treat or not to treat, that is the question
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Family history and risk of breast cancer: an analysis accounting for family structure
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Impact of Epithelial–Stromal Interactions on Peritumoral Fibroblasts in Ductal Carcinoma in Situ
Strell, C., Paulsson, J., Jin, S.-B., Tobin, N. P., Mezheyeuski, A., Roswall, P., Mutgan, C., Mitsios, N., Johansson, H., Wickberg, S. M., et al. (2019) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djy234 · Cited by 158
Metadata
- Authors
- Cowell, C. F., Weigelt, B., Sakr, R. A., Ng, C. K. Y., Hicks, J., King, T. A., & Reis-Filho, J. S.
- Venue
- Molecular Oncology
- Publisher
- Wiley
- Published
- 2013-07-12
- Volume
- 7
- Issue
- 5
- Pages
- 859-869
- ISSN
- 1574-7891 (ISSN-L)
- 1878-0261
- OpenAlex
- W1966934872
- Cited by
- 257
- References
- 76
- FWCI
- 11.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cowell, C. F., Weigelt, B., Sakr, R. A., Ng, C. K. Y., Hicks, J., King, T. A., & Reis-Filho, J. S. (2013). Progression from ductal carcinoma in situ to invasive breast cancer: Revisited. Molecular Oncology. https://doi.org/10.1016/j.molonc.2013.07.005
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
